Search Result

Search Results for " proteasome "

Targets

1363

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome
T63321	20S Proteasome activator 1		Proteasome
	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...		Proteasome
T12561	Proteasome-IN-1		Proteasome
	Proteasome-IN-1 is an inhibitor of proteasome.		Proteasome
T81371	Proteasome-IN-5		Proteasome
	Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].		Proteasome
T72762	Proteasome-IN-4
	Proteasome-IN-4, a non-covalent proteasome inhibitor (IC 50 = 8.39 nM), exhibits potent antiproliferative effects on RPMI-8226, MM-1S, and MV-4-11 cell lines, making it valuable for cancer research.
T71092	Proteasome-IN-3
	Proteasome-IN-3 is an inhibitor of proteasome-associated DUBs.
T81372	Proteasome-activating peptide 1
	Proteasome-activating peptide 1 enhances chymotrypsin-like proteasomal catalytic activity, boosting proteolytic rates both in vitro and within cultured cells. Additionally, it inhibits protein aggregation in a cellular m...
T62255	20S Proteasome-IN-4
	20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag...
T76243	Proteasome-activating peptide 1 TFA
	Proteasome-activating peptide 1 TFA is a potent activator of the proteasome, enhancing chymotrypsin-like proteasomal catalytic activity and thereby increasing proteolytic rates both in vitro and in culture. Additionally,...
T81373	Proteasome β2c/i-IN-1		Proteasome
	Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].		Proteasome
T78625	Z-Ala-Arg-Arg-AMC	Z-ARR-AMC,Fluorogenic Proteasome Substrate	Proteasome
	Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) serves as a fluorogenic substrate designed to assay the trypsin-like activity within the proteasome [1].		Proteasome
T9710	Dazcapistat		Cysteine Protease
	Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.		Cysteine Protease
T6432	Calpeptin		Apoptosis , Cysteine Protease , Proteasome
	Calpeptin is a potent, cell-permeable calpain inhibitor.		Apoptosis , Cysteine Protease , Proteasome
T9090	MUN57694		Proteasome
	MUN57694 is an inhibitor of 26S proteasome.		Proteasome
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
T13858	RA190		Proteasome
	RA190 inhibits proteasome function by covalently binding to cysteine 88 of ubiquitin receptor RPN13.		Proteasome
T7814	Alloxan monohydrate		Proteasome
	Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.		Proteasome
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T0372	Gabexate mesylate	FOY	Factor Xa , Serine Protease , Proteasome
	Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inh...		Factor Xa , Serine Protease , Proteasome
T1795	Carfilzomib	PR-171	Apoptosis , Proteasome , Autophagy
	Carfilzomib (PR-171) is a proteasome inhibitor that irreversibly binds to the chymotrypsin of the 20S proteasome. Carfilzomib has antitumor activity and may be used to treat multiple myeloma.		Apoptosis , Proteasome , Autophagy
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T2470	MDL-28170	Calpain Inhibitor III	Cysteine Protease , Proteasome
	MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.		Cysteine Protease , Proteasome
T9809	E3 ligase Ligand 23		Ligand for E3 Ligase
	E3 ligase Ligand 23 is a cereblon binder and degrades Ikaros or Aiolos through ubiquitin proteasome.		Ligand for E3 Ligase
T8397	Ixazomib citrate	MLN9708	Proteasome , Autophagy
	Ixazomib citrate (MLN9708) is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (IC50 of 3.4 nM ) with potential antineoplastic activity.		Proteasome , Autophagy
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome
T17011	TCH-165		Proteasome
	TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.		Proteasome
