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Cytoskeletal SignalingCadherin
Cadherins are a class of calcium-dependent cell adhesion proteins that mediate intercellular adhesion and signal transduction through homodimerisation, playing a pivotal role in embryonic development, tissue differentiation, and the maintenance of intercellular junctions. The cadherin family comprises numerous members, including E-cadherin (epithelial cell adhesion molecule) and N-cadherin (neuronal cell adhesion molecule). E-cadherin is primarily expressed in epithelial cells, where it is essential for maintaining epithelial polarity and tissue integrity. N-cadherin, conversely, plays a vital role in neural tissues, participating in neuronal migration and synapse formation. Dysfunction of cadherins is implicated in various diseases, including tumour invasion and metastasis, as well as neurodegenerative disorders
MC-1-F2
T696592376894-10-7In house
MC-1-F2 is a direct FOXC2 inhibitor with anticancer activity, inhibits cancer stem cell (CSC) characteristics, and reduces the invasive ability of castration-resistant prostate cancer (CRPC) cell lines. MC-1-F2 can be used to study prostate cancer.
- $153
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Tralokinumab
LP 0162, CAT-354
T767041044515-88-9
Tralokinumab is a fully human IgG4 monoclonal antibody with a high affinity for IL-13 alone. Tralokinumab's potential anti-inflammatory activity prevents IL-13 receptor interaction and subsequent downstream signaling and can be used to study atopic dermatitis (AD).
- $289
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N-Feruloyloctopamine
N-Feruloyloctopamine
TN196866648-44-0
N-Feruloyloctopamine is a natural product.
- $77
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ADH-1
Cited
Exherin
T2637229971-81-7
ADH-1 (Exherin) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
- $52
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CitedINS018 055
TNIK&MAP4K4-IN-2, INS018055
T875452828567-39-9
INS018 055 (TNIK&MAP4K4-IN-2) is a highly efficient TNIK and MAP4K4 inhibitor with antifibrotic activity. It can be used in research on idiopathic pulmonary fibrosis.
- $64
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Aristolactam I
Aristololactum, Aristololactam I, Aristolactam
T3S122713395-02-3
1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF-beta1 pathway. 3. Aristololactam I may be one of toxic metabolites in Chinese herbs containing AA which participate in renal damage and fibrosis.
- $55
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Lycorine hydrochloride Cited
Narcissine hydrochloride, Lycorine chloride, Licorine hydrochloride, Galanthidine hydrochloride, Amarylline hydrochloride
T27742188-68-3
Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.
- $39
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CitedADH-1 trifluoroacetate
Exherin trifluoroacetate
T16081135237-88-5
ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.
- $37
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Cadherin Peptide, avian Acetate
Cadherin Peptide, avian Acetate (127650-08-2 Free base)
T21662L
Cadherin Peptide, avian Acetate is a peptide with the sequence Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2. Cadherins are a class of type-1 transmembrane proteins.
- $57
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PF-03732010
PF03732010
T77475
PF-03732010 is a CHO-expressed humanized antibody targeting P-calmodulin with anti-tumor and anti-metastatic activity, inhibiting primary tumor growth and metastatic progression.
- $197
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PTA001_A4
Anti-CDH17/Cadherin-17 Antibody
T9901A-081
PTA001_A4 (Anti-CDH17/Cadherin-17 Antibody) is a humanized antibody targeting CDH17/Cadherin-17 with potential anti-tumor activity, inhibits the growth of tumor cells, and can be used for cancer research.
- $195
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Raludotatug
T813132610074-56-9
Raludotatug is a humanized immunoglobulin G1-kappa (IgG1κ) monoclonal antibody that exhibits antineoplastic properties through its specific targeting of cadherin-6 (CDH6), and when conjugated to a cytotoxic payload to form the antibody-drug conjugate Raludotatug deruxtecan.Raludotatug has demonstrated promising research potential in heavily pretreated, platinum-sensitive ovarian cancer.
- $247
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TKL002
TKL-002, TKL 002
T2128503098518-95-4
TKL002 is a blood-brain barrier-permeable inhibitor of the CTH/H₂S/NF-κB/EMT signaling axis. It induces G2/M phase cell cycle arrest and apoptosis in glioblastoma cells. TKL002 also inhibits the migration and invasion of glioblastoma cells by upregulating E-cadherin and downregulating N-cadherin and vimentin expression, and is used in glioblastoma research.
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Hakin-1
T213038346660-34-2
Hakin-1 is an inhibitor of the E3 ubiquitin ligase Hakai. It effectively blocks both overall ubiquitination mediated by Hakai and the specific ubiquitination of E-cadherin, thereby inhibiting the process of epithelial-mesenchymal transition (EMT). Hakin-1 can impede tumor progression and cancer metastasis and is utilized for research in colorectal cancer and other cancers.
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1,3-dimethoxy-5-(2-phenylethyl)benzene
TN1307978916-50-4
Black tea extract is derived from red tea and prevents the generation of ROS induced by inorganic arsenic (iAs), inhibits uncontrolled proliferation, epithelial-mesenchymal transition (EMT), and metastasis in HaCaT cells. It possesses anti-fibrotic activity and is applicable in skin cancer research.
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CQY684
PCA062 antibody
T9901A-1609
CQY684 (PCA062 antibody) is a human monoclonal antibody (mAb) that targets CDH3/P-cadherin. It stabilizes the X-dimer of P-cadherin, facilitating its endocytosis and directing it towards lysosomal degradation. CQY684 is applicable in studies of breast cancer, esophageal cancer, and head and neck cancers.
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CPS-021
T211043
CPS-021 is a selective PAK4PROTAC degrader with a DC50 of 50 nM. It demonstrates potent anti-migration and anti-invasion properties, significantly inhibiting the invasion and metastasis of tumor cells in an A549-luc lung metastasis mouse model.
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HDAC-IN-55
T785321268674-16-3
HDAC-IN-55(8j) is a small-molecule inhibitor that enhances E-cadherin expression and suppresses cancer cell proliferation [1].
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Anti-CDH17/Cadherin-17 Antibody (10C12)
T9901A-821
Anti-CDH17/Cadherin-17 Antibody (10C12) is a recombinant humanized monoclonal antibody targeting Cadherin-17 (CDH17, also known as LI-cadherin). CDH17 is a calcium-dependent cell adhesion protein expressed in normal intestinal epithelium and frequently overexpressed in various gastrointestinal tumors (such as colorectal, gastric, and liver cancers), making it a potential tumor marker.
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Ecad saRNA
T217363
Ecad saRNA is a small activating RNA that specifically targets E-cadherin.
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BAS00602705
T213736317321-89-4
BAS00602705 is an E-cadherin inhibitor that operates by disrupting the transmembrane interactions of E-cadherin molecules within the adhesion complex without permanently altering E-cadherin expression levels. It significantly suppresses the formation of invadopodia in pancreatic cancer cells. BAS00602705 can be used to investigate anti-invasive therapeutic strategies for cancers characterized by dysregulation of invadopodia activity mediated by E-cadherin, such as pancreatic ductal adenocarcinoma [PDAC].
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