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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
Fragment Libraries General Fragment Libraries Characteristic Fragment Libraries Custom Compound Library

BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2257 Tanshinone IIB 17397-93-2 98%
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
T16042 Metaldehyde 108-62-3 98%
Metaldehyde is used for snails and other gastropods pesticide against.
TN3404 Altholactone 65408-91-5 98%
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
T10434L2 AZD-5991 (S-enantiomer) 2143061-82-7 98%
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is an Mcl-1 inhibitor (IC50: 6.3 μM in FRET assay; Kd: 0.98 μM in SPR assa...
TN4604 Myricanone 32492-74-3 98%
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4307 Isolimonexic acid 73904-93-5 98%
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
T16694 Pyridoclax 1651890-44-6 98%
Pyridoclax is an inhibitor of potential Mcl-1.
TN1393 (-)-Anonaine 1862-41-5 98%
(-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DNA...
TN3614 Cearoin 52811-37-7 98%
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN1093 Ginsenoside F4 181225-33-2 98%
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
T14846 Bz 423 216691-95-1 98%
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
TN2063 Physalin B 23133-56-4 98%
Physalin B shows antimalarial, anti-Trypanosoma cruzi, anti-bacterial, anti- leukemia activities, it has the potential to be developed as an effective chemothera...
TN2149 Reynosin 28254-53-7 98%
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
TN5263 1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 569-83-5 98%
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid 57719-81-0 98%
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN5100 Taspine 602-07-3 98%
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
T6650 Sabutoclax 1228108-65-3 98%
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
TN3653 Cimidahurinine 142542-89-0 98%
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
T10434 AZD-5991 2143061-81-6 98%
AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
T14499 Bax activator-1 1638526-94-9 98%
Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].
Tanshinone IIB
TN2257
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
Metaldehyde
T16042
Metaldehyde is used for snails and other gastropods pesticide against.
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
AZD-5991 (S-enantiomer)
T10434L2
AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is an Mcl-1 inhibitor (IC50: 6.3 μM in FRET assay; Kd: 0.98 μM in SPR assa...
Myricanone
TN4604
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Isolimonexic acid
TN4307
Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
Pyridoclax
T16694
Pyridoclax is an inhibitor of potential Mcl-1.
(-)-Anonaine
TN1393
(-)-Anonaine has some anticancer activity, it induces apoptosis through Bax- and caspase-dependent pathways in human cervical cancer (HeLa) cells, it induces DNA...
Cearoin
TN3614
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Ginsenoside F4
TN1093
Ginsenoside F4 has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis, the mechanism is related to the mitochondrial dysfunction and the i...
Bz 423
T14846
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with selectivity for autoreactive lymphocytes and activates Bax and Bak.
Physalin B
TN2063
Physalin B shows antimalarial, anti-Trypanosoma cruzi, anti-bacterial, anti- leukemia activities, it has the potential to be developed as an effective chemothera...
Reynosin
TN2149
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reci...
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
TN5263
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Xanthohumol is effective against HIV-1 and...
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
Taspine
TN5100
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
Sabutoclax
T6650
Sabutoclax(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM, respectively.
Cimidahurinine
TN3653
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
AZD-5991
T10434
AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
Bax activator-1
T14499
Bax activator-1 (compound 106) is a Bax activator. It induces Bax-dependent tumor cell apoptosis[1].
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