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Biomacromolecule Related Reagents Biomacromolecule Related ReagentsOligonucleotides
Oligonucleotides are short single-stranded or double-stranded DNA or RNA molecules, including antisense oligonucleotides (ASOs), RNAi (RNA interference), microRNAs, and aptamer RNAs. ASO and RNAi oligonucleotides are primarily used to regulate gene and protein expression, while aptamer oligonucleotides function as chemical antibodies to modulate the activity of proteins and other macromolecules. TargetMol offers high-quality and diverse oligonucleotide-related products to help you efficiently advance your life science research.
ABI3BP Human Pre-designed siRNA Set A
T212654
ABI3BP Human Pre-designed siRNA Set A contains three siRNA pairs targeting various regions of the ABI3BP (Human) gene, along with a negative control, a FAM-labeled negative control, and a positive control.
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OR51E1 Human Pre-designed siRNA Set A
T212656
"OR51E1 Human Pre-designed siRNA Set A consists of three pairs of siRNA targeting different regions of the OR51E1 (Human) gene. It also includes a negative control, a FAM-labeled negative control, and a positive control."
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Ano5 Mouse Pre-designed siRNA Set A
T212709
The Ano5 Mouse Pre-designed siRNA Set A comprises three siRNA pairs specifically targeting different regions of the Ano5 (Mouse) gene. It also includes a negative control, a FAM-labeled negative control, and a positive control.
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SLC39A10 Human Pre-designed siRNA Set A
T212674
SLC39A10 Human Pre-designed siRNA Set A consists of three pairs of siRNAs targeting various regions of the SLC39A10 (Human) gene. The set also includes a negative control, a FAM-labeled negative control, and a positive control.
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ODN 2216 sodium
T212697
ODN 2216 sodium is a human-specific TLR9 (toll-like receptor 9) ligand or agonist. It induces significant production of IFN-α and IFN-β. The compound stimulates IFN-α through pDC (plasmacytoid dendritic cells) and produces IL-12(p40) via DC (dendritic cells). ODN 2216 triggers peripheral blood mononuclear cells (PBMC) to produce IFN-γ indirectly, mediated by IFN-α/β. Additionally, ODN 2216 sodium can activate NK cells and enhance IFN-γ production in TCR-triggered CD4+ T cells.
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CpG ODN 10101 sodium
ODN 10101 sodium
T212671
CpG ODN 10101 sodium is a synthetic oligodeoxynucleotide (ODN) that functions as a Toll-like receptor 9 (TLR9) agonist. When combined with HH2(VQLRIRVAVIRA-NH2), it serves as an effective inducer of cytokine/chemokine expression in vitro. CpG ODN 10101 sodium stimulates dendritic cells (DC) to secrete IFN and activates B cells. It possesses antiviral and immunomodulatory properties, influencing chronic HCV infection.
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Inotersen
ISIS-420915, ISIS420915, GSK-2998728, GSK2998728
T2105471492984-65-2
Inotersen (ISIS-420915) sodium is a 2′-O-methoxyethyl–modified antisense oligonucleotide that selectively targets transthyretin RNA, reduces TTR transcript and protein levels. Inotersen serves as a validated molecular tool for mechanistic and translational research into hereditary transthyretin amyloidosis polyneuropathy.
- $146
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OR51E2 Human Pre-designed siRNA Set A
T212675
OR51E2 Human Pre-designed siRNA Set A consists of three pairs of siRNA that are specifically designed to target various regions of the OR51E2 (Human) gene. Additionally, the set includes a negative control, a FAM-labeled negative control, and a positive control.
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NDUFS2 Human Pre-designed siRNA Set A
T212712
NDUFS2 Human Pre-designed siRNA Set A comprises three pairs of siRNA targeting various regions of the NDUFS2 (Human) gene. The set also includes a negative control, a FAM-labeled negative control, and a positive control.
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Plozasiran
ARO-APOC3
T2105492379776-40-4
Plozasiran, previously called ARO-APOC3, is a first-in-class investigational RNA interference (RNAi) therapeutic that is specifically designed to actively suppress hepatic production of apolipoprotein C-III (APOC3), a critical structural and functional component of triglyceride-rich lipoproteins (TRLs) and a central regulator of systemic triglyceride metabolism, thereby addressing dyslipidemia at the level of gene expression through targeted post-transcriptional silencing mechanisms.
