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Search Results for " antidepressant "

Targets

327

Compounds

42

Natural Products

3

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T78556 Antidepressant agent 5 Others
Antidepressant agent 5 is a 7-substituted tetrahydroisoquinoline derivative with antidepressant activity.Antidepressant agent 5 acts similarly to magnoflorine in the study of depression and can be used for the prevention...
T10332 Antidepressant agent 1 Others
Antidepressant agent 1 is a pyrazidole-halogeno-derivative with antidepressant effects. It also can be used to increase body temperature.
T75003 Antidepressant agent 4
Antidepressant agent 4 is an orally active antidepressant agent. Antidepressant agent 4 exhibits antidepressant, anxiolytic, performance enhancing and nootropic activities [1] .
T75002 Antidepressant agent 3
Antidepressant agent 3 is an orally active antidepressant agent. Antidepressant agent 3 exhibits antidepressant, anxiolytic, performance enhancing and nootropic activities [1] .
T62495 Antidepressant agent 2
Antidepressant agent 2 showed significant antidepressant effects with a MED value of 0.1 mg/kg.
T9787 Suvn-911 AChR
suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity.
T22052 BU 226 hydrochloride Imidazoline Receptor
BU 226 hydrochloride demonstrates affinity for imidazoline (I) receptors, in particular the I2 binding site with a Ki of 1.4 nM. BU 226 hydrochloride showed low (microM) affinity for alpha 2-adrenoceptors.
T13318 VU0650786 GluR
VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.
T2423 P7C3-A20 Others
P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.
T22605 Bifemelane hydrochloride MAO , Monoamine Oxidase
Bifemelane hydrochloride is a MAO inhibitor
T15090 Decoglurant RO4995819 GluR
Decoglurant (RO4995819) is a negative allosteric modulator of mGluR2 and mGluR3 and it also is developed as an antidepressant.
T18918 Azure B Azure B chloride MAO , Monoamine Oxidase
Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).
T21946 BIMU 8 5-HT Receptor
BIMU 8 is a selective agonist of 5-HT4 with EC50s of 18 nM, 77 nM, and 540 nM for wild-type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4.
T23070 Nisoxetine hydrochloride Sodium Channel , Monoamine Transporter , Norepinephrine
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor
T39341 FCPR03 PDE
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...
T16421 P-MPPI hydrochloride 5-HT Receptor
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
T8004 SNAP 94847 hydrochloride GPR , Melanin-concentrating Hormone Receptor (MCHR)
SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)
T21995 XAP044 GluR
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1].
T22453 Venlafaxine Wy 45030 Serotonin Transporter
Venlafaxine (Wy 45030), an arylalkanolamine serotonin-norepinephrine reuptake inhibitor (SNRI), is used to treat major generalised anxiety disorder (GAD), depressive disorder (MDD), panic disorder and social phobia.
T7601 Carbetocin Oxytocin Receptor
Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
TQ0311 GSK163090 Dopamine Receptor , 5-HT Receptor
GSK163090 is a specific and orally active 5-HT1A/B/D receptor antagonist (pKis: 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3).
T7780 Blarcamesine AE-37,AVex-73 AChR
Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
T15795 Luzindole N-0774 Melatonin Receptor , MT Receptor
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...
T1540 Doxepin hydrochloride Toruan,Doxepin HCl,Aponal,Novoxapin P450 , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it ap...
T0162 Quetiapine ICI204636,Quetiapin Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor
Quetiapine (ICI204636) is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antago...
T3086 Mesoridazine Besylate Mesoridazine benzenesulfonate,Serentil Dopamine Receptor , 5-HT Receptor
Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.
T19916 TRIM 1-(2-Trifluoromethylphenyl)imidazole NOS
TRIM (1-(2-Trifluoromethylphenyl)imidazole) is an inhibitor of nNOS.
T22051 BU 224 hydrochloride Imidazoline Receptor
BU 224 hydrochloride is a selective imidazoline I(2) binding site ligand and has antinociceptive and antidepressant-like activities.
T2371 Emapunil AC-5216,XBD-173 Others
Emapunil (XBD-173) is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO.
T0482 Sertraline hydrochloride Sertraline HCl,CP-51974-1 HCl 5-HT Receptor , Serotonin Transporter