T12579	RAMB4	PTP1B-IN-9	Proteasome
	RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.		Proteasome
T21510	PSI		Proteasome
	PSI is a proteasome inhibitor.		Proteasome
T6027	Delanzomib	CEP-18770	Apoptosis , NF-κB , Proteasome
	Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and peptidylglutamyl activities of the proteosome.		Apoptosis , NF-κB , Proteasome
T3695	Pepstatin	Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C	Amino Acids and Derivatives , Proteasome , HIV Protease , Autophagy
	Pepstatin (Pepsin Inhibitor S 735A) is a specific aspartic proteases inhibitor produced by actinomycetes, and inhibits the aspartic proteases cathepsin D, pepsin and renin.
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T39710	ARV-471	Vepdegestrant	Estrogen Receptor/ERR
	ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.		Estrogen Receptor/ERR
T6029	ONX-0914	ONX0914,PR-957,ONX 0914	Proteasome , HIV Protease , Antibacterial
	ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.		Proteasome , HIV Protease , Antibacterial
T13554	Arimoclomol maleate	BRX-220	HSP
	Arimoclomol maleate (BRX-220) (BRX-220) is a heat shock protein (HSP) co-inducer.		HSP
T6041	Oprozomib	PR-047,ONX 0912	Proteasome , Autophagy
	Oprozomib (PR-047) (ONX 0912) , an inhibitor for CT-L activity of 20S proteasome β5(IC50=36 nM)/LMP7(IC50=82 nM), is orally bioavailable. Oprozomib also has potential antineoplastic activity.		Proteasome , Autophagy
T10765	Eragidomide	CC-90009,Cereblon modulator 1	Apoptosis , Ligand for E3 Ligase , Molecular Glues
	Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.		Apoptosis , Ligand for E3 Ligase , Molecular Glues
T2154	MG-132	Z-LLL-al,Z-Leu-Leu-Leu-CHO	Apoptosis , Proteasome , Autophagy
	MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.		Apoptosis , Proteasome , Autophagy
T13553	Arimoclomol	BRX-220 free base	HSP
	Arimoclomol (BRX-220 free base) is a co-inducer of heat shock proteins (HSP) and can be used in studies about the treatment of amyotrophic lateral sclerosis (ALS).		HSP
T2399	Bortezomib	Radiciol,NSC 681239,MG 341,DPBA,Brotezamide,LDP 341	Apoptosis , NF-κB , Proteasome , Autophagy
	Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective. Bortezomib has antitumor activity and inhibits NF-κB, which can disrupt the cell cycle and induce apoptosis.		Apoptosis , NF-κB , Proteasome , Autophagy
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T12628	(R)-MG-132	(S,R,S)-(-)-MG-132,Z-Leu-D-leu-leu-al	Proteasome
	(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.		Proteasome
T61320	Immunoproteasome inhibitor 1
	Immunoproteasome inhibitor 1 is a highly potent and reversible inhibitor of both immunoproteasome and proteasome activity. It exhibits time-independent inhibitory effects on immunoproteasome subunits β5c, β1i, and β5i, w...
T2016	MLN9708	Ixazomib Citrate	Proteasome
	MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.		Proteasome
T1932	B-AP15	NSC 687852	Apoptosis , DUB
	B-AP15 (NSC-687852)(NSC-687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the 26S proteasome.		Apoptosis , DUB
T26754	BC-23	NSC 45382,BC 23,BC23,NSC-45382,NSC45382	Proteasome
	BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in the study of leukemias, lymphomas, gliomas, breast cancer, an...		Proteasome
T10061	(1S,2S)-Bortezomib	Bortezomib	Proteasome
	(1S,2S)-Bortezomib (Bortezomib) is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.		Proteasome
T21617	MG-115	Z-LL-Nva-CHO	Proteasome
	MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteas...		Proteasome
T7854	Bortezomib-pinanediol		Proteasome
	Bortezomib-pinanediol is a proteasome inhibitor. is a prodrug of Bortezomib.		Proteasome

