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MAPK ERK

ERK

ERK is a downstream component of an evolutionarily conserved signaling module that is activated by the Raf serine/threonine kinases. Raf activates the MAPK/ERK kinase (MEK)1/2 dual-specificity protein kinases, which then activate ERK1/2.
Cat No. product name
T6218 SelumetinibHOT Selumetinib (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM).
T6066 SCH772984HOT SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases.
T9141 ERK-IN-3 ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driv...
TN2346 Mogrol Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
TN1410 Asperulosidic acid Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and ...
TN1211 2-Hydroxy-3-methylanthraquinone 2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
TN1062 Peonidin chloride Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast c...
T2P2806 Hederacolchiside A1 Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering mem...
TQ0005 KO-947 KO-947 is a potent and specific inhibitor of ERK1/2 kinases.
TN1459 Bufarenogin Bufarenogin has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells.
T5727 CAFESTOL CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
T5535 ERK5-IN-2 ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
T5358 Longdaysin Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).
T5184 ERK5-IN-1 ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
T6S0117 Avicularin 1. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. 2. Avicularin in...
T6S0655 Corynoxeine 1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and ...
T5S2361 Epiberberine 1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
TN1441 Beta-Tocopherol Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.
TN1462 Cajanin Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
T4S0878 Prunetin 1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
TN1889 Lupalbigenin Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
TN2166 Rupestonic acid Rupestonic acid derivatives have an anti-influenza virus activity, they inhibit IAV by up-regulating HO-1-mediated IFN response.
TN2165 Rubrofusarin-6-O-beta-D-gentiobioside Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it...
TN2118 Lup-20(29)-en-28-oic acid Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
TN2114 Pseudoginsenoside Rh2 Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
TN1996 Nothofagin Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
TN1922 Meranzin hydrate Meranzin hydrate exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α±-amino-3-h...
TN1793 Isorhamnetin 3-O-galactoside Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
TN1490 Chrysoeriol Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilato...
TN1786 Isomeranzin Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
TN1775 Isocryptotanshinone Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative...
TN1751 Hydroxycitric acid (-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
TN1653 Fustin Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
TN1560 Dehydroeffusol Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties, it may antagonize the spasmogenic activity of various agents, and therefore, could be a...
TN1557 Decursinol angelate Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of th...
T4S2063 Tetrahydrocoptisine 1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
T5S0045 Isofraxidin 1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
T5S0168 Atractylenolide II 1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
T3714 SUN 11602 SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
T2416 BIX02189 BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
T3876 Loureirin B Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress...
T2654 GSK2656157 GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
T1842 XMD17109 XMD17-109 is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).
T6511 Ravoxertinib GDC-0994 is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).
T6183 ISRIB (trans-isomer) ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
T6818 DEL22379 DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ~0.5 μM.
T3857 Magnolin Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory a...
T6993 Sodium Tauroursodeoxycholate (TUDC) Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
T1933 NVP 231 NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
T3881 Vaccarin Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
T2027 ISRIB ISRIB is a potent and selective PERK inhibitor.
T3668 Galangin Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
T6139 A674563 A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T2961 Notoginsenoside R1 Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
TN2316 Xanthyletin Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting ants.
T4082 Astragaloside Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteas...
T3S2344 Dimethylacrylshikonin 1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combine...
T6S0525 Farrerol 1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
T6S1572 Sauchinone 1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
TMS2181 Trans-Zeatin Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.
T4518 Licochalcone D Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking ce...
T4S2326 Cornuside 1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human en...
T4091 LY3214996 LY-3214996 is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activi...
T6948 Pluripotin Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
T4092 AG 126 The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in viv...
T3166 VX-11e VX-11e is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.
T2356 Ro 3306 RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
T7005 Ulixertinib Ulixertinib (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.
T6083 AZD8330 AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
T1956 FR180204 FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.
TN2179 Saponarin Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
T12058 MK-2 Inhibitor III MK-2 Inhibitor III is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
T6139L A-674563 2HCl(552325-73-2(fb-2hcl)) A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
TN3711 Corylifol C Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
TMA1743 Ergosterol peroxide Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
TN3967 Epieriocalyxin A Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
TN3931 Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
TN3839 Desoxo-narchinol A Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TMA2474 Delta-Tocotrienol Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN3655 Cimiside E Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
TN4114 Gardenin A Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, bu...
