eos

EOS is a ceramide found in the outer layer of the epidermis in mammals. It is comprised of an ω-hydroxy very long-chain ceramide (C28-36) esterified to the essential fatty acid linoleic acid . The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte.

Pesampator (PF-04958242) is a potent, highly selective positive allosteric modulator of the AMPA receptor, with an EC50 of 310 nM and a Ki of 170 nM, also known as an AMPA potentiator [1].

EOS (d18:1/30:0/18:2) is a lipid molecule that can be used in life science related research. The CAS number of EOS (d18:1/30:0/18:2) is 97040-38-5.

EOS006215 is a humanized monoclonal antibody inhibitor targeting TREM-2. It has the ability to reprogram TREM2+ macrophages, significantly hindering their tumor-promoting activities and overcoming drug resistance. In mouse models with orthotopic 4T1 triple-negative breast cancer, EOS006215 reduces metastatic burden. Additionally, it notably inhibits tumor growth in anti-PD-1 resistant mouse models. EOS006215 is applicable for studies on triple-negative breast cancer (TNBC).

UCM-05194 is a selective LPA1 receptor agonist that can improve neuropathic pain and can be used in the study of progressive system diseases.

TP-353 (EOS-61973) is a CDK7 inhibitor.

PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor.

Belrestotug (EOS-448), an antagonistic anti-TIGIT (VSIG9, VSTM3) antibody of the human immunoglobulin G1 kappa (hIgG1 kappa) class, exhibits antineoplastic activity [1].

Volociximab (M200) is an IgG4 monoclonal antibody targeting the α5β1 integrin , with antiangiogenic, antitumor and anticancer activity, inhibits the growth of rabbit VX2 tumors and is used to study solid tumors.

EOS-984 is a balanced nucleoside transporter 1 (ENT1) inhibitor. EOS-984 can counteract the immunosuppressive effect of adenosine on T cells. Can be used for solid tumor related research

Neostigmine methyl sulfate (Syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis.

Neostigmine bromide is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

Creosol is an agent of Antioxidant and Antibacterial.

Neostigmine is a cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.

Jaslanceoside B is a natural product for research related to life sciences. The catalog number is TN5558 and the CAS number is 188300-82-5.

4-Deacetylneosolaniol is a useful organic compound for research related to life sciences. The catalog number is T124276 and the CAS number is 74833-39-9.

Neosenkirkine is a useful organic compound for research related to life sciences. The catalog number is T124633 and the CAS number is 57194-70-4.

Trigoneoside Xb is a natural product that can be used as a reference standard. The CAS number of Trigoneoside Xb is 290347-51-2.

Jaceoside is a useful organic compound for research related to life sciences. The catalog number is T125193 and the CAS number is 25474-11-7.

Luteosporin is a natural product that can be used as a reference standard.

7-Chlorocitreosein is a useful organic compound for research related to life sciences. The catalog number is T125513 and the CAS number is 18521-74-9.

Neosarranicine is a useful organic compound for research related to life sciences and the catalog number is T125984.

Neosarracine is a useful organic compound for research related to life sciences and the catalog number is T125985.

Methyl glucooleoside is a useful organic compound for research related to life sciences. The catalog number is T126324 and the CAS number is 115623-36-4.