264
28
674
8
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36692 | Fanotaprim | DHFR | |
Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor. Fanotaprim inhibits the growth of T. gondii strains with a TgDHFR IC50 of 1.57 ± 0.11 nM and a hDHFR IC50 of 308 ± 71 nM and a hDHFR to TgDHFR selectivity ratio o... | |||
T8464 | RA-9 | Apoptosis , DUB | |
RA-9 is a potent and selective proteasome-associated inhibitor of deubiquitinating enzymes (DUBs), with favorable toxicity profile and anticancer activity. RA-9 selectively induces apoptosis in ovarian cancer cell lines. | |||
T8507 | MAC-545496 | Antibacterial | |
MAC-545496 is a glycopeptide-resistance-associated protein R (GraR) inhibitor, is an antivirulence agent. | |||
T13336 | VTP50469 | Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase | |
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity. | |||
T14943 | CGP60474 | VEGFR , CDK , PKC | |
CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC. CGP60474 is also a highly potent anti-endotoxemic agent and inhibits cyclin-dependent kinase (CDK) potently. | |||
T10606 | BRD0705 | GSK-3 | |
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM). | |||
T15588 | Iobenguane sulfate | MIBG sulfate | Others |
Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmac... | |||
T4641 | Branaplam | LMI 070,NVS-SM1 | Others , Potassium Channel , DNA/RNA Synthesis |
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. | |||
T9962 | Mepolizumab | SB 240563 | IL Receptor |
Mepolizumab (SB 240563) is a humanized monoclonal antibody neutralizing IL-5. Mepolizumab can be used in studies about severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis. | |||
T6626 | PF-3758309 | PF-309,PF-03758309,PF 3758309 | Apoptosis , PAK |
PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition. | |||
T6351 | MGCD-265 analog | MGCD-265,Glesatinib | Apoptosis , VEGFR , c-Met/HGFR |
MGCD-265 analog (Glesatinib) is an orally bioavailable multitargeted tyrosine kinase inhibitor with potential antineoplastic activity with IC50 of 29 nM and 10 nM for c-Met and VEGFR2, respectively. | |||
T6496 | Vactosertib | TEW-7197,EW-7197 | ALK , TGF-beta/Smad |
Vactosertib (EW-7197) is an orally bioavailable inhibitor of the serine/threonine kinase, transforming growth factor (TGF)-beta receptor type 1 (TGFBR1), also known as activin receptor-like kinase 5 (ALK5), with potentia... | |||
T4230 | PF-3758309 hydrochloride | PF-03758309 hydrochloride | Apoptosis , PAK |
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hyd... | |||
T1950 | PND-1186 | PND1186,PND 1186,VS-4718,SR-2516 | Apoptosis , FAK |
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM). | |||
T28866 | Stemazole | Apoptosis | |
Stemazole is a novel small molecule human stem/progenitor cell proliferation activator that promotes the survival of human embryonic stem cells and maintains stemness, and promotes the survival of oligodendrocyte precurs... | |||
T13810 | Palmitoylcarnitine chloride | Others | |
Palmitoylcarnitine chloride selectively decreases cell survival in colorectal and prostate cancer cells by affecting on pro-inflammatory pathways, Ca2+ influx, and DHT-like effects. | |||
T17178 | Tulopafant | RP 59227 | PAFR |
Tulopafant (RP 59227) is a potent platelet-activating factor (PAF) antagonist that increases capillary patency and prolongs allograft heart survival. | |||
T60011 | HS220 | MAPK | |
HS220 is an inhibitor of TAK1 which plays a key role in the signaling pathways of inflammation and cell survival. | |||
T27830 | Lifarizine | RS 87476,RS 87476-000,RS-87476,RS-87476-000,RS87476 | Calcium Channel |
Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion. | |||
T2155 | Thiazovivin | ROCK | |
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC. | |||
T67980 | Coleneuramide | MCC-257 | Others |
Coleneuramide (MCC-257) enhances the effect of nerve growth factor (NGF) on cell survival and can be used to study diabetic polyneuropathy. | |||
T26641L | Apadenoson TFA | BAY 68-4986 TFA,Apadenoson TFA(250386-15-3 Free base),Discontinued TFA | Adenosine Receptor |
