Ile

Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.

Boc-Ile-Glu-Gly-Arg-AMC (IEGR-AMC) is a specific, highly fluorogenic substrate for clotting enzyme factor Xa (coagulation factor Xa) and is also hydrolyzed by acrosin from the ascidian Halocynthia roretzi.

H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM.

Phosphopeptide ligand for the src SH2 domain (IC50 = 1 μM). Blocks src interactions with EGFR and FAK.

Helicin is a syrB inducer found in the Rosaceae family. Helicin is hydrolyzed by the enzyme BglY.

H-Ile-Pro-Pro-OH acetate is a angiotensin-converting enzyme inhibitor (ACE) of milk-derived tripeptides.

L-Isoleucine (Ile) is an essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.

Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

Levitide is a neurohormone-like peptide which is from the skin of Xenopus laevis.

(±)-Jasmonic-L-isoleucine ((±)-JA-L-Ile) is a conjugate of the plant hormone jasmonic acid and the amino acid isoleucine, representing the active form in the jasmonic acid signaling pathway. (±)-Jasmonic-L-isoleucine regulates various biological processes in plants, including defense responses, growth and development, and stress adaptation.

Antho-riamide II is an inactive peptide isolated from sea anemone Anthopleura elegantissima.

Diprotin A (Ile-Pro-Ile) is a dipeptidyl peptidase IV (DPP-IV) inhibitor.

Lysyl aspartyl isoleucine (Tripeptide-10) is a bioactive peptide with anti-wrinkle effects and has been reported as a cosmetic ingredient.

S 2613 is a luminogenic peptide substrate.

Angiotensin (1-7) (ASP-ARG-VAL-TYR-ILE-HIS-PRO) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) , inhibits purified canine ACE activity (IC50=0.65 μM) with vasodilator and antiproliferative activities.

Dihexa (Hexanoyl-Tyr-Ile-Ahx-NH2) is an activator of the hepatocyte growth factor/c-Met (HGF/c-Met) system,it binds to HGF (Kd = 65 pM),and an analog of the peptide angiotensin IV.

T-kinin (Ile-Ser-bradykinin) is a bradykinin-containing peptide used in inflammation research [1] [2].

PTD2 (Ac-Gly-Val-Nle-Arg-Ile-NH2) is a potent and selective WHSC1 inhibitor, demonstrating micromolar affinity for its target [1].

BNC210 (IW-2143) is a α7 nAChR negative allosteric modulator. BNC210 has potent activity in animal models of anxiety and depression.

R 715, a bradykinin B1 receptor antagonist, inhibits contractions in isolated human umbilical cords that express bradykinin B1 receptors (pA2 = 8.49). When administered at doses of 200, 400, and 600 µg/kg, R 715 enhances latency to tail withdrawal in the tail-flick test for diabetic neuropathy mouse models induced by streptozotocin (STZ), signaling potential analgesic properties. Furthermore, at a 1 mg/kg per day dosage, it mitigates symptoms in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by MOG35-55 antigen peptide, such as reducing hind limb weakness and paralysis, improving gait symmetry, and decreasing spinal inflammation, neuron demyelination, and lesion monocyte invasion. Additionally, R 715 at 0.01 nmol/animal, administered intracerebroventricularly (i.c.v.), lowers mean arterial blood pressure and increases heart rate in spontaneously hypertensive rats, indicating cardiovascular effects.

Cathepsin L-IN-4 is a cathepsin L inhibitor with IC50 in the nanomolar range [1].

CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a short peptide inhibitor of chymase in the human heart.

Asudemotide is a bioactive chemical.

(Z-IETD)2-Rh 110 is a fluorescent substrate for caspase-8 (λex= 488 nm, λem= 523 nm) and can be used to measure caspase-8 activity and monitor apoptosis.