TN3614 Cearoin Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN3609 Catalposide Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN3541 Broussonin E Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
TN3539 Broussonin A Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
TN3525 Boehmenan (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in...
TN4107 Ganoderic acid X Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN4166 Griffipavixanthone Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN3397 Alpinumisoflavone Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T21295 BIX 02189 BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
T22996 ML-191 ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.
TN5153 Torilin Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
TN5100 Taspine Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
TN5011 Shizukaol B Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
TN4877 Quercetin 3,4'-dimethyl ether Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
TN4683 Nyasol Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
TN4179 Haginin A Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activ...
TN4490 Manassantin B Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
TN4489 Manassantin A Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN4469 (+)-Lyoniresinol Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activat...
TN4374 Kaerophyllin Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
TN4271 Isochamaejasmine Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the ...
TN4213 Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
TN3486 Bakkenolide IIIa Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Î...
TN3219 7,8-Didehydrocimigenol 7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of...
T12069 MK-8353 MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)
T14894 CC-90003 CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.
T11225 ERK-IN-2 ERK-IN-2 might lead to off-target toxicity and/or off-target activity at dose >10 μM.ERK-IN-2 is a potent, highly seletive and orally active ERK2 inhibitor prob...
T11224 ERK-IN-1 ERK-IN-1  is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is ...
T13680 Enniatin B1 Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activa...
T13679 Enniatin B Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) act...
T11201 Enniatin A1 Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of ...
T15377 Ravoxertinib hydrochloride Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).
T8472 ASTX029 ASTX029 is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.
T11228 ERK2 IN-1 ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
T10429 AZD-0364 AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1 (example 18; IC50: 0.6 nM).
T10299 AMG PERK 44 AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 ...
T14547 JWG-071 JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology...
T14360 AX-15836 AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
T12410 PERK-IN-3 PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).
T12409 PERK-IN-2 PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).
T11226 ERK1/2 inhibitor 1 ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
T10479 BAY885 BAY885 is a new ERK5 inhibitor.
TN3152 6-Acetonyldihydrochelerythrine 6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
TN3144 6,4'-Dihydroxy-7-methoxyflavanone 6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
TN3139 5alpha-Hydroxycostic acid 5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
TN3003 4-(3,4-Dimethoxyphenyl)-3-buten-1-ol (E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypop...
TN2995 4,10-Aromadendranediol 4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
TN2641 15-Methoxypinusolidic acid 15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
TL0016 Sulforaphene Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
T3S0209 Vincristine Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristin...
T13265 Urolithin B Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enha...
T2S1975 Ponicidin Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
T2S1040 Jolkinolide B Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
T16998 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decrea...
T16390 Omtriptolide Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.
T6S0619 Pachymic acid Pachymic acid is a natural product, and inhibits Akt and ERK signaling pathways.
T16159 Muramyl dipeptide Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipe...
T6324 BIX02188 BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...
Selumetinib HOT
T6218CAS 606143-52-6
Selumetinib (AZD6244) is an effective, specific inhibitor of MEK1 and ERK1/2 phosphorylation (IC50: 14/10 nM).
SCH772984 HOT
T6066CAS 942183-80-4
SCH 772984 is a potent inhibitor of ERK1/ERK2 (IC50: 4/1 nM) and has only weak inhibitory for other 300 tested kinases.
ERK-IN-3
T9141CAS 2055597-12-9
ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driv...
Mogrol
TN2346CAS 88930-15-8
Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
Asperulosidic acid
TN1410CAS 25368-11-0
Asperulosidic acid has anti-tumor, anti-oxidant, and anti-inflammatory activities.ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and ...
2-Hydroxy-3-methylanthraquinone
TN1211CAS 17241-40-6
2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activ...
Peonidin chloride
TN1062CAS 134-01-0
Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast c...
Hederacolchiside A1
T2P2806CAS 106577-39-3
Hederacolchiside A1 shows anti-leishmanial activity, it exhibits a strong antiproliferative activity on all stages of development of the parasite by altering mem...
