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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.

  • Epostane
    T6866480471-63-2In house
    Epostane (Win-32729) is a 3β-hydroxysteroid dehydrogenase inhibitor that acts by inhibiting the enzyme 3β-hydroxysteroid dehydrogenase, blocking progesterone production.
    • $623
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  • NCT-503
    T42131916571-90-8
    NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
    • $35
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    TargetMol | Citations Cited
  • Isomalt
    T796464519-82-0
    Isomalt (Palatinitol) is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside
    • $42
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  • Gossypol
    T6518303-45-7
    Gossypol (BL 193) Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
    • $35
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  • Methotrexate
    T148559-05-2
    Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
    • $38
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    TargetMol | Citations Cited
  • Benzyl alcohol
    T0732100-51-6
    Benzyl alcohol (Benzenemethanol), a colorless liquid, is an aromatic alcohol with a mild pleasant aromatic odor.
    • $40
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  • Diammonium Glycyrrhizinate
    T052279165-06-3
    Diammonium Glycyrrhizinate (Glycyrrhizin) , an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhibits 11-β-hydroxysteroid dehydrogenase and other enzymes involved in the metabolism of corticosteroids. Therefore, glycyrrhizic acid, the main and sweet component of licorice, has been studied for its ability to cause hypermineralocorticoidism with potassium loss and sodium retention, edema, increased blood pressure, as well as inhibited the renin-angiotensin-aldosterone system.
    • $35
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  • Ribavirin
    T068436791-04-5
    Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
    • $39
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  • Sodium dichloroacetate
    T36042156-56-1
    Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.
    • $31
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  • Mycophenolate Mofetil
    T6293128794-94-5
    Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).
    • $47
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  • Disulfiram
    T005497-77-8
    Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.
    • $50
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    TargetMol | Citations Cited
  • Perfluorooctanoic acid
    T9333335-67-1
    Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical.
    • $50
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  • Nitrophenide
    T21089537-91-7
    Nitrophenide (3,3'-Dinitrodiphenyl disulfide) inhibits mannitol-1-phosphate dehydrogenase (M1PDH), which catalyzes the committed enzymatic step in the mannitol cycle. Nitrophenide can be used as an anticoccidial agent.
    • $50
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  • hDHODH-IN-5
    T110292029049-77-0In house
    hDHODH-IN-5 is an inhibitor of human dihydroorotate dehydrogenase (hDHODH, IC50 = 0.91 μM).
    • $77
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  • ALDH2 modulator 1
    T678321629615-99-1In house
    ALDH2 modulator 1 is a potent and orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
    • $97
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  • DSM421
    T272142011769-21-2In house
    DSM421 (DSM-421) is a dihydrodehydrogenase inhibitor (DHODH) that is in preclinical development as a potential treatment option for malaria and has shown activity against field isolates of both P. falciparum and P. vivax.
    • $197
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  • SW209049
    T98591673558-59-2In house
    SW209049 is a stearoyl-CoA 9-desaturase inhibitor. SW209049 exhivits potent activity against H2122 cell with IC50 of 0.13uM.
    • $117
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  • WAY-311610
    T77606314051-55-3
    WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pain, inflammatory pain, and occipital neuralgia.
    • $195
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  • DHODH-IN-14
    T110231364791-93-4In house
    DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
    • $117
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  • DHODH-IN-1
    T110191800296-63-2In house
    DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.
    • $117
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  • 6PGD-IN-S3
    T263975539-66-2
    6PGD-IN-S3 (6PGD Inhibitor S3) is an inhibitor of 6-phosphogluconate dehydrogenase (6PGD).
    • $133
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  • IGP-1
    T2552627031-00-1In house
    iGP-1 is a mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor that can be used to study obesity.
    • $293
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  • DHODH-IN-4
    T110271148125-93-2In house
    DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity.
    • $117
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  • 11β-HSD1-IN-11
    T60149859721-81-6In house
    11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13 μM, respectively. 11β-Hsvd1-in-11 is a compound used as a chemical compound. 11β-HSD1-IN-11 is a hormone involved in regulating various physiological processes, such as metabolism, inflammation, and stress responses. 11β-Hd1-in-11 is a potential compound for the treatment of metabolic disorders, obesity, and certain inflammatory conditions.
    • $117
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  • DHODH-IN-13
    T110221364791-86-5In house
    DHODH-IN-13 is an inhibitor of DHODH with IC50 of 4.3 μM for rat liver. DHODH-IN-13 can be used in studies about rheumatoid arthritis.
    • $117
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  • AGI-14100
    T250061448346-43-7In house
    AGI-14100 is a novel and orally available mIDH1 inhibitor.AGI-14100 is used for the treatment of primary human myeloid leukemia.
    • $350
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  • DHODH-IN-12
    T110211263303-93-0In house
    DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
    • $117
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  • DHODH-IN-8
    T110301148126-03-7In house
    DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.
