SMI

Saccharin 1-methylimidazole (SMI) is a general-purpose activator used for DNA and RNA synthesis.

SMI-1074 is a ligand for a target protein used in PROTAC technology. It serves as a precursor for synthesizing compounds SMD-3236 and SMD-1087.

SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice.

(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.

SMI-16a (PIM1 2 Kinase Inhibitor VI) , a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1 2 kinases (IC50: 150 20 nM) while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 μM).

OSM-SMI-10B, a derivative of OSM-SMI-10, effectively inhibits Oncostatin M (OSM)-induced STAT3 phosphorylation in cancer cells when co-incubated with OSM [1].

OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor (EC50 of 3 μM in cells) that can be used to study OGT inhibition in different human cell lines.

OSMI-1 is an O-GlcNAc transferase (OGT) inhibitor (IC50=2.7 μM) that is orally active and cell-permeable. OSMI-1 inhibits protein O-GlcNA acetylation without qualitatively altering cell-surface N- or O- linked glycans.

OSMI-3 is a potent and cell-permeable inhibitor of O-GlcNAc transferase (OGT) for the study of cancer and cardiovascular disease.

Tetrofosmin is a phosphine developed to overcome the non-target uptake of radioligands by the generation of hetero-atomic compounds.

(S)-OSMI 3 (Ent-OSMI-3) has anti-inflammatory and anti-tumour activity and can be used to study diabetes and neurodegenerative diseases.

Isomyosmine is an isomer of myosine that inhibits nitrate reductase, has potential antiviral activity, reduces oxidative stress, can promote plant health and increase productivity and yield. Isomyosmine inhibits the release of TNF-α and can be used to study inflammation and coronavirus infection related to oxidoreductase.

Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.

SMIFH2 is formin homology 2 (FH2) domains inhibitor.

Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 microM (+)-eudesmin can induce neurite outgrowth and enhance nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

SMI481 (NPPM6748481) is the first small-molecule Sec14-like phosphatidylinositol transfer proteins (PITPs) inhibitor.

Fosmidomycin sodium salt (FR-31564 sodium salt) is an anti-infective antibiotic with anti-malarial activity that inhibits both Gram-negative and Gram-positive bacteria.

OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT).

Diosmin Impurity 8 is a useful organic compound for research related to life sciences and the catalog number is T125116.

Methyl jasminoside is a useful organic compound for research related to life sciences. The catalog number is T125271 and the CAS number is 229467-41-8.

Rosmic acid is a useful organic compound for research related to life sciences. The catalog number is T125434 and the CAS number is 197799-63-6.

Jasminoside N is a useful organic compound for research related to life sciences. The catalog number is T126179 and the CAS number is 1231710-13-6.