EDA

Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enhancing the expression of pro-apoptotic molecules in gastric cancer cells and has anti-cancer effects.

Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), integrates the cleavable ADC linker Mal-C2-Gly3-EDA with the potent cytotoxin PNU-159682.

Mal-C2-Gly3-EDA is a cleavable antibody-drug conjugate (ADC) linker with a Maleimide moiety, designed to facilitate ADC synthesis.

Gly2-EDA-PNU is a low-molecular-weight glycinine toxin molecule conjugate used for ADC synthesis. It is composed of the DNA topoisomerase I inhibitor PNU-159682 and the Gly2-EDA linker.

PNU-EDA is a part of the antibody-conjugated active molecule ADC. It is formed by coupling a cleavable ADC linker (EDA) with the payload PNU159682. PNU-EDA can be used for the synthesis of ADC compounds.

Mal-PEG4-VC-PAB-EDA-PNU159682 is a thiol-reactive Drug-linker. PNU159682 is a DNA topoisomerase II (Topo II) inhibitor and is commonly used in the synthesis of antibody-drug conjugates (ADCs).

PNU159682-EDA-Gly3 is a drug linker for antibody-drug conjugates (ADCs), prepared by connecting EDA-Gly3 with a potent DNA topoisomerase II inhibitor PNU159682.

PNU159682-EDA-D4 is a deuterium-labeled drug linker used for antibody-drug conjugates (ADCs). It is formed by combining PNU159682-D4 (a potent DNA topoisomerase II inhibitor) with EDA. It is commonly used in the synthesis of ADC compounds. The deuterium labeling can be used as a quantitative tracer during the drug development process.

Mal-VC-PAB-EDA-N-Ac-Calicheamicin is a drug-linker conjugate for ADCs, exhibiting potent antitumor activity. OncoFAP-GlyPro-MMAF is composed of the ADC toxin Calicheamicin and a linker. It is used in the synthesis of the ADC molecule PF-06647263.

PNU-EDA-Gly5 is a DNA topoisomerase I inhibitor-based oligo-glycine linker-payload used for the synthesis of antibody-drug conjugates (ADCs). It consists of the DNA topoisomerase I inhibitor PNU-159682 and the linker EDA-Gly5.

EDA-DA, an N-terminally tagged dipeptide probe, serves as a labeling agent for bacterial Peptidoglycan (PG), a fundamental component of the cell walls in most bacteria crucial for cellular division, shape retention, and hydrostatic pressure maintenance [1].

RH-EDA, a rhodamine-based turn-on fluorescent probe, detects hydroxyl radicals ([OH]) in living systems.

Fmoc-L-Asn(EDA-N3)-OH is a chemical compound equipped with an azide group used in click chemistry. Reports in the literature have demonstrated its application in the modification of α-amanitin, the deadliest member of the amatoxin peptide family produced by the death cap mushroom. α-Amanitin is a highly lethal natural compound (LD50=50-100 µg/kg), an orally ingested rigid bicyclic octapeptide, acting as a highly selective conformational inhibitor of RNA polymerase II.

Fmoc-EDA-N3 is a click chemistry reagent featuring an azide group. This compound can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules that contain an alkyne group. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules possessing DBCO or BCN groups.

Biotin-EDA TFA is a nucleophilic biotinylation reagent employed for conjugating various substrates and for identification and quantification using biotin-coupled fluorescent labels.

Biotin-EDA, an alkyl chain-based PROTAC linker, is utilized in PROTAC synthesis.

Edaravone (MCI-186) is a potent new free radical scavenger used for the therapy of patients with acute brain infarction.

Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has antitumor activity and inhibits tumor growth by inhibiting angiogenesis.

Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide) is a serotonin-norepinephrine-dopamine reuptake inhibitor and an antagonist of 5-HT2A, 5-HT2C, 5-HT3, and α1A-adrenergic receptors, which can be used to treat depression and anxiety.

Edasalonexent (CAT-1004) is an orally available NF-κB inhibitor designed to improve Duchenne muscular dystrophy.

Tedatioxetine (Lu AA24530) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with antidepressant properties.Tedatioxetine acts as a CYP2D6 substrate.

Vedaprofen (PM 150) inhibits COX-1 and reduces prostaglandin H2 synthesis with anti-inflammatory activities. Vedaprofen is an inhibitor of Escherichia coli sliding clamp with the IC50 of 222 μM and Ki of 131 μM.

Dronedarone hydrochloride (SR33589) is an amiodarone analog which has an effective and promising treatment for Atrial fibrillation.

Bedaquiline fumarate (TMC207), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. It blocks the proton pump for ATP synthase of mycobacteria. It is the first member of a new class of drugs called diarylquinolines.