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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13865 | Resorcinolnaphthalein | RAAS | |
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM). | |||
T26046 | Razoxane | Topoisomerase | |
Razoxane is used as an antimitotic agent with immunosuppressive properties. | |||
T10696 | CB2 modulator 1 | Cannabinoid Receptor | |
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia. | |||
T6683 | STF-62247 | STF 62247 | Estrogen/progestogen Receptor , Autophagy |
STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively. | |||
T2058 | Palosuran | ACT-058362 | GPR |
Palosuran (ACT-058362) (ACT-058362) is a new potent and specific antagonist of the human UT receptor. | |||
T0114 | Trichlormethiazide | Naqua,Metahydrin,Trichlormetazid | ATPase , Carbonic Anhydrase |
Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and ... | |||
T2583 | Cilastatin | MK0791 | Proteasome , Antibacterial , Antibiotic |
Cilastatin (MK0791) is a renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, IMIPENEM, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cila... | |||
T4989 | Fosfomycin Tromethamine | Antibacterial , Antibiotic | |
An antibiotic produced by Streptomyces fradiae. | |||
T8494 | NS-3-008 hydrochloride | NS-3-008 HCl | Others |
NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM). | |||
T7714 | Temocapil | Tyrosinase | |
Temocapril is an inhibitor of tyrosine kinase. | |||
T12883 | Fezagepras | PBI-4050,Setogepram | GPR |
Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions. | |||
T1410 | Torsemide | AC-4464,JDL-464,Torasemide | Na-K-Cl cotransporter |
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h... | |||
T9831 | MKC-1 | Ro-31-7453 | Apoptosis , Akt , Microtubule Associated , mTOR |
MKC-1 (Ro-31-7453) is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the format... | |||
T3131 | Fosfomycin calcium | Phosphomycin calcium salt,Fosmicin | Antibacterial , Antibiotic |
Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. | |||
T2456 | Tivozanib | AV-951,KRN951 | VEGFR , PDGFR , Ephrin Receptor |
Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. | |||
T4583 | PFI-2 hydrochloride | (R)-PFI-2 hydrochloride,PFI-2 HCl | Histone Methyltransferase |
PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2. | |||
T13748 | L-2-Hydroxyglutaric acid disodium | (S)-2-Hydroxyglutaric acid disodium | Histone Demethylase , Mitochondrial Metabolism |
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ... | |||
T16708 | R-268712 | ALK , TGF-beta/Smad | |
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor. | |||
T1615 | Irbesartan | SR-47436,BMS-186295 | Apoptosis , RAAS |
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. | |||
TQ0157 | EIPA | L593754,MH 12-43 | Sodium Channel , TRP/TRPV Channel |
EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis. | |||
T6698 | Temocapril hydrochloride | CS-622 HCl,Acecol,Temocapril HCl,CS-622 | RAAS |
Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension. | |||
T1987 | PFI-2 | PFI2,PFI 2,(R)-PFI-2 | Histone Methyltransferase |
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. | |||
T0248 | Clorprenaline hydrochloride | Clorprenaline HCl,NSC 334693 | Adrenergic Receptor |
Clorprenaline hydrochloride (Clorprenaline HCl) is a beta-2 adrenergic agonist with bronchodilator activity. | |||
T13142L | Theodrenaline hydrochloride | Theodrenaline hydrochloride(13460-98-5 Free base) | SARS-CoV |
Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia. | |||
T0871 | Noradrenaline bitartrate | Adrenergic Receptor | |
Norepinephrine bitartrate acts directly on the α- and β-adrenergic receptors. Norepinephrine Bitartrate is a bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the ... | |||
T1056 | Isoprenaline hydrochloride | NCI-c55630,Isoproterenol hydrochloride,Isoprenaline HCl | PI3K , Endogenous Metabolite , Adrenergic Receptor , PDE |
Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties. | |||
T0948 | Adrenalone hydrochloride | Adrenalone HCl | Adrenergic Receptor |
Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a loc... | |||
T32536 | L-Adrenalin ascorbinate | Tonhormon | |
l-Adrenalin ascorbinate is a bioactive chemical. | |||
T32697 | Levisoprenaline | (R)-Isoprenaline,Levisoprenalina,BRN-3203136,BRN 3203136,Proternol L | |
Levisoprenaline is a bioactive chemical. | |||
T27540 | Hexoprenaline Sulfate | ST-1512,Argocian,Gynipral | |