KO-947
TQ0005CAS 1695533-89-1
KO-947 is a potent and specific inhibitor of ERK1/2 kinases.
Bufarenogin
TN1459CAS 17008-65-0
Bufarenogin has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells.
CAFESTOL
T5727CAS 469-83-0
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells....
ERK5-IN-2
T5535CAS 1888305-96-1
ERK5-IN-2 is an orally active, sub-micromolar, selective ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
Longdaysin
T5358CAS 1353867-91-0
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 µM). It also can inhibit ERK2 (IC50: 52 µM).
ERK5-IN-1
T5184CAS 1234479-76-5
ERK5-IN-1 is a potent ERK5 inhibitor (IC50: 87 nM). It also inhibits LRRK2[G2019S] (IC50: 26 nM).
Avicularin
T6S0117CAS 572-30-5
1. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. 2. Avicularin in...
Corynoxeine
T6S0655CAS 630-94-4
1. Corynoxeine is a potent ERK1/2 inhibitor of key PDGF-BB-induced VSMC proliferation and may be useful in the prevention and treatment of vascular diseases and ...
Epiberberine
T5S2361CAS 6873-09-2
1. Epiberberine may be caused drug interactions based on CYP2D6 enzyme. 2. Epiberberine has anti-adipogenic effect is mediated by downregulation of the Raf/MEK1/...
Beta-Tocopherol
TN1441CAS 148-03-8
Dietary beta-tocopherol and linoleic acid, serum insulin,and waist circumference predict circulating sex hormone-binding globulin in premenopausal women.
Cajanin
TN1462CAS 32884-36-9
Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol ef...
Prunetin
T4S0878CAS 552-59-0
1. Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obes...
Lupalbigenin
TN1889CAS 76754-24-0
Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.
Rupestonic acid
TN2166CAS 115473-63-7
Rupestonic acid derivatives have an anti-influenza virus activity, they inhibit IAV by up-regulating HO-1-mediated IFN response.
Rubrofusarin-6-O-beta-D-gentiobioside
TN2165CAS 24577-90-0
Rubrofusarin-6-O-beta-D-gentiobioside can significantly decrease the expression of TGF-beta1 and fibronectin and NF-kappaB DNA binding activity, suggests that it...
Lup-20(29)-en-28-oic acid
TN2118CAS 848784-85-0
Lup-20(29)-en-28-oic acid exhibits anticancer activities in various cancer types, it Inhibits autophagic flux and synergistically enhances the anticancer activit...
Pseudoginsenoside Rh2
TN2114CAS 1370264-16-6
Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathw...
Nothofagin
TN1996CAS 11023-94-2
Nothofagin has antioxidant, and antithrombotic activities, it possesses anti-inflammatory activity by inhibiting hyperpermeability, expression of CAMs, and adhes...
Meranzin hydrate
TN1922CAS 5875-49-0
Meranzin hydrate exhibits antidepressive and prokinetic-like effects through the regulation of the common mediator, the alpha 2-adrenoceptor , and α±-amino-3-h...
Isorhamnetin 3-O-galactoside
TN1793CAS 6743-92-6
Isorhamnetin 3-O-galactoside shows antioxidant, anti-inflammatory, neuroprotective,and barrier protective activities, it could be used as a candidate therapeutic...
Chrysoeriol
TN1490CAS 491-71-4
Chrysoeriol has antioxidant, antiinflammatory, antitumor, antimicrobial, antiviral, and free radical scavenging activities, it also shows selective bronchodilato...
Isomeranzin
TN1786CAS 1088-17-1
Isomeranzin has anti-inflammatory activity, it suppresses inflammation by inhibiting M1 macrophage polarization through the p65, NF-κB and ERK pathway.
Isocryptotanshinone
TN1775CAS 22550-15-8
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative...
Hydroxycitric acid
TN1751CAS 6205-14-7
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to ac...
Fustin
TN1653CAS 20725-03-5
Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.
Dehydroeffusol
TN1560CAS 137319-34-7
Dehydroeffusol possesses anti-cancer, anxiolytic and sedative properties, it may antagonize the spasmogenic activity of various agents, and therefore, could be a...
