ilreceptor

Dupilumab (REGN-668) is a fully human monoclonal antibody targeting the alpha subunit of the interleukin-4 receptor, thereby inhibiting IL-4 and IL-13 signaling. As a systemic immunomodulator, it has demonstrated efficacy in improving atopic dermatitis.

Streptavidin is a protein tetramer purified from bacteria with a very high affinity for biotin and is commonly used for the purification or detection of various biomolecules. Streptavidin is immunologically active, inhibiting IL-2 synthesis and CD25 expression in T cells.

Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3 GM-CSF IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders.

Anakinra (Raleukin) is a cytokine inactivator and interleukin 1 receptor antagonist that can be used to study secondary phagocytic lymphohistiocytosis and rheumatoid arthritis.

AF 12198 Acetate is a novel low molecular weight antagonist of IL-1

RYTVELA TFA (H-Arg-Tyr-Thr-Val-Glu-Leu-Ala-OH) is a non-competitive metabotropic interleukin-1 receptor inhibitor with anti-inflammatory activity that inhibits upregulation of inflammation and uterine activation, and may be used for the prevention of preterm labor and for fetal protection.