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TEAD ligand-Linker Conjugate 3
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Catalog No. T217726 Copy Product Info
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TEAD ligand-Linker Conjugate 3 (A536) is an IAP-recruiting bifunctional degrader (IPD) in the ALP2 series, specifically targeting TEAD1, with a degradation DC50 of 110 nM for human TEAD1 and a maximum degradation efficiency (Dmax) of 51%. This compound binds effectively to cIAP1 and induces its degradation (IC50=122 nM), while also possessing good cell permeability. It is composed of ALP2 target protein ligand and PROTA Clinker, making it suitable for PROTAC synthesis. A536 demonstrates dose-dependent inhibition of cell proliferation in Hippo pathway-dependent human malignant mesothelioma cells and downregulates the transcriptional expression of the TEAD1 downstream target gene CTGF. Additionally, A536 is useful for studying mechanisms in malignancies with abnormal Hippo pathway activation, particularly in NF2-mutant mesothelioma.
TEAD ligand-Linker Conjugate 3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | TEAD ligand-Linker Conjugate 3 (A536) is an IAP-recruiting bifunctional degrader (IPD) in the ALP2 series, specifically targeting TEAD1, with a degradation DC50 of 110 nM for human TEAD1 and a maximum degradation efficiency (Dmax) of 51%. This compound binds effectively to cIAP1 and induces its degradation (IC50=122 nM), while also possessing good cell permeability. It is composed of ALP2 target protein ligand and PROTA Clinker, making it suitable for PROTAC synthesis. A536 demonstrates dose-dependent inhibition of cell proliferation in Hippo pathway-dependent human malignant mesothelioma cells and downregulates the transcriptional expression of the TEAD1 downstream target gene CTGF. Additionally, A536 is useful for studying mechanisms in malignancies with abnormal Hippo pathway activation, particularly in NF2-mutant mesothelioma. |
| Targets & IC50 | CIAP1:122 nM |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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