Sertraline hydrochloride (Sertraline HCl) is a selective serotonin uptake inhibitor that is used in the treatment of depression.
T26375 (S)-Amisulpride Esamisulpride,(S) Amisulpride,SEP-4199 Dopamine Receptor , 5-HT Receptor
(S)-Amisulpride ((S) Amisulpride) (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a Ki of 900 nM. (S)-Amisulpride has antipsychotic and antidepr...
T2141 Mecamylamine hydrochloride Inversine,Mevasin AChR
Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension.
T0472 Venlafaxine hydrochloride Venlafaxine HCl,Wy 45030 hydrochloride 5-HT Receptor , Serotonin Transporter
Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative that functions as a SEROTONIN AND NORADRENALINE REUPTAKE INHIBITOR (SNRI) and is used as an ANTIDEPRESSIVE AGENT.
T1445 Agomelatine Thymanax,S-20098,Valdoxan Melatonin Receptor , 5-HT Receptor
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
T4274 Melitracen hydrochloride Thymeol hydrochloride,Melixeran Dopamine Receptor , 5-HT Receptor
Melitracen hydrochloride (Thymeol hydrochloride) , an antidepressant, is used as potential dopamine D1/2 receptor antagonist to treat depression.
T6241 Quetiapine hemifumarate Quetiapine Fumarate,ICI-204636 Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
Quetiapine hemifumarate (ICI-204636), an atypical antipsychotic, is used in the treatment of bipolar I mania, schizophrenia, bipolar II depression, bipolar I depression.
T0137 Mirtazapine 6-Azamianserin,Org3770 Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor
Mirtazapine (6-Azamianserin) is a tetracyclic antidepressant with a somewhat unique mechanism of action. Mirtazapine therapy can be associated with transient asymptomatic elevations in serum aminotransferase levels and h...
T6493 Escitalopram Oxalate Cipralex,(S)-(+)Citalopram oxalate Others , 5-HT Receptor , Serotonin Transporter
Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM.
T1909 L-701324 L701324 NMDAR , iGluR
L-701324 is an NMDA receptor with high affinity and selectivity for the glycine site, used as an orally active and long-acting anticonvulsant.
T6714 URB-597 KDS-4103,FAAH Inhibitor II Mitophagy , FAAH , Autophagy
URB-597 (FAAH Inhibitor II) is an effective, orally bioavailable FAAH inhibitor (IC50: 4.6 nM), and no effect on other cannabinoid-related targets.
T0255 Clomipramine hydrochloride Clomipramine HCl,Anafranil Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine , GST
Clomipramine hydrochloride (Anafranil) is a tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demeth...
T21013 Clomipramine Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina 5-HT Receptor
Clomipramine (Clomicalm) is a tricyclic antidepressant (TCA). It is used for the treatment of the panic disorder, obsessive-compulsive disorder, major depressive disorder, and chronic pain. It may decrease the risk of su...
T6352 (-)-Dizocilpine maleate C13737,(-)-MK 801 (Maleate),(-)-MK 801 Maleate NMDAR , iGluR
(-)-Dizocilpine maleate ((-)-MK 801 (Maleate)) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
T7601L Carbetocin acetate Carbetocin acetate(37025-55-1 free base) Oxytocin Receptor
Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
T0205 Brompheniramine maleate Dimotane,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane 5-HT Receptor , Histamine Receptor
Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.
T3275 Nefazodone hydrochloride Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754 5-HT Receptor , Adrenergic Receptor
Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.
T4297 Flibanserin BIMT-17BS,Girosa,BIMT-17 Dopamine Receptor , 5-HT Receptor
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n...
T1327 Nortriptyline hydrochloride Desitriptyline HCl,EN-7048 hydrochloride,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride Apoptosis , Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR , Norepinephrine , Autophagy , Histamine Receptor , Drug Metabolite
Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
T6963 Reboxetine mesylate FCE20124 mesylate,Edronax,PNU155950E mesylate,PNU 155950E Adrenergic Receptor , Norepinephrine
Reboxetine mesylate (FCE20124 mesylate) is a norepinephrine reuptake inhibitor (Ki: 8.2 nM).
T6888 Methylene Blue methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9 Guanylate cyclase , Microtubule Associated , NO Synthase , Parasite , Monoamine Oxidase
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.

