immunology & inflammation related

11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.

8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activit

Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels

Meranzin, a bioactive compound derived from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) and isolated from Murraya exotica L. leaves, targets the alpha 2-adrenoceptor and engages the AMPA-ERK1/2–BDNF signaling pathway. It offers promising potential for preventing the comorbidity of atherosclerosis and depression due to its significant anti-inflammatory and analgesic properties.

Arnidiol, a pentacyclic triterpene isolated from Barleria Longiflora Linn, exhibits anti-inflammatory activity, notably inhibiting 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.

Enmein shows significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 microg/ml to 8.2 microg/ml

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.

3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the

3-O-Acetyl-16α-hydroxytrametenolic acid exhibits inhibitory activities against AAPH-induced hemolysis of red blood cells and demonstrates strong inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.

Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation.

Arjungenin, a triterpene derived from Terminalia arjuna, exhibits insect feeding-deterrent and growth inhibitory properties.

Bryodulcosigenin has anti-inflammatory effect, it shows potent inhibitory effects on EBV-EA induction.

Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.

Glucosyringic acid has immunosuppressive effect, it can inhibit the proliferation of murine B lymphocytes in vitro.

(+)-Isolariciresinol ((+)-Cyclolariciresinol) is extracted from Radix Isatidis, exhibits antioxidant and anti-inflammatory activities, and is applicable in rheumatism studies.

Kaempferol 3-O-β-D-galactopyranoside possesses antioxidant, anti-inflammatory, and antinociceptive activities.

Myricetin 3-O-glucoside (Myricetin 3-O-beta-D-glucopyranoside) is a flavonol extracted from Tibouchina paratropica, exhibiting anti-leishmania, anti-inflammatory, and antibacterial activities.

Djalonensone (Alternariol monomethyl ether), an Alternaria toxin, is a strong mutagen in Escherichia coli strain ND-160. Alternariol monomethyl ether has genotoxic properties, it can cause oxidative DNA damage. It also possesses cytotoxic and immunosuppressive properties.

Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane peroxidation induced by oxygen free radi

Chasmanine is a natural diterpenoid alkaloid with an IC50 of 6.78 mg/L for Fe2+ chelation activity and exhibits cytotoxicity against PC-3 and A-549 cells.

Cucurbitacins from Wilbrandia ebracteata have analgesic effects. Cucurbitacin S has anticancer and antiinflammatory activities.

Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice.

Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibite

Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats.