| T9121 |
AG-636 |
AG-636 is a potent, reversible, selective and orally active DHODH inhibitor(IC50 of 17 nM). It has strong anticancer effects.
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| T0746 |
Orotic acid |
Orotic acid is an intermediate product in pyrimidine metabolism.
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| T3019 |
Rheochrysidin |
Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenas...
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| T1165 |
Ethinamide |
Ethionamide is a nicotinamide derivative, with antibacterial activity, used to treat tuberculosis. Although the exact mechanism of action of ethionamide is unkno...
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| T0361 |
Isovaleramide |
Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases.
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| T0293 |
Metyrapone |
Metyrapone is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of...
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| T0972 |
Isoniazid |
Isoniazid is an antibacterial agent used primarily as a tuberculostatic.
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| T2901 |
Daidzin |
Daidzin is an isoflavone isolated from soya bean with anti-oxidant, anti-carcinogenic, and anti-atherosclerotic activities.
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| T1485 |
Methotrexate |
Methotrexate is a folate analog metabolic inhibitor with immunosuppressant and antineoplastic properties.
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| T0897 |
Furacilin |
Nitrofurazone is a topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial WOUNDS AND INJURIES and sk...
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| T0256 |
Lithium citrate tribasic tetrahydrate |
Lithium Citrate, the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways and me...
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| T1717 |
Mangostin |
Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree.
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| T0647 |
Tryptamine |
Tryptamine is a monoamine alkaloid found in animals, plants, and fungi. It contains an indole ring structure and is structurally analogous to the tryptophan. It ...
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| T0414 |
D-Mannitol |
Mannitol is a diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any ...
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| T3009 |
3-Nitropropanoic acid |
Bovinocidin is an irreversible inhibitor of succinate dehydrogenase.
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| T2601 |
Vidofludimus |
Vidofludimus (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
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| T1159 |
Leflunomide |
Leflunomide is an immunomodulatory agent used in the therapy of rheumatoid arthritis and psoriatic arthritis.
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| T0522 |
Diammonium Glycyrrhizinate |
Diammonium glycyrrhizinate, an extensively used anti-inflammatory agent, is isolated from the licorice root. It is metabolized to glycyrrhetinic acid, which inhi...
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| T2970 |
Rotenone |
Rotenone is a botanical insecticide that is an inhibitor of mitochondrial electron transport. Rotenone is widely distributed in the Leguminosae (Papilionoideae)....
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| T1869 |
PluriSln 1 |
PluriSln 1(NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism ...
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| T3494 |
LW6 |
LW6 is a novel HIF-1 inhibitor.
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| T1491 |
Atovaquone |
Atovaquone is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
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| T6157 |
CPI613 |
CPI-613, a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial meta...
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| T0054 |
Disulfiram |
Disulfiram is a carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the interme...
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| T4213 |
NCT503 |
NCT-503 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells.
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| T4295 |
(R)-GNE-140 |
(R)-GNE-140 is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.
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| T4173 |
R162 |
R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.
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| T0494 |
Tetramisole hydrochloride |
Tetramisole is used as an anthelmintic.
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| T0010 |
Mercaptopurine |
Mercaptopurine is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabo...
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| T5013 |
Brequinar |
Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
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| T3617 |
Ivosidenib |
Ivosidenib is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1), with potential antineoplastic activity. Ivosidenib specifically inhibits a...
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| T2650 |
MK8245 |
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
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| T3044 |
Teriflunomide |
Teriflunomide, a orally-available Pyrimidine Synthesis Inhibitor, is used to treat relapsing multiple sclerosis.
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| T1608 |
Exherin trifluoroacetate |
Exherin (ADH-1) is a cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitivel...
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| T0245 |
RS 61443 |
RS 61443 is an immunosuppressant, a non-competitive, selective and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH)
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| T2043 |
IDH1-IN-1 |
Mutant IDH1-IN-1 is a potent mutant IDH1 R132 h inhibitor with IC50 < 0.1 uM.
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| T2104 |
AGI5198 |
AGI-5198 is a highly effective and specific inhibitor of IDH1 R132H/R132C mutants (IC50: 0.07/0.16 μM).
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| T1473 |
Trilostane |
Trilostane is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase...
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| T3175 |
AZ33 |
AZ-33 is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analy...
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| T2741 |
Glycyrrhizin |
Glycyrrhizic acid is a triterpenoid saponinl with anti-tumor and anti-diabetic activities.