Compounds

Proteasome inhibitor IX

T21854

Synonym: PS-IX,AM114

Target: Proteasome

20S Proteasome activator 1

Proteasome-activating peptide 1

T81372

Synonym:

Target:

20S Proteasome-IN-4

T62255

Synonym:

Target:

Proteasome-activating peptide 1 TFA

T76243

Synonym:

Target:

Proteasome β2c/i-IN-1

Synonym: Z-ARR-AMC,Fluorogenic Proteasome Substrate

Target: Cysteine Protease

Calpeptin

T6432

Synonym:

Target: Apoptosis, Cysteine Protease, Proteasome

Target: Apoptosis, Proteasome, Caspase

Target: Proteasome, Caspase, Autophagy

PI-1840

T6941

Synonym: PI 1840

Target: PARP, Proteasome

DD1

T8978

Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111

Target: Factor Xa, Serine Protease, Proteasome

Carfilzomib

T1795

Synonym: PR-171

Target: Apoptosis, Proteasome, Autophagy

UT-34

T13273

Synonym:

Target: Androgen Receptor

MDL-28170

T2470

Synonym: Calpain Inhibitor III

Target: Cysteine Protease, Proteasome

E3 ligase Ligand 23

T9809

Synonym:

Target: Ligand for E3 Ligase

Ixazomib citrate

T8397

Synonym: MLN9708

Target: Proteasome, Autophagy

Target: Apoptosis, NF-κB, Proteasome

Pepstatin

T3695

Synonym: Pepstatin A,Pepsin Inhibitor S 735A,Ahpatinin C

Target: Amino Acids and Derivatives, Proteasome, HIV Protease, Autophagy

PROTAC BRAF-V600E degrader-1

Synonym: Vepdegestrant

Target: Estrogen Receptor/ERR

ONX-0914

T6029

Synonym: ONX0914,PR-957,ONX 0914

Target: Proteasome, HIV Protease, Antibacterial

Synonym: PR-047,ONX 0912

Target: Proteasome, Autophagy

Eragidomide

T10765

Synonym: CC-90009,Cereblon modulator 1

Target: Apoptosis, Ligand for E3 Ligase, Molecular Glues

MG-132

T2154

Synonym: Z-LLL-al,Z-Leu-Leu-Leu-CHO

Target: Apoptosis, Proteasome, Autophagy

Arimoclomol

T13553

Synonym: BRX-220 free base

Target: HSP

Bortezomib

T2399

Synonym: Radiciol,NSC 681239,MG 341,DPBA,Brotezamide,LDP 341

Target: Apoptosis, NF-κB, Proteasome, Autophagy

MG-101

T6583

Synonym: ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101

Target: Cysteine Protease, Proteasome

(R)-MG-132

T12628

Synonym: (S,R,S)-(-)-MG-132,Z-Leu-D-leu-leu-al

Target: Proteasome

Immunoproteasome inhibitor 1

Synonym: Ixazomib Citrate

Target: Apoptosis, DUB

BC-23

T26754

Synonym: NSC 45382,BC 23,BC23,NSC-45382,NSC45382

Synonym: Z-LL-Nva-CHO

Target: Proteasome

Bortezomib-pinanediol

T7854

Synonym:

