Shopping Cart

Remove All
Your shopping cart is currently empty

Metabolism

ATP Citrate Lyase

(11)

Acetyl-CoA Carboxylase

Amino Acids and Derivatives

Angiotensin-converting Enzyme (ACE)

Endogenous Metabolite

Glutathione Peroxidase

(30)

HIF/HIF Prolyl-Hydroxylase

Indoleamine 2,3-Dioxygenase (IDO)

(30)

Isocitrate Dehydrogenase (IDH)

Mitochondrial Metabolism

(76)

N-Acetylglucosaminyltransferase

Procollagen C Proteinase

(1)

Prolyl Endopeptidase (PREP)

Reactive Oxygen Species

Serine/threonin kinase

(46)

Stearoyl-CoA Desaturase (SCD)

Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.

Filter Signaling PathwaysMetabolismDehydrogenase

Epostane
T6866480471-63-2In house
Epostane (Win-32729) is a 3β-hydroxysteroid dehydrogenase inhibitor that acts by inhibiting the enzyme 3β-hydroxysteroid dehydrogenase, blocking progesterone production.
- $623
In Stock
Size
QTY
View more
Manitimus
T11941202057-76-9
Manitimus (FK778) is an inhibitor of dehydroorotate dehydrogenase and an immunosuppressant with immunosuppressive and antiproliferative activity, prevents vascular remodeling after mechanical endothelial injury, and can be used to study immune dysfunction.
- $197
In Stock
Size
QTY
View more
Succinyl phosphonate trisodium salt
T13019864167-45-3
Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC).
- $138
In Stock
Size
QTY
View more
Galloflavin
T22336568-80-9
Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticancer agent.
- $36
In Stock
Size
QTY
View more
HSD-016
T63569946396-92-5In house
HSD-016 is an orally active, selective and potent type 1 11β-hydroxysteroid dehydrogenase (11β-HSD1) inhibitor with strong inhibitory effects on human, mouse and rat 11β-HSD1.HSD-016 can be used in the study of diabetes and metabolic syndrome.
- $80
In Stock
Size
QTY
View more
Rotenone
T297083-79-4
Rotenone (Rotocide) is a natural product and a botanical insecticide. Rotenone is a mitochondrial electron transport complex I inhibitor that promotes the production of reactive oxygen species in mitochondria and induces apoptosis.
- $42
In Stock
Size
QTY
View more
Cited
NCT-503
T42131916571-90-8
NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 µM) with no activity against other dehydrogenases. NCT-503 has antitumor activity and inhibits the growth of PHGDH-dependent tumors.
- $35
In Stock
Size
QTY
View more
Cited
4-Hydroxynonenal
T1014875899-68-2
4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
- $48
In Stock
Size
QTY
View more
Ivosidenib
T36171448347-49-6
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
- $42
In Stock
Size
QTY
View more
Alda-1
T2662349438-38-6
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).
- $35
In Stock
Size
QTY
View more
Methotrexate
T148559-05-2
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
- $38
In Stock
Size
QTY
View more
Cited
FX-11
T15362213971-34-7
FX-11 (LDHA Inhibitor FX11) is A potent, selective and competitive specific inhibitor of lactate dehydrogenase A (LDHA) with a Ki of 8 μM. FX-11 can activate PKM2 (pyruvate kinase M2). FX-11 can reduce ATP levels, induce oxidative stress and ROS production, and cause cell death. FX-11 appeared antitumor activity during xenotransplantation of lymphoma and pancreatic cancer.
- $41
In Stock
Size
QTY
View more
A939572
T45151032229-33-6
A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
- $39
In Stock
Size
QTY
View more
Cited
Disulfiram
T005497-77-8
Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15 1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.
- $50
In Stock
Size
QTY
View more
Cited
Sodium dichloroacetate
T36042156-56-1
Sodium dichloroacetate (BCA) , a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.
- $31
In Stock
Size
QTY
View more
Cited
4-Hydroxyderricin
T1014655912-03-3
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.
- $122
In Stock
Size
QTY
View more
BAY-2402234
T145012225819-06-5
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor of human DHODH enzymatic activity.
- $183
In Stock
Size
QTY
View more
Cited
CPS-11
T23911145945-21-7In house
CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.
- $397
In Stock
Size
QTY
View more
CAY10566
T14878944808-88-2
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl
- $47
In Stock
Size
QTY
View more
Sodium Oxamate
T19831565-73-1
Sodium Oxamate (Oxamic acid sodium salt) is an LDH inhibitor that specifically inhibits LDHA. Sodium Oxamate has antitumor activity and induces cell cycle arrest and apoptosis.
- $31
In Stock
Size
QTY
View more
Cited
Ribavirin
T068436791-04-5
Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
- $39
In Stock
Size
QTY
View more
Cited
Nanaomycin A
T1626952934-83-5
Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
- $370
35 days
Size
QTY
View more
SW033291
T2121459147-39-8
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
- $34
In Stock
Size
QTY
View more
(R)-GNE-140
T42952003234-63-5
(R)-GNE-140 (GNE-140) is an effective LDHA LDHB inhibitor (IC50s: 3 5 nM) and is 18-fold more potent than S enantiomer.
- $67
In Stock
Size
QTY
View more
Cited
AZD 4017
T143881024033-43-9
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
- $67
In Stock
Size
QTY
View more
Brequinar
T501396187-53-0
Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
- $41
In Stock
Size
QTY
View more
Cited
Mycophenolate Mofetil
T6293128794-94-5
Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).
- $47
In Stock
Size
QTY
View more
Perfluorooctanoic acid
T9333335-67-1
Perfluorooctanoic acid (PFOA) (PFOA) is a persistent and widespread industry-made chemical.
- $50
In Stock
Size
QTY
View more
LW6
T3494934593-90-5
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
- $39
In Stock
Size
QTY
View more
Cited
CP-642931
T31070300551-49-9In house
CP-642931 (Sorbitol dehydrogenase-IN-1) is an orally active and highly potent sorbitol dehydrogenase inhibitor for the study of diabetes and cardiovascular disease.
- $716
In Stock
Size
QTY
View more
alpha-Mangostin
T17176147-11-1
alpha-Mangostin (Mangostin) is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
- $41
In Stock
Size
QTY
View more
Leflunomide
T115975706-12-6
Leflunomide (HWA486) is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
- $39
In Stock
Size
QTY
View more
GSK2837808A
T154351445879-21-9
GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 values of 1.9 nM for LDHA and 14 nM for LDHB.
- $40
In Stock
Size
QTY
View more
Cited
IMPDH2-IN-2
T623381434517-02-8In house
IMPDH2-IN-2 is a potent inhibitor of inosine 5'-monophosphate dehydrogenase (IMPDH) (Ki,app: 14 μM) and a potential anti-tuberculosis agent, exhibiting moderate antibacterial effects with MIC values of 6.3 and 11 μM in minimal GAST Fe and rich 7H9 ADC Tween media, respectively.
- $100
In Stock
Size
QTY
View more
Etamicastat hydrochloride
T11238L677773-32-9
Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a peripherally selective dopamine beta-hydroxylase inhibitor that reduces hypertension.
- $129
In Stock
Size
QTY
View more
Glycyrrhizic acid
T27411405-86-3
Glycyrrhizic acid (Glycyrrhizin) is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
- $29
In Stock
Size
QTY
View more
Cited
G6PDi-1
T86402457232-14-1
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
- $32
In Stock
Size
QTY
View more
RRX-001
T7400925206-65-1
RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity
- $48
In Stock
Size
QTY
View more
Cited
Tiazofurin
T4068660084-10-8
Tiazofurin (NSC-286193) is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotide (TAD), a potent IMP dehydrogenase (IMPDH) inhibitor.
- $257
In Stock
Size
QTY
View more
Tryptamine
T064761-54-1
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It is found in trace amounts in the brains of mammals and is recognized to play a role as a neuro
- $50
In Stock
Size
QTY
View more
hDHODH-IN-4
T110281644156-56-8In house
hDHODH-IN-4 (DHODH-IN-5) is a potent inhibitor of human dihydrogen dehydrogenase (DHODH). For human recombinant DHODH, its pIC50 is 7.8. hDHODH-IN-4 inhibits measles virus replication with a pMIC50 of 8.8.
- $68
In Stock
Size
QTY
View more
KPLH1130
T11765906669-07-6
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macrophage polarization and mitigates proinflammatory reactions.
- $76
In Stock
Size
QTY
View more
Devimistat
T615795809-78-2
Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potential chemopreventive and antineoplastic activities, and has been used in trials studying the treatment of Cancer, Lymphoma, Solid Tumors, Advanced Cancer, and Pancreatic Cancer, among others.
- $53
In Stock
Size
QTY
View more
Daidzin
T2901552-66-9
Daidzin (Daidzoside) is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
- $37
In Stock
Size
QTY
View more
Cited
AVN-944
T1979297730-17-7
AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
- $54
In Stock
Size
QTY
View more
Farudodstat
T103841035688-66-4
Farudodstat (ASLAN003) is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity, showing potential as a first-in-class candidate in AML [Acute Myeloid Leukemia].
- $43
In Stock
Size
QTY
View more
Enasidenib
T23461446502-11-9
Enasidenib (AG-221) is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineoplastic activity.
- $39
In Stock
Size
QTY
View more
Methotrexate disodium
T80037413-34-5
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
- $34
In Stock
Size
QTY
View more
CVT-10216
T150221005334-57-5
CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (IC50: 1.3 μM). CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects.
- $43
In Stock
Size
QTY
View more
IGP-1
T2552627031-00-1In house
iGP-1 is a mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor that can be used to study obesity.
- $293
In Stock
Size
QTY
View more

Go to page 1

Page of 5