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Sodium Channel

Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0037 Halazone 80-13-7 90%
Halazone
Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
TN3910 Ecdysone 3604-87-3 100%
Ecdysone
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signal...
T6782 Benzocaine hydrochloride 23239-88-5
Benzocaine hydrochloride
Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at...
T3029 Sparteine sulfate 299-39-8
Sparteine sulfate
Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
TN3042 4-Hydroxycinnamamide 194940-15-3 98%
4-Hydroxycinnamamide
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
T78060 ProTx II TFA 98%
ProTx II TFA
ProTx-II TFA is a potent and highly selective Nav1.7 sodium channel blocker, exhibiting an IC50 of 0.3 nM and demonstrating at least 100-fold selectivity over ot...
T78955 Analgesic agent-2 98%
Analgesic agent-2
Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the human NaV1...
T79246 6-Iodoamiloride 60398-23-4 98%
6-Iodoamiloride
6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM. It also effectively inhibits ASIC3-mediated curre...
T79280 Nav1.3 channel inhibitor 1 98%
Nav1.3 channel inhibitor 1
Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM. It has the ab...
T79398 Ancistrotecine B 98%
Ancistrotecine B
Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].
T79834 Aneratrigine 2097163-74-9 98%
Aneratrigine
Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].
T80039 ATX-II 60748-45-0 98%
ATX-II
ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pu...
T80042 GpTx-1 1661050-12-9 98%
GpTx-1
GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1].
T80043 µ-Conotoxin-CnIIIC 936616-33-0 98%
µ-Conotoxin-CnIIIC
μ-Conotoxin-CnIIIC, a 22-residue conopeptide derived from Conus consors, acts as a potent and persistent NaV1.4 channel blocker, exhibiting analgesic, anaestheti...
T80049 µ-Conotoxin GIIIB 140678-12-2 98%
µ-Conotoxin GIIIB
μ-Conotoxin GIIIB, a 22-residue polypeptide derived from the venom of the piscivorous cone snail Conus geographus, serves as an inhibitor of the Na V 1.4 channel...
T80159 µ-Conotoxin KIIIA 884469-67-4 98%
µ-Conotoxin KIIIA
μ-Conotoxin KIIIA, an analgesic compound derived from Conus kinoshitai, selectively inhibits mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2), o...
T80162 Aah II 98%
Aah II
Aah II, a sodium channel modulator, is a toxin derived from the venom of the scorpion Androctonus australis [1] [2].
T80163 μ-Conotoxin PIIIA 184840-20-8 98%
μ-Conotoxin PIIIA
μ-Conotoxin PIIIA, isolated from Conus purpurascens [1] [2], is a blocker of the sodium channel NaV 1.4.
T80168 Scorpion toxin Tf2 98%
Scorpion toxin Tf2
Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion Tityus fasciolatus, acts as an activator of the neuronal voltage-g...
T80169 ProTx-III 98%
ProTx-III
ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodium cha...
Halazone
T0037
Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.
Ecdysone
TN3910
Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signal...
Benzocaine hydrochloride
T6782
Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at...
Sparteine sulfate
T3029
Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
4-Hydroxycinnamamide
TN3042
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
ProTx II TFA
T78060
ProTx-II TFA is a potent and highly selective Nav1.7 sodium channel blocker, exhibiting an IC50 of 0.3 nM and demonstrating at least 100-fold selectivity over ot...
Analgesic agent-2
T78955
Analgesic Agent-2, a selective orally active inhibitor of the NaV1.8 channel, demonstrates an IC50 of 50.18 nM in HEK293 cells that stably express the human NaV1...
6-Iodoamiloride
T79246
6-Iodoamiloride is a potent inhibitor of acid-sensing ion channel 1 (ASIC1), exhibiting an IC50 value of 88 nM. It also effectively inhibits ASIC3-mediated curre...
Nav1.3 channel inhibitor 1
T79280
Nav1.3 Channel Inhibitor 1 (Compound 15b) is a state-dependent inhibitor of the voltage-gated sodium channel Na v 1.3, with an IC50 value of 20 nM. It has the ab...
Ancistrotecine B
T79398
Ancistrotecine B (Compound 2), a Nav1.7 channel inhibitor (IC50: 0.73 μM), has been shown to alleviate inflammatory pain in mice [1].
Aneratrigine
T79834
Aneratrigine is a blocker of the sodium channel protein type 9 subunit alpha, utilized in research on neuropathic pain diseases [1].
ATX-II
T80039
ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pu...
GpTx-1
T80042
GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1].
µ-Conotoxin-CnIIIC
T80043
μ-Conotoxin-CnIIIC, a 22-residue conopeptide derived from Conus consors, acts as a potent and persistent NaV1.4 channel blocker, exhibiting analgesic, anaestheti...
µ-Conotoxin GIIIB
T80049
μ-Conotoxin GIIIB, a 22-residue polypeptide derived from the venom of the piscivorous cone snail Conus geographus, serves as an inhibitor of the Na V 1.4 channel...
µ-Conotoxin KIIIA
T80159
μ-Conotoxin KIIIA, an analgesic compound derived from Conus kinoshitai, selectively inhibits mammalian neuronal voltage-gated sodium channels (VGSCs) (Nav1.2), o...
Aah II
T80162
Aah II, a sodium channel modulator, is a toxin derived from the venom of the scorpion Androctonus australis [1] [2].
μ-Conotoxin PIIIA
T80163
μ-Conotoxin PIIIA, isolated from Conus purpurascens [1] [2], is a blocker of the sodium channel NaV 1.4.
Scorpion toxin Tf2
T80168
Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion Tityus fasciolatus, acts as an activator of the neuronal voltage-g...
ProTx-III
T80169
ProTx-III, a spider venom peptide derived from the Peruvian green velvet tarantula, functions as a selective and potent inhibitor of the voltage-gated sodium cha...
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TargetMol