Hexoprenaline Sulfate is a selective beta2-adrenoreceptor agonist. Hexoprenaline Sulfate is active in man as a bronchodilator by the oral or intravenous routes and by inhalation. Hexoprenaline Sulfate is indicated for us... | |||
T33361 | Metiprenaline | Egyt 402,Egyt-402,Egyt402 | |
Metiprenaline is a biochemical. | |||
T25984 | Prenalterol | H80/62,H-80/62,H 80/62 | |
Prenalterol is a selective β1-adrenergic receptor agonist. Prenalterol has no effect on gut smooth muscle contractile activity. Prenalterol has potential to be used for researching cardiovascular disease [1]. | |||
T69000 | Prenalterol hydrochloride | ||
Prenalterol hydrochloride is a partial adrenergic agonist with functional beta 1-receptor specificity and inotropic effect. It is effective in the treatment of acute cardiac failure, postmyocardial infarction low-output ... | |||
T13142 | Theodrenaline | (±)-Theodrenaline | Others |
Theodrenaline is a cardiac stimulant, also acts as an agent of anti-hypotensive together with cafedrine. | |||
T68979 | Prenalterol (free base) | ||
Prenalterol (free base) is a selective inotropic beta-adrenoceptor agonist. It is used as a cardiac stimulant. | |||
T25499 | Hexoprenaline | ||
Hexoprenaline is a stimulant of adrenergic beta 2 receptors used as a bronchodilator, antiasthmatic agent, and tocolytic agent. | |||
T60261 | Clorprenaline | ||
Clorprenaline is a potent agonist of β2-adrenergic. Clorprenaline promotes animal muscular mass growth and decreases fat accumulation that is a potential new lean meat-boosting feed additive [1]. | |||
T69151 | Adrenaline sulfate | ||
Adrenaline sulfate is a orally active hormone secreted by the medulla of the adrenal glands. Adrenaline sulfate is an α-adrenergic and β-adrenergic receptor agonist. Adrenaline sulfate can be used in the treatment of ana... | |||
T1400L | Demeclocycline | Ledermycin,Bioterciclin,Deteclo,Declostatin,Deganol | Antibacterial |
Demeclocycline (Declostatin) is a tetracycline antibiotic produced by a strain of Streptomyces aureofaciens.Demeclocycline has antimicrobial activity and inhibits the action of vasopressin on the renal tubules, leading t... | |||
T24270 | KS370G | KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide | |
KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s... | |||
T3064 | VTP-27999 | VTP27999 | RAAS |
VTP-27999 is an alkyl amine Renin inhibitor. VTP-27999 has been used in trials studying the basic science of Renal Function. | |||
T27323 | FK-453 | FK453,FK 453 | Adenosine Receptor |
FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity. | |||
TP1049L | Ornipressin Acetate(3397-23-7,free) | Orpressin,POR-8 | Others |
Ornipressin Acetate (POR-8) is a potent vasoconstrictor, hemostatic and renal agent. | |||
T22882 | JP1302 | Adrenergic Receptor | |
JP1302 is a selective α2C adrenoceptor antagonist with a Kb value of 16 nM and a Ki of 28 nM for human α2C receptors.JP1302 has antidepressant activity, disrupts the FACT complex and degrades histone H1.JP1302 has been u... | |||
T50000 | 2-Iodohippuric Acid | Others | |
2-Iodohippuric Acid is an organic compound that can be used to measure renal clearance for renal function studies, and for the diagnosis of certain diseases, such as liver and kidney disease. In addition, it is used in t... | |||
T16777 | ROC-325 | Apoptosis , Autophagy | |
ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity. | |||
T13881 | Dicirenone | SC26304 | ATPase , Glucocorticoid Receptor |
Dicirenone (SC26304) inhibits the Mineralocorticoid receptor (MR), aldosterone regulation of the urinary K+:Na+ ratio, and aldosterone binding to renal cytoplasmic and nuclear receptors. | |||
T2316 | Omarigliptin | MK-3102 | Proteasome , DPP-4 |
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. | |||
T14076 | A 839977 | A839977,A-839977 | P2X Receptor , Calcium Channel |
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis. | |||
T1430 | Betamipron | CS-443,N-Benzoyl-β-alanine | Antibacterial , Antibiotic |
Betamipron (CS-443) is used combination with panipenem to prevent nephrotoxicity and inhibit panipenem uptake into the renal tubule. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5669 | Citric acid monohydrate | Others | |
Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients a... | |||
T5S0636 | Citric acid | Citro,Citretten | Apoptosis , Others , Endogenous Metabolite , Antibacterial , Antibiotic |
1. Citric acid (Citro) (1-2 g/kg) can decrease brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation. 2. Citric acid denture cleansers can reduce C. albicans biofilm accumulation and cell viabili... | |||
T22311 | Djenkolic Acid | jengkolic acid,Djenkolate,S,S'-Methylenebiscysteine | Others |