Apadenoson TFA is a potent adenosine A2A receptor (A2AR) agonist that can be used to improve survival in patients infected with SARS. | |||
T3106 | C-DIM12 | Apoptosis , Others | |
C-DIM12 induced expression of Nurr1-regulated genes. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure ... | |||
T16757 | Risdiplam | RO7034067,RG7916 | DNA/RNA Synthesis |
Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor neuron (SMN) protein levels[1]. | |||
T16859 | SBI-425 | Others | |
SBI-425 is an effective and orally bioavailable inhibitor of tissue-nonspecific alkaline phosphatase (TNAP). SBI-425 effectively inhibits TNAP in the vasculature and improves cardiovascular parameters and survival withou... | |||
T16964 | SYM2206 | SYM-2206,SYM 2206 | Sodium Channel , iGluR |
SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated sustained currents and decreasing the survival of pancreati... | |||
T9411 | KX2-361 | Others , Microtubule Associated , Src | |
KX2-361 is a orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma | |||
T37292 | M62812 | TLR | |
TLR4 inhibitor. Inhibits LPS-induced NF-κB activation in HEK293 cells (IC50 = 2.4 μg/mL). Also inhibits LPS-induced cytokine production and procoagulant effects in PBMCs and HUVECs. Prolongs survival in a mouse septic sh... | |||
T0349 | Riluzole | PK 26124,RP-54274 | GABA Receptor , Sodium Channel , NMDAR |
Riluzole (RP-54274) is a glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS. | |||
T10397 | ATN-161 trifluoroacetate salt | ATN-161 TFA salt | Integrin |
ATN-161 trifluoroacetate salt (ATN-161 TFA salt) is a novel integrin α5β1 antagonist that inhibits angiogenesis and growth of liver metastases and improves survival in a murine model. | |||
T4605 | NT157 | IGF-1R , STAT | |
NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival. | |||
T40498L | Dentonin acetate | Dentonin acetate (400090-20-2 Free base) | Others |
Dentonin acetate enhances osteogenesis and facilitates immature adherent cell survival. Dentonin acetate, a synthetic fragment derived from MEPE, can be used in phosphate homeostasis and bone metabolism studies. | |||
T61859 | MK-28 | Antiviral , PERK | |
MK-28 is a selective PERK agonist that reduces toxicity and prolongs survival in a Huntington's disease model.MK-28 has a significant killing effect on MK28 gastric cancer cells. | |||
T24133 | HDAC8-IN-20a | HDAC8 IN 20a,HDAC8IN20a,HDAC8 inhibitor-20a,HDAC8 inhibitor 20a | HDAC |
HDAC8-IN-20a (HDAC8 inhibitor-20a) is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals. | |||
T9468 | FR054 | Others | |
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and su... | |||
T5483 | DMX-5804 | DMX-5084 | MAPK |
DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice. | |||
T8366 | Mitochonic acid 5 | MA-5 | Mitochondrial Metabolism |
Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of f... | |||
T25125 | AZA197 | AZA 197,AZA-197 | CDK |
AZA197 (AZA-197) is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downregulation of PAK1 activity. | |||
T70388 | (S)-Enitociclib | VIP152 | CDK |
(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription of anti-apoptotic and pro-survival proteins. | |||
T3626 | Acalabrutinib | ACP-196 | BTK |
Acalabrutinib (ACP-196), also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and pre... | |||
T72984 | (Rac)-SHIN2 | Others | |
(Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor that enhances NOTCH1-driven in vivo survival of primary T-ALL in mice and can be used to study T-cell acute lymphoblastic leukemia (T-ALL). | |||
T16695 | Pyrintegrin | Integrin | |
Pyrintegrin is an β1-integrin agonist that promotes embryonic stem cells' survival. Pyrintegrin can be used as a podocyte-protective agent. Pyrintegrin enhances cell-extracellular matrix adhesion-mediated integrin signal... | |||
T4235 | Roblitinib | FGF-401 | FGFR |
Roblitinib (FGF-401) is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, Roblitinib binds to and inhibits the activity of FGFR4, which leads ... | |||
T9552 | BAZ1A-IN-1 | Epigenetic Reader Domain | |
