bacteria

Dirithromycin (LY237216) is a macrolide glycopeptide antibiotic. It is used to treat many different types of bacterial infections, such as bronchitis, pneumonia, tonsillitis, and even skin infections.

Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes, uncouples oxidative phosphorylation, and inhibits ATPase of rat liver mitochondria. The substance is primarily used as a biochemical tool to study the role of divalent cations in various biological systems.

Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.

Terbinafine hydrochloride (KWD 2019) is a synthetic allylamine derivative structurally related to naftifine. Terbinafine is active against dermatophytes.

Anti gram-positive negative bacteria agent 1 is an antibiotic conjugated with a synthetic MECAM-based siderophore, designed to combat both gram-positive and gram-negative bacteria.

Antibacterial compound 2 is a potent antimicrobial agent effective against many human veterinary pathogens, inhibiting multi-drug resistant staphylococci, enterococci and streptococci, as well as anaerobic bacteria.

(2S)-4-biphenyl-4-yl-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide is a LpxC inhibitor with IC50 >95.2 nM.

Bacterial α-Amylase is an enzyme produced by bacteria that catalyzes the hydrolysis reaction of starch into smaller sugar molecules such as maltose and glucose, and can be used to study starch metabolism and enzymatic mechanisms.

Antibacterial compound 1 is an antibacterial compound.

4-(4,5-dibromo-6-oxo-1,6-dihydropyridazin-1-yl)benzene-1-sulfonamide is a sulfonamide derivative used in the synthesis of building blocks for various supramolecular structures such as metal-organic skeletons and coordination polymers. It has antiproliferative activity against a variety of tumor cell lines.

Antibacterial agent 131 is a compound with antibacterial properties.

Antibacterial agent 132 showed antimicrobial activity against C. parapsilosis (ATCC 22019) and C. krusei (ATCC 6258) with MIC90 values of <0.06 μg mL and 62.50 μg mL, respectively. Antibacterial agent 132 inhibited aromatase enzyme with IC50 of 0.047 μM.

Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.

Antibacterial agent 26 is an antimicrobial compound that is a potent DHFR inhibitor (S. aureus DHFR Ki of 0.020 nM).

Antibacterial agent 246 (compound A33) demonstrates a minimum inhibitory concentration (MIC) ranging from 0.5 to 4 μg mL against 23 species of Gram-positive bacteria. When used in combination with Polymyxin E, it inhibits the growth of various Gram-negative bacteria, showing a partial inhibitory concentration index of 0.066.

Antibacterial agent 62 is a novel redox cycle anti-tuberculosis compound exhibiting significant bactericidal activity against both growing and phenotypically resistant non-growing (nutrient deficient) bacteria.

Antibacterial Agent 160 is a potent antibacterial agent that rapidly eradicates bacteria and inhibits the formation of bacterial biofilms. It disrupts the normal functioning of DNA, resulting in cellular death [1].

Aztreonam-siderophore conjugate 63 is an antibacterial agent that exhibits efficacy against Gram-negative bacteria through the linkage of aztreonam to a siderophore mimetic.

Antibacterial agent 245 (Dc-2) serves as an antimicrobial agent effective against plant pathogenic fungi and bacteria, displaying an EC50 of 1.29 μg mL against Botrytis cinerea.

Antibacterial Agent 123 (Compound 111) serves as an effective membrane-disrupting agent targeting antibiotic-resistant Gram-positive bacteria [1].

Antibacterialagent 267 (Compound h19) is a derivative of pleuromutilin with potent antibacterial activity against Gram-positive bacteria. It demonstrates efficacy in a mouse model infected with methicillin-resistant Staphylococcus aureus (MRSA).

Antibacterial agent 12, a biaryloxazolidinone analogue, effectively combats both antibiotic-susceptible and antibiotic-resistant Gram-positive bacteria [1].

Antibacterial Agent 154 (Compound 7), a Fluoroquinolone derivative, exhibits broad-spectrum efficacy against both Gram-positive and Gram-negative bacteria when administered orally. It has been shown to be effective in vivo using a mouse model of staphylococcal sepsis [1].

Antibacterialagent 258 (Compound 11e) is an antimicrobial agent capable of disrupting bacterial cell membranes and inhibiting various Gram-positive bacteria, with a MIC of 1-2 μg mL against Staphylococcus aureus. It exhibits low hemolytic activity and cytotoxicity, and demonstrates anti-infective properties in mouse models.