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Transferases,EC 2

Transferases catalyse the transfer of specific functional groups (e.g. a methyl or glycosyl group) from one molecule (called the donor) to another (called the acceptor).They are involved in hundreds of different biochemical pathways throughout biology, and are integral to some of life's most important processes. Described primarily based on the type of biochemical group transferred, transferases can be divided into ten categories,These categories comprise over 450 different unique enzymes. In the EC numbering system, transferases have been given a classification of EC2.

GALNT2 Protein, Human, Recombinant (His)
TMPY-03810
GALNT2, also known as GalNAc-T2, is a member of the GalNAc-transferases family. Members of this family transfer an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. GALNT2 may play a role in lipid metabolism. It catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT2 has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b.
  • $600
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HER2/ERBB2 Protein, Human, Recombinant (aa 1-652, His)
TMPY-01137
Expression system: HEK293 Cells
Length: 1-652, Extracellular Domain
Activity: SPR、Octet RED、ELISA、Cells
  • $329
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SPR-compatible buffer
DDOST Protein, Human, Recombinant
TMPY-02050
The enzyme oligosaccharyltransferase (dolichyl-diphosphooligosaccharide-protein glycosyltransferase) (DDOST), or 48-kDa subunit (OST48) is one of the catalytic subunits in this complex, exerts a typical type I membrane topology, containing a large luminal domain, a hydrophobic transmembrane domain and a short cytosolic peptide tail. DDOST OST48 catalyzes the transfer of a high-mannose oligosaccharide (GlcNac2Man9Glc3) from a dolichol-linked oligosaccharide donor (dolichol-P-GlcNac2Man9Glc3) onto the asparagine acceptor site within an Asn-X-Ser Thr consensus motif in nascent polypeptide chains across the membrane of the endoplasmic reticulum. The mammalian oligosaccharyltransferase (OST) is an oligomeric complex composed of three type I transmembrane proteins of the endoplasmic reticulum: ribophorin I (RI), ribophorin II (RII), and OST48. OST48 is not a glycoprotein and is not recognized by antibodies to either ribophorin. Like ribophorins I and II, OST48 was found to be an integral membrane protein, with the majority of the polypeptide located within the lumen of the endoplasmic reticulum (ER). OST48 does not show significant amino acid sequence homology to either ribophorin I or II. It had been found that only the luminal domain of RI contains ER retention information. The dilysine motif in OST48 functions as an ER localization motif because OST48 in which the two lysine residues are replaced by serine (OST48ss) is no longer retained in the ER and is found instead also at the plasma membrane.
  • $801
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PDK4 Protein, Mouse, Recombinant (His & GST)
TMPY-04445
Pyruvate dehydrogenase kinase 4 (PDK4) is a mitochondrial protein that regulates the TCA cycle.PDK4, a vital mitochondrial protein, controls the switch between glycolysis and oxidative phosphorylation based upon nutrient availability.Pyruvate dehydrogenase kinase 4 (PDK4) mRNA has been reported as an up-regulated gene in the heart and skeletal muscle of carnitine-deficient juvenile visceral steatosis (JVS) mice under fed conditions. PDK4 plays an important role in the inhibition of glucose oxidation via the phosphorylation of pyruvate dehydrogenase complex (PDC).PDK4 gene expression is stimulated by thyroid hormone (T(3)), glucocorticoids, and long chain fatty acids.
  • $498
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FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00395
FGFR1 alpha (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 42 kDa and the accession number is P11362-7.
  • $814
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SPR-compatible buffer
ST6GAL1 Protein, Mouse, Recombinant (His)
TMPY-02371
Expression system: HEK293 Cells
Length: 27-403, Partial
Activity: Enzyme activity
  • $451
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TRIM21 Protein, Human, Recombinant (His)
TMPY-05306
Expression system: Baculovirus Insect Cells
Length: 1-475, Full Length
Activity: Not Tested
  • $517
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MERTK/Mer Protein, Mouse, Recombinant (His)
TMPK-01022
Expression system: HEK293 Cells
Length: 19-497, Partial
Activity: Not Tested
  • $418
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SPR-compatible buffer
Lck Protein, Human, Recombinant (His)
TMPH-02275
Expression system: E. coli
Length: 1-539, Full Length of Isoform 3
Activity: Not Tested
  • $198
20 days
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Buffer-exchangeable
AMPK (G1/B2/A1) Heterotrimer Protein, Human, Recombinant (His & GST)
TMPY-04452
AMPK (G1 B2 A1) Heterotrimer Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 160 kDa and the accession number is P54619&O43741&Q13131-1.
