Microtubule Associated

Microtubule-associated protein tau (26-44) is a synthetic peptide with an amino group conjugated to glutamine and a carboxyl group conjugated to lysine.

Cemadotin free base(LU103793 free base) is a novel anti-limiting peptide , an analog of Dolastatin 15, a naturally occurring cytotoxic peptide that blocks mitosis and inhibits microtubules (tubulin) with a Ki of 1 μM. Cemadotin is used in research against cancer.

Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in antibody-drug conjugates.

Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing peptide and inhibits Aβ aggregation and Aβ-induced neurotoxicity. Davunetide acetate possesses neuroprotective, neurotrophic, and cognitive protective properties.

Dolastatin 10 (DLS 10) is a potent peptide with antimitotic properties, effectively inhibiting tubulin polymerization.

Dolastatin 15, a depsipeptide derived from Dolabella auricularia, is a potent antimitotic agent structurally related to the anti-tubulin agent Dolastatin 10. Dolastatin 15 can be used as an ADC cytotoxin and it induces cell cycle arrest and apoptosis in m

Davunetide, an eight-amino-acid peptide (NAPVSIPQ), demonstrates potent neuroprotection in vitro and in vivo, enhances functional daily behaviors in schizophrenia patients, and increases memory scores in individuals with amnestic mild cognitive impairment.

Highly neurotoxic cell-permeable analog of PHF6. Induces aggregation of Tau peptides.

Tau Peptide (275-305), also known as the R2 domain fragment, represents the second repeat unit of the microtubule-binding domain of the Alzheimer's tau peptide. Tau Peptide (275-305) is considered crucial in determining the biochemical characteristics of the complete tau protein.

Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau-derived hexapeptide.

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 exhibits serum stability and is non-toxic to neuronal cells, selectively inhibiting tau fibrillization over Aβ 42.

P34cdc2 Kinase Fragment plays a crucial role in yeast mitosis by ensuring the completion of DNA replication and regulates microtubule polymerization in Xenopus oocytes meiosis by phosphorylating mitogen-activated protein 2 (MAP2) [1] [2].

Acetyl-PHF5 amide is a tau peptide with amyloidogenic properties. It can undergo polymerization to form filamentous structures [1].

Tau protein (592-597), Human (TFA) is a peptide fragment of human Tau protein.

Microtubule-Associated Protein (142-161) (human) is a polypeptide identified through polypeptide screening. Polypeptide screening is a research tool primarily utilizing immunoassays to gather active polypeptides. This technique is applied in protein interaction studies, functional analysis, antigen epitope screening, and particularly in the research and development of active molecules.

P160 peptide is a breast cancer-targeting peptide that binds to the keratin 1 (KRT1) receptor in breast cancer cells, with a Kd of approximately 1.1 μM. It shows significant potential for targeted drug delivery to breast cancer cells. P160 peptide enhances the cellular uptake and anticancer activity of the pro-apoptotic antimicrobial peptide MccJ25 (microcin J25). It is applicable in cancer research studies.

Breastcancertargeting peptide 18–4 is a keratin 1 (KRT1) receptor-targeting peptide with a dissociation constant (Kd) of 0.98 μM. Its amino acid sequence is WxEAAYQrFL, and it is an analogue of the P160 peptide. When covalently bonded with the anticancer peptide MccJ25, it significantly enhances MccJ25 uptake in breast cancer cells and boosts its anticancer efficacy. The IC50 values for this covalent compound are 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR, respectively.