Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.

Cat No.	product name
T9121	AG-636	AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
T0746	Orotic acid	Orotic acid is an intermediate product in pyrimidine metabolism.
T3019	Rheochrysidin	Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogena...
T1165	Ethinamide	Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkn...
T0361	Isovaleramide	Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
T0293	Metyrapone	Metyrapone is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis o...
T0972	Isoniazid	Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
T2901	Daidzin	Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T1485	Methotrexate	Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
T0897	Furacilin	Nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and s...
T0256	Lithium citrate tribasic tetrahydrate	Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
T1717	Mangostin	Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
T0647	Tryptamine	Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
T0414	D-Mannitol	Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any...
T3009	3-Nitropropanoic acid	Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
T2601	Vidofludimus	Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T1159	Leflunomide	Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T0522	Diammonium Glycyrrhizinate	Diammonium glycyrrhizinate, an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inh...
T2970	Rotenone	Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)...
T1869	PluriSln 1	PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism...
T3494	LW6	LW6 is a novel HIF-1 inhibitor.
T1491	Atovaquone	Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
T6157	CPI613	CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial met...
T0054	Disulfiram	Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the interm...
T4213	NCT503	NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
T4295	(R)-GNE-140	(R)-GNE-140 is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
T4173	R162	R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
T0494	Tetramisole hydrochloride	Tetramisole is used as an anthelmintic.
T0010	Mercaptopurine	Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metab...
T5013	Brequinar	Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
T3617	Ivosidenib	Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits ...
T2650	MK8245	MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
T3044	Teriflunomide	Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
T1608	Exherin trifluoroacetate	Exherin (ADH-1) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitive...
T0245	RS 61443	RS 61443 is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
T2043	IDH1-IN-1	Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
T2104	AGI5198	AGI-5198 is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
T1473	Trilostane	Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenas...
T3175	AZ33	AZ-33 is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR anal...
T2741	Glycyrrhizin	Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
T6384	Ammonium Glycyrrhizinate	Ammonium Glycyrrhizinate inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
T1809	AGI6780	AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T2346	Enasidenib	Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineop...
T1374	2-Picolinyl hydrazide	2-Picolinyl hydrazide is an effective inhibitor of Catalase-peroxidase-NAPDH.
T0036	Enoxolone	Enoxolone is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
T6903	NCT501	NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
T3444	Merimepodib	Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
T2637	Exherin	Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
T1335	Mycophenolic acid	Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
T2447	AZD7545	AZD7545 is a potent PDHK inhibitor.
T1979	AVN944	AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
T6518	Gossypol	Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
T2662	Alda-1	Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH21 and the Asian E487K mutant ALDH22 forms of mitochondrial aldehyde dehydrog...
T0684	Ribavirin	Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T3542	BVT14225	BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
T2057	BVT 2733	BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
T2121	SW033291	SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
T6293	Mycophenolate Mofetil	Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrog...
T4515	A939572	A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
T9003	CVT-11127	CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
T13356	XEN723	XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
T14878	CAY10566	CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 ...
T14884	CBR-5884	CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in ca...
T15022	CVT-10216	CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (...
T15362	FX-11	FX-11 is a potent inhibitor of lactate dehydrogenase A (LDHA) (IC50: 23.3 μM for HeLa cell and Ki: 8 μM).
T13019	Succinyl phosphonate trisodium salt	Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)
T13054	T-3764518	T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
T11238L	Etamicastat hydrochloride	Etamicastat can be used in the research of cardiovascular diseases.Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hy...
T11238	Etamicastat	Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor ...
T11611	IDH1 Inhibitor 2	IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
T15435	GSK2837808A	GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).
T16068	MF-438	MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
T13453	CGRP antagonist 1	CGRP antagonist 1 is a highly potent antagonist of CGRP receptor(Ki and IC50 of 35 and 57 nM, respectively).
T10384	ASLAN003	ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-c...
T16161	Mutant IDH1 inhibitor	Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
T16269	Nanaomycin A	Nanaomycin A is the first selective DNMT3B inhibitor (IC50: 500 nM). Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum (...
T8332	Bipenquinate	Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis.
T16384	Olutasidenib	Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pe...
T16384	Olutasidenib	Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pe...
T11829	LDH-IN-1	LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
T22253	AG-120 (racemic)	AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic act...
TJS1382	Taraxerone	Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease ...
T23533	WIN 18446	inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
T8640	G6PDi-1	G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
T8767	PfDHODH-IN-2	PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 µM) inhibitor . It is us...
T19831	Sodium Oxamate	Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis ...
T14780	BRD9185	BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
T12663	(Rac)-BMS-816336	(Rac)-BMS-816336 is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme inhibitor...
T5427	GSK1940029	GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
T10160	11β-HSD1-IN-1	11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
T5S2195	Sibiricose A5	Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induce...
T5702	Tenuifoliside B	Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive i...
T5705	Glomeratose A	Glomeratose A is a lactate dehydrogenase inhibitor.
T7400	RRX-001	RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity
TQ0042	BAY-1436032	BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
T7741	DS-1001b	DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1)
T7835	CM 10	CM 10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.
T2S2211	Tenuifoliside C	Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation c...
T8003	Methotrexate disodium	Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
TN1298	6''-O-Acetylglycitin	6''-O-Acetylglycitin is a potential nutriceutical, it is also a potent LDH inhibitor.
TN1829	Kakkalide	Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.
T12196	NCT-505	NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1)(IC50 of 7 nM).
T10140	4-Diethylaminobenzaldehyde	4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
T12614	(R)-BMS-816336	(R)-BMS-816336 is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme(IC50s o...
T10140	4-Diethylaminobenzaldehyde	4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
T11019	DHODH-IN-1	DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.
T11020	DHODH-IN-11	DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
T11022	DHODH-IN-13	DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH...
T11023	DHODH-IN-14	DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DH...
T11024	DHODH-IN-15	DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH....
T11030	DHODH-IN-8	DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM a...
T11031	DHODH-IN-9	DHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. DHODH-IN-9 and pMIC50 of 7.4 have antiviral ef...
T14383	AZD8329	AZD8329 is a potent inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)(IC50 of 9 nM for human 11β-HSD1), and displays excellent selectivity vers...
T14388	AZD 4017	AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
T14501	BAY-2402234	BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor...
T12614L	BMS-816336	BMS-816336 is a novel, orally bioavailable inhibitor, and potent against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 n...
T0732	Benzyl alcohol	Benzyl alcohol, a colorless liquid, is an aromatic alcohol with a mild pleasant aromatic odor.