BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.

Cat. No.	Product name	CAS No.	Purity
T12629L	MIK665	1799631-75-6	98%
T12629L	MIK665 (S-64315) has an inhibitory effect on myeloid leukemia.
T77332	TV 3279	209394-29-6	98%
T77332	TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SO...
TN2180	Sappanchalcone	94344-54-4	98%
TN2180	Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN3404	Altholactone	65408-91-5	98%
TN3404	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2257	Tanshinone IIB	17397-93-2	98%
TN2257	Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4394	Kobophenol A	124027-58-3	98%
TN4394	Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T10434	AZD-5991	2143061-81-6	98%
T10434	AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
T12824	S55746 hydrochloride	1448525-91-4	98%
T12824	S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
TN1642	Ferruginol	514-62-5	98%
TN1642	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
T13454	(S)-Purvalanol B	2310135-61-4	98%
T13454	(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .
TN3587	Capillarisin	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4877	Quercetin 3,4'-dimethyl ether	33429-83-3	98%
TN4877	Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
T13338	WEHI-9625	2595314-46-6	98%
T13338	WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
TN3708	Coronarin D	119188-37-3	98%
TN3708	Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T11968	MCL-1/BCL-2-IN-1	2493256-46-3	98%
T11968	MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].
T14846	Bz 423	216691-95-1	98%
T14846	Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
T16089	MK-0674	887781-62-6	98%
T16089	MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
T10463	Bax inhibitor peptide V5	579492-81-2	98%
T10463	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
TN4774	Physalin A	23027-91-0	98%
TN4774	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T6650	Sabutoclax	1228108-65-3	98%
T6650	Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.