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| T6384 |
Ammonium Glycyrrhizinate |
Ammonium Glycyrrhizinate inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
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| T1809 |
AGI6780 |
AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.
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| T2346 |
Enasidenib |
Enasidenib is an orally available inhibitor of specific mutant forms of the mitochondrial enzyme isocitrate dehydrogenase type 2 (IDH2), with potential antineopl...
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| T1374 |
2-Picolinyl hydrazide |
2-Picolinyl hydrazide is an effective inhibitor of Catalase-peroxidase-NAPDH.
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| T0036 |
Enoxolone |
Enoxolone is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.
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| T6903 |
NCT501 |
NCT-501 is a potent and selective inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1) with IC50 of 40 nM.
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| T3444 |
Merimepodib |
Merimepodib is a novel noncompetitive inhibitor of Inosine monophosphate dehydrogenase(IMPDH).
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| T2637 |
Exherin |
Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
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| T1335 |
Mycophenolic acid |
Mycophenolic acid is an inosine monophosphate dehydrogenase(IMPDH) inhibitor with anti-proliferative activity.
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| T2447 |
AZD7545 |
AZD7545 is a potent PDHK inhibitor.
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| T1979 |
AVN944 |
AVN-944(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.
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| T6518 |
Gossypol |
Gossypol Acetate is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.
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| T2662 |
Alda-1 |
Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydroge...
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| T0684 |
Ribavirin |
Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
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| T3542 |
BVT14225 |
BVT-14225 is a selective 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor (IC50=52 nM).
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| T2057 |
BVT 2733 |
BVT 2733 is a new, non-steroidal, isoform-specific inhibitor of 11β-HSD1.
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| T2121 |
SW033291 |
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
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| T6293 |
Mycophenolate Mofetil |
Mycophenolate mofetil, an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydroge...
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| T4515 |
A939572 |
A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
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| T9003 |
CVT-11127 |
CVT-11127 is an StearoylCoA Desaturase-1 (SCD1) inhibitor.
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| T13453 |
CGRP antagonist 1 |
CGRP antagonist 1 is a highly potent antagonist of CGRP receptor(Ki and IC50 of 35 and 57 nM, respectively).
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| T14878 |
CAY10566 |
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 c...
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| T14884 |
CBR-5884 |
CBR-5884 is an selective, active of phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in can...
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| T15022 |
CVT-10216 |
CVT-10216 is a Potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50: 29 nM). CVT-10216 also has inhibitory effect of ALDH-1 (I...
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| T15362 |
FX-11 |
FX-11 is a potent inhibitor of lactate dehydrogenase A (LDHA) (IC50: 23.3 μM for HeLa cell and Ki: 8 μM).
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| T13019 |
Succinyl phosphonate trisodium salt |
Succinyl phosphonate trisodium salt is an inhibitor of α-ketoglutarate dehydrogenase (KGDHC)
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| T13054 |
T-3764518 |
T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
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| T11238L |
Etamicastat hydrochloride |
Etamicastat can be used in the research of cardiovascular diseases.Etamicastat hydrochloride (BIA 5-453 hydrochloride) is a potent and reversible dopamine-β-hyd...
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| T11238 |
Etamicastat |
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor w...
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| T11611 |
IDH1 Inhibitor 2 |
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
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| T15435 |
GSK2837808A |
GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).
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| T16068 |
MF-438 |
MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
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| T13356 |
XEN723 |
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
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| T16161 |
Mutant IDH1 inhibitor |
Mutant IDH1 inhibitor is an effective inhibitor of mutant IDH1 R132H (IC50: < 72 nM).
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| T10384 |
ASLAN003 |
ASLAN003 is an orally active and potent inhibitor of DHODH (Human Dihydroorotate Dehydrogenase) with antitumor activity. It has the potential to be a first-in-cl...
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| T16269 |
Nanaomycin A |
Nanaomycin A is the first selective DNMT3B inhibitor (IC50: 500 nM). Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum (I...
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| T8332 |
Bipenquinate |
Bipenquinate is a potent and selective inhibitor of dihydroorotate dehydrogenase (DHODH) with IC50 of 20 nM, blocking de novo pyrimidine biosynthesis.
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| T16384 |
Olutasidenib |
Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pen...
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| T16384 |
Olutasidenib |
Olutasidenib is under the study in the treatment of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Olutasidenib is a highly effective, brain pen...
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| T11829 |
LDH-IN-1 |
LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).
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| T22253 |
AG-120 (racemic) |
AG-120 (racemic), the racemic mixture of AG-120, is an orally available isocitrate dehydrogenase type 1 (IDH1) inhibitor, and shows potential antineoplastic acti...