    • $117
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  • 11β-HSD1-IN-12
    T72814872506-67-7
    11β-HSD1-IN-12 is an 11β-HSD1 inhibitor.11β-HSD1-IN-12 is implicated in the conversion of glucocorticoids in vivo and can be used to study metabolic syndrome and obesity.
    • $195
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  • Metapramine
    T6033021730-16-5In house
    Metapramine (19560 RP) is a novel psychostimulant, an N-methyl-D-aspartate receptor (NMDA) antagonist with antidepressant and anti-injury perception activity that promotes increased levels of acetylcholine in the striatum.
    • $293
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  • BI-187004
    T95941303515-32-3
    BI-187004 is an 11β-hydroxysteroid dehydrogenase 1 inhibitor.
    • $73
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  • DHODH-IN-15
    T110241364791-88-7In house
    DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis.
    • $195
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  • CB29
    T25209315239-63-5In house
    CB29 is a specific inhibitor of aldehyde dehydrogenase 3A1 (ALDH3A1).
    • $195
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  • BMS-823778
    T713941140897-32-0In house
    BMS-823778 is a potent inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) for the study of type 2 diabetes.
    • $293 TargetMol
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  • Proguanil hydrochloride
    T4382637-32-1
    Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.
    • $50
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  • 11β-HSD1-IN-1
    T101601203956-47-1In house
    11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
    • $117
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  • hDHODH-IN-7
    T110311644156-41-1In house
    hDHODH-IN-7 (DHODH-IN-9) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. hDHODH-IN-7 and pMIC50 of 7.4 have antiviral effects.
    • $117
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  • 11β-HSD1 inibitor 17
    T67903946394-50-9In house
    11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).
    • $258
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  • CPS-11
    T23911145945-21-7In house
    CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue that has significant antitumor activity and exhibits a wider range of activity and highly potent effects on the MM (multiple myeloma) cell line.
    • $397
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  • IDH2R140Q-IN-2
    T797452749568-16-7In house
    IDH2R140Q-IN-2 is an orally active and potent IDH2R140Q inhibitor with an IC50 of 29 nM.IDH2R140Q-IN-2 possesses potential antitumour activity, reducing D2HG production in TF-1 cell lines carrying the IDH2R140Q mutation (IC50 of 10 nM) and inhibiting tumour tissue D2HG levels.IDH2R140Q-IN-2 is suitable for the study of acute myeloid leukaemia (AML).
    • $397 TargetMol
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  • GSK1940029
    T54271150701-66-8In house
    GSK1940029 (SCD inhibitor 1) is a stearoyl-coa desaturase (SCD) inhibitor.
    • $123 TargetMol
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  • hDHODH-IN-3
    T110251644156-80-8In house
    hDHODH-IN-3 is an inhibitor of human dihydroorotate dehydrogenase with a pMIC50 value of 8.6. hDHODH-IN-3 can inhibit measles virus replication.
    • $58
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  • PHGDH-IN-3
    T731432893778-31-7In house
    PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH. PHGDH-IN-3 can be used in studies about cancer.
    • $98
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  • NCT-502
    T162771542213-00-2In house
    NCT-502 (N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide) is a human phosphoglycerate dehydrogenase inhibitor, cytotoxic to PHGDH-dependent cancer cells. It decreases glucose-derived serine production and it has an IC50 of 3.7 μM against PHGDH.
    • $33
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  • hDHODH-IN-4
    T110281644156-56-8In house
    hDHODH-IN-4 (DHODH-IN-5) is a potent inhibitor of human dihydrogen dehydrogenase (DHODH). For human recombinant DHODH, its pIC50 is 7.8. hDHODH-IN-4 inhibits measles virus replication with a pMIC50 of 8.8.
    • $91
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  • AZD8329
    T143831048668-70-7In house
    AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11ß-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM) and dog recombinant 11β-HSD1. AZD8329 has a higher affinity for 11β-HSD1 than human recombinant 11β-HSD2 and 17 AZD8329 has the ability to reduce the activity of 11β-HSD1 in adipose tissue and liver samples.
    • $766
    Backorder
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  • ALDH1A3-IN-2
    T60240886502-08-5In house
    ALDH1A3-IN-2 is a potent ALDH1A3 inhibitor with an IC50 of 0.30 μM.ALDH1A3-IN-2 has potential for cancer disease research.
    • $68
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  • DHODH-IN-17
    T6036416344-26-6In house
    DHODH-IN-17 is a human DHODH inhibitor with an IC50 of 0.40 μM. DHODH-IN-17 is a 2- anilino nicotinic acid that can be used in the study of acute myeloid leukemia (AML).
    • $64
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  • HSD-016
    T63569946396-92-5In house
    HSD-016 is an orally active, selective and potent type 1 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitor with strong inhibitory effects on human, mouse and rat 11β-HSD1.HSD-016 can be used in the study of diabetes and metabolic syndrome.
    • $80
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  • GSK2837808A
    T154351445879-21-9
    GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).
    • $40
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    TargetMol | Citations Cited