4i

4i (CHEMBL1269981) is a 5-HT3 receptor antagonist,It modulates the serotonergic system.

O4I1 is an effective Oct3/4 inducer.

IL4I1-IN-1 is a selective inhibitor of interleukin 4 induced protein 1 (IL4I1). It suppresses the IL4I1-mediated oxidation and deamination of phenylalanine, thereby reducing the production of phenylpyruvate, H2O2, and NH3. This compound holds potential for research into cancers with high IL4I1 expression, such as endometrial cancer, ovarian cancer, and triple-negative breast cancer.

O4I2 is an effective Oct3/4 inducer in various human cell lines including human fibroblasts.

PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.

O4I4 is an OCT4-inducing compound capable of activating endogenous OCT4 and its associated signaling pathways in a variety of cell lines, with the advantage of metabolic stability.Oct4-inducing Compound 4 has shown anti-aging effects in Cryptobacterium hidradii nematodes and Drosophila, and O4I4 can be used as a substitute for exogenous OCT4 to reprogram human fibroblasts to a pluripotent state, with potential applications in regenerative medicine.

Ub4ix, a DUB/26S proteasome inhibitor, safeguards K48-linked Ub chains against cleavage by deubiquitinating enzymes (DUBs) and inhibits the proteasomal degradation of Ub-tagged proteins. Additionally, it diminishes the viability of Hela cells and triggers apoptosis, exhibiting an IC 50 value of 1.6 μM.

LTB4-IN-1 (Anti-inflammatory agent 2) with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4).

KDM4-IN-4 (compound 47) is a potent inhibitor of histone lysine demethylase 4 (KDM4), with a binding constant of approximately 80 μM for the KDM4A-Tudor domain. It inhibits H3K4Me3 binding to the Tudor domain in cellular contexts with an EC50 value of 105 μM, holding potential for anticancer research applications [1].

Zavondemstat (QC8222 free base) is a histone lysine demethylase 4 (KDM4) inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.

TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis

KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.

SID 3712249 is an inhibitor of the biogenesis of microRNA-544 (miR-544).

Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor with IC50 = 1.1~2.6 nM for TrkA/TrkB/TrkC and antinociceptive effects. It is also a selective type II PTK6 inhibitor with IC50 = 76 nM and has antitumor effects.

CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively.

IL-4 inhibitor is an inhibitor of IL-4.1It binds to IL-4 with a Kdvalue of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50= 1.81 μM). It is selective for IL-4 over IL-13 (EC50= 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50= 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

IRAK4-IN-10 (compound 75) is a potent IRAK4 inhibitor (IC50 = 1.5 nM) that can block the MyD88-dependent signaling pathway and has research potential in inflammatory diseases, autoimmune diseases, and cancer.

IRAK4-IN-8 (VI-177) is an IRAK4 inhibitor used to study diseases related to cancer and inflammation.

(3,5-Dimethyl-4-isoxazolyl)methanol ,with CAS No. 19788-36-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (3,5-Dimethyl-4-isoxazolyl)methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4-Isopropylaniline ,with CAS No. 99-88-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-Isopropylaniline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(S)-4-Isopropyl-2-oxazolidinone ,with CAS No. 17016-83-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (S)-4-Isopropyl-2-oxazolidinone provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

4'-(2-Methylpropyl)acetophenone (4-Isobutylacetophenone) is used as pharmaceutical intermediates.

Chlorindanol (Lanesta) is a new antiseptic agent. It is nonallergenic and appears to be suitable for use as a topical antiseptic or sanitizer.

4-Isopropylbenzoic acid (Cumic acid) is an aromatic monoterpenoid isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid shows antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive mushroom tyrosinase inhibitor.