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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10861 | Collagen proline hydroxylase inhibitor-1 | Others | |
Collagen proline hydroxylase inhibitor-1 exhibits antifibroproliferative activity. | |||
T65816 | Prolyl-4-hydroxylase Inhibitor 11 | Others | |
Prolyl-4-hydroxylase Inhibitor 11, a novel proline 4-hydroxylase inhibitor, shows protective effects against oxidative stress and Cu(II) toxicity in Chlorella vulgaris. | |||
T60796 | Cholesterol 24-hydroxylase-IN-1 | ||
Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) with IC50 of 8.5 nM that can cross blood-brain barrier [1]. | |||
T10862 | Collagen proline hydroxylase inhibitor | Others | |
Collagen proline hydroxylase inhibitor is an inhibitor collagen proline hydroxylase and useful for antifibrotic proliferative agents. | |||
T12547 | Prolyl Hydroxylase inhibitor 1 | Others | |
Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM). | |||
T78898 | Lysyl hydroxylase 2-IN-2 | Monoamine Oxidase | |
Lysyl Hydroxylase 2-IN-2 (compound 13) is a potent inhibitor of Lysyl Hydroxylase 2 (LH2), exhibiting an IC50 of approximately 500 nM. It effectively inhibits cell migration in 344SQ WT cells without affecting the migrat... | |||
T78889 | Lysyl hydroxylase 2-IN-1 | Monoamine Oxidase | |
"Lysyl Hydroxylase 2-IN-1 (compound 12) is a selective inhibitor of lysyl hydroxylase 2 (LH2) with an IC50 of approximately 300 nM and demonstrates specificity for LH2 over LH1 and LH3 [1]." | |||
T82731 | Cholesterol 24-hydroxylase-IN-2 | ||
Cholesterol 24-hydroxylase-IN-2 is a potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1), exhibiting an IC50 value of 5.4 nM, and has potential applications in mammalian imaging of this enzyme [1]. | |||
T20700 | Racemetirosine | Others | |
Racemetirosine is an inhibitor of Tyrosine 3-monooxygenase, and consequently it inhibits the synthesis of catecholamines. | |||
T64336 | Izilendustat | HIF/HIF Prolyl-Hydroxylase | |
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis. | |||
T21506 | Telotristat | Hydroxylase | |
Telotristat is the active metabolite of LX1606(Telotristat etiprate), which is an orally bioavailable tryptophan hydroxylase (TPH) inhibitor and shows potential antiserotonergic activity. | |||
T19654 | Guanoclor | VATENSOL | Others |
Guanoclor (VATENSOL) (INN), also known as guanochlor, is a sympatholytic drug. It is known to bind to non-adrenergic sites in pig kidney membranes. | |||
T15796 | LX-1031 | Hydroxylase , LPA Receptor | |
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally. | |||
T6S0071 | Fraxinellone | HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1 | |
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding... | |||
T1896 | Ro 61-8048 | Hydroxylase | |
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM. | |||
T3169 | KC7F2 | HIF/HIF Prolyl-Hydroxylase , HIF | |
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity. | |||
T8153 | Glycohyodeoxycholic acid | Others , Endogenous Metabolite | |
glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans. | |||
T7694 | 6-fluoro-DL-Tryptophan | 5-HT Receptor | |
6-fluoro-DL-Tryptophan is an inhibitor of serotonin (5-HT) synthesis. | |||
T22022 | Adaptaquin | HIF | |
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2]. | |||
T5684 | Ethyl 3,4-dihydroxybenzoate | Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy | |
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain. |