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Biomacromolecule Related ReagentsNucleotides
Nucleotides are the fundamental building blocks of nucleic acids, DNA and RNA. Each nucleotide consists of a nitrogenous base, a five-carbon sugar (ribose or deoxyribose), and one or more phosphate groups; thus, a nucleotide can be defined as a nucleoside with an attached phosphate moiety.Beyond their structural role in nucleic acids, free nucleotides play central roles in cellular metabolism. For example, adenosine triphosphate (ATP) serves as the primary energy currency of the cell, while guanosine triphosphate (GTP) is essential for protein synthesis and signal transduction. Modified nucleotides and nucleotide analogs are also indispensable tools in molecular diagnostics, gene sequencing, and enzymology research.
2'-3'-cyclic GMP-AMP sodium
T10065L2734858-36-5In house
2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a second messenger in cellular innate immunity, catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. It binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines.
- $247
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Dazostinag disodium
T724822553413-93-5In house
Dazostinag disodium (TAK-676) is a synthetic novel interferon gene (STING) agonist that triggers STING signaling pathway activation and type I interferon activation. Dazostinag disodium (TAK-676) is also a highly effective immune system modulator with complete resolution and lasting memory of T cell immunity and the ability to promote lasting interferon-dependent anti-tumor immune responses.
- $498
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Bucladesine sodium
Cited
Sodium dibutyryl cAMP, Dibutyryl-cAMP sodium salt, Dibutyryl-cAMP, DC2797, dbcAMP, Bucladesine sodium salt, Bucladesine
T141816980-89-5
Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-inflammatory activity.
- $31
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CitedUDP-glucuronic acid trisodium
UDP-glucuronic acid trisodium
T1959563700-19-6
UDP-glucuronic acid trisodium (UDP-glucuronic acid trisodium) is an indispensable precursor for vital glycoconjugates in various biological domains. These glycoconjugates encompass mammalian glycosaminoglycans, plant cell wall polysaccharides, and bacterial capsule glycoglycerolipids.
- $32
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Cyclic-di-GMP disodium
cyclic diguanylate disodium, Cyclic di-GMP (sodium salt), c-di-GMP disodium, 5GP-5GP disodium, 3',5'-Cyclic diguanylic acid
T369832222132-40-1
Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer.
- $139
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ATP Cited
Triphosphoric acid adenosine ester, Triphosphaden, Atipi, Ara-ATP, Adenosine triphosphate
T2008956-65-5
ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specific purinergic receptors to mediate a variety of processes including neurotransmission, inflammation, apoptosis, and bone remodeling.
- $34
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CitedRemdesivir Cited
GS-5734
T77661809249-37-3
Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19.
- $116
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CitedBzATP triethylammonium salt
TP2226112898-15-4
BzATP triethylammonium salt is a P2X7 receptor agonist.
- $41
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NADPH tetrasodium salt
T70922646-71-1
NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an endogenous inhibitor of ferroptosis.
- $50
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ADU-S100 ammonium salt
ML RR-S2 CDA ammonium salt, MIW815 ammonium salt
T10252L21638750-96-5
ADU-S100 ammonium salt is an activator of stimulator of interferon genes (STING). ADU-S100 ammonium salt leads to potent and systemic tumor regression and immunity.
- $1,250
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Polyinosinic-polycytidylic acid Cited
Poly(I:C)
T2317124939-03-5
Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA) analog and an agonist of TLR3 as well as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5). It can induce innate immune responses in mammals and serve as a vaccine adjuvant to enhance both innate and adaptive immunity, while modulating the tumor microenvironment and directly inducing apoptosis in cancer cells. Poly(I:C) is commonly used to establish acute respiratory distress syndrome (ARDS) animal models for studying immune responses and disease mechanisms.
- $45
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Citedβ-Nicotinamide mononucleotide Cited
β-NM, NMN
T47211094-61-7
β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
- $30
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Cited8-Bromo-cAMP sodium salt Cited
8-Bromo-cAMP(sodium salt), 8-Br-Camp sodium salt
T674776939-46-3
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase（PKA）, but resistant to degradation by cyclic AMP phosphodiesterase.
- $41
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CitedCarba-NAD sodium
Carba-NAD sodium (112345-60-5 Free base)
T84348L1
Carba-NAD sodium is a carbocyclic analog of NAD+ and is a good competitive inhibitor of calf spleen NAD+ glycohydrolase.
- $195
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ATPγS tetralithium salt
ATP-gamma-S tetralithium salt
T2259293839-89-5In house
ATPγS tetralithium salt is a good substrate for RNA-stimulated nucleotide hydrolysis and RNA unwinding activity of eIF4A.
- $67
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GDP-L-fucose
T7404115839-70-0
GDP-L-fucose is a nucleotide sugar widely found in fungi and plants, playing a role in both the slave and secondary remedial metabolic pathways.
- $263
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Sofosbuvir Cited
PSI-7977, GS 7977
T66761190307-88-0
Sofosbuvir (GS 7977) is a uridine monophosphate analog inhibitor of hepatitis C virus (HCV) polymerase NS5B that is used as an antiviral agent in the treatment of chronic hepatitis C.
- $45
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CitedGuanosine 5'-diphosphate
GDP
T7210146-91-8
Guanosine 5'-diphosphate (GDP) as Potential Iron Mobilizer, Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway.
- $37
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dFdCTP trisodium
Gemcitabine triphosphate trisodium
T75252L
dFdCTP trisodium (Gemcitabine triphosphate trisodium) is a Gemcitabine derivative that is cytotoxic and inhibits processes required for DNA synthesis. dFdCTP trisodium inhibits T-araCTP and araCTP, which dopes DNA and terminates DNA Inhibits T-araCTP and araCTP.
- $245
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NAD+ Cited
β-Nicotinamide Adenine Dinucleotide, β-NAD, β-DPN, DPN, Cozymase
T160953-84-9
NAD+ (β-Nicotinamide Adenine Dinucleotide) is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).
- $41
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CitedAcetyl Coenzyme A trisodium
Acetyl-CoA trisodium
T37958102029-73-2
Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is an important compound in glucose metabolism and lipid metabolism and is involved in the tricarboxylic acid cycle.
- $54
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UDP-g acid
T89492616-64-0
UDP-g acid is a sugar used in the production of polysaccharides and is an intermediate in the biosynthesis of ascorbic acid
- $95
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AMP-PCP disodium
T13547L7414-56-4
AMP-PCP disodium, an ATP analogue, binds to the N-terminal domain of Hsp90 with a Kd value of 3.8 μM, facilitating the formation of an active Hsp90 homodimer.
- $61
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UDP-GlcNAc Disodium Salt
Uridine 5′-diphospho-N-acetylglucosamine, UDP-α-D-N-Acetylglucosamine Disodium Salt
T1959691183-98-1
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a nucleotide sugar synthesized from glucose through the hexosamine biosynthetic pathway (HBP).
- $30
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