BAZ1A-IN-1 is a potent BAZ1A inhibitor with the KD value of 0.52 μM for the BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-survival activity against cancer cell lines with high BAZ1A expression, but weak or no activity ag... | |||
T39965 | NF-κΒ activator 1 | NF-κB | |
NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide ... | |||
T3336 | Rg3039 | PF-06687859 | Others |
Rg3039 (PF-06687859) is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an... | |||
T3708 | BP-1-102 | STAT | |
BP-1-102 is an orally active, effective and specific STAT3 inhibitor. BP-1-102 binds Stat3 (Kd: 504 nM), then blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhi... | |||
T67914 | Insecticidal agent 364 | mTOR , Autophagy | |
Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein. Insecticidal agent 364 has antitumor activity, and by inhibiting mTOR, Insecticidal agent 364 aims to disrupt signaling p... | |||
T23601 | ABC1183 | ABC 1183,ABC-1183 | GSK-3 , CDK |
ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen ... | |||
T3980 | Su1498 | Tyrphostin SU 1498,AG 1498 | VEGFR |
Su1498 (Tyrphostin SU 1498) is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), having negligible activity at several other serine/threonine and tyrosine kinases.1,... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15544 | Iberin | NSC 321801 | Endogenous Metabolite |
Iberin (NSC-321801) induces apoptosis and inhibits cell survival (IC50 = 2.3 μM). Iberin is an analog of sulforaphane. | |||
TN2285 | DL-Tryptophan | (±)-Tryptophan,Tryptophan | Serotonin Transporter , Endogenous Metabolite |
DL-Tryptophan ((±)-Tryptophan) containing dipeptides are interesting ingredients for functional foods as a natural prevention for hypertension with reduced side effects due to its selective inhibition of the C-domain. Lo... | |||
TN1038 | Galgravin | Apoptosis | |
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protec... | |||
T5773 | Moslosooflavone | 5-hydroxy-7,8-dimethoxyflavone | NF-κB , Reactive Oxygen Species |
Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activi... | |||
T4A2462 | Telocinobufagin | Telobufotoxin,Telocinobufogenin | Others |
1. Telocinobufagin (Telobufotoxin) is the major endogenous digitalis-like factor. 2. Telocinobufagin significantly decreases the bacterial burdens in the spleen and prolongs the survival time of FIST-immunized mice chall... | |||
TN1040 | Skullcapflavone II | COX , Antibacterial , TGF-beta/Smad | |
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of al... | |||
TN6835 | (E)-β-Farnesene | (6E)-7,11-dimethyl-3-methylidenedodeca-1,6,10-triene,trans-β-Farnesene | Antifungal |
(E)-β-Farnesene (trans-β-Farnesene) is a sesquiterpene hydrocarbon present in Phlomis aurea Decne and is the main component of many aphid alarm pheromones that interrupt aphid feeding. (E)-β-Farnesene impairs development... | |||
TN7225 | 2'-Hydroxy-3,4-dimethoxychalcone | Antioxidant , Parasite | |
2'-Hydroxy-3,4-dimethoxychalcone, a chalcone compound isolated from the roots of Sophora japonica, has antioxidant activity and inhibited the intracellular survival of Lactobacillus donovani Parasite EC.50 Values ranged ... | |||
T5679 | (E)-Ferulic acid | trans-Ferulic acid,(E)-Coniferic acid | BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite |
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr... | |||
T4900 | Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate | (±)-Jasmonic Acid methyl ester,(±)-Methyl Jasmonate | Others , Endogenous Metabolite |
Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester)induces the synthesis of proteinase inhibitors in plant leaves. In cancer cells, it suppresses proliferation and induces apoptosis. Mo... | |||
TN1831 | Macranthoside A | Kalopanaxsaponin H | Antioxidant |
Macranthoside A (Kalopanaxsaponin H) is a triterpenoid glycoside extracted from rehmannia and belongs to the iridoterpenoid synthesis. Macranthoside A has anti-inflammatory, antioxidant, antibacterial and neuroprotective... | |||
T4S2126 | Ginkgetin | Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy | |
1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 ... | |||