Djenkolic Acid (S,S'-Methylenebiscysteine) is a naturally occurring sulfur-containing amino acid extracted from djenkol beans(Archidendron pauciflorum), which is native to Southeast Asia. It is an uncommon but important ... | |||
T8262 | Fosfomycin sodium | Fosfomycin Disodium | Antibacterial , Antibiotic |
Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an e... | |||
T3999 | D(+)-Galactosamine hydrochloride | D-Galactosamine HCl | Others |
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice. | |||
T3033 | Deoxycorticosterone acetate | DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate | Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor |
Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid. | |||
T8150 | Nudifloramide | 1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide | PARP , Endogenous Metabolite |
Nudifloramide (1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide) is one of the end degradation products of nicotinamide-adenine dinucleotide (NAD). | |||
T1071L | DL-Adrenaline Hydrochloride | Adrenergic Receptor | |
DL-Adrenaline Hydrochloride is the hydrochloride salt of the naturally occurring sympathomimetic amine with vasoconstricting, intraocular pressure-reducing activities. | |||
TN4258 | Isocuparenal | Others | |
Isocuparenal is a natural product for research related to life sciences. The catalog number is TN4258 and the CAS number is 16982-01-7. | |||
TN6974 | (-)-Isobicyclogermacrenal | ||
(-)-Isobicyclogermacrenal is a natural product. | |||
T3P2855 | Chamigrenal | EGFR , NOS , PAFR , COX , Prostaglandin Receptor | |
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor an... | |||
T20173 | Noradrenaline tartrate | NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate | |
Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceru... | |||
T4238 | Glycocyamine | 2-Guanidinoacetic acid,Guanidoacetic acid | Others , Endogenous Metabolite |
Glycocyamine (2-Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird. Glycocyamine is an important marker for renal failure, kidney... | |||
TQ0119 | Cirsimaritin | GABA Receptor | |
Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors. | |||
T4959 | DL-Mannitol | Mannitol | Others |
DL-Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake | |||
TN2430 | Glucodigifucoside | ||
Glucodigifucoside, a cardiac glycoside that can be isolated from digitalis seeds, is specifically cytotoxic to human renal adenocarcinoma cells. | |||
T7344 | SDMA | NG,NG'-Dimethyl-L-arginine,Symmetric dimethylarginine | Endogenous Metabolite |
SDMA (Symmetric dimethylarginine) is the most potent endogenous inhibitor of nitric oxide synthase (NOS), with higher levels in patients with end-stage renal disease (ESRD). | |||
T0414 | D-Mannitol | Mannite,Mannitol,Osmitrol | Apoptosis , Dehydrogenase , Endogenous Metabolite |
D-Mannitol (Mannitol) is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to t... | |||
T5289 | N-Acetyl-L-arginine dihydrate | N-Ac-L-arg-OH | Others , Endogenous Metabolite |
N-Acetyl-L-arginine dihydrate (N-Ac-L-arg-OH) is one of the guanidino compounds found elevated in the serum of a hemodialyzed renal insufficient (uremic) pediatric population. | |||
T1436 | 4-Aminohippuric Acid | p-Aminohippuric acid | Amino Acids and Derivatives , Endogenous Metabolite |
4-Aminohippuric Acid is the glycine amide of 4-aminobenzoic acid. Its sodium salt is used as a diagnostic aid to measure effective renal plasma flow (ERPF) and excretory capacity. | |||
T5040 | Medroxyprogesterone | Estrogen/progestogen Receptor , Progesterone Receptor | |
Medroxyprogesterone is used in the treatment of renal carcinoma. It is a synthetic progestational hormone used in veterinary practice as an estrus regulator. | |||
T3869 | Skimmin | Skimmine | Others |
Skimmin (Skimmine) has anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis... | |||
T2S0850 | Malic acid | E 296,2-Hydroxysuccinic acid,Hydroxybutanedioic acid,FDA 2018,Deoxytetraric acid,Pomalus acid | Others , Endogenous Metabolite |
1. Malic acid (Pomalus acid) did reduce populations of L. monocytogenes on poultry. 2. Malic acid supplementation may be useful for conservative treatment of calcium renal stone disease by virtue of its capacity to induc... | |||
T3857 | Magnolin | (+)-Magnolin | ERK |
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects. | |||
T7040 | Angiotensin II human | DRVYIHPF,Angiotensin II,Hypertensin II,Ang II | Apoptosis , RAAS |