Compounds

Antidepressant agent 5
T78556
Synonym:
Target: Others
Antidepressant agent 1
T10332
Synonym:
Target: Others
Antidepressant agent 4
T75003
Synonym:
Target:
Antidepressant agent 3
T75002
Synonym:
Target:
Antidepressant agent 2
T62495
Synonym:
Target:
suvn-911
T9787
Synonym:
Target: AChR
BU 226 hydrochloride
T22052
Synonym:
Target: Imidazoline Receptor
VU0650786
T13318
Synonym:
Target: GluR
P7C3-A20
T2423
Synonym:
Target: Others
Bifemelane hydrochloride
T22605
Synonym:
Target: MAO, Monoamine Oxidase
Decoglurant
T15090
Synonym: RO4995819
Target: GluR
Azure B
T18918
Synonym: Azure B chloride
Target: MAO, Monoamine Oxidase
BIMU 8
T21946
Synonym:
Target: 5-HT Receptor
Nisoxetine hydrochloride
T23070
Synonym:
Target: Sodium Channel, Monoamine Transporter, Norepinephrine
FCPR03
T39341
Synonym:
Target: PDE
p-MPPI hydrochloride
T16421
Synonym:
Target: 5-HT Receptor
SNAP 94847 hydrochloride
T8004
Synonym:
Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)
XAP044
T21995
Synonym:
Target: GluR
Venlafaxine
T22453
Synonym: Wy 45030
Target: Serotonin Transporter
Carbetocin
T7601
Synonym:
Target: Oxytocin Receptor
GSK163090
TQ0311
Synonym:
Target: Dopamine Receptor, 5-HT Receptor
Blarcamesine
T7780
Synonym: AE-37,AVex-73
Target: AChR
Luzindole
T15795
Synonym: N-0774
Target: Melatonin Receptor, MT Receptor
Doxepin hydrochloride
T1540
Synonym: Toruan,Doxepin HCl,Aponal,Novoxapin
Target: P450, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor
Quetiapine
T0162
Synonym: ICI204636,Quetiapin
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Histamine Receptor
Mesoridazine Besylate
T3086
Synonym: Mesoridazine benzenesulfonate,Serentil
Target: Dopamine Receptor, 5-HT Receptor
TRIM
T19916
Synonym: 1-(2-Trifluoromethylphenyl)imidazole
Target: NOS
BU 224 hydrochloride
T22051
Synonym:
Target: Imidazoline Receptor
Emapunil
T2371
Synonym: AC-5216,XBD-173
Target: Others
Sertraline hydrochloride
T0482
Synonym: Sertraline HCl,CP-51974-1 HCl
Target: 5-HT Receptor, Serotonin Transporter
(S)-Amisulpride
T26375
Synonym: Esamisulpride,(S) Amisulpride,SEP-4199
Target: Dopamine Receptor, 5-HT Receptor
Mecamylamine hydrochloride
T2141
Synonym: Inversine,Mevasin
Target: AChR
Venlafaxine hydrochloride
T0472
Synonym: Venlafaxine HCl,Wy 45030 hydrochloride
Target: 5-HT Receptor, Serotonin Transporter
Agomelatine
T1445
Synonym: Thymanax,S-20098,Valdoxan
Target: Melatonin Receptor, 5-HT Receptor
Melitracen hydrochloride
T4274
Synonym: Thymeol hydrochloride,Melixeran
Target: Dopamine Receptor, 5-HT Receptor
Quetiapine hemifumarate
T6241
Synonym: Quetiapine Fumarate,ICI-204636
Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor
Mirtazapine
T0137
Synonym: 6-Azamianserin,Org3770
Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor
Escitalopram Oxalate
T6493
Synonym: Cipralex,(S)-(+)Citalopram oxalate
Target: Others, 5-HT Receptor, Serotonin Transporter
L-701324
T1909
Synonym: L701324
Target: NMDAR, iGluR
URB-597
T6714
Synonym: KDS-4103,FAAH Inhibitor II
Target: Mitophagy, FAAH, Autophagy
Clomipramine hydrochloride
T0255
Synonym: Clomipramine HCl,Anafranil
Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine, GST
Clomipramine
T21013
Synonym: Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina
Target: 5-HT Receptor
(-)-Dizocilpine maleate
T6352
Synonym: C13737,(-)-MK 801 (Maleate),(-)-MK 801 Maleate
Target: NMDAR, iGluR
Carbetocin acetate
T7601L
Synonym: Carbetocin acetate(37025-55-1 free base)
Target: Oxytocin Receptor
Brompheniramine maleate
T0205
Synonym: Dimotane,Rolabromophen,Brompheniramine hydrogen maleate,Dimetane
Target: 5-HT Receptor, Histamine Receptor
Nefazodone hydrochloride
T3275
Synonym: Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754
Target: 5-HT Receptor, Adrenergic Receptor
Flibanserin
T4297
Synonym: BIMT-17BS,Girosa,BIMT-17
Target: Dopamine Receptor, 5-HT Receptor
Nortriptyline hydrochloride
T1327
Synonym: Desitriptyline HCl,EN-7048 hydrochloride,Desmethylamitriptyline hydrochloride,ELF-101 hydrochloride