T2S1865 | Octyl gallate | Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8 | Antioxidant , Influenza Virus , Reactive Oxygen Species , Antibacterial , Antifungal , HSV |
1. Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. 2. Octyl Gallate has antimetastatic activity. 3. Octyl Gallate shows antimicrobial activity against H. pylori, ... | |||
T2S0843 | Negletein | 7-O-Methylbaicalein,Baicalein-7-methylether | IL Receptor , TNF , NOS , Interleukin |
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n... | |||
T3S0027 | Picropodophyllotoxin | AXL 1717,Picropodophyllin | IGF-1R |
Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti... | |||
TN1889 | Lupalbigenin | ERK , Akt , Topoisomerase | |
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins. | |||
TN3218 | 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one | Beta Amyloid , PI3K , mTOR | |
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may provide new insights on drug discovery of Alzheimer's dise... | |||
TN2691 | 2',3'-Dehydrosalannol | BCL , Akt , Caspase | |
2',3'-Dehydrosalannol possesses antifeedant activity against Spodptera litura. It shows anticancer effects on triple-negative breast cancer(TNBC), it inhibits cathepsin-mediated pro-survival signaling which resulted in g... | |||
T38295 | Calpinactam | ||
Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 μg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam ... | |||
T81814 | Methyl Ganoderic acid B | ||
Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1]. | |||
T3765 | L-asarinin | (-)-Episesamin | Others |
L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft he... | |||
T80403 | Nv-CATH | ||
Nv-CATH, an antibacterial peptide derived from frogs, exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria, and significantly enhances survival in mice facing lethal Staphylococcus aureu... | |||
T36845 | Isogarcinol | ||
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppres... | |||
T35750 | Trypacidin | ||
Trypacidin is a fungal metabolite originally isolated fromA. fumigatus.1It is active againstB. subtilisandM. bovis(MICs = 12.5 and 1.25 μg/ml, respectively), as well asT. cruziandT. gondii(MICs = 5-10 and 10-20 μg/ml, re... | |||
TN4774 | Physalin A | ERK , BCL , p38 MAPK , NF-κB , Androgen Receptor , ROS , JAK , JNK , STAT , p53 , Autophagy | |
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and dow... | |||
T83862 | Bactobolin A hydrochloride | BN-183B | |
Bactobolin A, a microbial metabolite initially derived from Pseudomonas, exhibits both antibiotic and anticancer properties. It demonstrates activity against various bacteria including S. aureus, S. epidermidis, S. faeca... | |||
T35751 | Violacein | ||
Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserin... | |||
T36563 | (E)-Guggulsterone | ||
Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulat... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03451 | SPF30 Protein, Human, Recombinant (His) | Human | E. coli |
SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been iden... | |||
TMPY-02792 | GDNF Protein, Human, Recombinant (HEK293) | Human | HEK293 |
Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact... | |||
TMPJ-00090 | FGF-9 Protein, Human, Recombinant | Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inc... | |||
TMPY-02614 | NGFR/p75NTR Protein, Human, Recombinant (hFc) | Human | HEK293 |
Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. The h... | |||
TMPY-01458 | GFR Alpha-3/GFRA3 Protein, Human, Recombinant (His) | Human | HEK293 |
Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF... | |||
TMPY-01864 | CNTF Protein, Human, Recombinant (His) | Human | E. coli |
Ciliary neurotrophic factor (CNTF) is a member of the cytokine family. It is a polypeptide hormone that has functions in promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. Its act... | |||
TMPY-05510 | BDNF Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B... | |||
TMPY-02646 | NSE/ENO2 Protein, Human, Recombinant (His) | Human | E. coli |