Angiotensin II human (Ang II) is a biologically active peptide, a vasoconstrictor. Angiotensin II interacts with AT1R and AT2R to regulate blood pressure, stimulate sympathetic nerves, and increase aldosterone biosynthes... | |||
T3005 | 4-Hydroxychalcone | P-Cinnamoylphenol | Others , NF-κB |
4-Hydroxychalcone (P-Cinnamoylphenol) attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. | |||
T1614 | Hydrocortisone | Cortisol | Glucocorticoid Receptor , Endogenous Metabolite |
Hydrocortisone (Cortisol) is a glucocorticoid hormone secreted by the adrenocortex. Hydrocortisone agonizes the glucocorticoid receptor, which promotes proteolytic metabolism, gluconeogenesis, capillary wall stabilizatio... | |||
T20793 | Magnesium Lithospermate B | Monomethyl lithospermate B,Lithospermate B | Others |
Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from is... | |||
T4904 | 1-Methylguanidine hydrochloride | Others , Endogenous Metabolite | |
Methylguanidine (MG) is a guanidine compound deriving from protein catabolism. It is also a product of putrefaction. Methylguanidine is a suspected uraemic toxin that accumulates in renal failure, however it also exhibit... | |||
T3S1227 | Aristolactam I | Aristolactam,Aristololactam I,Aristololactum | Apoptosis , Caspase |
1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF... | |||
PDK0014 | 3-Methylxanthine | Endogenous Metabolite | |
3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.3-Methylxanthine inhibited xanthine crystallization, it could ... | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T3414 | Morroniside | Apoptosis , MMP , Pyroptosis | |
Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal damage and human umbilical vein endothelial cells, by inhib... | |||
T2S2043 | Dracorhodin perchlorate | Dracorhodin perochlorate,Dracohodin perochlorate | Apoptosis , Others |
Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate... | |||
T5248 | (R)-3-Hydroxybutanoic acid | Others , Endogenous Metabolite | |
3-hydroxybutyric acid is involved in the synthesis and degradation of ketone bodies. Like the other ketone bodies (acetoacetate and acetone), levels of beta-hydroxybutyrate are raised in the blood and urine in ketosis. B... | |||
T3877 | Esculentoside A | NF-κB , COX | |
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways. Esculentoside A may be useful for the treatment of autoimmun... | |||
T6S1917 | Schisandrol B | Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B | P450 , Reactive Oxygen Species , Autophagy |
1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a... | |||
T8053 | N-Acetyl-L-arginine | Ac-Arg-OH | Endogenous Metabolite |
N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-... | |||
T4938 | Potassium 1H-indol-3-yl sulfate | Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate | AhR , Endogenous Metabolite |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm... | |||
T13670 | (E)-Ligustilide | Others | |
(E)-Ligustilide has renal protection and was isolated from Angelica sinensis. | |||
TN1912 | Marinobufogenin | Marinobufagenin | ATPase , EGFR |
Marinobufagenin, a cardiotonic steroid, its increased concentrations are important in the cardiac disease and oxidant stress state seen with renal failure. | |||
T72798 | Ganodermaones B | ||
Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression . | |||
T83110 | Angulatin K | ||
Angulatin K, a sesquiterpene polyol ester naturally occurring in the root bark of Celastrus angulatus [1], exhibits anti-cancer properties effective against a variety of solid tumors, including renal, breast, and lung. | |||
TN4381 | Karounidiol | Others | |
Karounidiol exhibits cytotoxicity especially against a human renal cancer, it markedly suppresses the promoting effect of TPA (1 microgram/mouse) on skin tumor formation in mice following initiation with 7,12-dimethylben... | |||
T11513 | Gum arabic | Arabic gum | Others |
Gum Arabic is an anti-oxidant and can protect against experimental hepatic-, renal- and cardiac toxicities. Gum Arabic also can be used in immunohistochemistry. Gum Arabic is a branched-chain, complex polysaccharide deri... | |||
T13749 | L-2-Hydroxyglutaric acid | (S)-2-Hydroxyglutaric acid | Others |
L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively. L-2-Hydroxyglutaric acid is an epigenetic modifier and putative oncometabolite in ren... | |||
TN3380 | Alloisoimperatorin | AChR | |
Alloisoimperatorin is a candidate of AChE inhibitors, it displays potent antioxidant effects against the DPPH radical and against renal epithelial cell injury by using AAPH to generate peroxyl radicals in vitro. Alloisoi... | |||
