Ferroportin is a transmembrane protein primarily responsible for the exocytosis of intracellular iron ions. Ferroportin plays a key role in intestinal epithelial cells, macrophages, and hepatocytes, and has been associated with a variety of disorders of iron metabolism disorders and infertility, such as hemochromatosis and iron deficiency anemia.

Filter HomeSignaling PathwaysMembrane transporter/Ion channelFerroportin

Vamifeport

T395202095668-10-1

Vamifeport (VIT-2763) is a novel orally active inhibitor that targets iron transport proteins and reduces markers of hemolysis in the SCD Townes model.VIT-2763 improves anemia and erythropoiesis, ameliorates vascular inflammation, and can be studied in β-thalassemia.

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Ferroportin-IN-1

T629542443432-65-1

Ferroportin-IN-1 is an inhibitor of the iron transport protein Ferroportin, which regulates cellular iron efflux and metabolism to study diseases caused by iron-modulating deficiencies or disorders of iron metabolism, used in metabolism studies such as thalassemia, sickle cell disease, and hemochromatosis.

$293

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LY2928057

T77383

LY2928057 is a humanized monoclonal antibody targeting the iron transporter SLC40A1, an iron-regulatory inhibitor used in cardiovascular disease research.

$447

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Pyrimidinone 8

T20504265004-42-4

Pyrimidinone 8 is a reversible, linear non-competitive inhibitor of divalent metal transporter 1 (DMT1) with a Ki of 20 μM (hDMT1). It does not affect the surface expression of hDMT1 and is not influenced by extracellular pH. Pyrimidinone 8 inhibits hDMT1-mediated iron uptake, with an IC50 of 13.8 μM.

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10-14 weeks

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Rusfertide

TP26181628323-80-7

Rusfertide, a peptide mimetic of natural hepcidin, targets and degrades ferroportin, thereby reducing serum iron and transferrin saturation, which helps regulate red blood cell production. It ameliorates conditions such as polycythemia vera, β-thalassemia, and hereditary hemochromatosis [1] [2].

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