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Biomacromolecule Related ReagentsNucleosides
Nucleosides are essential biological molecules that function both as signaling mediators and as precursors for nucleotide synthesis, which is required for DNA and RNA production. Structurally, nucleosides are glycosylamines composed of a nitrogenous base linked to a five-carbon sugar (ribose or deoxyribose), nucleosides can also be regarded as nucleotides lacking a phosphate group. Nucleosides and their analogs are widely employed in biomedical research and therapeutic development. Chemical modifications are frequently introduced to enhance their stability, bioavailability, and functional performance in applications such as signaling pathway studies, diagnostics, and sequencing technologies.
Puromycin dihydrochloride
Cited
Puromycin 2HCl, CL13900 dihydrochloride
T221958-58-2
Puromycin dihydrochloride (CL13900 dihydrochloride) is a cinnamamide adenosine antibiotic and an inhibitor of protein synthesis. Puromycin dihydrochloride inhibits protein synthesis by binding to RNA and has antitumor and antitrypanosomal activity.
- $30
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CitedTanzisertib
CC-930
T14895899805-25-5
Tanzisertib (CC-930) (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.
- $35
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Gemcitabine Cited
NSC 613327, LY188011
T025195058-81-4
Gemcitabine (LY188011) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis. Gemcitabine has antitumor and antimetabolic activities. Gemcitabine induces autophagy and apoptosis.
- $34
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Cited3-Deazaadenosine hydrochloride
T1011186583-19-9
3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 µM). It has anti-inflammatory, anti-proliferative, and anti-HIV activity.
- $128
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5-BrdU Cited
BUdR, Broxuridine, Bromodeoxyuridine, BRDU, 5-bromo-2'-deoxyuridine
T679459-14-3
5-BrdU (Broxuridine) is a nucleoside analogue. 5-BrdU is used to detect proliferating cells and compete with thymidine for incorporation into DNA.
- $34
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CitedMolnupiravir
MK-4482, Lagevrio, EIDD-2801, 2349386-89-4
T609512492423-29-5
Molnupiravir (EIDD-2801) is an isopropyl ester prodrug of the ribonucleoside analog EIDD-1931 with oral bioavailability. Molnupiravir can be used in the study of COVID-19, seasonal and pandemic influenza, and has broad-spectrum antiviral activity against multiple coronaviruses and influenza viruses, such as SARS-CoV-2, MERS-CoV, SARS-CoV.
- $34
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Sinefungin Cited
Antibiotic 32232RP, Adenosyl-Ornithine, A-9145
T1688658944-73-3In house
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.
- $222
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CitedDecitabine Cited
NSC 127716, Dacogen, 5-Aza-CdR, 5-Aza-2'-deoxycytidine
T15082353-33-5
Decitabine (Deoxycytidine) is a deoxycytidine analog, a DNA methyltransferase inhibitor with oral activity. Decitabine has antitumor activity and antimetabolic activity. Decitabine induces cell cycle arrest and apoptosis.
- $35
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CitedFludarabine Cited
NSC 118218, Fludarabinum, F-ara-A
T103821679-14-1
Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.
- $50
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Cited5-Ethynyl-2'-deoxyuridine Cited
T1734161135-33-9
5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.
- $33
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CitedSangivamycin
NSC 65346, BA-90912
T960518417-89-5
Sangivamycin (NSC-65346) is an effective inhibitor of protein kinase C (PKC, Ki = 10 μM). Sangivamycin exhibits antiproliferative activity against a variety of human cancers.
- $128
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Nicotinamide riboside chloride Cited
T622023111-00-4
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
- $31
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CitedTrifluridine/tipiracil hydrochloride mixture Cited
Trifluridine-tipiracil hydrochloride mixture, TAS-102, TAS102, TAS 102
T3658733030-01-8
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and tipiracil hydrochloride (TTP) in a 2:1 molar ratio.
- $33
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CitedCytarabine Cited
Cytosine β-D-arabinofuranoside, Cytosine Arabinoside, Ara-C, Arabinocytidine
T1272147-94-4
Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.
ApoptosisAutophagyDNA/RNA SynthesisEndogenous MetaboliteHSVNucleoside Antimetabolite/AnalogVirus Protease
- $30
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CitedAICAR Cited
NSC105823, AICAR (Acadesine), AICA Riboside, Acadesine
T14772627-69-2
AICAR (Acadesine) is an AMPK activator. AICAR has the functions of metabolic regulation, muscle function regulation, anti-cancer effect, neuroprotection and anti-aging.
- $30
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CitedSAH Cited
SAH (S-Adenosylhomocysteine)
TQ0208979-92-0
SAH (SAH (S-Adenosylhomocysteine)) is an inhibitor for the METTL3-METTL14 heterodimer complex (METTL3-14, IC50: 0.9 μM).
- $36
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CitedAzvudine
RO-0622, FNC
T144891011529-10-4
Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
- $57
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O-Propargyl-Puromycin
O-Propargylpuromycin, OP-puro
T122841416561-90-4In house
O-Propargyl-Puromycin (OP-puro) is a potent protein synthesis inhibitor, a puromycin acetylene analog.
- $46
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5-Azacytidine Cited
NSC 102816, Mylosar, Ladakamycin, Azacitidine, 5-AzaC
T1339320-67-2
5-Azacytidine (Ladakamycin) is a cytidine nucleoside analog, a DNA methylation inhibitor with specificity. 5-Azacytidine regulates gene expression by decreasing the level of DNA methylation. 5-Azacytidine induces autophagy and has antitumor activity.
- $33
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CitedUridine Cited
β-Uridine, Uridin, NSC 20256
T222158-96-8
Uridine (Uridin) is a nucleoside compound, one of the four bases that make up RNA, that replaces thymine in DNA during transcription and pairs with adenine.
- $54
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CitedATG7-IN-1 Cited
ATG7-IN-1
T397052226229-87-2In house
ATG7-IN-1 is a selective ATG7 inhibitor with an IC50 of 62 nM.
- $329
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CitedPinometostat Cited
EPZ-5676
T30991380288-87-8
Pinometostat (EPZ-5676) is a potent DOT1L histone methyltransferase inhibitor (Ki=80 pM). Pinometostat has antitumor activity and can be used in experiments to study a variety of leukemia treatments.
- $34
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CitedNelarabine
Nelzarabine, GW 506U78, 506U78
T6603121032-29-9
Nelarabine (GW 506U78) is a purine nucleoside analog and DNA synthesis inhibitor with IC50 from 0.067-2.15 μM in tumor cells.
- $36
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Puromycin aminonucleoside Cited
NSC 3056
T1668458-60-6
Puromycin aminonucleoside (NSC 3056) is an aminonucleoside antibiotic and a purine analog of puromycin. It can reversibly inhibit dipeptidyl peptidase and cytosolic alanine aminopeptidase, increase podocyte permeability by regulating ZO-1 in an oxidative stress-dependent manner, induce apoptosis, and promote the secretion of migrasomes. It is commonly used to induce nephrotic syndrome models in research.
- $39
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