TMA1743 | Ergosterol peroxide | ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection | |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr... | |||
T38484 | Englerin A | (-)-Englerin A | TRP/TRPV Channel |
Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer activities that induces necrosis in human renal cancer cells. | |||
TN3753 | Dalbergioidin | Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad | |
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00797 | LDHB Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LD... | |||
TMPJ-00724 | LDHA Protein, Human, Recombinant (His) | Human | E. coli |
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region,... | |||
TMPJ-00755 | CRYAB Protein, Human, Recombinant (His) | Human | E. coli |
α Crystallin B Chain (CRYAB) is a cytoplasmic protein that belongs to the small heat shock protein (HSP20) family. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectiv... | |||
TMPJ-01010 | PLA2G16 Protein, Human, Recombinant (His) | Human | E. coli |
Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differenti... | |||
TMPH-02880 | Renalase Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
TMPY-02881 | RAGE Protein, Human, Recombinant | Human | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPY-02927 | RAGE Protein, Human, Recombinant (His) | Human | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPY-02956 | Apolipoprotein L/APOL1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney... | |||
TMPY-01735 | Carbonic Anhydrase 2 Protein, Human, Recombinant (His) | Human | E. coli |
The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bi... | |||
TMPY-01050 | Cadherin 6/CDH6 Protein, Human, Recombinant (His) | Human | HEK293 |
Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morpho regulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progres... | |||
TMPY-03014 | Osteoactivin/GPNMB Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
GPNMB belongs to the PMEL / NMB family, also known as Osteoactivin and Hematopoietic growth factor-inducible neurokinin 1 ( HGFIN ), is a transmembrane glycoprotein that is expressed in numerous cells, including osteocla... | |||
TMPY-00767 | Cystatin C Protein, Human, Recombinant (His) | Human | HEK293 |
Cystatin C, also known as Cystatin-3 (CST3) is a secreted type 2 cysteine protease inhibitor synthesized in all nucleated cells, has been proposed as a replacement for serum creatinine for the assessment of renal functio... | |||
TMPY-01691 | Clusterin Protein, Human, Recombinant (CLU34, His) | Human | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-01694 | Clusterin Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot... | |||
TMPY-00988 | Lipocalin-2/LCN2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells,... | |||
TMPY-00873 | Lipocalin-2/LCN2 Protein, Human, Recombinant (His) | Human | HEK293 |
Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated neutrophils, however, many other cells,... | |||
TMPY-00665 | Aminopeptidase N/CD13 Protein, Human, Recombinant (I603M, His) | Human | HEK293 |
Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 fam... | |||
TMPJ-00071 | EPO/Erythropoietin Protein, Human, Recombinant (His) | Human | Human Cells |
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoi... | |||
TMPY-00639 | EPO/Erythropoietin Protein, Human, Recombinant (hFc) | Human | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-00443 | EPO/Erythropoietin Protein, Mouse, Recombinant | Mouse | HEK293 |
Erythropoietin is a member of the EPO / TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. Erythropoietin can be found in the plasma and regulates red cell production by promoting... | |||
TMPY-01727 | GLA/alpha-Galactosidase A Protein, Human, Recombinant (His) | Human | HEK293 |
Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap... | |||
TMPY-01882 | HE4 Protein, Human, Recombinant (His) | Human | HEK293 |
WAP four-disulfide core domain protein 2, also known as Epididymal secretory protein E4, Major epididymis-specific protein E4, Putative protease inhibitor WAP5, WFDC2 and HE4, is a secreted protein that contains two WAP ... | |||
TMPY-00853 | IL-1RA Protein, Human, Recombinant | Human | E. coli |
Interleukin-1 receptor antagonist (IL-1RA) also known as IL1RN is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A), and interleukin 1, beta (IL1B), and mo... | |||
TMPY-04483 | IRAK4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4... | |||
TMPY-01167 | E-Selectin/CD62E Protein, Human, Recombinant (His) | Human | HEK293 |
