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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

Nectin-4

Nectin-4 is a cell adhesion molecule belonging to the Nectin family, primarily expressed in epithelial and neural cells. Through interactions with other Nectin family members, Nectin-4 participates in intercellular adhesion and polarity formation. In oncology, Nectin-4 exhibits high expression in multiple cancers, including bladder, breast, and lung cancers, making it a potential target for tumour diagnosis and therapy.

Filter HomeSignaling PathwaysImmunology/InflammationNectin-4

Enfortumab

T774051448664-46-7

Enfortumab is a monoclonal antibody against Nectin-4.Enfortumab can be used to synthesize antibody-drug couplings (enfortumab vedotin) and can also be used in conjunction with platinum compounds to study uroepithelial cancers.

$228

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Enfortumab vedotin-ejfv

T780651346452-25-2

Enfortumab vedotin-ejfv (Padcev) is an ADC compound targeting Nectin-4 with anti-tumor activity, used in the study of urothelial carcinoma.

$835

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N188 TFA

TP2776

N188 TFA is a radiolabeled ligand based on a bicyclic peptide scaffold, targeting the protein nectin-4, which is overexpressed in various tumors. It can be efficiently labeled with the radioactive isotope 68Ga to form 68Ga-N188, suitable for positron emission tomography (PET) imaging. The development of N188 TFA and its radiolabeled form, 68Ga-N188, holds potential for the diagnosis and treatment of cancers such as urothelial carcinoma.

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