b3

LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.

Saikosaponin b3 is isolated from the roots of Bupleurum falcatum L.. Saikosaponin b3 inhibits ACTH-induced lipolysis in the fat cells and exhibits analgesic effects.

Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.

Fumonisin B3, a mycotoxin derived from fusarium fungi, is a member of fumonisins.

Procyanidin B3-3-O-gallate is a naturally occurring tannin compound found in the plant Sanguisorba officinal.

Ilexoside K is a natural product from Ilex pubescens.

Niacin (Nicotinic acid) is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.

Nicotinamide, a vitamin B3 derivative, is an inhibitor of SIRT1 (IC50=50-180 μM) and SIRT2 (IC50=2 μM). Nicotinamide can be used as a precursor of nicotinamide adenine dinucleotide or NAD+, which can be supplemented by dietary intake and can prevent or treat melanoglossia and pellagra.

Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory properties. Upon ophthalmic administration, bromfenac binds to and inhibits cyclooxygenase II (COX II), an enzyme that converts arachidonic acid to cyclic endoperoxides, which are prostaglandin (PG) precursors. By inhibiting PG formation, bromfenac prevents PG-induced inflammation, vasodilation, leukocytosis, disruption of the blood-aqueous humor barrier, increased vascular permeability, and elevated intraocular pressure (IOP).

β3-AR agonist 1 is a highly selective, and orally available agonist of β3-adrenergic receptor (EC50: 18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).

β3-AR agonist 2 is a potent and selective agonist of β3-adrenergic receptor (β3-AR with an EC50 of 8 nM).

Clostomycin B2 is a bioactive chemical.

Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

Nicotinamide-D4 is a deuterium-labelled compound of Nicotinamide (TMSM-1731) for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.

Niacin (Standard) is the analytical standard of Niacin (Vitamin B3). As an essential water-soluble nutrient and a primary precursor to the coenzymes NAD+ and NADP+, it plays a fundamental role in cellular energy metabolism, gene expression, and the regulation of apoptosis. Niacin acts as an agonist for the GPR109A receptor, modulating lipid profiles and exerting anti-inflammatory effects. It is a cornerstone molecule in research concerning cardiovascular health, metabolic homeostasis, and the mechanisms of aging.

Nicotinamide-13C6 (Standard) is a reference standard of Nicotinamide-13C6 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-13C6 is a 13C-labeled form of Nicotinamide. As a vitamin B3, Nicotinamide plays a crucial role in cellular physiology by supporting NAD+ redox homeostasis and serving as a substrate for a class of enzymes that catalyze non-redox reactions. It is also known as a SIRT1 inhibitor.

Nicotinamide-15N,13C3 (Standard) is a reference standard of Nicotinamide-15N,13C3 intended for quantitative analysis, quality control, and related biochemical research applications. Nicotinamide-15N,13C3 is a form of nicotinamide labeled with 13C and 15N. Nicotinamide, a vitamin B3, is crucial in cellular physiology by maintaining NAD+ redox balance and supplying NAD+ as a substrate for enzymes catalyzing non-redox reactions. Nicotinamide also acts as an SIRT1 inhibitor.

2′′-N-Formimidoylistamycin B (Istamycin B3) can be found in Streptomyces species.

NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM).

H1L1A1B3, an ionizable cationic lipid, is commonly used alongside other lipids to create lipid nanoparticles (LNPs) designed for the delivery of circular RNA (circRNA) both in vitro and in vivo.

Prostaglandin B3 (PGB3) is a secondary alcohol belonging to the prostaglandin B class, characterized by its relatively low affinity for human PPARγ, exhibiting a K_i value greater than 1 mM, in contrast to PGB1 and PGB2, which have K_i values of 26.28 ± 8.7 μM and 77 ± 37.7 μM, respectively [1].

Vitamin B3-d4 (nicotinic acid-d4) is a tetradeuterated stable isotope label of natural vitamin B3 (nicotinic acid) used to track the metabolism of vitamin B3 in the body. Vitamin B3-d4 is commonly used in pharmacokinetic studies of vitamin B3 and for isotope tracing of nicotinic acid metabolic pathways.

Procyanidin B3 (Standard) is a reference standard for research and analysis in studies involving Procyanidin B3. Procyanidin B3(B3) is a procyanidin dimer that is widely studied due to its high abundance in the human diet and antioxidant activity.

Vitamin B3-D4 (Standard) is a reference standard of Vitamin B3-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Vitamin B3-d4 (Nicotinic acid-(ring-d4)) is the deuterium substitute for Niacin and is used to track Niacin metabolism in the body.