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EVs inducer-1
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Catalog No. T218875 Copy Product Info
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EVs inducer-1 is an inducer of extracellular vesicle (EVs) release with immune-stimulatory effects. It inhibits tubulin polymerization, enhancing the release of immunostimulatory EVs from antigen-presenting cells. This compound also increases EV particle release from dendritic cells and boosts CD63 reporter gene activity. Additionally, EVs inducer-1 can suppress the viability of proliferating cells and serves as a valuable tool for research in immunoregulation.
EVs inducer-1
Cas No. 710280-48-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | EVs inducer-1 is an inducer of extracellular vesicle (EVs) release with immune-stimulatory effects. It inhibits tubulin polymerization, enhancing the release of immunostimulatory EVs from antigen-presenting cells. This compound also increases EV particle release from dendritic cells and boosts CD63 reporter gene activity. Additionally, EVs inducer-1 can suppress the viability of proliferating cells and serves as a valuable tool for research in immunoregulation. |
| In vitro | EVs inducer-1 (Compound 1) at a concentration of 10 μM for 48 hours significantly enhances the release of EVs mediated by CD63 in human CD63 Tluc-CD9 EmGFP THP-1 reporter cells. When applied at 10 μM for 20 hours, it exhibits minimal cytotoxicity in primary mBMDC and hPBMC but can inhibit the viability of Jurkat, Ramos, RAW264.7, NIH3T3, and C2C12 cells. Additionally, EVs inducer-1 (0-10 μM) demonstrates a dose-dependent inhibition of tubulin polymerization in cell-free biochemical assays. |
| Molecular Weight | 355.41 |
| Formula | C21H13N3OS |
| Cas No. | 710280-48-1 |
| Smiles | N=1N=C(OC1C=2C=NC=C(C2)C=3SC=CC3)C4=CC=CC=5C=CC=CC54 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: EVs inducer-1 in vitro | EVs inducer-1 formula | EVs inducer-1 molecular weight
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