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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40459 | Transcriptional Intermediary Factor 2 (TIF2) (740-753) | Transcriptional Intermediary Factor 2 (TIF2) (740-753) | |
Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a 14-amino acid peptide that serves as a coactivator of TIF-2 protein. It specifically covers residues 740-753 of the TIF-2 protein. | |||
T7833 | TLX agonist 1 | Others | |
TLX agonist 1 is an orphan nuclear receptor tailless (TLX, NR2E1) modulator | |||
T2252 | UNC 669 | UNC669 | Epigenetic Reader Domain |
UNC 669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3. | |||
T8763 | PTGR2-IN-1 | PTGR2-IN-22 | Others |
PTGR2-IN-1 is a potent inhibito of PTGR2r(IC50 : 0.7 μM). It increases 15-keto-PGE2-dependent PPARγ transcriptional activity in PTGR2-transfected HEK293T cells. | |||
T9205 | NCGC00378430 | Phosphatase , Others | |
NCGC00378430 is a potent SIX1/EYA2 interaction inhibitor that disrupts the SIX1/EYA2 complex, EMT, and Metastasis. | |||
T9061 | EN4 | EN4 MYC inhibitor | c-Myc |
EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, an... | |||
T8421 | TED-347 | YAP | |
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability. | |||
T16074 | Mifobate | SR-202 | PPAR |
Mifobate (SR-202) is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1]. | |||
T7539 | O6-Benzylguanine | Apoptosis , DNA Alkylation , DNA/RNA Synthesis | |
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. | |||
T8494 | NS-3-008 hydrochloride | NS-3-008 HCl | Others |
NS-3-008 hydrochloride (NS-3-008 HCl) is a transcriptional G0/G1 switch 2 (G0s2) inhibitor( IC50 of 2.25 μM). | |||
T3206 | NKL 22 | Histone Deacetylase Inhibitor IV,PAOA | HDAC |
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor. | |||
T7440 | P,p'-DDE | p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene | Androgen Receptor , Drug Metabolite |
p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT | |||
T20789 | S-23 | (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23 | Androgen Receptor |
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal ve... | |||
T10239 | Acolbifene | EM-652,SCH 57068 | Estrogen Receptor/ERR |
Acolbifene (SCH 57068) is a selective antagonist of estrogen receptors with IC50s of 2 nM and 0.4 nM for estradiol-induced transcriptional activity of ERα and ERβ. Acolbifene shows an anticarcinogenic property. | |||
T1802 | ZLN005 | Autophagy | |
ZLN005 is an effective and tissue-specific transcriptional activator of PGC-1α. | |||
T21082 | 2,5-Dihydroxybiphenyl | TFIIH Modulator 12,TFIIH Modulator12 | Others |
2,5-Dihydroxybiphenyl (TFIIH Modulator12), a small molecule destabilization inducer, induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity. | |||
T21083 | TFIIH Modulator-19 | TFIIH Modulator19,TFIIH Modulator 19 | Others |
TFIIH Modulator-19 induces the dimerization of trichothiodystrophy group A protein to modulate TFIIH transcriptional activity. | |||
T9566 | PY-60 | Annexin A , YAP | |
PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional program in the adult animal capable of remodeling the epidermi... | |||
T1818 | Tenovin-6 | Tenovin 6 | Dehydrogenase , Sirtuin , Autophagy |
Tenovin-6 is a p53 transcriptional activity agonist. | |||
T1930 | JSH-23 | NF-κB | |
JSH-23, an NF-κB inhibitor(IC50= 7.1 μM), suppresses the transcriptional activity. | |||
T5128 | RGX-104 hydrochloride | SB742881,RGX-104 HCl | Liver X Receptor |
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity via transcriptional activation of the ApoE gene. | |||
T8981 | WAY-169916 | WAY 169916,WAY169916 | NF-κB |
WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity. | |||
T12928 | SK33 | Androgen Receptor | |
SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity. | |||
T6113 | ICG-001 | Apoptosis , Epigenetic Reader Domain , Wnt/beta-catenin | |
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. | |||
T24827 | SR 16832 | SR-16832,SR16832 | PPAR |
SR 16832 is a dual-site PPARγ inhibitor. It also inhibits the binding of endogenous ligands and transcriptional activity of PPARγ, more effectively than the orthosteric covalent antagonist GW 9662 and T 0070907. | |||
T13169 | TM-25659 | Others | |
TM-25659 is a modulator of transcriptional co-activator with PDZ-binding motif (TAZ), with anti-osteoporotic and anti-obesity activities. | |||
T69760 | TT-10 | TAZ-K | YAP |
TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease research, specifically for conditions characterized by loss o... | |||
T3221 | Oct3/4-inducer-1 | 2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile | Others , OCT |
Oct3/4-inducer-1 (2-(4-(4-methoxybenzyloxy)phenyl)acetonitrile) is an OCT3/4 inducer that promotes the expression and stabilization of OCT3/4 and enhances its transcriptional activity in a variety of human cells. | |||
T1535 | Sodium 4-phenylbutyrate | Sodium Phenylbutyrate,Buphenyl,TriButyrate | Apoptosis , HDAC , Autophagy |
Sodium 4-phenylbutyrate (TriButyrate), a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, inc... | |||
T6861 | IMR-1 | Gamma-secretase | |
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | |||
T17252 | SIM-688 | SIM688 | Estrogen/progestogen Receptor , NF-κB |
SIM-688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells). | |||
T3540 | IMR-1A | Gamma-secretase , Drug Metabolite | |
IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L. | |||
T21746 | Terameprocol | tetramethyl Nordihydroguaiaretic Acid,EM-1421 | HIV Protease |
Terameprocol (EM-1421) is a synthetic tetra-methylated derivative of nordihydroguaiaretic acid (NDGA) and transcriptional inhibitor with potential antiviral, antiangiogenic, and antineoplastic activities. Terameprocol sh... | |||
T1935 | LDN193189 | LDN-193189,DM-3189,LDN 193189 | ALK , TGF-beta/Smad |
LDN193189 (LDN-193189) (DM 3189) is a selective BMP signaling inhibitor, inhibiting the transcriptional activity of ALK2 and ALK3 (IC50s: 0.8/0.8/5.3/16.7 nM for ALK1/2/3/6). | |||
T8477 | IQ-3 | JNK | |
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α an... | |||
T15363 | FzM1.8 | Wnt/beta-catenin | |
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway. | |||
T7358 | YK11 | Androgen Receptor | |
YK11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM, with osteogenic activity. | |||
TP1267L | CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate | CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base) | Others |
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate corresponding to amino acids 148-156 of the BRLF1. BRLF1 is a transcriptional activator that binds directly to a GC-rich motif present in some Epstein-Barr virus (EB... | |||
T60019 | VPC-70063 | Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- | Apoptosis , PARP , c-Myc |
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C do... | |||
T23840 | BUR1 | BMP upregulator-1,BMP upregulator 1,BUR 1,BUR-1 | CDK |
BUR1 is a selective BMP upregulator that acts by increasing the expression of Inhibitor of DNA binding 1 and inducing BMP2 and PTGS2 expression. | |||
T8979 | AEM1 | Nrf2 | |
AEM1 is an inhibitor of deregulated NRF2 transcriptional activity in cancer. AEM1 acts by broadly decreasing the expression of NRF2 controlled genes, sensitizing A549 cells to various chemotherapeutic agents, and inhibit... | |||
T35348 | LDN-193189 2HCl | LDN-193189 2HCl,DM-3189 2HCl | ALK , TGF-beta/Smad |
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited ... | |||
T3144 | BML-284 | Wnt agonist 1 | Wnt/beta-catenin |
BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator. | |||
T2237 | ICG001 | Epigenetic Reader Domain , Wnt/beta-catenin | |
ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coacti... | |||
T9573 | GSK3685032 | DNA Methyltransferase | |
GSK3685032 is a non-covalent and selective DNMT1 inhibitor(IC50 = 36 nM). The inhibitory effect is time-independent and reversible. GSK3685032 induces loss of DNA methylation and transcriptional activation and inhibits c... | |||
T28502 | Ralaniten | EPI-002 | Androgen Receptor |
Ralaniten (EPI-002) is a potent, specific, and orally active antagonist of the androgen receptor N-terminal structural domain (AR-NTD).Ralaniten inhibits AR transcriptional activity with an IC50 value of 7.4 μM.Ralanites... | |||
T9179 | CLP-3094 | 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE | Androgen Receptor |
CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) is a potent androgen receptor BF3 (binding function 3) inhibitor. BF3-IN-1 inhibits AR transcriptional activity with IC50 of 4 μM. CLP-3094 is a selective and potent GP... | |||
T21505 | Suberoyl bis-hydroxamic acid | SBHA,Suberohydroxamic acid | Apoptosis , HDAC |
Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on ... | |||
T62568 | IXA6 | IRE1 | |