Target: Proteasome

Cat No.	Product Name	Synonyms	Targets
T3786	Tomatine	lycopersicin	Apoptosis , Proteasome
	Tomatine (lycopersicin) is an antiproliferatve agent of breast adenocarcinoma cells.		Apoptosis , Proteasome
T3028	Tripterin	Celastrol,Tripterine	Apoptosis , Mitophagy , Proteasome , Autophagy
	Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodula...		Apoptosis , Mitophagy , Proteasome , Autophagy
T6830	Epoxomicin	BU-4061T,BU-4061T,Aids010837	Apoptosis , Proteasome
	Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited...		Apoptosis , Proteasome
T4S21320	ISOGINKGETIN	4',4'''-Dimethylamentoflavone	MMP , Others
	1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti...		MMP , Others
T2745	18α-Glycyrrhetinic acid	Enoxolone,Glycyrrhetinic acid	Apoptosis , NF-κB , Proteasome
	18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis.		Apoptosis , NF-κB , Proteasome
T7917	4'-Hydroxychalcone	2-Benzal-4-Hydroxyacetophenone	Proteasome
	4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activity		Proteasome
T16012	Marizomib	NPI-0052,Salinosporamide A,ML858	Proteasome
	Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 20S proteasomes with IC50s of 3.5, 28, and 430 nM, respectiv...		Proteasome
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
T4S1615	Sanggenon C	Sanggenone C	NF-κB
	1. Sanggenon C (Sanggenone C) inhibits tumor cellular proteasomal activity and cell viability, via induction of cell cycle arrest and cell death , inhibiting the proteasome function. 2. Sanggenon C and O inhibited NO pro...		NF-κB
T15702	Lactacystin		Proteasome
	Lactacystin is an antibiotic Streptomyces spp. the metabolite and is an effective and selective proteasome inhibitor (IC50: 4.8 μM for 20S proteasome). Lactacystin inhibits cell growth and induces neurite outgrowth and a...		Proteasome
TN3228	7-Hydroxy-3-(4-hydroxybenzyl)chroman		Others
	7-Hydroxy-3-(4-hydroxybenzyl)chroman shows moderate inhibitory activity against a chymotrypsin-like activity of the proteasome.		Others
TN1354	Aaptamine		c-Myc , TNF , p53
	Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.		c-Myc , TNF , p53
T75623	Sadopeptins A
	Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
T75624	Sadopeptins B
	Sadopeptins B, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
T10238	Aclacinomycin A hydrochloride	Aclarubicin hydrochloride	Proteasome
	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinom...		Proteasome
T75488	Leptosphaerodione
	Leptosphaerodione, a compound derived from the Remotididymella sp. fungus, functions as a potent inhibitor of the ubiquitin-proteasome system (UPS) and demonstrates cytotoxic effects in HeLa cells with an IC50 value of 3...
T79941	Antimycin A2c		Apoptosis
	Anticancer Agent 141 (Compound AE), an antimycin alkaloid, exhibits inhibitory potential against HPV-infected cervical cancer. It impedes HeLa cell proliferation by arresting the cell cycle at the S phase and induces cas...		Apoptosis

Natural Products

Tomatine

T3786

Synonym: lycopersicin

Target: Apoptosis, Proteasome

Tripterin

T3028

Synonym: Celastrol,Tripterine

Target: Apoptosis, Mitophagy, Proteasome, Autophagy

Epoxomicin

T6830

Synonym: BU-4061T,BU-4061T,Aids010837

Target: Apoptosis, Proteasome

ISOGINKGETIN

T4S21320

Synonym: 4',4'''-Dimethylamentoflavone

Target: MMP, Others

18α-Glycyrrhetinic acid

T2745

Synonym: Enoxolone,Glycyrrhetinic acid

Target: Apoptosis, NF-κB, Proteasome

4'-Hydroxychalcone

T7917

Synonym: 2-Benzal-4-Hydroxyacetophenone

Target: Proteasome

Marizomib

T16012

Synonym: NPI-0052,Salinosporamide A,ML858

Target: Proteasome

Steviol

T2S1837

Synonym: NSC 226902,Hydroxydehydrostevic acid

Target: Others

Sanggenon C

T4S1615

Synonym: Sanggenone C

7-Hydroxy-3-(4-hydroxybenzyl)chroman

Target: c-Myc, TNF, p53

Aclacinomycin A hydrochloride

T10238

Synonym: Aclarubicin hydrochloride

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00703	Gankyrin Protein, Human, Recombinant	Human	E. coli
	Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblast...
TMPY-00607	PSMB6 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	PSMB6 subunit belongs to the 20S proteasomal subunit family, which plays an importance role in the antigen presentation by MHC class I molecular. Proteasome subunit beta type 6 (PSMB6) is a member of 20S proteasomal subu...
TMPY-04078	PSMA3 Protein, Human, Recombinant (His)	Human	E. coli