Decursinol angelate
TN1557CAS 130848-06-5
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of th...
Tetrahydrocoptisine
T4S2063CAS 7461-02-1
1. Tetrahydrocoptisine has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibit...
Isofraxidin
T5S0045CAS 486-21-5
1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
Atractylenolide II
T5S0168CAS 73069-14-4
1. Atractylenolide II has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK ...
SUN 11602
T3714CAS 704869-38-5
SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor. It mimics the neuroprotective effects of bFGF and prevent...
BIX02189
T2416CAS 1094614-85-3
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM.
Loureirin B
T3876CAS 119425-90-0
Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress...
GSK2656157
T2654CAS 1337532-29-2
GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay. The selectivty is 500-fold higher against a panel of 300 ...
XMD17109
T1842CAS 1435488-37-1
XMD17-109 is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).
Ravoxertinib
T6511CAS 1453848-26-4
GDC-0994 is an effective and orally available ERK1/2 inhibitor (IC50: 1.1/0.3 nM).
ISRIB (trans-isomer)
T6183CAS 1597403-47-8
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a effective and specific PERK inhibitor (IC50: 5 nM).
DEL22379
T6818CAS 181223-80-3
DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ~0.5 μM.
magnolin
T3857CAS 31008-18-1
Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory a...
Sodium Tauroursodeoxycholate (TUDC)
T6993CAS 35807-85-3
Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.
NVP 231
T1933CAS 362003-83-6
NVP-231 is a potent, specific and reversible CerK inhibitor(IC50=12±2 nM) that competitively inhibits ceramide binding to CerK.
Vaccarin
T3881CAS 53452-16-7
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylation...
ISRIB
T2027CAS 548470-11-7
ISRIB is a potent and selective PERK inhibitor.
Galangin
T3668CAS 548-83-4
Galangin is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
A674563
T6139CAS 552325-73-2
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
Notoginsenoside R1
T2961CAS 80418-24-2
Notoginsenoside R1 has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
Xanthyletin
TN2316CAS 553-19-5
Xanthyletin has anti-inflammatory, anti-tumor and anti-bacterial activities, it also inhibits symbiotic fungus cultivated by leaf-cutting ants.
Astragaloside
T4082CAS T4082
Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteas...
Dimethylacrylshikonin
T3S2344CAS 24502-79-2
1. Dimethylacrylshikonin is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combine...
Farrerol
T6S0525CAS 24211-30-1
1. Farrerol has antioxidative activity.2. Farrerol modulates TAP and BNBD5 gene expression in mammary gland, enhances bMEC defense against S. aureus infection an...
Sauchinone
T6S1572CAS 177931-17-8
1. Sauchinone is a useful adjunctive treatment for bacterial infection. 2. Sauchinone, an active lignan found in Saururus chinensis, to regulate the activation o...
trans-Zeatin
TMS2181CAS 1637-39-4
Trans-Zeatina is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.
Licochalcone D
T4518CAS 144506-15-0
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking ce...
Cornuside
T4S2326CAS 131189-57-6
1. Cornuside has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human en...
LY3214996
T4091CAS 1951483-29-6
LY-3214996 is a potent and selective, orally available inhibitor of the extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activi...
Pluripotin
T6948CAS 839707-37-8
Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
AG 126
T4092CAS 118409-62-4
The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. It blocks the production of TNF-α in vitro2 and in viv...
VX-11e
T3166CAS 896720-20-0
VX-11e is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent.
Ro 3306
T2356CAS 872573-93-8
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
Ulixertinib
T7005CAS 869886-67-9
Ulixertinib (BVD-523, VRT752271) is an effective and reversible ERK1/ERK2 inhibitor. The IC50 of Ulixertinib is less than 0.3 nM for ERK2.
AZD8330
T6083CAS 869357-68-6
AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
FR180204
T1956CAS 865362-74-9
FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2.
Saponarin
TN2179CAS 20310-89-8
Saponarin shows in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.