Target: Apoptosis, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor, Drug Metabolite
Reboxetine mesylate
T6963
Synonym: FCE20124 mesylate,Edronax,PNU155950E mesylate,PNU 155950E
Target: Adrenergic Receptor, Norepinephrine
Methylene Blue
T6888
Synonym: methylthioninium chloride,CI-52015,Tetramethylthionine chloride,Basic Blue 9
Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase
1 2 3 4 5 6 7
Cat No. Product Name Synonyms Targets
T5661 Methyl isoeugenol Others
methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food addit...
T3886 Rosavin Rosavidin P450
Rosavin (Rosavidin) has antidepressant and anxiolytic actions, helps balance all the neurotransmitters.
T3856 Tenuifoliside A ERK , Others
Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.
T3933 Jatrorrhizine Yatrorizine,neprotin MAO , 5-HT Receptor , Antibacterial , AChE
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...
T2771 Orcinol glucoside Sakakin Antioxidant
Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects.
T5648 Purpurin 1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin MAO , Antibacterial , Antibiotic , Antifungal
Purpurin (Verantin) was a reversible and competitive inhibitor of MAO-A with a Ki value of 0.422μM. it exhibits anti-angiogenic, antifungal, antibiotic, and antioxidative activities.
T4912 Jatrorrhizine chloride Yatrorhizine chloride,Neprotine chloride Others , 5-HT Receptor , OCT , Antibacterial , AChE
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...
T19931 Gentisein NSC 329491,NSC329491,NSC-329491 Serotonin Transporter
Gentisein (NSC-329491), the major metabolite of Mangiferin, shows the most potent serotonin uptake inhibition with an IC50 value of 4.7 µM[1][2]
T0185 Escitalopram Seroplex,S-(+)-Citalopram,(S)-Citalopram Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor
Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patien...
T9112 (-)-Perillaldehyde AhR , ROS , Nrf2
(-)-Perillaldehyde shows antibacterial activity.
TN2865 (E)-3,4,5-Trimethoxycinnamic acid O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid Others
(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum.
T7475 S-Adenosyl-L-methionine AdoMet,Ademetionine,SAMe,S-Adenosyl methionine Others , Endogenous Metabolite
S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder.
T3698 Alpha-Asarone α-Asarone,trans-Asarone P450 , GABA Receptor , HMG-CoA Reductase
alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.
T5S2195 Sibiricose A5 Dehydrogenase
Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.
T7521 Azaphen Pipofezin hydrochloride,Pipofezine hydrochloride,Azafen 5-HT Receptor , Serotonin Transporter
Azaphen (Pipofezin hydrochloride) is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity.
T10146 4-Hydroxyderricin Dehydrogenase , MAO
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant acti...
T5S2204 Sibiricose A6 Antioxidant
1. Sibiricose A6 displays antidepressant-like action, it may prevent or relieve depression. 2. Sibiricose A6 shows potent antioxidant activity.
T7448 4-Hydroxyisoleucine 4-​Hydroxy-​L-​isoleucine Others
4-Hydroxyisoleucine (4-Hydroxy-L-isoleucine) has antidepressant-like, antidyslipidemic, and antihyperglycemic effects. It displays an insulinotropic activity.
T5S0331 Isoliquiritin Neoisoliquritin p53 , Antifungal
1. Isoliquiritin (Neoisoliquritin) has antitussive effects. 2. Isoliquiritin has antidepressant-like effects. 3. Isoliquiritin, liquiritin and isoliquirigenin inhibits the p53-dependent pathway and shows crosstalk betwee...
TN4114 Gardenin A ERK , LDL , MAPK , PKA , PKC
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
T3003 5-hydroxytryptophan NSC-92523 Others , Endogenous Metabolite
5-hydroxytryptophan (NSC-92523) is the immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
T0783 Mianserin hydrochloride Mianserin HCl,Org GB 94,ORG GB-94 HCl Dopamine Receptor , 5-HT Receptor , Opioid Receptor , Adrenergic Receptor , Histamine Receptor
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematolog...
TN6489 Regaloside A Others