IXA6 is a novel IRE1/XBP1s agonist with potential vasoprotective activity that activates IRE1-XBP1s signaling and XBP1s transcriptional response, which can be used to study neurodegenerative diseases such as Parkinson's ... | |||
T8799 | (E/Z)-IT-603 | IT603 | Others , NF-κB |
(E/Z)-IT-603 is a cell-permeable c-Rel inhibitor (IC50: 3μM). IT-603 directly and reversibly binds to c-Rel to change its conformation and blocks its DNA binding and transcriptional activity. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN2100 | Pratensein | Others , NF-κB | |
Pratensein as a novel transcriptional up-regulator of scavenger receptor class B type I in HepG2 cells. | |||
T5754 | Kavain | NF-κB , GABA Receptor | |
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF. | |||
T3918 | Ginsenoside Rb3 | Gypenoside IV | NF-κB , COX , NO Synthase |
Ginsenoside Rb3 (Gypenoside IV) is a natural triterpenoid saponin, exhibiting inhibition effect on TNFα-induced NF-κB transcriptional activity. It also inhibits the induction of COX-2 and iNOS mRNA. | |||
T5773 | Moslosooflavone | 5-hydroxy-7,8-dimethoxyflavone | NF-κB , Reactive Oxygen Species |
Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activi... | |||
T30969 | Clitocine | Apoptosis , BCL | |
Clitocine, an adenosine analogue derived from mushrooms, is a potent transcriptional readout agent, an inhibitor of nonsense mutations, and has anticancer activity, inducing the production of p53 protein in cells carryin... | |||
T5681 | ETHYL CAFFEATE | ETHYL 3,4-DIHYDROXYCINNAMATE | NF-κB , COX , PGE Synthase , NO Synthase |
Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related s... | |||
TL0007 | Bisdemethoxycurcumin | Curcumin III,Didemethoxycurcumin | Epigenetic Reader Domain , Wnt/beta-catenin |
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac... | |||
T7030 | Anemarsaponin B | p38 MAPK , NF-κB , MEK , COX , NO Synthase | |
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity, possibly via the p38 MAP kinase pathway. Anemarsaponin B c... | |||
T5S0890 | Oleandrin | Neriostene,Folinerin,Foliandrin | Apoptosis , ATPase , Potassium Channel , Sodium Channel |
1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ... | |||
T6S1543 | Dehydrodiisoeugenol | Others , NF-κB , COX , Antibacterial | |
1. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated ... | |||
TN1724 | Harmalol hydrochloride | Harmidol hydrochloride | P450 , Antioxidant |
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits ... | |||
T6S1665 | Irisflorentin | Others , NO Synthase | |
1. Irisflorentin blocks apoptosis pathways, by exerting its effects by promoting rpn-3 expression to enhance the activity of proteasomes and down-regulating egl-1 expression. 2. Irisflorentin has anti-inflammatory mechan... | |||
T23825 | Bryononic acid | ||
Bryononic acid is a new cucurbitane-type triterpenoid. Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo. | |||
T80904 | Ulmoidol | ||
Ulmoidol mitigates neuroinflammation by inhibiting the PU.1 (transcriptional) signaling pathway. | |||
TN3539 | Broussonin A | ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt | |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-lucife... | |||
TN3537 | Braylin | IL Receptor , TNF , NF-κB | |
Braylin has anti-inflammatory, antinociceptive and immunomodulatory effects, which possibly act through the glucocorticoid receptor activation and by inhibition of the transcriptional activity of NF-κB. Braylin is also ... | |||
T79961 | Aloeresin G | ||
Aloeresin G, a chromone glycoside isolated from Aloe, exhibits a moderate inhibitory effect on TNFα-induced NF-κB transcriptional activity, evidenced by an IC50 of 40.02 μM [1]. | |||
T71795 | Norstictic acid | ||
Norstictic acid is a potent, selective allosteric transcriptional regulator that exhibits anticancer, antioxidant, and antimicrobial activities. | |||
TN4383 | Kazinol U | IL Receptor , IκB/IKK , NOS , NF-κB | |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-... | |||
TN4016 | Ethyl 2,4,6-trihydroxybenzoate | Liver X Receptor | |
Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing lipid accumulation in HepG2 cells. It suppresses cellular ch... | |||
T11834 | Leelamine hydrochloride | Others | |
Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabin... | |||
T73815 | TMC-205 | ||
TMC-205, a natural fungal metabolite, exhibits antiproliferative effects against cancer cell lines and functions as a transcriptional up-regulator of the SV40 promoter [1]. | |||
TN1347 | 8-Prenylkaempferol | p38 MAPK , NF-κB , PI3K | |
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-induced RANTES production acts by blocking PI3K-mediated tran... | |||
TN5880 | Mesuol | ||
Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and p... | |||
TWS0787 | Oroxin A | Baicalin-7-glucoside | PPAR , Glucosidase |
Oroxin A (Baicalin-7-glucoside) is a partial PPARγ agonist that can activate PPARγ transcriptional activation in vitro and in vivo. Oroxin A also exhibited inhibitory activity against α-glucosidase and antioxidant capaci... | |||
TN5369 | Dehydroleucodine | Dehydroleucodin | |
Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating a... | |||
T79965 | 11-Oxoisomogroside V | ||
11-Oxoisomogroside V (compound 3), a cucurbitacin derived from Luo Han Guo extract, enhances the transcriptional activity of PGC-1α. Luciferase assay data demonstrates that at concentrations of 10 μM and 20 μM, 11-Oxoiso... | |||
T72208 | 1-Dehydro-[10]-gingerdione | ||
1-Dehydro-[10]-gingerdione inhibits IKKβ activity by targeting its activation loop, thereby preventing IKKβ-mediated phosphorylation of IκBα in macrophages stimulated by agonists. Furthermore, this compound suppresses LP... | |||
T75487 | 7-Hydroxyneolamellarin A | ||
7-Hydroxyneolamellarin A, a natural product from the sponge Dendrilla nigra, serves as a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α). It effectively reduces the accumulation of HIF-1α protein and suppresses ... | |||
T79962 | Aloenin aglycone | Others | |
Aloenin aglycone (compound 13), an inhibitor of NF-κB, can be sourced from aloe exudate. It impedes TNFα-stimulated NF-κB transcriptional activity, showing an IC 50 of 18.7 μM. At a concentration of 10 μM, aloenin aglyco... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03395 | PC4/SUB1 Protein, Human, Recombinant (His) | Human | E. coli |
SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptio... | |||
TMPJ-00986 | CTCF Protein, Human, Recombinant | Human | E. coli |
Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in pri... | |||
TMPJ-00914 | YY1 Protein, Human, Recombinant (His) | Human | E. coli |
Transcriptional repressor protein YY1(YY1)contains 4 C2H2-type zinc fingers and belongs to the YY transcription factor family. Multifunctional transcription factor exhibits positive and negative control on a large number... | |||
TMPH-01208 | DEAF1 Protein, Human, Recombinant (His) | Human | E. coli |
Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid respon... | |||
TMPH-00005 | YAP1 Protein, Human, Recombinant (Isoform 9, His) | Human | Yeast |
TMPY-02603 | STAT6 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6... | |||
TMPY-05449 | IL-33 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... | |||
TMPY-02789 | IL-33 Protein, Canine, Recombinant | Canine | E. coli |
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... | |||
TMPY-00861 | IL-33 Protein, Human, Recombinant | Human | E. coli |
Interleukin 33 (IL-33), also known as DVS27 or NF-HEV (Nuclear Factor from High Endothelial Venules), is a pro-inflammatory protein and a chromatin-associated cytokine of the IL-1 family with high sequence and structural... | |||
TMPH-00009 | OGT Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc... | |||
TMPY-03407 | NQO1 Protein, Human, Recombinant (His) | Human | E. coli |
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-... | |||
TMPJ-00778 | HER2/ERBB2 Protein, Human, Recombinant (His) | Human | Human Cells |
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and different... | |||
TMPY-03650 | BirA Protein, E. coli, Recombinant (His & MBP) | E. coli | E. coli |
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these prote... | |||
TMPY-03564 | TSPAN8 Protein, Human, Recombinant (His) | Human | HEK293 |
Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a nega... | |||
TMPY-06844 | CD93/C1qR1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-06027 | CD93/C1qR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-02268 | CD93/C1qR1 Protein, Human, Recombinant (His) | Human | HEK293 |
CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93/C1qR is a highly glycosylated transmembrane protei... | |||
TMPY-00382 | Thioredoxin/TRX Protein, Mouse, Recombinant | Mouse | E. coli |
Thioredoxin, also known as ATL-derived factor, Surface-associated sulphydryl protein, SASP and TXN, is a nucleus, cytoplasm and secreted protein that belongs to the thioredoxin family. Thioredoxins are proteins that act ... | |||