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involv... | |||
TMPY-05053 | ANGPTL2 Protein, Human, Recombinant (His) | Human | HEK293 |
The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism... | |||
TMPY-02788 | IL-2 Protein, Mouse, Recombinant | Mouse | E. coli |
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleuki... | |||
TMPY-02457 | IL-2 Protein, Rat, Recombinant | Rat | E. coli |
Interleukin-2, also known as a T-cell growth factor, TCGF, Aldesleukin, and IL2, is a secreted protein that belongs to the IL-2 family. Interleukin-2 / IL-2 was the first interleukin molecule to be discovered. Interleuki... | |||
TMPH-02270 | Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential rol... | |||
TMPY-01675 | RAGE Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPY-01716 | RAGE Protein, Human, Recombinant (hFc) | Human | HEK293 |
Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certai... | |||
TMPJ-00504 | Serpin A8 Protein, Human, Recombinant (His) | Human | Human Cells |
Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hyperten... | |||
TMPY-00089 | TMIGD1 Protein, Human, Recombinant (His) | Human | HEK293 |
The transmembrane and immunoglobulin domain-containing 1 (TMIGD1) is a novel tumor suppressor that is highly expressed in normal renal tubular epithelial cells, but it is downregulated in human renal cancer. TMIGD1 is a ... | |||
TMPK-00526 | LRG1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular... | |||
TMPY-04872 | TMIGD1 Protein, Human, Recombinant (mFc) | Human | HEK293 |
The transmembrane and immunoglobulin domain-containing 1 (TMIGD1) is a novel tumor suppressor that is highly expressed in normal renal tubular epithelial cells, but it is downregulated in human renal cancer. TMIGD1 is a ... | |||
TMPK-01128 | LRG1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular... | |||
TMPH-02818 | Osteocalcin Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. | |||
TMPH-02743 | Klk1b5 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Data support a completely novel mechanism in which miR-382 targets kallikrein 5 and contributes to the development of renal inner medullary interstitial fibrosis. PMID: 22202692 | |||
TMPH-00269 | GPR52 Protein, Bovine, Recombinant (His & KSI) | Bovine | E. coli |
Data support a completely novel mechanism in which miR-382 targets kallikrein 5 and contributes to the development of renal inner medullary interstitial fibrosis. PMID: 22202692 | |||
TMPH-03018 | MeTAP1 Protein, Mycobacterium tuberculosis, Recombinant (His) | Mycobacterium tuberculosis | E. coli |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. | |||
TMPH-02191 | Tetraspanin-2/TSPAN2 Protein, Human, Recombinant | Human | E. coli |
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. | |||
TMPH-03269 | COMMD5 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
Hcarg localizes to the rat chromosome 7 between the markers Mit3 and Mit4. We identified a BglII RFLP between BN.lx and SHR rats. PMID: 11871861 HCaRG regulates renal epithelial cell growth and differentiation causing G(... | |||
TMPJ-00931 | Serpin A4 Protein, Human, Recombinant (His) | Human | Human Cells |
Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and sec... | |||
TMPH-01456 | Human herpesvirus 6B (HHV-6 variant B) (strain Z29) Glycoprotein Q1 (His & Myc) | HHV-6B | E. coli |
Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B. In the... | |||
TMPY-03460 | DCXR Protein, Human, Recombinant (His) | Human | E. coli |
DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and dist... | |||
TMPY-02111 | Carbonic Anhydrase 2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bi... | |||
TMPY-02418 | Kynureninase/KYNU Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranili... | |||
TMPY-02479 | Kynureninase/KYNU Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
KYNU (Kynureninase) is a Protein Coding gene. KYNU is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranili... | |||
TMPY-02931 | Cadherin 6/CDH6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morpho regulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progres... | |||
TMPH-01695 | MLKL Protein, Human, Recombinant (His) | Human | Yeast |
Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel... | |||
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Cat No. | Product Name | ||
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L8700 | Ferroptosis Compound Library | 800 compounds | |
A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study; |