TMPY-03612	PSME1 Protein, Human, Recombinant (His)	Human	E. coli
	PA28A, also known as PSME1, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed ...
TMPY-03610	PSME2 Protein, Human, Recombinant (His)	Human	E. coli
	PSME2, also known as PA28b, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is composed ...
TMPY-03614	PSME3 Protein, Human, Recombinant (His)	Human	E. coli
	PSME3, also known as PA28-gamma, is a subunit of proteasome. The 26S proteasome multicatalytic proteinase complex has a highly ordered structure composed of 2 complexes, a 2S core and a 19S regulator. The 2S core is comp...
TMPY-02101	KEAP1 Protein, Human, Recombinant (His & GST & Avi)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03888	KEAP1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03432	KEAP1 Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-02205	Beta-Catenin Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p...
TMPH-03762	TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)	Mouse	E. coli
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-02953	TPP2 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-03757	TPP2 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-02250	TPP2 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-02300	RAD23A Protein, Human, Recombinant (His)	Human	E. coli
	Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chain...
TMPH-02284	USP26 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
TMPH-01203	DCAF16 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Functions as a substrate recognition component for CUL4-DDB1 E3 ubiquitin-protein ligase complex, which mediates ubiquitination and proteasome-dependent degradation of nuclear proteins.
TMPJ-01386	STUB1 Protein, Human, Recombinant	Human	E. coli
	E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its ...
TMPH-00849	PSMD14 Protein, Human, Recombinant (His & MBP)	Human	Baculovirus
	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded o...
TMPH-02630	MDM2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional ...
TMPH-01605	BAG6 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which main...
TMPH-01606	BAG6 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which main...
TMPH-00269	GPR52 Protein, Bovine, Recombinant (His & KSI)	Bovine	E. coli
	G- protein coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA...
TMPH-01833	Human Papilloma Virus type 16 (HPV 16) Protein E6 (His)	HPV 16	Yeast
	Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ...
TMPH-01832	Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His)	HPV 16	E. coli
	Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host UBE3A/E6-AP ...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
TMPH-01264	PELI1 Protein, Human, Recombinant (His)	Human	Baculovirus
	E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Me...
TMPH-01522	HIV-2 (subtype A, isolate ROD) Protein Vpx (His)	HIV-2	Yeast
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-03509	Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO)	SIV	E. coli
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-03495	IFN gamma Protein, Sheep, Recombinant (His)	Sheep	Yeast
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPH-00775	IFN gamma Protein, Goat, Recombinant (His & Myc)	Goat	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPH-01521	HIV-2 (subtype A, isolate BEN) Protein Vpx (His)	HIV-2	E. coli
	Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by...
TMPH-03494	IFN gamma Protein, Sheep, Recombinant (E. coli, His)	Sheep	E. coli
	Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentatio...
TMPJ-00661	PDCD5 Protein, Human, Recombinant (His)	Human	E. coli
	Programmed Cell Death Protein 5 (PDCD5) is a member of the PDCD5 family. PDCD5 is expressed in tumor cells during apoptosis, independent of apoptosis-inducing stimuli. This protein may function in the process of apoptosi...
TMPJ-01013	VCP Protein, Human, Recombinant (His)	Human	E. coli
	Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxi...
TMPJ-01131	UBE2V2 Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2) is an enzyme that belongs to the ubiquitin-conjugating enzyme family. UBE2V2 can be detected in the placenta, colon, liver, and skin. It forms a heterodimer with UBE2N....
TMPJ-01310	TRIM5 Protein, Human, Recombinant (His)	Human	E. coli
	Tripartite motif-containing Motif 5 is a protein that in humans is encoded by the TRIM5 gene.It is a 493 amino acids protein that belongs to the TRIM/RBCC family.It contains 1 B box-type zinc finger, 1 B30.2/SPRY domain ...
TMPY-03870	EDEM2 Protein, Human, Recombinant (His)	Human	HEK293
	EDEM2, also known as C2orf31, belongs to a family of proteins involved in ER-associated degradation (ERAD) of glycoproteins. In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and ...
TMPY-01865	BLMH Protein, Mouse, Recombinant (His)	Mouse	E. coli
	The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide...
TMPH-01261	NEDD4L Protein, Human, Recombinant (GST)	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by trig...
TMPH-00340	ATG1 Protein, Candida glabrata, Recombinant (His)	Candida glabrata	E. coli
	Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein ...
TMPH-01269	SMURF2 Protein, Human, Recombinant (His)	Human	E. coli
	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMA...
TMPY-00651	BACE1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00678	BACE1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPY-00652	BACE1 Protein, Human, Recombinant	Human	HEK293
	Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPH-01520	HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc)	HIV-1	E. coli
	During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPY-00752	BACE1 Protein, Human, Recombinant (His)	Human	HEK293
	Beta-site APP-cleaving enzyme 1 (BACE1) is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. In the brain, This protein is expressed highly in the substantia nigra, locus c...
TMPH-01519	HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)	HIV-1	E. coli
	During virus replication, may deplete host UNG protein, and incude G2-M cell cycle arrest. Acts by targeting specific host proteins for degradation by the 26S proteasome, through association with the cellular CUL4A-DDB1 ...
TMPH-01073	CD81 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalizati...
TMPH-01738	NLRP1 Protein, Human, Recombinant (GST)	Human	E. coli
	Acts as the sensor component of the NLRP1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis. Inflammasomes are supramolecular comple...
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Gankyrin Protein, Human, Recombinant

