T10256 |
Afatinib D6
|
1313874-96-2
|
98%
|
|
Afatinib D6 (BIBW 2992 D6) is a deuterium-labeled Afatinib. Afatinib is an irreversible EGFR family inhibitor.
|
T9927 |
Panitumumab
|
339177-26-3
|
98%
|
|
Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).
|
TN4638 |
Neolinine
|
112515-37-4
|
98%
|
|
Neolinine(at 10uM) shows significant hERG K+ channel inhibition activity.
|
T61016 |
EMI1
|
35773-42-3
|
98%
|
|
EMI1 is an inhibitor of EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S. EMI1 has research value in the research of mutant EGFR-associated, drug-resistant no...
|
TN1871 |
Ligustroside
|
35897-92-8
|
98%
|
|
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
|
TN3525 |
Boehmenan
|
57296-22-7
|
98%
|
|
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
|
T10531 |
BGB-102
|
807640-87-5
|
98%
|
|
BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
|
T11157 |
EGFR-IN-1
|
1625677-63-5
|
98%
|
|
EGFR-IN-1 displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells. Antitumor activity. EGFR-IN-1 is an orally a...
|
TN4213 |
Hirsutenone
|
41137-87-5
|
98%
|
|
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
|
T10556 |
BKI-1369
|
1951431-22-3
|
98%
|
|
BKI-1369 is a bumped kinase inhibitor. BKI-1369 increases hERG-inhibitory activity (IC50:1.52 μM).
|
T4183 |
Lavendustin A
|
125697-92-9
|
98%
|
|
lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
|
T13743 |
JH-XI-10-02
|
2209085-22-1
|
98%
|
|
JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrade...
|
T2460 |
JAK 3 inhibitor IV
|
58753-54-1
|
98%
|
|
JAK 3 inhibitor IV is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutam...
|
T19489 |
O-Desmethyl gefitinib D8
|
T19489
|
98%
|
|
O-Desmethyl gefitinib D8 is a deuterium labeled O-Desmethyl gefitinib that is an active metabolite of Gefitinib in human plasma.
|
T12175 |
Naquotinib mesylate
|
1448237-05-5
|
98%
|
|
Naquotinib mesylate is an orally available, mutant-selective and irreversible inhibitor of EGFR(iC50s of 8-33 nM and 230 nM for toward EGFR mutants and EGFR).
|
TN3711 |
Corylifol C
|
775351-91-2
|
98%
|
|
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
|
T16362 |
Nuvenzepine
|
96487-37-5
|
98%
|
|
Nuvenzepine is an antagonist of mAChR. It has the potential for gastrospasm treatment.
|
T2518 |
ARRY-380 (analog )
|
937265-83-3
|
98%
|
|
ARRY-380 is a potent and selective HER2 inhibitor.
|
TN5100 |
Taspine
|
602-07-3
|
98%
|
|
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
|
T11717 |
JHU395
|
2079938-92-2
|
98%
|
|
JHU395 delivers 6-diazo-5-oxo-L-norleucine (DON) to malignant peripheral nerve sheath tumor (MPNST) in vitro and in vivo, and has antitumor activity in MPNST. JH...
|