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Cytoskeletal SignalingCadherin
Cadherins are a class of calcium-dependent cell adhesion proteins that mediate intercellular adhesion and signal transduction through homodimerisation, playing a pivotal role in embryonic development, tissue differentiation, and the maintenance of intercellular junctions. The cadherin family comprises numerous members, including E-cadherin (epithelial cell adhesion molecule) and N-cadherin (neuronal cell adhesion molecule). E-cadherin is primarily expressed in epithelial cells, where it is essential for maintaining epithelial polarity and tissue integrity. N-cadherin, conversely, plays a vital role in neural tissues, participating in neuronal migration and synapse formation. Dysfunction of cadherins is implicated in various diseases, including tumour invasion and metastasis, as well as neurodegenerative disorders
ADH-1
Cited
T2637229971-81-7
ADH-1 (Exherin) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
- $52
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CitedLycorine hydrochloride Cited
T27742188-68-3
Lycorine hydrochloride (Narcissine hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.It is an HCV inhibitor with strong activity.
- $39
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CitedML327
T42521883510-31-3
ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
- $44
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ADH-1 trifluoroacetate
T16081135237-88-5
ADH-1 trifluoroacetate (Exherin trifluoroacetate) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis.
- $37
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Cadherin Peptide, avian Acetate
T21662L
Cadherin Peptide, avian Acetate is a peptide with the sequence Leu-Arg-Ala-His-Ala-Val-Asp-Val-Asn-Gly-NH2. Cadherins are a class of type-1 transmembrane proteins.
- $57
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PTA001_A4
T9901A-081
PTA001_A4 (Anti-CDH17/Cadherin-17 Antibody) is a humanized antibody targeting CDH17/Cadherin-17 with potential anti-tumor activity, inhibits the growth of tumor cells, and can be used for cancer research.
- $195
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Raludotatug
T813132610074-56-9
Raludotatug is a humanized immunoglobulin G1-kappa (IgG1κ) monoclonal antibody that exhibits antineoplastic properties through its specific targeting of cadherin-6 (CDH6), and when conjugated to a cytotoxic payload to form the antibody-drug conjugate Raludotatug deruxtecan.Raludotatug has demonstrated promising research potential in heavily pretreated, platinum-sensitive ovarian cancer.
- $247
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Anti-CDH17/Cadherin-17 Antibody (10C12)
T9901A-821
Anti-CDH17/Cadherin-17 Antibody (10C12) is a human-derived antibody produced in CHO cells, targeting CDH17. For isotype control, refer to HumanIgG1kappa, Isotype Control.
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anti-TNBC agent-9
T206779
Anti-TNBC agent-9 (Compound 3as) is an anticancer agent used for treating triple-negative breast cancer (TNBC). It exhibits significant inhibitory activity against MDA-MB-453 cells, with an IC50 value of 8.5 μM. Anti-TNBC agent-9 impedes tumor cell migration by upregulating E-cadherin and downregulating N-cadherin, matrix metalloproteinase 2 (MMP2), and MMP9. Additionally, it inhibits tumor cell proliferation by inducing apoptosis, achieved through the increased expression of pro-apoptotic protein BAX and decreased expression of anti-apoptotic protein BCL-2.
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FF-21101
T9901A-1001
FF-21101 is a human IgG1 monoclonal antibody (mAb) that specifically targets CDH3/P-cadherin. It is suggested to use the isotype control, Human IgG1 kappa, for reference.
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