Regaloside A is a phenylpropane derived from lily of the valley that shows DPPH free radical scavenging activity at 160 ppm.Regaloside A has anti-inflammatory activity and antidepressant activity.
T0439 L-Tryptophan (S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane Amino Acids and Derivatives , Endogenous Metabolite
L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of ...
T4S1990 Carvacrol Karvakrol,O-Thymol,cymophenol Apoptosis , Others , Gamma-secretase , Endogenous Metabolite , Antifungal
1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopami...
T1045 Trimipramine maleate Surmontil maleate Dopamine Receptor , 5-HT Receptor , Antibacterial , Adrenergic Receptor , Norepinephrine , Histamine Receptor
Trimipramine maleate (Surmontil maleate) appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. Trimipramine Mal...
TN1377 α-Spinasterol alpha-Spinasterol COX , Antibacterial , TRP/TRPV Channel
α-Spinasterol is a transient receptor potential vanilloid 1 (TRPV1) antagonist, has anti-inflammatory, antidepressant, antioxidant and antinociceptive effects. α-Spinasterol inhibits COX-1 andCOX-2 activities with IC50 v...
T1379 L-5-Hydroxytryptophan L-oxitriptan,Oxitriptan,L-5-HTP Amino Acids and Derivatives , Endogenous Metabolite
L-5-Hydroxytryptophan (L-5-HTP) is the immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
TN1420 Bacopaside I Others
Bacopaside I is a saponin isolated from Bacopa monniera. Bacopaside I is a modulator of Aquaporin-1 channel, has neuroprotective functions, it has anti-Alzheimer's disease, it ameliorates cognitive impairment in APP/PS1 ...
T3386 Kaempferitrin Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside cell cycle arrest , Glucokinase , IGF-1R
Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor effects against HeLa cells. Kaempferitrin stimulates glucos...
T7033 Rosmanol Antioxidant , COX
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and a...
TN1393 (-)-Anonaine Apoptosis , Antioxidant , Parasite , Antifungal
(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces ...
TN5166 Trans-Methylisoeugenol Parasite , GST
Trans-Methylisoeugenol is a compound with insecticidal activity isolated from Acorus calamus L. It is a natural food flavor. It is a natural food flavor with anxiolytic and antidepressant properties and moderately revers...
T3S1553 Trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein COX , Endogenous Metabolite
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...
T6S0721 Orientin Lutexin,Luteolin-8-glucoside Others
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier int...
T3779 Crocin II Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B Caspase , COX , NO Synthase
Crocin II (Crocetin gentiobiosylglucosyl ester) has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expres...
T4S0797 Berberine Berberin,Umbellatine Reactive Oxygen Species , Topoisomerase , Endogenous Metabolite , Antibacterial , Antibiotic , Autophagy
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3....
TN1755 Hyperforin 5-HT Receptor , COX
Hyperforin acts as an angiogenesis inhibitor, it as a possible antidepressant component of hypericum extracts.
T15541 Hyperforin dicyclohexylammonium salt Hyperforin DCHA Others
Hyperforin dicyclohexylammonium salt is a transient receptor canonical 6 channel activator with antidepressant effect. It modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels.
TN1415 Auraptenol 5-HT Receptor
Auraptenol possesses robust antidepressant-like efficacy in mice.
T73844 Nortriptyline
Nortriptyline (Desmethylamitriptyline), the main active metabolite of Amitriptyline, is a tricyclic antidepressant used to relieve the symptoms of depression. Nortriptyline is a potent autophagy inhibitor [1] [2] .
TN5147 Tilifodiolide IL Receptor , TNF , GABA Receptor
Tilifodiolide exerts in vitro and in vivo anti-inflammatory activity and in vivo antinociceptive effects. Tilifodiolide exerted antidiarrheal activity by decreasing the intestinal fluid accumulation and vasorelaxant effe...