MK-2 Inhibitor III
T12058CAS 1186648-22-5
MK-2 Inhibitor III is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
A-674563 2HCl(552325-73-2(fb-2hcl))
T6139LCAS T6139L
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
Corylifol C
TN3711CAS 775351-91-2
Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factor receptor...
Ergosterol peroxide
TMA1743CAS 2061-64-5
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
Epieriocalyxin A
TN3967CAS 191545-24-1
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid
TN3931CAS 57719-81-0
Ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid has anti-cancer activity, it induces apoptosis of human malignant cancer cells, it also inhibits hepatocellular ...
Desoxo-narchinol A
TN3839CAS 53859-06-6
Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
Delta-Tocotrienol
TMA2474CAS 25612-59-3
Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
Cimiside E
TN3655CAS 154822-57-8
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
Gardenin A
TN4114CAS 21187-73-5
Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, bu...
Cearoin
TN3614CAS 52811-37-7
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Catalposide
TN3609CAS 6736-85-2
Catalposide possesses antioxidant, anti-apoptotic, anti-microbial, anti-tumoral, and anti-inflammatory properties. Catalposide is a potent inducer of HO-1 and HO...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Broussonin E
TN3541CAS 90902-21-9
Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
Broussonin A
TN3539CAS 73731-87-0
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, tra...
Boehmenan
TN3525CAS 57296-22-7
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in...
Ganoderic acid X
TN4107CAS 86377-53-9
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
Griffipavixanthone
TN4166CAS 219649-95-3
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
Alpinumisoflavone
TN3397CAS 34086-50-5
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
Physalin A
TN4774CAS 23027-91-0
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
BIX 02189
T21295CAS 1265916-41-3
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
ML-191
T22996CAS 931695-79-3
ML-191 is an inhibitor of LPI-induced phosphorylation of ERK1/2.
Torilin
TN5153CAS 13018-10-5
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
Taspine
TN5100CAS 602-07-3
Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of H...
Shizukaol B
TN5011CAS 142279-40-1
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinfl...
Quercetin 3,4'-dimethyl ether
TN4877CAS 33429-83-3
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
Nyasol
TN4683CAS 96895-25-9
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory ...
Haginin A
TN4179CAS 74174-29-1
Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activ...
Manassantin B
TN4490CAS 88497-88-5
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-...
Manassantin A
TN4489CAS 88497-87-4
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
(+)-Lyoniresinol
TN4469CAS 14464-90-5
Lyoniresinol has antioxidant effect, it shows robust anti-melanogenic activity, decreases tyrosinase activity and melanin biosynthesis in B16F10 cells by activat...
Kaerophyllin
TN4374CAS 75590-33-9
Kaerophyllin has anti-fibrotic effects, it can protect the rat liver from TAA-caused injury and fibrogenesis by suppressing hepatic inflammation and inhibiting H...
Isochamaejasmine
TN4271CAS 93859-63-3
Isochamaejasmine has inhibition of NF-kappaB activation, which could reverse the anti-apoptotic effect; it induces apoptosis in leukemia cells by inhibiting the ...
Hirsutenone
TN4213CAS 41137-87-5
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
Bakkenolide IIIa
TN3486CAS 915289-60-0
Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-Î...
7,8-Didehydrocimigenol
TN3219CAS 150972-72-8
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of...
MK-8353
T12069CAS 1184173-73-6
MK-8353 is a potent, selective and orally available inhibitor of ERK1/2 (IC50s of 23.0 nM and 8.8 nM, respectively)
CC-90003
T14894CAS 1621999-82-3
CC-90003 is a selective inhibitor of ERK 1/2. It has antitumor activity.
ERK-IN-2
T11225CAS T11225
ERK-IN-2 might lead to off-target toxicity and/or off-target activity at dose >10 μM.ERK-IN-2 is a potent, highly seletive and orally active ERK2 inhibitor prob...
ERK-IN-1
T11224CAS 1715025-32-3
ERK-IN-1  is a RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is ...
Enniatin B1
T13680CAS 19914-20-6
Enniatin B1 crosss the blood-brain barrier. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activa...
Enniatin B
T13679CAS 917-13-5
Enniatins B decreases the activation of ERK (p44/p42). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) act...
