c 11

C-11 is a tubulin inhibitor and functions as an ADC cytotoxin, exhibiting cytotoxicity for carcinoma cell lines.

Mito-apocynin (C11) is a mitochondria-targeting antioxidant that works by targeting and neutralizing reactive oxygen species (ROS) produced during cellular respiration. Triphenylphosphonium bromide has been found to be effective in preventing mitochondrial dysfunction, which is a major cause of the aging process and various diseases. It has anti-inflammatory, anti-apoptotic and antioxidant activities.

STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α/β receptor (IFNAR).References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018). STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway.1 It induces secretion of type I IFN from THF and MM6 cells when used at a concentration of 50 μM. STING agonist C11 induces phosphorylation of IFN regulatory factor 3 (IRF3) and increases expression of IFIT1 and viperin, but not IL-1β, IL-6, or IL-8 in THF cells in a STING-dependent manner. It reduces viral titers of chikungunya, Venezuelan equine encephalitis, o'nyong-nyong, Mayaro, and Ross River viruses grown in THF cells (EC90s = 16.44, 16.7, 18.84, 25.19, and 22.57 μM, respectively), an effect that is dependent on the presence of STING and the IFN-α/β receptor (IFNAR). References1. Gall, B., Pryke, K., Abraham, J., et al. Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway. J. Virol. 92(6), e01913-01917 (2018).

IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.

LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist of the GPR174 receptor with an EC50 value of 34 nM.

Thalidomide-4-OH-C11-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), comprising Thalidomide-4-OH and the corresponding linker. Thalidomide-4-OH-C11-OH acts as a Cereblon ligand to recruit CRBN protein and serves as a key intermediate for synthesizing complete PROTAC molecules, such as PROTAC GPX4 degrader-4.

Thalidomide-O-C11-acid is a synthetic E3 ligase ligand-linker conjugate, featuring a cereblon ligand derived from Thalidomide and a single linker, and is utilized in the synthesis of PROTAC [Proteolysis Targeting Chimeras].

Pomalidomide-C11-NH2 is a derivative of pomalidomide that acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN) and is used to recruit cereblon protein. Pomalidomide-C11-NH2 can be attached via a linker to a protein ligand, forming a PROTAC.

Thalidomide-O-amido-C11-COOH (Compound IMiD acid 1) is a compound that acts as an E3 ligase ligand and linker for the CRBN (Cereblon) conjugate. This compound is useful in synthesizing PROTACs targeting the degradation of DOT1L.

Thalidomide-amine-C11-acid is an E3 ligase ligand-linker conjugate composed of Thalidomide 5-fluoride and a linker. This compound is utilized in the synthesis of JQAD1.

Pomalidomide-C11-azide is a synthetic E3 ligase ligand-linker conjugate (E3ligaseligand-linker conjugate) used for synthesizing PROTACBRD3 degrader-1.

Thalidomide-4-O-C11-Br is an E3 ligase ligand-linker conjugate, consisting of a Thalidomide-based CRBN ligand and a linker. This compound can connect with a protein ligand via the linker to form PROTACEZH2 Degrader-23.

Thalidomide-5-O-C11-NH2 hydrochloride, a thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1].

Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-based cereblon ligand for CRBN protein recruitment, capable of conjugation to a protein ligand via a linker to create PROTACs [1].

Pomalidomide-C11-NH2 hydrochloride is a cereblon (CRBN) ligand derived from Pomalidomide used to recruit the CRBN protein. This compound can be conjugated with a linker to the protein ligand to assemble a PROTAC [1].

Pomalidomide-5-C11-NH2 hydrochloride is a Pomalidomide-derived cereblon (CRBN) ligand that facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to create a PROTAC [1].

C11-BODIPY 505/515 Glucosyl ceramide is a glucosyl ceramide tagged with C11-BODIPY 505/515, which can be utilized in the preparation of lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).

16:0 C11 BODIPY 505/515 DG is a DG labeled with C11-BODIPY 505/515, utilized in the formulation of lipid nanoparticles for drug delivery applications (Ex/Em = 505/515 nm).

C11-BODIPY 505/515 Galactosyl ceramide is a Galactosyl ceramide labeled with C11-BODIPY 505/515, which can be utilized in the preparation of lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).

C11-BODIPY 505/515 GM3 ammonium is a GM3 ammonium compound labeled with C11-BODIPY 505/515, suitable for preparing lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).

C11-BODIPY 505/515 Ceramide-1-phosphate ammonium is a Ceramide-1-phosphate ammonium compound labeled with C11-BODIPY 505/515, applicable in the preparation of lipid nanoparticles for drug delivery [Ex/Em = 505/515 nm].

C11-BODIPY 505/515 Sphingomyelin is a sphingomyelin labeled with C11-BODIPY 505/515, which can be utilized for preparing lipid nanoparticles for drug delivery (Ex/Em = 505/515 nm).

RGA-C11 is a detergent.

C11-PEG4-alcohol is a linker composed of an aliphatic carbon chain and a PEG chain. The hydrophilic PEG chain enhances the compound's solubility in aqueous media. The hydroxyl group can be further derivatized or replaced with other reactive functional groups.