TP2160L1 |
YAP-TEAD-IN-1 acetate
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YAP-TEAD-IN-1 acetate (1659305-78-8 Free base) |
YAP
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YAP-TEAD-IN-1 acetate 是一种有效的、竞争性的 YAP-TEAD 相互作用抑制剂,IC50 为 25 nM。 |
T60218 |
YAP/TAZ inhibitor-2
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YAP
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YAP/TAZ inhibitor-2 是一种有效的具有口服活性的TEAD-YAP/TAZ 抑制剂,EC50值为 3 nM。YAP/TAZ inhibitor-2 具有抗增殖和抗肿瘤活性。 |
TP2160 |
YAP-TEAD-IN-1
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Others
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YAP-TEAD-IN-1 is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity to TE... |
T13364 |
YAP/TAZ inhibitor-1
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ROCK
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YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay). |
TP2160L |
YAP-TEAD-IN-1 TFA
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Others
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YAP-TEAD-IN-1 TFA is a competitive inhibitor of YAP–TEAD interaction (IC50: 25 nM). It shows a higher binding affinity t... |
T7038 |
4-Methylayapin
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4-METHYL-6,7-METHYLENEDIOXYCOUMARIN,4-甲基-6,7-亚甲基二氧代香豆素 |
Others
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4-Methylayapin 用作中间体。 |
TN1489 |
3'-Methoxyapiin
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3'-甲氧基芹菜苷,3'-Methoxy apiin,Graveobioside B |
Others
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3'-Methoxyapiin 是一种来自 Eminium spiculatum 植物的类黄酮。 |
T9053 |
Lats-IN-1
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Others
,
YAP
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Lats-IN-1 是一种 ATP 竞争性的、高效的Lats1和Lats2激酶抑制剂,能促进有丝分裂后哺乳动物组织的 Yap 依赖性增殖。 |
T22372 |
MYF-01-37
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1-[3-Methyl-3-[3-(trifluoromethyl)anilino]pyrrolidin-1-yl]prop-2-en-1-one |
Others
,
YAP
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MYF-01-37 是共价TEAD 抑制剂,靶向 Cys380,能够可逆地抑制 YAP/TEAD 相互作用。 |
T3112 |
Verteporfin
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CL 318952,BPD-MA,维替泊芬 |
Autophagy
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VDA
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YAP
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Apoptosis
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Verteporfin 是一种用于光动力疗法的光敏剂,用于消除与年龄相关的黄斑变性等疾病相关的眼内异常血管。 它是一种苯并卟啉衍生物单酸环A,可抑制YAP 的活性。 |
T8421 |
TED-347
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YAP
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TED-347 是不可逆的、共价的 YAP-TEAD 蛋白质-蛋白质相互作用变构抑制剂,对 TEAD4•Yap1 蛋白质-蛋白质相互作用的 EC50为 5.9 μM。它与 TEAD4 中央口袋内的 Cys-367 特异性共价结合(Ki:10... |
TMPY-06815 |
SYAP1 Protein, Human, Recombinant (His Tag)
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Synapse-associated protein 1 (SYAP1), also known as PRO3113 and BSTA, belongs to the synapse-associated BSD domain famil... |
TN2422 |
6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide
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Others
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6-hydroxyapigenin-6-O-β-D-glucoside-7-O-β-D-glucuronide is a natural product from Carthamus tinctorius Linn. |
TMPY-02648 |
PACAP receptor/ADCYAP1R1 Protein, Human, Recombinant (hFc Tag)
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Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors ( Adcyap1r1) significan... |
TN1210 |
2-Hydroxy-1-Methoxyaporphine
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P450
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2-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosi... |
TN2353 |
8-Hydroxyapigenin
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Others
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8-Hydroxyapigenin is Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., deriv... |
TN2907 |
3,6-Dimethoxyapigenin
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Others
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Standard reference |
T9566 |
PY-60
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YAP
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Annexin A
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PY-60 有效激活针对膜联蛋白 A2 (Kd = 1.4 µM) 的 YAP 转录活性。 PY-60 在能够通过增殖重塑表皮的成年动物中激活促增殖、依赖于 YAP 的转录程序。 |
T67872 |
VT104
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YAP
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VT104是一种有效的YAP/TAZ 抑制剂,具有口服活性,可用于癌症研究。VT104阻止内源性TEAD1和TEAD3蛋白棕榈酰化。 |
T62077 |
VT103
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VT103 是一种 VT101 的类似物,是一种选择性的、口服具有活力的 TEAD1 蛋白棕榈酰化抑制剂。 VT103 能够抑制 YAP/TAZ-TEAD 促进的基因转录,阻断 TEADauto-palmitoylation,并阻断 YAP... |