esterase

Roxatidine Acetate hydrochloride (HOE 760) is a specific and competitive histamin H2-receptor antagonist. It inhibits gastric acid secretion and ulcer formation.

Cholesterol esterase, also known as bile salt-stimulated lipase and carboxyl ester lipase, is an enzyme responsible for hydrolyzing cholesterol ester into cholesterol and free fatty acid within the intestinal lumen. This enzyme, synthesized and stored in zymogen granules within acinar cells, plays a crucial role in accelerating cholesterol absorption [1] [2].

Human leukocyte esterase is a biocatalyst and a pivotal enzyme in new biocatalyst technology. Enzyme engineering focuses on improving the kinetics of enzyme reactions, substrate selectivity, and activity under extreme conditions (such as low or high pH). By incorporating stimuli-responsive modifications to these enzymes, dynamic control of activity also becomes feasible.

Whole Leukocyte Esterase, Human (Unsonicated White Blood Cell Esterase, WBC Esterase) is a biomaterial or organic compound applicable in life science research.

Carboxylesterase-IN-3 is a potent inhibitor of Carboxylesterase Notum (IC50 ≤ 10 nM).Carboxylesterase-IN-3 has the potential to study cancer diseases.

Carboxylesterase-IN-2 is a potent Carboxylesterase Notum inhibitor (IC50 <= 10 nM).Carboxylesterase-IN-2 has potential for the study of cancer diseases.

Butyrylcholinesterase (BCHE), Horse Serum (also known as BCHE, BuChE, PCHE, pseudocholinesterase, plasmacholinesterase, Acylcholine acyl-hydrolase, Choline esterase, butyryl) is a biomaterial or organic compound utilized in life science research.

Phosphodiesterase-IN-3 (Example 20) is an inhibitor of phosphodiesterase 4B, with IC50 values for PDE4B1 and PDE4D3 of less than 10 nM and between 10-100 nM, respectively. Phosphodiesterase-IN-3 shows potential for research in idiopathic pulmonary fibrosis.

Phosphodiesterase-IN-4 (compound 18) is a potent inhibitor of Tyrosyl-DNA phosphodiesterase 1 (TDP1) and exhibits inhibitory effects on colorectal cancer cells, with an IC50 of 6.9 μM.

Phosphodiesterase-IN-2 (Compound C7) is an orally active and selective inhibitor of phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. It enhances hepatic microsomal stability and reduces blood-brain barrier permeability. Phosphodiesterase-IN-2 exhibits favorable pharmacokinetic properties in mouse models and can alleviate isoprenaline-induced cardiac hypertrophy.

Phosphodiesterase 4 (PDE4) inhibitor is an inhibitor of PDE4 with an IC50 value of 0.10 μM for the human recombinant enzyme.

Carboxylesterase-IN-1, a novel pesticide, inhibits carboxylesterase at 50 μg/mL, demonstrating inhibitory activity comparable to the established inhibitor (triphenyl phosphate).

Notum pectinacetylesterase-1 is a Notum Pectinacetylesterase inhibitor with IC50 < 0.025 μM.

Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) with an IC50 of 2.13 μM and human carboxylesterase 1A (hCES1A) with an IC50 of 0.055 μM.

Carboxylesterases (CESs), carboxylate hydrolases broadly distributed in nature and prevalent in mammalian liver, play a significant role in biochemical research. These enzymes facilitate the hydrolysis of diverse substrates, encompassing esters, thioesters, carbamates, and amides, resulting in the conversion of carboxylic acid esters into their respective alcohols and carboxylic acids [1].

Acetylcholinesterase (ACHE) is an enzyme found in the neuromuscular junction and cholinergic synapses. It catalyzes the hydrolysis of acetylcholine, terminating synaptic neuronal transmission and signal propagation. ACHE can be used for research on biosensors.

Phosphodiesterase 2 (II), a key enzyme prominently involved in the hydrolysis of vital second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), is frequently utilized in biochemical research. This enzyme is expressed across various tissues including the adrenal medulla, brain, heart, platelets, macrophages, and endothelial cells, playing a significant role in the regulation of diverse intracellular processes [1].

Phosphodiesterase (PDE), an enzyme capable of catalyzing the hydrolysis of the 3' ring phosphate bond in cyclic nucleotides, plays a crucial role in biochemical research and acts as a vital regulator in signal transduction processes involving the second messenger molecules cAMP and cGMP. Distinguished by their specificity to cyclic nucleotides, PDEs are categorized into different types ranging from PDE1 to PDE11, presenting potential significance in the study and treatment of various diseases [1].

Sphingomyelin phosphodiesterase, a hydrolase, plays a crucial role in sphingomyelin metabolism by catalyzing the conversion of sphingomyelin into phosphocholine and ceramide. Furthermore, it is instrumental in cellular differentiation, immune and inflammatory responses, as well as intracellular cholesterol trafficking and metabolism [1] [2].

Phosphodiesterase-IN-1 (Compound 7), a phosphodiesterase (PDE) inhibitor, exhibits anti-Plasmodium and antiproliferative activities. It effectively inhibits P. falciparum (strain 3D7) with an IC 50 value of 0.64 μM [1].

Phosphatidylinositolphosphodiesterase hydrolyzes phosphatidylinositol to produce a mixture of diacylglycerol and inositol 1- and 1,2-cyclic phosphate esters.

Fluorescein diacetate (Di-O-acetylfluorescein) is a cell permeable esterase-substrate for hGSTP1-1.

4,4'-Dimethoxybenzil (p-Anisil) is a human intestinal carboxyl esterase (hiCE) inhibitor( Ki : 70 nM).

Compound 2058-74-4, with CAS No. 2058-74-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound 2058-74-4 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.