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S7, a peptide antagonist of the IL-6 receptor, concentration-dependently inhibits IL-6 binding to its receptor. At 50 µM, S7 suppresses IL-6-triggered elevations in VEGF levels within C-33 A cervical cancer cells and RPMI-8226 B cell lymphocytes. It significantly reduces tumor volume in a C-33 A cervical cancer mouse xenograft model with IL-6 overexpression, following a dosage regimen of 50 mg/kg bi-daily. Moreover, when linked to cysteine on lipid nanoparticles (LNPs) encapsulating doxorubicin, S7 enhances glioma targeting and improves survival rates in a U251 glioblastoma mouse xenograft model.

S7, an IL-6 receptor antagonist, prevents the interaction between IL-6 and IL-6R, thereby inhibiting angiogenesis and tumor growth [1].

(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside is a coumarin glycoside [1].

rel-(3aR,4S,7R,7aS)-3a,4,7,7a-Tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione is a useful organic compound for research related to life sciences. The catalog number is T64449 and the CAS number is 6265-30-1.

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-7,10,13-trimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid is a useful organic compound for research related to life sciences and the catalog number is T64669.

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-Methyl 4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylate is a useful organic compound for research related to life sciences and the catalog number is T65298.

(3aR,4S,7R,7aS)-Hexahydro-4,7-methanoisobenzofuran-1,3-dione is a useful organic compound for research related to life sciences. The catalog number is T65552 and the CAS number is 14166-28-0.

t-Butyl (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-isopropylidenedioxy-6-heptenoate is a useful organic compound for research related to life sciences. The catalog number is T66069 and the CAS number is 147489-06-3.

(7R,8R,9S,13S,14S,17S)-7-(9-Bromononyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol is a useful organic compound for research related to life sciences. The catalog number is T66315 and the CAS number is 875573-67-4.

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66996 and the CAS number is 104239-97-6.

(2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR,9bR)-2,9b-Dihydroxy-4a,6a-dimethylhexadecahydro-1H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-7(7aH)-one is a useful organic compound for research related to life sciences. The catalog number is T67508 and the CAS number is 82543-16-6.

(4aR,4bS,6aS,7S,9aS,9bS,11aR)-4a,6a-Dimethyl-2-oxohexadecahydro-1H-indeno[5,4-f]quinoline-7-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67601 and the CAS number is 103335-55-3.

(3S,7S)-5,6-Dehydro-4''-de-O-methylcentrolobine is a natural product from Alpinia blepharocalyx.

7,4'-Dihydroxy-3'-prenylflavan has antibacterial activity.

MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

6-[(3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-1H-pyridine-3,4-dicarbonitrile is a biologically active compound, which is utilized for research in the fields of chemistry and life sciences.

(2S,3AS,7aS)-Octahydroindole-2-carboxylic acid is a valuable organic compound employed in life science research.

(S,R,S)-AHPC-Me-C7 ester is an E3 ligase ligand-linker conjugate used to synthesize BCL-XL PROTAC degraders[1].

(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), composed of N-Boc-7-aminoheptanoic acid and the corresponding linker. It is utilized in the synthesis of dTAGV-1-NEG.

(S,R,S)-AHPC-Me-N-Boc-7-aminoheptanoic acid is a conjugate serving as an E3 ligase ligand and linker, specifically used for the synthesis of PROTACdTAGV-1 TFA.

(R,S,S)-VH032-Me-N-Boc-7-aminoheptanoic acid TFA is a conjugate that consists of an E3 ubiquitin ligase ligand and a linker. This compound is useful for synthesizing dTAGV-1 hydrochloride.

PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway.

Novel oxylipins, referred to as docosanoids, have been derived from C22polyunsaturated fatty acids 7(S),17(S)-dihydroxy-8(E),10(Z),13(Z),15(E),19(Z)-Docosapentaenoic acid (7(S),17(S)-hydroxy DPA) is a DPA-derived analog of the 17(S)-dihydroxy series of docosanoids known as protectins. Protectin D1, a DHA-derived dihydroxy fatty acid, exhibits potent anti-inflammatory activities.1,2,3Potentially, 7(S),17(S)-hydroxy DPA demonstrates similar properties; however, its biological activity has yet to be determined. 1.Serhan, C.N., Gotlinger, K., Hong, S., et al.Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: Assignments of dihydroxy-containing docosatrienesJ. Immunol.176(3)1848-1859(2006) 2.Ariel, A., and Serhan, C.N.Resolvins and protectins in the termination program of acute inflammationTRENDS in Immunology28(4)176-183(2007) 3.Schwab, J.M., Chiang, N., Arita, M., et al.Resolvin E1 and protectin D1 activate inflammation-resolution programmesNature447(7146)869-874(2007)

(S,R,S)-AHPC-C7-amine, also known as VH032-C7-amine, is a chemically synthesized conjugate that serves as an E3 ligase ligand-linker, combining the VH032-based VHL ligand with a specific linker for the degradation of estrogen-related receptor α (ERRα) PROTAC.