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KL 465
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Catalog No. T207775Cas No. 3057446-82-6
KL 465 is a degrader of MAGE-A3. The degradation of MAGE-A3 caused by KL 465 leads to reduced viability of cancer cells, and this effect is dependent on the VHL protein.
KL 465
🥰Excellent
Catalog No. T207775Cas No. 3057446-82-6
KL 465 is a degrader of MAGE-A3. The degradation of MAGE-A3 caused by KL 465 leads to reduced viability of cancer cells, and this effect is dependent on the VHL protein.
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Product Introduction
Bioactivity
Chemical Properties
| Description | KL 465 is a degrader of MAGE-A3. The degradation of MAGE-A3 caused by KL 465 leads to reduced viability of cancer cells, and this effect is dependent on the VHL protein. |
| In vitro | KL 465 is a MAGE-A3 Degrader (PROTAC) with a DC50 of 2 μM and a maximum degradation (Dmax) of 60%. It works by degrading MAGE-A3, subsequently reducing cancer cell viability, and its activity is dependent on the von Hippel-Lindau protein (VHL). |
| Molecular Weight | 1021.19 |
| Formula | C56H60N8O9S |
| Cas No. | 3057446-82-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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