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Results for "antidepressant" in TargetMol Product Catalog
  • Inhibitor Products
    370
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Antidepressant agent 5
T785561071049-42-7
Antidepressant agent 5 is a 7-substituted tetrahydroisoquinoline derivative with antidepressant activity.Antidepressant agent 5 acts similarly to magnoflorine in the study of depression and can be used for the prevention and treatment of depressive disorders.
  • $195
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Antidepressant agent 4
T75003
Antidepressant agent 4, an orally active compound, demonstrates efficacy as an antidepressant with additional anxiolytic, performance-enhancing, and nootropic activities [1].
  • Inquiry Price
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Antidepressant agent 3
T75002
Antidepressant agent 3, an orally active compound, showcases multifaceted pharmacological properties including antidepressant, anxiolytic, performance-enhancing, and nootropic activities [1].
  • Inquiry Price
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Antidepressant agent 2
T62495
Antidepressant agent 2 showed significant antidepressant effects with a MED value of 0.1 mg/kg.
  • $1,520
10-14 weeks
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QTY
Antidepressant agent 1
T1033267411-41-0
Antidepressant agent 1 is a pyrazidole-halogeno-derivative with antidepressant effects. It also can be used to increase body temperature.
  • $68
5 days
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NV-5138
T122702095886-80-7In house
NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.
  • $91
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Mianserin hydrochloride
T078321535-47-7
Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant effects. it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors. It may cause drowsiness and hematological problems.
  • $32
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Orientin
T6S072128608-75-5
1. Orientin (Luteolin-8-glucoside) may be regarded as a candidate therapeutic agent for treatment of vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway. 2. Orientin protects vascular barrier integrity by inhibiting hyperpermeability, expression of CAMs, and adhesion and migration of leukocytes, thereby endorsing its usefulness as a therapy for vascular inflammatory diseases. 3. Orientin has neuroprotection effect by the intracellular mediation of caspase activity; may alleviate cognitive deficits and oxidative stress in AD mice; can exert antidepressant-like effects on CUMS mice, specifically by improving central oxidative stress, neurotransmission, and neuroplasticity.
  • $29
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TargetMol | Citations Cited
L-Tryptophan
T043973-22-3
L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of INDOLE ALKALOIDS in plants. It can be a precursor to NIACIN, although inefficiently in mammals.
  • $30
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TargetMol | Citations Cited
Vilazodone
T1279163521-12-8
Vilazodone (SB659746A) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and a 5-HT-1A receptor partial agonist, with antidepressant and anti-anxiety activities. Vilazodone inhibits the reuptake of serotonin from the synaptic cleft while stimulating the release of 5-HT into the synaptic cleft. This increases the concentration of 5-HT in the synaptic cleft and potentiates serotonergic neurotransmission in the central nervous system.
  • $54
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CP 316311
T15008175139-41-0In house
CP 316311 is a specific CRF1 receptor antagonist with potential antidepressant activity and may be used in the study of depression.
  • $293
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Methyl isoeugenol
T566193-16-3
methyl isoeugenol (MIE) is a natural food flavour that constitutes 93.7% of an essential oil from Pimenta pseudocaryophyllus leaf. The leaf extracts of this species are used as a calming agent. As a ubiquitous food additive, the application of MIE for tre
  • $42
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Berberine
T4S07972086-83-1
1. Berberine (Umbellatine) is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism. 2. Berberine may as a broad-spectrum anti-microbial medicine, a complementary therapeutic agent for HIV/AIDS. 3. Berberine seems to act as an herbal antidepressant and a neuroprotector against neurodegenerative disorders. 4. Berberine is used in histology for staining heparin in mast cells. As a natural dye, berberine has a colour index of 7516. 5. Berberine reduces hepatic fat content in rats with nonalcoholic fatty liver disease; also prevents proliferation of hepatic stellate cells (HSCs), which are central for the development of fibrosis during liver injury. 6. Berberine can ameliorate proinflammatory cytokines-induced intestinal epithelial tight junction damage in vitro, and berberine may be one of the targeted therapeutic agents that can restore barrier function in intestinal disease states. 7. Berberine has antineoplastic effects, including breast cancer, leukemia, melanoma, epidermoid carcinoma, hepatoma, pancreatic cancer, oral carcinoma, tongue carcinoma, glioblastoma, prostate carcinoma and gastric carcinoma, etc.
  • $50
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TargetMol | Citations Cited
Fluoxetine hydrochloride
T0450L56296-78-7
Fluoxetine hydrochloride (Lilly110140) is the first highly specific serotonin uptake inhibitor. It is used as an antidepressant and often has a more acceptable side-effects profile than traditional antidepressants.
  • $48
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5-hydroxytryptophan
T300356-69-9
5-hydroxytryptophan (NSC-92523) is the immediate precursor in the biosynthesis of SEROTONIN from tryptophan. It is used as an antiepileptic and antidepressant.
  • $50
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Carvacrol
T4S1990499-75-2
1. Carvacrol (O-Thymol) presents anxiolytic effects. 2. 5-Isopropyl-2-methylphenol presents antinociceptive activity. 3. Carvacrol presents antidepressant effects, seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems.
  • $42
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Blarcamesine
T7780195615-83-9
Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.
  • $40
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(+)-OSU 6162
T60027160777-43-5In house
(+)-OSU 6162 (Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, (3R)-) is an agonist of 5-HT Receptor with anti-Alzheimer and antidepressant activities.
  • $117
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Zometapine
T3531651022-73-2In house
Zometapine (CI 716) is an antidepressant compound that is a derivative of pyrazole and diazepine.
  • $293 TargetMol
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Tabernanthalog
T602212483829-58-7
Tabernanthalog (TBG) is a 5-HT2A agonist. In rodents,Tabernanthalog has been found to promote structural neuroplasticity, reduce alcohol-seeking and heroin-seeking behavior, and produce antidepressant effects.
  • $195
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Teniloxazine
T6796362473-79-4In house
Teniloxazine is an orally available antidepressant compound with anti-hypoxic properties.
  • $210
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Tedatioxetine
T34795508233-95-2In house
Tedatioxetine (Lu AA24530) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with antidepressant properties.Tedatioxetine acts as a CYP2D6 substrate.
  • $293
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Emoxipine
T86242364-75-2
Emoxipine (2-ETHYL-3-HYDROXY-6-METHYLPYRIDINE) is an antidepressant agent.
  • $50
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Fengabine
T2731080018-06-0In house
Fengabine (SL-79229) is a GABA receptor agonist with antidepressant activity and is used to treat depression.
  • $76
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NSI-189 Phosphate
T212441270138-41-4
NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.
  • $50
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Mesoridazine Besylate
T308632672-69-8
Mesoridazine Besylate (Serentil) is a piperidine neuroleptic drug belonging to the class of drugs called phenothiazines, used in the treatment of schizophrenia. It is a metabolite of thioridazine.
  • $70
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Nitroxazepine
T1223247439-36-1
Nitroxazepine (CIBA 2330Go) is a serotonin-norepinephrine reuptake inhibitor, and treatment depression. Nitroxazepine is a tricyclic antidepressant (TCA) for the research of depression
  • $79
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(-)-Anonaine
TN13931862-41-5In house
(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.
  • $340
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Gardenin A
TN411421187-73-5
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
  • $197
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AV-101
T26686153152-32-0In house
AV-101 (4-Cl-KYN) , a prodrug antagonist at the glycine site of the NMDA receptor, has antidepressant activity and reduces levodopa-induced dyskinesia in MPTP monkeys.
  • $192
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Quinupramine
T6070731721-17-2In house
Quinupramine (LM 208) is an orally available classical tricyclic antidepressant compound with a strong affinity for muscarinic and 5-HT receptors.Quinupramine crosses the central nervous system and can be used in the study of neurologic disorders.
  • $462
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Litoxetine
T6795686811-09-8In house
Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently reduced the number of regurgitations and vomiting and delayed the onset of vomiting. Litoxetine has an affinity for brain 5HT3 receptors (Ki = 85 nM).
  • $98
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Nemifitide acetate(173240-15-8 free base)
TP1127L1
Nemifitide acetate(173240-15-8 free base) (INN 00835 acetate) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. It is a peptide analog of melanocyte-inhibiting factor (MIF).
  • $121
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Roxindole
T26126112192-04-8
Roxindole (EMD 49980) is a selective dopamine autoreceptor and 5-HT1A dual agonist and inhibitor of 5-hydroxytryptamine (5-HT) uptake with antipsychotic and antidepressant activity.Roxindole can be used to study Parkinson's and neurodivergence.
  • $293
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M40 acetate(143896-17-7 free base)
TP1992L
M40 acetate is a potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
  • $196
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Sarizotan HCl
T70044195068-07-6In house
Sarizotan HCl (EMD 128130 HCl) is an hERG channel inhibitor and 5-hydroxytryptamine 5-HT1A receptor agonist with potential antidepressant effects for the study of Parkinson's Dyskinesia.
  • $293
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Riparin III
T26091112356-54-4
Riparin III (Riparin) is a smooth muscle relaxant that inhibits CaCl2-induced contractions.Riparin III has potential antioxidant, anti-inflammatory, and antidepressant properties, and may reverse the most abnormal behavioral and neurochemical changes induced by corticosterone.
  • $293
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Mianserin
T2142824219-97-4
Mianserin, an H1 receptor reverse agonist, is a psychoactive compound in the tetracyclic antidepressant (TeCA) treatment family. Mianserin has antidepressant, antianxiety, antiemetic, hypotrophic, hypnotic and antihistamine effects, and can be used as a combination of norepinephrine and specific serotonin to treat depression.
  • $397
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ORM-10921
T28267610782-82-6In house
ORM-10921 is an α2C-adrenoceptor antagonist that has shown antipsychotic and antidepressant activity in animal studies.
  • $397
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Pridefine
T246615370-41-2
Pridefine (Pridefina) is a pyrrolidine derivative, a reuptake blocker of catecholamines and serotonin, with antidepressant activity.
  • $293
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Azaphen
T752124853-80-3
Azaphen (Pipofezin hydrochloride) is the reuptake of serotonin inhibitor.with antidepressant action and has sedative effects, suggesting antihistamine activity.
  • $135
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EMDT
T11183263744-72-5In house
EMDT oxalate is a selective 5-HT6 agonist, and has antidepressant effects.
  • $84
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Burapitant
T69140537034-22-3In house
Burapitant (SSR 240600) is a novel non-peptide tachykinin neurokinin 1 (NK) receptor antagonist with anti-coke oven and antidepressant activity.
  • $988
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Trans-Methylisoeugenol
TN51666379-72-2
Trans-Methylisoeugenol is a compound with insecticidal activity isolated from Acorus calamus L. It is a natural food flavor. It is a natural food flavor with anxiolytic and antidepressant properties and moderately reversible inhibition of glutathione S-transferases (GSTs) (0.2 to 5.4 mmol for human GSTs and 0.4 to 4.9 mmol for rat GSTs).
  • $84
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Sarizotan 2HCl
T70044L177976-12-4In house
Sarizotan 2HCl is an hERG channel inhibitor and 5-hydroxytryptamine 5-HT1A receptor agonist with potential antidepressant effects for the study of Parkinsonian movement disorders.
  • $195
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Atibeprone
T71934153420-96-3In house
Atibeprone is a MAO-B inhibitor with antidepressant activity for the study of Parkinson's disease.
  • $80
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7-Methoxy-1-naphthylacetonitrile
T9896138113-08-3
7-Methoxy-1-naphthylacetonitrile is one of the impurities of agomelatine, an antidepressant.
  • $50
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Rapastinel acetate
T3407L491872-39-0
Rapastinel acetate is a modulator of N-methyl-D-aspartate (NMDA) receptor and a partial agonist of glycine site long-lasting antidepressant effects.
  • $195
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Napitane
T26363L148152-63-0In house
napitane (A 75200) is a novel catecholamine uptake inhibitor with inhibitory effects on α-adrenergic receptors and potential antidepressant activity for the study of depression.
  • $329
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Metapramine
T6033021730-16-5In house
Metapramine (19560 RP) is a novel psychostimulant, an N-methyl-D-aspartate receptor (NMDA) antagonist with antidepressant and anti-injury perception activity that promotes increased levels of acetylcholine in the striatum.
  • $293
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