BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat No.	product name
T0186	Docetaxel trihydrate	Docetaxel is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the th...
T0448	Dexibuprofen	Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T10434	AZD-5991	AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
T10434L	AZD-5991 Racemate	AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is an Mcl-1 inhibitor (IC50: <3 nM in FRET assay).
T10434L2	AZD-5991 S-enantiomer	AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is an Mcl-1 inhibitor (IC50: 6.3 μM in FRET assay; Kd: 0.98 μM in SPR a...
T10463	Bax inhibitor peptide V5	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
T10483	Bcl-2/Bcl-xl inhibitor 1	Bcl-2/Bcl-xl inhibitor 1 is a dual Bcl-2 and Bcl-xl inhibitor (IC50s: 2 nM and 5.9 nM for Bcl-2 and Bcl-xl) with anti-tumor activity. It is extracted from paten...
T10485	PROTAC Bcl2 degrader-1	PROTAC Bcl2 degrader-1 is a PROTAC, which potently and selectively induces the degradation of Mcl-1 (IC50: 11.81 μM) and Bcl-2 (IC50: 4.94 μM; DC50: 3.0 μM).
T10577	BM 957	BM 957 is an effective Bcl-2 and Bcl-xL inhibitor (Kis: 1.2 and <1 nM; IC50s: 5.4 and 6.0 nM).
T10990	Dehydrocorydaline chloride	Dehydrocorydaline chloride is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.
T1119	Rasagiline	Rasagiline is an inhibitor of monamine oxidase used as adjunctive therapy in combination with levodopa and carbidopa in the management of Parkinsons disease.
T11944	Maritoclax	Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM.
T11968	MCL-1/BCL-2-IN-1	MCL-1/BCL-2-IN-2 is a selective and potent Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively.
T11972	Mcl-1 inhibitor 3	Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate...
T11973	Mcl1-IN-11	Mcl1-IN-11 (Compound G) is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.06 and 4.2 μM, respectively.
T11974	Mcl1-IN-12	Mcl1-IN-12 has anti-tumor activity.It is a selective Mcl-1 inhibitor, less potent at Bcl-2, with Kis of 0.29 and 3.1 μM, respectively.
T11975	PROTAC Mcl1 degrader-1	PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide ...
T11977	Mcl1-IN-9	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
T12041	MIM1	MIM1 is an myeloid cell factor 1 (Mcl-1) inhibitor.
T12186	Navitoclax-piperazine	Navitoclax-piperazine is an inhibitor of B-cell lymphoma extra large (BCL-XL).
T12824	S55746 hydrochloride	S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
T12824L	S55746	S55746 is an effective and selective BCL-2 inhibitor (Ki: 1.3 nM and a Kd of 3.9 nM).
T13337	WEHI-539 hydrochloride	WEHI-539 hydrochloride is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
T13337L	WEHI-539	WEHI-539 is a selective Bcl-XL inhibitor (IC50: 1.1 nM).
T13338	WEHI-9625	WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
T13454	(S)-Purvalanol B	(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase.
T13922	Thevetiaflavone	Thevetiaflavone could up-regulate the expression of Bcl‑2 and down-regulate that of Bax and caspase‑3.
T14071	A-385358	A-385358 is a Bcl-XL inhibitor. For Bcl-XL and Bcl-2, the Kis values are 0.80 and 67 nM, respectively.
T14213	AMG-176	AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
T14376	AZD4320	AZD4320 is an inhibitor of BH3-mimicking dual BCL2/BCLxL. For KPUM-MS3, KPUM-UH1, and STR-428 cells, the IC50s values are 26 nM, 17 nM, and 170 nM , respectivel...
T14499	Bax activator-1	Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].
T14561	BI-3812	BI-3812 is an inhibitor of BCL6. Which inhibiting the BTB domain of BCL6 (IC50: 3 nM). BI-3812 also has antitumor activity.
T14834	BT2	BT2 is a BCKDC kinase (BDK) inhibitor with an IC50 of 3.19 μM. BT2 (compound 4) is also a potent and selective Mcl-1 inhibitor with a Ki value of 59 μM. BT2 b...
T14846	Bz 423	Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
T1493	BH3I1	BH3I-1 is a Bcl-2 antagonist.
T16028	Mcl1-IN-2	Mcl1-IN-2 is a myeloid cell factor 1 (Mcl-1) inhibitor.
T16042	Metaldehyde	Metaldehyde is used for snails and other gastropods pesticide against.
T16043	Metaproterenol	Metaproterenol also has anti-inflammatory activity. Metaproterenol is a direct-acting sympathomimetic and a β2-adrenergic receptor (β2AR) agonist (IC50: 68 nM...
T16045	Methotrexate metabolite	Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent. Methotrexate is the active metabolite of Methotr...
T16089	MK-0674	MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat ...