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TASP0390325 (Synonyms: TASP-0390325, TASP 0390325)

Name: TASP0390325
Brand: TargetMol
SKU: T28926
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T28926 Copy Product Info

Purity: 98.62%

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TASP0390325 is an orally active and high affinity arginine pressin receptor 1B (V1B receptor) antagonist that shows antidepressant and anxiolytic activity in animal studies and blocks V1B receptors in the anterior pituitary gland in vivo.

TASP0390325

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Catalog No. T28926

Synonyms TASP-0390325, TASP 0390325

Cas No. 1642187-96-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$52	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$455	In Stock	In Stock
50 mg	$787	In Stock	In Stock
100 mg	$1,280	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.62%

Appearance:Solid

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	TASP0390325 is an orally active and high affinity arginine pressin receptor 1B (V1B receptor) antagonist that shows antidepressant and anxiolytic activity in animal studies and blocks V1B receptors in the anterior pituitary gland in vivo.
In vivo	In male Sprague-Dawley (SD) rats weighing 211-246 g, oral administration of TASP0390325 (suspended in 0.5% methylcellulose 400) at doses of 0.3 and 1 mg/kg antagonized the increase in plasma ACTH levels induced by CRF/dDAVP at the dose of 1 mg/kg. In contrast, the doses of 0.3 and 1.0 mg/kg did not significantly affect basal ACTH levels[1].
Synonyms	TASP-0390325, TASP 0390325

Chemical Properties

Molecular Weight	554.44
Formula	C₂₅H₃₀Cl₂FN₅O₄
Cas No.	1642187-96-9
Smiles	Cl.O=C1C2=CC(OCCCN3CCOCC3)=CN=C2N=C(C=4C=CC(F)=C(Cl)C4)N1CC(=O)NC(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (144.29 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8036 mL	9.0181 mL	18.0362 mL	90.1811 mL
5 mM	0.3607 mL	1.8036 mL	3.6072 mL	18.0362 mL
10 mM	0.1804 mL	0.9018 mL	1.8036 mL	9.0181 mL
20 mM	0.0902 mL	0.4509 mL	0.9018 mL	4.5091 mL
50 mM	0.0361 mL	0.1804 mL	0.3607 mL	1.8036 mL
100 mM	0.0180 mL	0.0902 mL	0.1804 mL	0.9018 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc