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Metabolism Dehydrogenase

Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Cat No. product name
T9121 AG-636 AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
T0746 Orotic acid Orotic acid is an intermediate product in pyrimidine metabolism.
T3019 Rheochrysidin Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogena...
T1165 Ethinamide Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkn...
T0361 Isovaleramide Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
T0293 Metyrapone Metyrapone is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis o...
T0972 Isoniazid Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
T2901 Daidzin Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
T1485 Methotrexate Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
T0897 Furacilin Nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and s...
T0256 Lithium citrate tribasic tetrahydrate Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
T1717 Mangostin Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
T0647 Tryptamine Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
T0414 D-Mannitol Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any...
T3009 3-Nitropropanoic acid Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
T2601 Vidofludimus Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T1159 Leflunomide Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
T0522 Diammonium Glycyrrhizinate Diammonium glycyrrhizinate, an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inh...
T2970 Rotenone Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)...
T1869 PluriSln 1 PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism...
T3494 LW6 LW6 is a novel HIF-1 inhibitor.
T1491 Atovaquone Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
T6157 CPI613 CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial met...
T0054 Disulfiram Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the interm...
T4213 NCT503 NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
T4295 (R)-GNE-140 (R)-GNE-140 is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
T4173 R162 R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
T0494 Tetramisole hydrochloride Tetramisole is used as an anthelmintic.
T0010 Mercaptopurine Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metab...
T5013 Brequinar Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
T3617 Ivosidenib Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits ...
T2650 MK8245 MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
T3044 Teriflunomide Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
T1608 Exherin trifluoroacetate Exherin (ADH-1) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitive...
T0245 RS 61443 RS 61443 is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
T2043 IDH1-IN-1 Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
T2104 AGI5198 AGI-5198 is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
T1473 Trilostane Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenas...
T3175 AZ33 AZ-33 is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR anal...
T2741 Glycyrrhizin Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
T6384 Ammonium Glycyrrhizinate Ammonium Glycyrrhizinate inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
T1809 AGI6780 AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
T2346 Enasidenib Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineop...
T1374 2-Picolinyl hydrazide 2-Picolinyl hydrazide is an effective inhibitor of Catalase-peroxidase-NAPDH.
T0036 Enoxolone Enoxolone is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
T6903 NCT501 NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
T3444 Merimepodib Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
T2637 Exherin Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
T1335 Mycophenolic acid Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
T2447 AZD7545 AZD7545 is a potent PDHK inhibitor.
T1979 AVN944 AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
T6518 Gossypol Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
T2662 Alda-1 Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrog...
T0684 Ribavirin Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
T3542 BVT14225 BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
T2057 BVT 2733 BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
T2121 SW033291 SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
T6293 Mycophenolate Mofetil Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrog...
T4515 A939572 A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
T9003 CVT-11127 CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
T13356 XEN723 XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
T14878 CAY10566 CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 ...
T14884 CBR-5884 CBR-5884 is an  selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in ca...
T15022 CVT-10216 CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2)  (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (...
T15362 FX-11 FX-11 is a potent inhibitor of lactate dehydrogenase A (LDHA) (IC50: 23.3 μM for HeLa cell and Ki: 8 μM).
T13019 Succinyl phosphonate trisodium salt Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)
T13054 T-3764518 T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
T11238L Etamicastat hydrochloride Etamicastat can be used in the research of cardiovascular diseases.Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hy...
T11238 Etamicastat Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor ...
T11611 IDH1 Inhibitor 2 IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
T15435 GSK2837808A GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).
T16068 MF-438 MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
T13453 CGRP antagonist 1 CGRP antagonist 1 is a highly potent antagonist of CGRP receptor(Ki and IC50 of 35 and 57 nM, respectively).
T10384 ASLAN003 ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-c...
T16161 Mutant IDH1 inhibitor Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
T16269 Nanaomycin A Nanaomycin A is the first selective DNMT3B inhibitor (IC50: 500 nM). Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum (...
T8332 Bipenquinate Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis.
T16384 Olutasidenib Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pe...
T16384 Olutasidenib Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pe...
T11829 LDH-IN-1 LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
T22253 AG-120 (racemic) AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic act...
TJS1382 Taraxerone Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease ...
T23533 WIN 18446 inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
T8640 G6PDi-1 G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
T8767 PfDHODH-IN-2 PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 µM) inhibitor . It is us...
T19831 Sodium Oxamate Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis ...
T14780 BRD9185 BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
T12663 (Rac)-BMS-816336 (Rac)-BMS-816336 is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme inhibitor...
T5427 GSK1940029 GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
T10160 11β-HSD1-IN-1 11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
T5S2195 Sibiricose A5 Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induce...
T5702 Tenuifoliside B Tenuifoliside B is a natural product from  the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive i...
T5705 Glomeratose A Glomeratose A is a lactate dehydrogenase inhibitor.
T7400 RRX-001 RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity
TQ0042 BAY-1436032 BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
T7741 DS-1001b DS-1001b is an  inhibitor of  mutant IDH-1 (Isocitrate Dehydrogenase-1)
T7835 CM 10 CM 10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.
T2S2211 Tenuifoliside C Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation c...
T8003 Methotrexate disodium Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
TN1298 6''-O-Acetylglycitin 6''-O-Acetylglycitin is a potential nutriceutical, it is also a potent LDH inhibitor.
TN1829 Kakkalide Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.
T12196 NCT-505 NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1)(IC50 of 7 nM).
T10140 4-Diethylaminobenzaldehyde 4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
T12614 (R)-BMS-816336 (R)-BMS-816336 is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme(IC50s o...
T10140 4-Diethylaminobenzaldehyde 4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
T11019 DHODH-IN-1 DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.
T11020 DHODH-IN-11 DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
T11022 DHODH-IN-13 DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH...
T11023 DHODH-IN-14 DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DH...
T11024 DHODH-IN-15 DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH....
T11030 DHODH-IN-8 DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM a...
T11031 DHODH-IN-9 DHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. DHODH-IN-9 and pMIC50 of 7.4 have antiviral ef...
T14383 AZD8329 AZD8329 is a potent inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)(IC50 of 9 nM for human 11β-HSD1), and displays excellent selectivity vers...
T14388 AZD 4017 AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
T14501 BAY-2402234 BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor...
T12614L BMS-816336 BMS-816336 is a novel, orally bioavailable inhibitor, and potent against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 n...
T0732 Benzyl alcohol Benzyl alcohol, a colorless liquid, is an aromatic alcohol with a mild pleasant aromatic odor.
AG-636
T9121CAS 1623416-31-8
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
Orotic acid
T0746CAS 65-86-1
Orotic acid is an intermediate product in pyrimidine metabolism.
Rheochrysidin
T3019CAS 521-61-9
Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogena...
Ethinamide
T1165CAS 536-33-4
Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkn...
Isovaleramide
T0361CAS 541-46-8
Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
Metyrapone
T0293CAS 54-36-4
Metyrapone is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis o...
Isoniazid
T0972CAS 54-85-3
Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
Daidzin
T2901CAS 552-66-9
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
Methotrexate
T1485CAS 59-05-2
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
Furacilin
T0897CAS 59-87-0
Nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and s...
Lithium citrate tribasic tetrahydrate
T0256CAS 6080-58-6
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and m...
Mangostin
T1717CAS 6147-11-1
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
Tryptamine
T0647CAS 61-54-1
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It...
D-Mannitol
T0414CAS 69-65-8
Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any...
3-Nitropropanoic acid
T3009CAS 504-88-1
Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
Vidofludimus
T2601CAS 717824-30-1
Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
Leflunomide
T1159CAS 75706-12-6
Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
Diammonium Glycyrrhizinate
T0522CAS 79165-06-3
Diammonium glycyrrhizinate, an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inh...
Rotenone
T2970CAS 83-79-4
Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)...
PluriSln 1
T1869CAS 91396-88-2
PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism...
LW6
T3494CAS 934593-90-5
LW6 is a novel HIF-1 inhibitor.