TMPJ-00703

Species: Human

Expression System: E. coli

PSMB6 Protein, Mouse, Recombinant (His)

TMPY-00607

Species: Mouse

Expression System: E. coli

PSMA3 Protein, Human, Recombinant (His)

TMPY-04078

Species: Human

Expression System: E. coli

PSME1 Protein, Human, Recombinant (His)

TMPY-03612

Species: Human

Expression System: E. coli

PSME2 Protein, Human, Recombinant (His)

TMPY-03610

Species: Human

Expression System: E. coli

PSME3 Protein, Human, Recombinant (His)

TMPY-03614

Species: Human

Expression System: E. coli

KEAP1 Protein, Human, Recombinant (His & GST & Avi)

TMPY-02101

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant (His & GST)

TMPY-03888

Species: Human

Expression System: Baculovirus-Insect Cells

KEAP1 Protein, Human, Recombinant

TMPY-03432

Species: Human

Expression System: Baculovirus-Insect Cells

Beta-Catenin Protein, Human, Recombinant (His & GST)

TMPY-02205

Species: Human

Expression System: Baculovirus-Insect Cells

TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)

TMPH-03762

Species: Mouse

Expression System: E. coli

TPP2 Protein, Mouse, Recombinant (His & Myc)

TMPH-02953

Species: Mouse

Expression System: Baculovirus

TPP2 Protein, Human, Recombinant (E. coli, His & Myc)

TMPH-03757

Species: Human

Expression System: E. coli

TPP2 Protein, Human, Recombinant (His & Myc)

TMPH-02250

Species: Human

Expression System: Baculovirus

RAD23A Protein, Human, Recombinant (His)

TMPH-02300

Species: Human

Expression System: E. coli

USP26 Protein, Human, Recombinant (His)

TMPH-02284

Species: Human

Expression System: E. coli

DCAF16 Protein, Human, Recombinant (His & Myc)

TMPH-01203

Species: Human

Expression System: E. coli

STUB1 Protein, Human, Recombinant

TMPJ-01386

Species: Human

Expression System: E. coli

PSMD14 Protein, Human, Recombinant (His & MBP)

TMPH-00849

Species: Human

Expression System: Baculovirus

MDM2 Protein, Mouse, Recombinant (His)

TMPH-02630

Species: Mouse

Expression System: E. coli

BAG6 Protein, Human, Recombinant (E. coli, His & Myc)

TMPH-01605

Species: Human

Expression System: E. coli

BAG6 Protein, Human, Recombinant (His & Myc)

TMPH-01606

Species: Human

Expression System: Baculovirus

GPR52 Protein, Bovine, Recombinant (His & KSI)

TMPH-00269

Species: Bovine

Expression System: E. coli

Human Papilloma Virus type 16 (HPV 16) Protein E6 (His)

TMPH-01833

Species: HPV 16

Expression System: Yeast

Human Papilloma Virus type 16 (HPV 16) Protein E6 (E. coli, His)