The combination of silencing ENO2 and 2-deoxyglucose (2-DG) synergistically inhibited leukemia cell survival. ENO2 may be a biological marker for monitoring chemotherapeutic efficacy and relapse in ALL. Reduced ENO2 expr... | |||
TMPY-00834 | IGF1R/CD221 Protein, Human, Recombinant (His) | Human | HEK293 |
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide... | |||
TMPY-04830 | GAS6 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin ... | |||
TMPY-00804 | FGF-9 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Fibroblast growth factor 9 (FGF9) also known as Glia-activating factor or Heparin-binding growth factor 9, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell sur... | |||
TMPY-01601 | AXL Protein, Human, Recombinant (His) | Human | HEK293 |
Axl receptor tyrosine kinase, together with Tyro3 and Mer, constitute the TAM family of receptor tyrosine kinases. In the nervous system, Axl and its ligand Growth-arrest-specific protein 6 (Gas6) are expressed on multip... | |||
TMPY-03382 | FGF-6 Protein, Human, Recombinant | Human | E. coli |
FGF6, also known as FGF-6, belongs to the fibroblast growth factor (FGF) family. Members of this family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, includi... | |||
TMPY-03958 | TGF alpha Protein, Human, Recombinant | Human | E. coli |
The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared... | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-03104 | FGF-17 Protein, Human, Recombinant | Human | E. coli |
FGF-13, also known as FGF17, belongs to the fibroblast growth factor (FGF) family. Members of this family show broad mitogenic and cell survival activities, and play a role in a variety of biological processes including ... | |||
TMPJ-00135 | BDNF Protein, Human/Murine/Rat, Recombinant | Human,Mouse,Rat | E. coli |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I... | |||
TMPY-02483 | ATP citrate lyase/ACLY Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP... | |||
TMPJ-00562 | PDGF-BB Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P... | |||
TMPY-02676 | EGFR Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-04818 | EGFR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPJ-00166 | SCF Protein, Mouse, Recombinant | Mouse | E. coli |
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gameto... | |||
TMPJ-00035 | IL-4 Protein, Human, Recombinant (His) | Human | Human Cells |
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal ce... | |||
TMPY-04529 | EGFR Protein, Human, Recombinant (aa 668-1210, His & GST) | Human | Baculovirus-Insect Cells |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPY-00742 | EGFR Protein, Human, Recombinant (His) | Human | HEK293 |
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR p... | |||
TMPJ-01471 | Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant | Human/Mouse/Rat | Human Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purifi... | |||
TMPJ-00059 | IL-7 Protein, Human, Recombinant (His) | Human | Human Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions... | |||
TMPY-04069 | Neurotrophin 3 Protein, Human, Recombinant | Human | E. coli |
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely relate... | |||
TMPY-00740 | SDF-1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPY-04874 | IL-23 P19/IL23A Protein, Human, Recombinant (hFc) | Human | HEK293 |
IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, t... | |||
TMPY-04052 | IL-17RB Protein, Human, Recombinant (His) | Human | HEK293 |
IL17RB (Interleukin 17 Receptor B) is a Protein Coding gene. IL17RB is the receptor for IL17E, the only member of the IL17 family promoting Th2 reactions. IL17RB is induced on human macrophages by IL4 and enhanced by TGF... | |||
TMPY-00476 | ITGB1 Protein, Human, Recombinant (His) | Human | HEK293 |
ITGB1 (Integrin Subunit Beta 1) is a Protein Coding gene. This gene encodes a beta subunit, which is a type 1 transmembrane protein of the integrin beta chain family. ITGB1 is a heterodimeric cell-surface receptor involv... | |||
TMPY-05296 | IL-34 Protein, Human, Recombinant (His) | Human | CHO |
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt... | |||
