smi — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3058	(Z)-SMI-4a	TCS PIM-1 4a,SMI-4a	Pim
	(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.		Pim
T3989	SMI-16a	PIM1/2 Kinase Inhibitor VI	Pim
	SMI-16a (PIM1/2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against...		Pim
T6974	Saccharin 1-methylimidazole	SMI,Saccharin 1-methylimidazole (SMI)	DNA/RNA Synthesis
	Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.		DNA/RNA Synthesis
T26195	SMI481	NPPM-6748-481,NPPM 6748-481,NPPM6748481,SMI-481 SMI 481,NPPM 6748481	Others
	SMI481 (NPPM6748481) is the first small-molecule Sec14-like phosphatidylinositol transfer proteins (PITPs) inhibitor.		Others
T4215	TCS-PIM-1-4a	SMI-4a	Apoptosis , Pim
	TCS-PIM-1-4a (SMI-4a), a Pim inhibitor, blocks mTORC1 activity through activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines (IC50=0.8-40 μM).		Apoptosis , Pim
T24808	SMI-6860766	TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766
	SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice.
T74733	OSM-SMI-10B
	OSM-SMI-10B, a derivative of OSM-SMI-10, effectively inhibits Oncostatin M (OSM)-induced STAT3 phosphorylation in cancer cells when co-incubated with OSM [1].
T16290	NIK SMI1		NF-κB
	NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).		NF-κB
T16901	SMIP004		Apoptosis , Others , E1/E2/E3 Enzyme
	SMIP004 is an SKP2 E3 ligase inhibitor. SMIP004 is a cancer cell-selective apoptosis inducer of human prostate cancer cells.		Apoptosis , Others , E1/E2/E3 Enzyme
T11315	Fosmidomycin sodium salt	FR-31564 sodium salt	Antibiotic , Parasite
	Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.		Antibiotic , Parasite
TN6797	Isoneochamaejasmin A		Others
	Isoneochamaejasmin A (INCA), a biflavonoid, is one of main active ingredients in the dried root of Stellera chamaejasme L., a widely used traditional Chinese medicine.		Others
T23372	SMIFH2		Others
	SMIFH2 is formin homology 2 (FH2) domains inhibitor.		Others
T12328	OSMI-4		Others
	OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells), which can be used to study OGT inhibition in different human cell lines.		Others
T2P2898	Neodiosmin	Diosmetin-7-neohesperidoside,Diosmetin-7-O-neohesperidoside	Antioxidant
	1. Neodiosmin (Diosmetin-7-O-neohesperidoside) has poor aqueous solubility but exerts a good debittering effect and is a strong antioxidant with potential applications in foods, beverages, and pharmaceutical preparations...		Antioxidant
T4370	Resminostat hydrochloride	4SC-201 hydrochloride,RAS2410 hydrochloride	HDAC
	Resminostat hydrochloride (RAS2410 hydrochloride) is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8 (IC50: 877 nM).		HDAC
T0878	Diosmin	Venosmine,Diosmil,Barosmin	Aryl Hydrocarbon Receptor , Norepinephrine
	Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.		Aryl Hydrocarbon Receptor , Norepinephrine
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T83646	(S)-OSMI 3	Ent-OSMI-3	Others
	(S)-OSMI 3 (Ent-OSMI-3) has anti-inflammatory and anti-tumour activity and can be used to study diabetes and neurodegenerative diseases.		Others
T12327	OSMI-3		Others
	OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.		Others
T22746	Tesmilifene fumarate	DPPE fumarate	Histamine Receptor
	Tesmilifene fumarate (DPPE fumarate) (DPPE fumarate) is an H1C receptor antagonist。		Histamine Receptor