TMPH-01832

Species: HPV 16

Expression System: E. coli

Ubiquilin-1 Protein, Human, Recombinant (His & Myc)

TMPH-02282

Species: Human

Expression System: E. coli

PELI1 Protein, Human, Recombinant (His)

TMPH-01264

Species: Human

Expression System: Baculovirus

HIV-2 (subtype A, isolate ROD) Protein Vpx (His)

TMPH-01522

Species: HIV-2

Expression System: Yeast

Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO)

TMPH-03509

Species: SIV

Expression System: E. coli

IFN gamma Protein, Sheep, Recombinant (His)

TMPH-03495

Species: Sheep

Expression System: Yeast

IFN gamma Protein, Goat, Recombinant (His & Myc)

TMPH-00775

Species: Goat

Expression System: E. coli

HIV-2 (subtype A, isolate BEN) Protein Vpx (His)

TMPH-01521

Species: HIV-2

Expression System: E. coli

IFN gamma Protein, Sheep, Recombinant (E. coli, His)

TMPH-03494

Species: Sheep

Expression System: E. coli

PDCD5 Protein, Human, Recombinant (His)

TMPJ-00661

Species: Human

Expression System: E. coli

VCP Protein, Human, Recombinant (His)

TMPJ-01013

Species: Human

Expression System: E. coli

UBE2V2 Protein, Human, Recombinant (His)

TMPJ-01131

Species: Human

Expression System: E. coli

TRIM5 Protein, Human, Recombinant (His)

TMPJ-01310

Species: Human

Expression System: E. coli

EDEM2 Protein, Human, Recombinant (His)

TMPY-03870

Species: Human

Expression System: HEK293

BLMH Protein, Mouse, Recombinant (His)

TMPY-01865

Species: Mouse

Expression System: E. coli

NEDD4L Protein, Human, Recombinant (GST)

TMPH-01261

Species: Human

Expression System: E. coli

ATG1 Protein, Candida glabrata, Recombinant (His)

TMPH-00340

Species: Candida glabrata

Expression System: E. coli

SMURF2 Protein, Human, Recombinant (His)

TMPH-01269

Species: Human

Expression System: E. coli

BACE1 Protein, Human, Recombinant (hFc)

TMPY-00651

Species: Human

Expression System: HEK293

BACE1 Protein, Mouse, Recombinant (His)

TMPY-00678

Species: Mouse

Expression System: HEK293

BACE1 Protein, Human, Recombinant

TMPY-00652

Species: Human

Expression System: HEK293

HIV-1 (group M, subtype K, isolate 96CM-MP535) Protein Vpr (His & Myc)

TMPH-01520

Species: HIV-1

Expression System: E. coli

BACE1 Protein, Human, Recombinant (His)

TMPY-00752

Species: Human

Expression System: HEK293

HIV-1 (group M, subtype C, isolate 92BR025) Protein Vpr (His & Myc)

TMPH-01519

Species: HIV-1

Expression System: E. coli

CD81 Protein, Human, Recombinant (His & SUMO)

TMPH-01073

Species: Human

Expression System: E. coli

NLRP1 Protein, Human, Recombinant (GST)

TMPH-01738

Species: Human

Expression System: E. coli

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Cat No.	Product Name
L8600	Ubiquitination Compound Library	214 compounds
	A unique collection of 214 ubiquitination related small chemicals can be used for high throughput and high content screening；
L1100	Protease Inhibitor Library	344 compounds
	A unique collection of 344 protease and proteasome inhibitors for research in chemical genomics, and drug screening;
L8500	HIF-1 Signaling Pathway Compound Library	1352 compounds
	A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；
L3800	NF-κB Signaling Compound Library	740 compounds
	A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;

Libraries

Ubiquitination Compound Library

L8600

Compounds: 214

Protease Inhibitor Library

L1100

Compounds: 344

HIF-1 Signaling Pathway Compound Library

L8500

Compounds: 1352

NF-κB Signaling Compound Library

L3800

Compounds: 740