TMPY-02591 | SDF-1 Protein, Human, Recombinant | Human | E. coli |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPY-02820 | SDF-1 Protein, Human, Recombinant (isoform a) | Human | E. coli |
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f... | |||
TMPJ-01391 | BAFF/TNFSF13B Protein, Mouse, Recombinant (mFc) | Mouse | Human Cells |
TNFSF13B/TNFSF20 belongs to the tumor necrosis factor family. It abundantly is expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bo... | |||
TMPY-00986 | IL-34 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
IL34 (Interleukin 34) is a Protein Coding gene. IL-34, also known as uncharacterized protein C16 or f77 homolog, belongs to the IL-34 family. IL-34 is a cytokine that promotes the differentiation and viability of monocyt... | |||
TMPJ-01469 | NGF Protein, Human, Recombinant (E. colli) | Mouse | E.coli |
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family ... | |||
TMPJ-00038 | IL-7 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 a... | |||
TMPY-06985 | NGF Protein, Human, Recombinant (HEK293) | Human | HEK293 |
Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits,... | |||
TMPY-06935 | FGF-21 Protein, Human, Recombinant | Human | E. coli |
Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes ... | |||
TMPY-01010 | NGF Protein, Human, Recombinant | Human | CHO |
Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits,... | |||
TMPY-02626 | FGF-18 Protein, Human, Recombinant (His) | Human | HEK293 |
Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes... | |||
TMPY-05004 | FGF-4 Protein, Human, Recombinant | Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati... | |||
TMPY-02938 | REG4 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be inv... | |||
TMPY-01963 | IL-21 Protein, Human, Recombinant | Human | E. coli |
IL21 belongs to the IL-15/IL-21 family. It is a cytokine with immunoregulatory activity. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellul... | |||
TMPJ-00103 | CD28 Protein, Human/Cynomolgus, Recombinant (His) | Human,Cynomolgus | Human Cells |
T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of th... | |||
TMPY-01613 | Periostin/OSF-2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ... | |||
TMPY-01020 | Periostin/OSF-2 Protein, Human, Recombinant (His) | Human | HEK293 |
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ... | |||
TMPJ-01466 | Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His) | Human | Human Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits ... | |||
------------------------ More ------------------------ |
Cat No. | Product Name | ||
---|---|---|---|
L2196 | Anti-Ovarian Cancer Compound Library | 1888 compounds | |
A unique collection of 1888 compounds with anti-ovarian cancer therapeutic activity, can be used for anti-ovarian cancer drug discovery and pharmacological study; | |||
L1400 | MAPK Inhibitor Library | 367 compounds | |
A unique collection of 367 compounds targeting MAPK signaling for drug discovery in MAPK related diseases; | |||
L2192 | Anti-Pancreatic Cancer Compound Library | 2267 compounds | |
A unique collection of 2267 pancreatic cancer related compounds can be used in HTS and HCS; | |||
L8700 | Ferroptosis Compound Library | 800 compounds | |
A unique collection of 800 ferroptosis signaling pathway related compounds, a powerful tool for new target identification, drug discovery, and mechanism study; | |||
L1300 | PI3K-AKT-mTOR Compound Library | 425 compounds | |
A unique collection of 425 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling; | |||
L2600 | Neuronal Signaling Compound Library | 2540 compounds | |
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs; | |||
L1310 | Cytoskeletal Signaling Pathway Compound Library | 773 compounds | |
A unique collection of 773 cytoskeleton-related compounds, can be used for HTS and HCS; | |||
L6740 | Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library | 386 compounds | |
A collection of 386 TCM monomers with anti-colorectal activity. An effective tool for drug development and pharmacological studies. |