Atovaquone
T1491CAS 95233-18-4
Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
CPI613
T6157CAS 95809-78-2
CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial met...
Disulfiram
T0054CAS 97-77-8
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the interm...
NCT503
T4213CAS 1916571-90-8
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
(R)-GNE-140
T4295CAS 2003234-63-5
(R)-GNE-140 is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
R162
T4173CAS 64302-87-0
R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
Tetramisole hydrochloride
T0494CAS 5086-74-8
Tetramisole is used as an anthelmintic.
Mercaptopurine
T0010CAS 50-44-2
Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metab...
Brequinar
T5013CAS 96187-53-0
Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
Ivosidenib
T3617CAS 1448347-49-6
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits ...
MK8245
T2650CAS 1030612-90-8
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
Teriflunomide
T3044CAS 108605-62-5
Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
Exherin trifluoroacetate
T1608CAS 1135237-88-5
Exherin (ADH-1) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitive...
RS 61443
T0245CAS 115007-34-6
RS 61443 is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
IDH1-IN-1
T2043CAS 1355326-21-4
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
AGI5198
T2104CAS 1355326-35-0
AGI-5198 is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
Trilostane
T1473CAS 13647-35-3
Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenas...
AZ33
T3175CAS 1370290-34-8
AZ-33 is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR anal...
Glycyrrhizin
T2741CAS 1405-86-3
Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
Ammonium Glycyrrhizinate
T6384CAS 1407-03-0
Ammonium Glycyrrhizinate inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
AGI6780
T1809CAS 1432660-47-3
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
Enasidenib
T2346CAS 1446502-11-9
Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineop...
2-Picolinyl hydrazide
T1374CAS 1452-63-7
2-Picolinyl hydrazide is an effective inhibitor of Catalase-peroxidase-NAPDH.
Enoxolone
T0036CAS 471-53-4
Enoxolone is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
NCT501
T6903CAS 1802088-50-1
NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
Merimepodib
T3444CAS 198821-22-6
Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
Exherin
T2637CAS 229971-81-7
Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
Mycophenolic acid
T1335CAS 24280-93-1
Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
AZD7545
T2447CAS 252017-04-2
AZD7545 is a potent PDHK inhibitor.
AVN944
T1979CAS 297730-17-7
AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
Gossypol
T6518CAS 303-45-7
Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
Alda-1
T2662CAS 349438-38-6
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrog...
Ribavirin
T0684CAS 36791-04-5
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
BVT14225
T3542CAS 376638-65-2
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
BVT 2733
T2057CAS 376640-41-4
BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
SW033291
T2121CAS 459147-39-8
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
Mycophenolate Mofetil
T6293CAS 128794-94-5
Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrog...
A939572
T4515CAS 1032229-33-6
A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
CVT-11127
T9003CAS 1018674-83-3
CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
XEN723
T13356CAS 1072803-08-7
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
CAY10566
T14878CAS 944808-88-2
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 ...
CBR-5884
T14884CAS 681159-27-3
CBR-5884 is an  selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in ca...
CVT-10216
T15022CAS 1005334-57-5
CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2)  (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (...
FX-11
T15362CAS 213971-34-7
FX-11 is a potent inhibitor of lactate dehydrogenase A (LDHA) (IC50: 23.3 μM for HeLa cell and Ki: 8 μM).
Succinyl phosphonate trisodium salt
T13019CAS 864167-45-3
Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)
T-3764518
T13054CAS 1809151-56-1
T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
Etamicastat hydrochloride
T11238LCAS 677773-32-9
Etamicastat can be used in the research of cardiovascular diseases.Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hy...
Etamicastat
T11238CAS 760173-05-5
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor ...
IDH1 Inhibitor 2
T11611CAS 2244895-42-7
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
GSK2837808A
T15435CAS 1445879-21-9
GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).
MF-438
T16068CAS 921605-87-0
MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
CGRP antagonist 1
T13453CAS 1123757-49-2
CGRP antagonist 1 is a highly potent antagonist of CGRP receptor(Ki and IC50 of 35 and 57 nM, respectively).