Natural Products

Methyl isoeugenol
T5661
Synonym:
Target: Others
Rosavin
T3886
Synonym: Rosavidin
Target: P450
Tenuifoliside A
T3856
Synonym:
Target: ERK, Others
Jatrorrhizine
T3933
Synonym: Yatrorizine,neprotin
Target: MAO, 5-HT Receptor, Antibacterial, AChE
Orcinol glucoside
T2771
Synonym: Sakakin
Target: Antioxidant
Purpurin
T5648
Synonym: 1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin
Target: MAO, Antibacterial, Antibiotic, Antifungal
Jatrorrhizine chloride
T4912
Synonym: Yatrorhizine chloride,Neprotine chloride
Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE
Gentisein
T19931
Synonym: NSC 329491,NSC329491,NSC-329491
Target: Serotonin Transporter
Escitalopram
T0185
Synonym: Seroplex,S-(+)-Citalopram,(S)-Citalopram
Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Adrenergic Receptor, AChR, Norepinephrine, Histamine Receptor
(-)-Perillaldehyde
T9112
Synonym:
Target: AhR, ROS, Nrf2
(E)-3,4,5-Trimethoxycinnamic acid
TN2865
Synonym: O-Methylsinapic acid,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid
Target: Others
S-Adenosyl-L-methionine
T7475
Synonym: AdoMet,Ademetionine,SAMe,S-Adenosyl methionine
Target: Others, Endogenous Metabolite
alpha-Asarone
T3698
Synonym: α-Asarone,trans-Asarone
Target: P450, GABA Receptor, HMG-CoA Reductase
Sibiricose A5
T5S2195
Synonym:
Target: Dehydrogenase
Azaphen
T7521
Synonym: Pipofezin hydrochloride,Pipofezine hydrochloride,Azafen
Target: 5-HT Receptor, Serotonin Transporter
4-Hydroxyderricin
T10146
Synonym:
Target: Dehydrogenase, MAO
Sibiricose A6
T5S2204
Synonym:
Target: Antioxidant
4-Hydroxyisoleucine
T7448
Synonym: 4-​Hydroxy-​L-​isoleucine
Target: Others
Isoliquiritin
T5S0331
Synonym: Neoisoliquritin
Target: p53, Antifungal
Gardenin A
TN4114
Synonym:
Target: ERK, LDL, MAPK, PKA, PKC
5-hydroxytryptophan
T3003
Synonym: NSC-92523
Target: Others, Endogenous Metabolite
Mianserin hydrochloride
T0783
Synonym: Mianserin HCl,Org GB 94,ORG GB-94 HCl
Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor
Regaloside A
TN6489
Synonym:
Target: Others
L-Tryptophan
T0439
Synonym: (S)-Tryptophan,Tryptophan,L-Tryptophane,Tryptophane
Target: Amino Acids and Derivatives, Endogenous Metabolite
Carvacrol
T4S1990
Synonym: Karvakrol,O-Thymol,cymophenol
