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Ferroportin

Ferroportin is a transmembrane protein primarily responsible for the exocytosis of intracellular iron ions. Ferroportin plays a key role in intestinal epithelial cells, macrophages, and hepatocytes, and has been associated with a variety of disorders of iron metabolism disorders and infertility, such as hemochromatosis and iron deficiency anemia.

Vamifeport
T395202095668-10-1
Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.
  • $67
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Ferroportin-IN-1
T629542443432-65-1
Ferroportin-IN-1 is an inhibitor of the iron transport protein Ferroportin, which regulates cellular iron efflux and metabolism to study diseases caused by iron-modulating deficiencies or disorders of iron metabolism, used in metabolism studies such as thalassemia, sickle cell disease, and hemochromatosis.
  • $293
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LY2928057
T77383
LY2928057 is a humanized monoclonal antibody targeting the iron transporter SLC40A1, an iron-regulatory inhibitor used in cardiovascular disease research.
  • $447
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Pyrimidinone 8
T20504265004-42-4
Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.
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10-14 weeks
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Rusfertide
TP26181628323-80-7
Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].
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