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Membrane transporter/Ion channel

Monoamine Transporter

(53)

Monocarboxylate transporter

Na-K-Cl cotransporter

Sodium-dependent phosphate transporter

Ferroportin

Ferroportin is a transmembrane protein primarily responsible for the exocytosis of intracellular iron ions. Ferroportin plays a key role in intestinal epithelial cells, macrophages, and hepatocytes, and has been associated with a variety of disorders of iron metabolism disorders and infertility, such as hemochromatosis and iron deficiency anemia.

Filter HomeSignaling PathwaysMembrane transporter/Ion channelFerroportin

Vamifeport

VIT-2763

T395202095668-10-1

Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.

Ferroportin Ferroptosis

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Ferroportin-IN-1

T629542443432-65-1

Ferroportin-IN-1 is an inhibitor of the iron transport protein Ferroportin, which regulates cellular iron efflux and metabolism to study diseases caused by iron-modulating deficiencies or disorders of iron metabolism, used in metabolism studies such as thalassemia, sickle cell disease, and hemochromatosis.

Ferroportin

$293

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Fursultiamine

Judolor, Diteftin, Alinamin F

T4552804-30-8

Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency.

Ferroportin Mitochondrial Metabolism NF-κB Others VEGFR

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Hepcidin antagonist-1

T61144338965-09-6In house

Hepcidin antagonist-1 is an iron-modulating antagonist.Hepcidin antagonist-1 can be used to study metabolic disorders such as iron-deficiency diseases and anemia.

Ferroportin Others

$198

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DMT1 blocker 1

T110631354790-56-9In house

DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo.

Ferroportin Others

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DMT1 blocker 2

T110641062648-63-8

DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.

Ferroportin Others

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LY2928057

LY 2928057

T77383

LY2928057 is a humanized monoclonal antibody targeting the iron transporter SLC40A1, an iron-regulatory inhibitor used in cardiovascular disease research.

Ferroportin

$372

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Pyrimidinone 8

T20504265004-42-4

Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.

Ferroportin

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10-14 weeks

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Anti-SLC40A1 Antibody

T9901A-1415

Anti-SLC40A1 Antibody is a human-derived antibody expressed in CHO cells, targeting SLC40A1, with a predicted molecular weight (MW) of 150 kDa.

Ferroportin

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Anti-Hepcidin/HAMP Antibody

T9901A-1412

Anti-Hepcidin/HAMP Antibody is a human-derived antibody produced in CHO cells, targeting Hepcidin/HAMP. It features a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for this antibody can be referenced as HumanIgG1kappa, Isotype Control.

Ferroportin

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Rusfertide

PTG-300

TP26181628323-80-7

Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].

Ferroportin