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BCL

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN2180 Sappanchalcone 94344-54-4 97.00%
Sappanchalcone
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
TN3404 Altholactone 65408-91-5 98%
Altholactone
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
TN2257 Tanshinone IIB 17397-93-2 98%
Tanshinone IIB
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
TN4394 Kobophenol A 124027-58-3 98%
Kobophenol A
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
T10434 AZD-5991 2143061-81-6 98%
AZD-5991
AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
T12824 S55746 hydrochloride 1448525-91-4 98%
S55746 hydrochloride
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
TN1642 Ferruginol 514-62-5 98%
Ferruginol
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
T13454 (S)-Purvalanol B 2310135-61-4 98%
(S)-Purvalanol B
(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .
TN3587 Capillarisin 56365-38-9 98%
Capillarisin
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4877 Quercetin 3,4'-dimethyl ether 33429-83-3 98%
Quercetin 3,4'-dimethyl ether
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
T13338 WEHI-9625 2595314-46-6 98%
WEHI-9625
WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
T30969 Clitocine 105798-74-1 98%
Clitocine
Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activi...
TN3708 Coronarin D 119188-37-3 98%
Coronarin D
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
T11968 MCL-1/BCL-2-IN-1 2493256-46-3 98%
MCL-1/BCL-2-IN-1
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].
T16089 MK-0674 887781-62-6 98%
MK-0674
MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
T10463 Bax inhibitor peptide V5 579492-81-2 98%
Bax inhibitor peptide V5
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
TN4774 Physalin A 23027-91-0 98%
Physalin A
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN4999 Serratenediol 2239-24-9 98%
Serratenediol
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
T16694 Pyridoclax 1651890-44-6 98%
Pyridoclax
Pyridoclax is an inhibitor of potential Mcl-1.
T13922 Thevetiaflavone 29376-68-9 98%
Thevetiaflavone
Thevetiaflavone (2-Genistein-5-methyl ether) is a natural flavonoid from Wikstroemia indica that inhibits the leakage of lactate dehydrogenase from the cytoplasm...
Sappanchalcone
TN2180
Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.
Altholactone
TN3404
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
Tanshinone IIB
TN2257
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a...
Kobophenol A
TN4394
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
AZD-5991
T10434
AZD-5991 is a potent and selective Mcl-1 inhibitor (IC50: 0.7 nM in FRET assay; Kd: 0.17 nM in SPR assay).
S55746 hydrochloride
T12824
S55746 hydrochloride is a potent, orally active and selective inhibitor of BCL-2(Ki of 1.3 nM and a Kd of 3.9 nM),with antitumor activity with low toxicity.
Ferruginol
TN1642
Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce ap...
(S)-Purvalanol B
T13454
(S)-Purvalanol B is the S enantiomer of Purvalanol B. Purvalanol B is an inhibitor of cyclin-dependent kinase(CDK) .
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Quercetin 3,4'-dimethyl ether
TN4877
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
WEHI-9625
T13338
WEHI-9625 is a tricyclic sulfone small molecule apoptosis inhibitor (EC50: 69 nM).
Clitocine
T30969
Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activi...
Coronarin D
TN3708
Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration...
MCL-1/BCL-2-IN-1
T11968
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective dual inhibitor of Mcl-1 and Bcl-2 with IC 50 s of 4.45 and 3.18 μM, respectively [1].
MK-0674
T16089
MK-0674 is an effective and selective cathepsin K inhibitor (IC50: 0.4 nM). It also displays 1156, 1465, 11857, and 243 fold selectivity over Cat B, Cat F, Cat L...
Bax inhibitor peptide V5
T10463
Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
Serratenediol
TN4999
Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects be...
Pyridoclax
T16694
Pyridoclax is an inhibitor of potential Mcl-1.
Thevetiaflavone
T13922
Thevetiaflavone (2-Genistein-5-methyl ether) is a natural flavonoid from Wikstroemia indica that inhibits the leakage of lactate dehydrogenase from the cytoplasm...
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TargetMol