ASLAN003
T10384CAS 1035688-66-4
ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-c...
Mutant IDH1 inhibitor
T16161CAS 1429180-08-4
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
Nanaomycin A
T16269CAS 52934-83-5
Nanaomycin A is the first selective DNMT3B inhibitor (IC50: 500 nM). Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum (...
Bipenquinate
T8332CAS 96201-88-6
Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis.
Olutasidenib
T16384CAS 1887014-12-1
Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pe...
Olutasidenib
T16384CAS 1887014-12-1
Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pe...
LDH-IN-1
T11829CAS 1964515-43-2
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
AG-120 (racemic)
T22253CAS 1448346-63-1
AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic act...
Taraxerone
TJS1382CAS 514-07-8
Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease ...
WIN 18446
T23533CAS 1477-57-2
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
G6PDi-1
T8640CAS T8640
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
PfDHODH-IN-2
T8767CAS 425629-94-3
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 µM) inhibitor . It is us...
Sodium Oxamate
T19831CAS 565-73-1
Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis ...
BRD9185
T14780CAS 2057420-29-6
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
(Rac)-BMS-816336
T12663CAS T12663
(Rac)-BMS-816336 is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme inhibitor...
GSK1940029
T5427CAS 1150701-66-8
GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
11β-HSD1-IN-1
T10160CAS 1203956-47-1
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
Sibiricose A5
T5S2195CAS 107912-97-0
Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induce...
Tenuifoliside B
T5702CAS 139726-36-6
Tenuifoliside B is a natural product from  the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive i...
Glomeratose A
T5705CAS 202471-84-9
Glomeratose A is a lactate dehydrogenase inhibitor.
RRX-001
T7400CAS 925206-65-1
RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity
BAY-1436032
TQ0042CAS 1803274-65-8
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
DS-1001b
T7741CAS 1898207-64-1
DS-1001b is an  inhibitor of  mutant IDH-1 (Isocitrate Dehydrogenase-1)
CM 10
T7835CAS 692269-09-3
CM 10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.
Tenuifoliside C
T2S2211CAS 139726-37-7
Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation c...
Methotrexate disodium
T8003CAS 7413-34-5
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
6''-O-Acetylglycitin
TN1298CAS 134859-96-4
6''-O-Acetylglycitin is a potential nutriceutical, it is also a potent LDH inhibitor.
Kakkalide
TN1829CAS 58274-56-9
Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.
NCT-505
T12196CAS 2231079-74-4
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1)(IC50 of 7 nM).
4-Diethylaminobenzaldehyde
T10140CAS 120-21-8
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
(R)-BMS-816336
T12614CAS 1009583-83-8
(R)-BMS-816336 is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme(IC50s o...
4-Diethylaminobenzaldehyde
T10140CAS 120-21-8
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
DHODH-IN-1
T11019CAS 1800296-63-2
DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.
DHODH-IN-11
T11020CAS 1263303-95-2
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
DHODH-IN-13
T11022CAS 1364791-86-5
DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH...
DHODH-IN-14
T11023CAS 1364791-93-4
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DH...
DHODH-IN-15
T11024CAS 1364791-88-7
DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH....
DHODH-IN-8
T11030CAS 1148126-03-7
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM a...
DHODH-IN-9
T11031CAS 1644156-41-1
DHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. DHODH-IN-9 and pMIC50 of 7.4 have antiviral ef...
AZD8329
T14383CAS 1048668-70-7
AZD8329 is a potent inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)(IC50 of 9 nM for human 11β-HSD1), and displays excellent selectivity vers...
AZD 4017
T14388CAS 1024033-43-9
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
BAY-2402234
T14501CAS 2225819-06-5
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor...
BMS-816336
T12614LCAS 1009583-20-3
BMS-816336 is a novel, orally bioavailable inhibitor, and potent against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 n...
Benzyl alcohol
T0732CAS 100-51-6
Benzyl alcohol, a colorless liquid, is an aromatic alcohol with a mild pleasant aromatic odor.