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LasB-IN-3
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Catalog No. T217756 Copy Product Info
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LasB-IN-3 is an inhibitor of the elastase (LasB) in Pseudomonas aeruginosa, with an IC50 of 8.5 nM. It shows an IC50 of 58.9 nM against the Met128Val mutant. LasB-IN-3 binds to the active sites of both the wild-type and Met128Val mutant LasB, chelating zinc ions and forming hydrogen bonds and CH-π interactions, thus inhibiting the proteolytic activity of LasB. Additionally, LasB-IN-3 enhances the survival rate in a mouse model of acute lung injury induced by LasB. This compound is applicable for studies related to Pseudomonas aeruginosa infections.
LasB-IN-3
Cas No. 2762675-42-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LasB-IN-3 is an inhibitor of the elastase (LasB) in Pseudomonas aeruginosa, with an IC50 of 8.5 nM. It shows an IC50 of 58.9 nM against the Met128Val mutant. LasB-IN-3 binds to the active sites of both the wild-type and Met128Val mutant LasB, chelating zinc ions and forming hydrogen bonds and CH-π interactions, thus inhibiting the proteolytic activity of LasB. Additionally, LasB-IN-3 enhances the survival rate in a mouse model of acute lung injury induced by LasB. This compound is applicable for studies related to Pseudomonas aeruginosa infections. |
| In vitro | LasB-IN-3 (Compound 21) is a potent inhibitor of wild-type Pseudomonas aeruginosa LasB, with an IC50 of 8.5 ± 0.5 nM, though its activity decreases approximately 7-fold against the Met128Val mutant (IC50 = 58.9 nM). The compound demonstrates an IC50 of 45 nM in the presence of porcine pulmonary surfactant, with reduced activity attributed to a 37.2 ± 0.8% binding rate to surfactant proteins. LasB-IN-3 (0-100 μM) exhibits very low cytotoxicity towards human A549, HepG2, and HEK293 cell lines. |
| In vivo | LasB-IN-3 (Compound 21) (300 μM; intranasal instillation ) achieves a 100% survival rate in C57BL/6 mice with acute lung injury induced by LasB. |
| Molecular Weight | 381.79 |
| Formula | C18H21ClNO4P |
| Cas No. | 2762675-42-1 |
| Smiles | O=C(NC1=CC=C(C=C1)C=2C=CC(Cl)=CC2)C(CC(C)C)P(=O)(O)O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: LasB-IN-3 in vivo | LasB-IN-3 in vitro | LasB-IN-3 formula | LasB-IN-3 molecular weight
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