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| T22336 |
Galloflavin |
Galloflavin inhibits both the A and B isoforms of lactate dehydrogenase with Ki of 5.46 µM and 15.06 µM, respectively. Galloflavin is also a potential anticanc...
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| TJS1382 |
Taraxerone |
Taraxerone has allelopathic and antifungal effects.Taraxerone prevents catalase, superoxide dismutase, and reduces glutathione concentrations from the decrease i...
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| T23533 |
WIN 18446 |
inhibitor of aldehyde dehydrogenase 1a2 (ALDH1a2)
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| T8640 |
G6PDi-1 |
G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.
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| T8767 |
PfDHODH-IN-2 |
PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 µM) inhibitor . It is use...
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| T19831 |
Sodium Oxamate |
Sodium Oxamate is an LDH inhibitor. Sodium oxamate (SO) induces G2/M cell cycle arrest via downregulation of the CDK1/cyclin B1 pathway and promotes apoptosis t...
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| T14780 |
BRD9185 |
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
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| T12663 |
(Rac)-BMS-816336 |
(Rac)-BMS-816336 is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme inhibitor(...
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| T5427 |
GSK1940029 |
GSK1940029 is a stearoyl-coa desaturase (SCD) inhibitor.
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| T10160 |
11β-HSD1-IN-1 |
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
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| T5S2195 |
Sibiricose A5 |
Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced...
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| T5702 |
Tenuifoliside B |
Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive im...
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| T5705 |
Glomeratose A |
Glomeratose A is a lactate dehydrogenase inhibitor.
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| T7400 |
RRX-001 |
RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity
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| TQ0042 |
BAY-1436032 |
BAY-1436032 is a novel, selective and orally available inhibitor of pan-mutant isocitrate dehydrogenase 1 (IDH1).
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| T7741 |
DS-1001b |
DS-1001b is an inhibitor of mutant IDH-1 (Isocitrate Dehydrogenase-1)
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| T7835 |
CM 10 |
CM 10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.
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| T2S2211 |
Tenuifoliside C |
Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation ca...
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| T8003 |
Methotrexate disodium |
Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor
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| TN1298 |
6''-O-Acetylglycitin |
6''-O-Acetylglycitin is a potential nutriceutical, it is also a potent LDH inhibitor.
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| TN1829 |
Kakkalide |
Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.
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| T12196 |
NCT-505 |
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1)(IC50 of 7 nM).
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| T10140 |
4-Diethylaminobenzaldehyde |
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
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| T12614 |
(R)-BMS-816336 |
(R)-BMS-816336 is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme(IC50s of...
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| T10140 |
4-Diethylaminobenzaldehyde |
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1). It displays a potent anti-androgenic effect (IC50: 1.71...
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| T11019 |
DHODH-IN-1 |
DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 25 nM. DHODH-IN-1 is an inhibitor of the pyrimidine biosynthetic pathway.
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| T11020 |
DHODH-IN-11 |
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
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| T11022 |
DHODH-IN-13 |
DHODH-IN-13 is the hydroxyfuran analogue of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 4.3 μM for rat liver DHODH....
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| T11023 |
DHODH-IN-14 |
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 μM mouse liver DHODH. DHO...
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| T11024 |
DHODH-IN-15 |
DHODH-IN-15 is the hydroxyfuran analogue of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 11 μM for rat liver DHODH. ...
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| T11030 |
DHODH-IN-8 |
DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM an...
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| T11031 |
DHODH-IN-9 |
DHODH-IN-9 (Compound 10k) is a nitrogen-containing analog and is a human dihydrorotatory dehydrogenase inhibitor. DHODH-IN-9 and pMIC50 of 7.4 have antiviral eff...
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| T14383 |
AZD8329 |
AZD8329 is a potent inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)(IC50 of 9 nM for human 11β-HSD1), and displays excellent selectivity versu...
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| T14388 |
AZD 4017 |
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
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| T14501 |
BAY-2402234 |
BAY-2402234 is an inhibitor of dihydroorotate dehydrogenase (DHODH) for the treatment of myeloid malignancies.BAY 2402234 is a selective low-nanomolar inhibitor ...
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| T12614L |
BMS-816336 |
BMS-816336 is a novel, orally bioavailable inhibitor, and potent against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 nM...
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| T0732 |
Benzyl alcohol |
Benzyl alcohol, a colorless liquid, is an aromatic alcohol with a mild pleasant aromatic odor.
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