  • $904
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CSK Protein, Mouse, Recombinant
TMPY-04760
CSK Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 50.9 kDa and the accession number is P41241.
  • $498
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PKM2 Protein, Human, Recombinant (His)
TMPY-04465
PKM2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 59 kDa and the accession number is P14618-1.
  • $398
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p38 gamma/MAPK12 Protein, Human, Recombinant (His & GST)
TMPY-04429
p38 gamma MAPK12 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 69.8 kDa and the accession number is P53778.
  • $498
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GSTK1 Protein, Human, Recombinant
TMPY-03450
Expression system: E. coli
Length: 2-226, Partial
Activity: Not Tested
  • $700
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HER2/ERBB2 Protein, Human, Recombinant (His)
TMPJ-00778
Expression system: HEK293 Cells
Length: 23-652, Extracellular Domain
Activity: BLI
  • $75
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SPR-compatible buffer
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
TMPK-00450
Expression system: HEK293 Cells
Length: 27-756, Partial
Activity: ELISA
  • $418
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SPR-compatible buffer
LCAT Protein, Mouse, Recombinant (His)
TMPK-00835
Lecithin:cholesterol acyltransferase (LCAT) is the only enzyme capable of esterifying cholesterol in plasma, thus determining the maturation of high-density lipoproteins. Because it maintains an unesterified cholesterol gradient between peripheral cells and extracellular acceptors, for a long time, LCAT has been considered as a key enzyme in reverse cholesterol transport.
  • $371
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SPR-compatible buffer
GST Protein, Schistosoma japonicum, Recombinant
TMPY-02157
Expression system: Baculovirus Insect Cells
Length: 1-218, Full Length
Activity: Not Tested
  • $398
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ART1 Protein, Human, Recombinant (His)
TMPY-06532
ART1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.55 kDa and the accession number is NP_004305.2.
  • $600
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SPR-compatible buffer
ATP citrate lyase/ACLY Protein, Human, Recombinant (His)
TMPY-02483
ATP citrate lyase, also known as Acly or Acl, is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is composed of two polymer chains which are polypeptides in human. ATP citrate lyase is responsible for catalyzing the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, along with the hydrolysis of ATP. A definitive role for ATP citrate lyase in tumorigenesis has emerged from ATP citrate lyase RNAi and chemical inhibitor studies, showing that ATP citrate lyase inhibition limits tumor cell proliferation and survival and induces differentiation in vitro. In vivo, it reduces tumor growth leading to a cytostatic effect and induces differentiation.
  • $386
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UBE2L6 Protein, Human, Recombinant (His)
TMPY-02842
UBCH8, also known as UBE2L6, belongs to the ubiquitin-conjugating enzyme family. The family of ubiquitin-conjugating (E2) enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain. These domains accommodate the ATP-activated ubiquitin (Ub) or ubiquitin-like (UBL) protein via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the E1 and E3 enzymes and connect activation to covalent modification. By doing so, E2s differentiate effects on downstream substrates, either with a single Ub UBL molecule or as a chain. UBCH8 is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. It catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. UBCH8 functions in the E6 E6-AP-induced ubiquitination of p53 TP53 and promotes ubiquitination and subsequent proteasomal degradation of FLT3. At protein level, it is present in natural killer cells.
  • $700
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CDK2 Protein, Human, Recombinant (His)
TMPY-04542
Expression system: Baculovirus Insect Cells
Length: 1-298, Full Length
Activity: No Kinase Activity
  • $498
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SULT1A1 Protein, Human, Recombinant (His)
TMPY-02062
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroids and neurotransmitters, and certain xenobiotics, including N-hydroxy-2-acetylaminoflourine and phenolic compounds, like alpha-naphthol. SULTs may be involved in the individual genetic disposition, species differences, and organotropisms for toxicological effects of chemicals. Particularly SULT1A1 (Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1), a member of the sulfotransferase 1 subfamily, which is a major pathway for drug metabolism in humans. Humans have at least 10 functional SULT genes. There has been an explosion in information on sulfotransferase polymorphisms and their functional consequences. An Arg213His polymorphism in SULT1A1 has a strong influence on the level of enzyme protein and activity in platelets, which have been widely used for phenotyping. Statistically significant associations were observed between the SULT1A1 genotype (Arg213His) and age, obesity and certain neoplasias (mammary, pulmonary, esophageal and urothelial cancer). Furthermore, the polymorphism of the SULT1A1 may be closely associated with breast cancer.
  • $600
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AKT1 Protein, Human, Recombinant (His)
TMPY-04552
Expression system: Baculovirus Insect Cells
Length: 1-480, Full Length
Activity: Not Tested
  • $320
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