- $221
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Donidalorsen
ISIS-721744 free acid, ISIS721744 free acid, IONIS-PKK-LRX free acid
T2105482304692-48-4
Donidalorsen is an antisense oligonucleotide engineered to selectively reduce the production of prekallikrein (PKK), a key upstream mediator in inflammatory cascade activation, and is used in hereditary angioedema research to investigate bradykinin-driven inflammation, acute attack prevention mechanisms, and RNA-targeted therapeutic strategies.
- $315
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ODN TTAGGG sodium
ODN A151 sodium
T212668
ODN TTAGGG sodium, an inhibitory oligonucleotide (ODN), is an antagonist of TLR9, AIM2, and cGAS. It exerts immunosuppressive effects by inhibiting AIM2 inflammasome activation and cGAS activation through competitive interaction with DNA. This compound can be utilized in research on autoimmune diseases such as lupus. The sequence for ODN TTAGGG is 5'-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-T-T-A-G-G-G-3'.
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Custirsen sodium
OGX-011 sodium
T212652
Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin, an anti-apoptotic protein. Clusterin expression is upregulated in response to chemotherapy and contributes to drug resistance.
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CHRNA7 Human Pre-designed siRNA Set A
T212691
CHRNA7 Human Pre-designed siRNA Set A contains three pairs of siRNAs targeting various regions of the CHRNA7 (Human) gene, along with a negative control, a FAM-labeled negative control, and a positive control.
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CAV1 Human Pre-designed siRNA Set A
T212683
The CAV1 Human Pre-designed siRNA Set A consists of three pairs of siRNA targeting different regions of the CAV1 (Human) gene, along with a negative control, a FAM-labeled negative control, and a positive control.
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Glb1 Mouse Pre-designed siRNA Set A
T212679
Glb1 Mouse Pre-designed siRNA Set A includes siRNAs targeting the Glb1 gene (Mouse), along with a negative control, a positive control, and a FAM-labeled negative control.
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ASXL1 Human Pre-designed siRNA Set A
T212662
ASXL1 Human Pre-designed siRNA Set A comprises three pairs of siRNA designed for different regions of the ASXL1 (Human) gene. The set also includes a negative control, a FAM-labeled negative control, and a positive control.
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ISD sodium
T212681
ISD (interferon stimulatory DNA) sodium is a 45 bp double-stranded non-CpG oligomer derived from the genome of Listeria monocytogenes. Upon transfection into cells, ISD sodium significantly boosts the expression of IFN-β. This ISD-induced response is mediated by the STING-TBK1-IRF3 signaling pathway.
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AS 1411 sodium
AGRO-100 sodium
T212708
AS1411 sodium is a nucleolin-targeting nucleic acid aptamer with antitumor properties.
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RANGAP1 Human Pre-designed siRNA Set A
T212660
RANGAP1 Human Pre-designed siRNA Set A consists of three pairs of siRNA targeting various regions of the RANGAP1 (Human) gene, along with a negative control, a FAM-labeled negative control, and a positive control.
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ATG5 Human Pre-designed siRNA Set A
T212647
The ATG5 Human Pre-designed siRNA Set A comprises three pairs of siRNA targeted at various regions of the ATG5 (Human) gene, along with a negative control, a FAM-labeled negative control, and a positive control.
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ODN 1826 sodium
CpG 1826 sodium
T212687
ODN 1826 sodium is a class B CpG ODN (oligodeoxynucleotide) and a TLR9 agonist. It induces the production of NO and iNOS and enhances apoptosis. ODN 1826 sodium boosts immune surveillance and increases the size of atherosclerotic plaques. It exhibits antitumor activity against lung cancer, glioma, and melanoma.
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Teprasiran sodium
QPI-1002 sodium
T2126852169310-72-7
Teprasiran sodium is a small interfering RNA (siRNA) that inhibits p53-mediated cell death in acute kidney injury.
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ODN 1668 sodium
T212714
ODN 1668 sodium is a B class CpG ODN (oligodeoxynucleotide) recognized as a TLR-9 agonist. It demonstrates potent immunomodulatory effects by enhancing the level of IgG2 subtype antibodies and stimulating both T cell and B cell immune responses, making it useful for vaccine adjuvant research. Additionally, CpG ODN 1668 sodium induces antibacterial immune responses in orange-spotted grouper through a CaTLR9-dependent pathway. Sequence: 5’-tccatgacgttcctgatgct-3’.
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