Target: Apoptosis, Others, Gamma-secretase, Endogenous Metabolite, Antifungal
Trimipramine maleate
T1045
Synonym: Surmontil maleate
Target: Dopamine Receptor, 5-HT Receptor, Antibacterial, Adrenergic Receptor, Norepinephrine, Histamine Receptor
α-Spinasterol
TN1377
Synonym: alpha-Spinasterol
Target: COX, Antibacterial, TRP/TRPV Channel
L-5-Hydroxytryptophan
T1379
Synonym: L-oxitriptan,Oxitriptan,L-5-HTP
Target: Amino Acids and Derivatives, Endogenous Metabolite
Bacopaside I
TN1420
Synonym:
Target: Others
Kaempferitrin
T3386
Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside
Target: cell cycle arrest, Glucokinase, IGF-1R
Rosmanol
T7033
Synonym:
Target: Antioxidant, COX
(-)-Anonaine
TN1393
Synonym:
Target: Apoptosis, Antioxidant, Parasite, Antifungal
Trans-Methylisoeugenol
TN5166
Synonym:
Target: Parasite, GST
trans-Cinnamaldehyde
T3S1553
Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein
Target: COX, Endogenous Metabolite
Orientin
T6S0721
Synonym: Lutexin,Luteolin-8-glucoside
Target: Others
Crocin II
T3779
Synonym: Crocin 2,Crocetin gentiobiosylglucosyl ester,Tricrocin,Crocin B
Target: Caspase, COX, NO Synthase
Berberine
T4S0797
Synonym: Berberin,Umbellatine
Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy
Hyperforin
TN1755
Synonym:
Target: 5-HT Receptor, COX
Hyperforin dicyclohexylammonium salt
T15541
Synonym: Hyperforin DCHA
Target: Others
Auraptenol
TN1415
Synonym:
Target: 5-HT Receptor
Nortriptyline
T73844
Synonym:
Target:
Tilifodiolide
TN5147
Synonym:
Target: IL Receptor, TNF, GABA Receptor

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00791 NsLTP Protein, Helianthus annuus, Recombinant (His & Myc) Helianthus annuus E. coli
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding c...
TMPH-00790 Hantaan virus (strain 76-118) Envelopment polyprotein (His) HTNV HEK293
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding c...
TMPH-00789 Hamster polyomavirus (HaPyV) VP1 Protein (His & Myc) HaPyV E. coli
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic...
Cat No. Product Name
L9860 Antidepressant Compound Library

1181 compounds
1181 compounds associated with depression that can be used for high-throughput and high-content screening
TargetMol