Enniatin A1
T11201CAS 4530-21-6
Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of ...
Ravoxertinib hydrochloride
T15377CAS 2070009-58-2
Ravoxertinib hydrochloride is an orally bioavailable and selective inhibitor for ERK kinase activity (IC50: 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively).
ASTX029
T8472CAS 2095719-92-7
ASTX029 is a selective and orally bioavailable extracellular signal-regulated kinases 1 and 2 (ERK 1/2) inhibitor, with potential antineoplastic activity.
ERK2 IN-1
T11228CAS 1093061-47-2
ERK2 IN-1 is a selective ERK2 inhibitor with an IC50 of 7 nM.
AZD-0364
T10429CAS 2097416-76-5
AZD-0364 is a potent and selective ERK2 inhibitor extracted from patent WO2017080979A1 (example 18; IC50: 0.6 nM).
AMG PERK 44
T10299CAS 1883548-84-2
AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 ...
JWG-071
T14547CAS 2250323-50-1
JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology...
AX-15836
T14360CAS 2035509-96-5
AX-15836 is an inhibitor of ERK5 (IC50 : 8 nM).
PERK-IN-3
T12410CAS 1337532-08-7
PERK-IN-3 is a potent inhibitor of PERK(IC50 of 7.4 nM).
PERK-IN-2
T12409CAS 1337531-83-5
PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).
ERK1/2 inhibitor 1
T11226CAS 2095719-90-5
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
BAY885
T10479CAS 2307249-33-6
BAY885 is a new ERK5 inhibitor.
6-Acetonyldihydrochelerythrine
TN3152CAS 22864-92-2
6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therape...
Pinusolide
TL0014CAS 31685-80-0
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
6,4'-Dihydroxy-7-methoxyflavanone
TN3144CAS 189689-32-5
6,4'-Dihydroxy-7-methoxyflavanone has antioxidant, anti-inflammatory and neuroprotective effects. It shows inhibition of osteoclasts differentiation and function...
5alpha-Hydroxycostic acid
TN3139CAS 132185-83-2
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
4-(3,4-Dimethoxyphenyl)-3-buten-1-ol
TN3003CAS 69768-97-4
(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypop...
4,10-Aromadendranediol
TN2995CAS 70051-38-6
4,10-Aromadendranediol exhibits neurite outgrowth-inducing activity in neurons via activation of the ERK signaling pathway, which may be beneficial to the treatm...
15-Methoxypinusolidic acid
TN2641CAS 769928-72-5
15-Methoxypinusolidic acid has anti-inflammatory effects, it inhibits LPS-induced iNOS expression and NO production, independent on MAPK and NF-kappaB. 15-Methox...
Sulforaphene
TL0016CAS 592-95-0
Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes canc...
Vincristine
T3S0209CAS 57-22-7
Vincristine-induced nociceptive painful sensation, may be due to its potential of antioxidative, neuroprotective and calcium channel inhibitory action.Vincristin...
Urolithin B
T13265CAS 1139-83-9
Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enha...
Ponicidin
T2S1975CAS 52617-37-5
Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
Jolkinolide B
T2S1040CAS 37905-08-1
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
Tauroursodeoxycholate dihydrate
T16998CAS 117609-50-4
Tauroursodeoxycholate dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate also inhibits ERK. Tauroursodeoxycholate significantly decrea...
Omtriptolide
T16390CAS 195883-06-8
Omtriptolide, triptolide purified from the Chinese herb, is a water-soluble derivative prodrug.
Pachymic acid
T6S0619CAS 29070-92-6
Pachymic acid is a natural product, and inhibits Akt and ERK signaling pathways.
Muramyl dipeptide
T16159CAS 53678-77-6
Muramyl dipeptide is a synthetic immunoreactive peptide, consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipe...
BIX02188
T6324CAS 1094614-84-2
BIX02188 is a specific MEK5 inhibitor (IC50: 4.3 nM), also inhibits ERK5 catalytic activity (IC50: 810 nM), and does not inhibit closely related kinases MEK1/2, ...