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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN. They also catalyze the reverse reaction, for instance alcohol dehydrogenase not only oxidizes ethanol to acetaldehyde in animals but also produces ethanol from acetaldehyde in yeast.
Cat. No. Product name CAS No. Purity Chemical Structure
T13453 CGRP antagonist 1 1123757-49-2 98%
CGRP antagonist 1 is a highly potent antagonist of CGRP receptor(Ki and IC50 of 35 and 57 nM, respectively).
TN1298 6''-O-Acetylglycitin 134859-96-4 98%
6''-O-Acetylglycitin is a potential nutriceutical, it is also a potent LDH inhibitor.
T2637 ADH-1 229971-81-7 98%
Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
T13054 T-3764518 1809151-56-1 98%
T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
T14383 AZD8329 1048668-70-7 98%
AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11ß-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM...
T11238 Etamicastat 760173-05-5 98%
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor wit...
T12663 (Rac)-BMS-816336 T12663 98%
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzym...
T11611 IDH1 Inhibitor 2 2244895-42-7 98%
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
T12614L BMS-816336 1009583-20-3 98%
BMS-816336 is a novel, orally bioavailable inhibitor, and potent against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 nM[1...
T14780 BRD9185 2057420-29-6 98%
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
T10148 4-Hydroxynonenal 75899-68-2 98%
4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
T14388 AZD 4017 1024033-43-9 98%
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
T15551 IDH889 1429179-07-6 98%
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μ...
T9974 WAY-324168 663214-48-0 98%
WAY-324168 is a compound with antiproliferative activity.
T37190 L-Allylglycine 16338-48-0 98%
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
T40686 Tiazofurin 60084-10-8 98%
Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotid...
T77606 WAY-311610 314051-55-3 98%
WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pa...
T10146 4-Hydroxyderricin 55912-03-3 98%
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-h...
T77579 JC2-11 937820-89-8 98%
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical ...
T12196 NCT-505 2231079-74-4 98%
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1)(IC50 of 7 nM).
CGRP antagonist 1
T13453
CGRP antagonist 1 is a highly potent antagonist of CGRP receptor(Ki and IC50 of 35 and 57 nM, respectively).
6''-O-Acetylglycitin
TN1298
6''-O-Acetylglycitin is a potential nutriceutical, it is also a potent LDH inhibitor.
ADH-1
T2637
Exherin (ADH-1) is an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion with potential antineoplastic and antiangiogenic activities.
T-3764518
T13054
T-3764518 is a novel and potent inhibitor of stearoyl coenzyme A desaturase (SCD)(IC50 of 4.7 nM).
AZD8329
T14383
AZD8329 is a selectable and potent inhibitor of human recombinant 11β-HSD1 and isolated human adipocyte 11ß-HSD1 and is an inhibitor of rat 11β-HSD1 (IC50 - 89nM...
Etamicastat
T11238
Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor wit...
(Rac)-BMS-816336
T12663
(Rac)-BMS-816336 (Compound 6n) is a racemate of BMS-816336. (Rac)-BMS-816336 is a potent human and mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzym...
IDH1 Inhibitor 2
T11611
IDH1 Inhibitor 2 (compound 13) is a potent IDH1 inhibitor via direct covalent modification of His315 (IC50: 110 nM).
BMS-816336
T12614L
BMS-816336 is a novel, orally bioavailable inhibitor, and potent against human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with an IC50 of 3.0 nM[1...
BRD9185
T14780
BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
4-Hydroxynonenal
T10148
4-Hydroxynonenal (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).
AZD 4017
T14388
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
IDH889
T15551
IDH889 is a brain penetrant, an allosteric and mutant specific IDH1 inhibitor. IDH889 has effective selectivity for IDH1 R132* mutations (IC50s: 0.02 μM, 0.072 μ...
WAY-324168
T9974
WAY-324168 is a compound with antiproliferative activity.
L-Allylglycine
T37190
L-Allylglycine is an amino acid derivative that reduces glutamate decarboxylase (GAD) activity by 60% when administered at a dose of 39.8 μmol/g per hour ex vivo...
Tiazofurin
T40686
Tiazofurin is a synthetic nucleoside analogue with antineoplastic activity. Tiazofurin is anabolized intracellularly to tiazole-4-carboxamide adenine dinucleotid...
WAY-311610
T77606
WAY-311610 is an 11β-hydroxysteroid dehydrogenase HSD11B1 inhibitor that inhibits the 11β-HSD1 enzyme with an IC = 0.34 μM.It can be used to study neuropathic pa...
4-Hydroxyderricin
T10146
4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-h...
JC2-11
T77579
JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical ...
NCT-505
T12196
NCT-505 is a potent and selective inhibitor of aldehyde dehydrogenase (ALDH1A1)(IC50 of 7 nM).
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