TMPY-03888 | KEAP1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ... | |||
TMPY-02030 | CD82 Protein, Human, Recombinant (His) | Human | HEK293 |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetras... | |||
TMPY-03432 | KEAP1 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ... | |||
TMPY-02101 | KEAP1 Protein, Human, Recombinant (His & GST & Avi) | Human | Baculovirus-Insect Cells |
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ... | |||
TMPY-01188 | PARP Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N... | |||
TMPY-01725 | Leptin Receptor Protein, Human, Recombinant (His) | Human | HEK293 |
Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-spe... | |||
TMPY-00856 | TCCR Protein, Human, Recombinant (hFc) | Human | HEK293 |
The interleukin-27 receptor is a type I cytokine receptor for interleukin-27. It is a heterodimer composed of the interleukin 27 receptor, alpha subunit, and glycoprotein 130. WSX-1/IL-27R, a class I cytokine receptor th... | |||
TMPY-02130 | Argonaute-2 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small... | |||
TMPY-01186 | Argonaute-2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small... | |||
TMPY-04483 | IRAK4 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4... | |||
TMPH-01900 | DDX5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop r... | |||
TMPY-05426 | CREG1 Protein, Human, Recombinant (His) | Human | HEK293 |
CREG1 belongs to the CREG family. It is a adenovirus E1A protein which both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Thus it may contribute to the transcripti... | |||
TMPH-02319 | ZSCAN1 Protein, Human, Recombinant (His & Myc) | Human | Baculovirus |
May be involved in transcriptional regulation. | |||
TMPH-03177 | RhlR Protein, Pseudomonas aeruginosa, Recombinant (His & Myc & SUMO) | Pseudomonas aeruginosa | E. coli |
Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-bu... | |||
TMPH-02804 | NRL Protein, Mouse, Recombinant (His & Myc & SUMO) | Mouse | E. coli |
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transc... | |||
TMPH-02227 | ERG Protein, Human, Recombinant (His) | Human | Yeast |
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. | |||
TMPH-01349 | FOXL2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis th... | |||
TMPH-00365 | Chicken anemia virus (isolate USA 26p4) Apoptin Protein (His) | CAV | E. coli |
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. | |||
TMPY-03559 | CREG1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
CREG1 belongs to the CREG family. It is a adenovirus E1A protein which both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Thus it may contribute to the transcripti... | |||
TMPY-03420 | CREG1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CREG1 belongs to the CREG family. It is a adenovirus E1A protein which both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Thus it may contribute to the transcripti... | |||
TMPH-01243 | ID1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcription... | |||
TMPH-01755 | NRL Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transc... | |||
TMPH-01851 | PSIP1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens ... | |||
TMPH-02318 | ZBTB32 Protein, Human, Recombinant (His) | Human | E. coli |
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from bin... | |||
TMPH-01794 | NR2F6 Protein, Human, Recombinant (His & Myc) | Human | HEK293 |
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are a... | |||
TMPH-00366 | Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (GST) | CAV | E. coli |
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. | |||
TMPH-00367 | Chicken anemia virus (isolate Germany Cuxhaven-1) Apoptin Protein (His & SUMO) | CAV | E. coli |
May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle. | |||
TMPH-01795 | NR2F6 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are a... | |||
TMPH-01345 | FIZ1 Protein, Human, Recombinant (His) | Human | E. coli |
May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation. | |||
TMPH-01601 | Lactoylglutathione lyase/GLO1 Protein, Human, Recombinant (GST) | Human | E. coli |
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteocl... | |||
TMPH-00660 | NikR Protein, E. coli, Recombinant (His) | E. coli | E. coli |
Transcriptional repressor of the nikABCDE operon. Is active in the presence of excessive concentrations of intracellular nickel. | |||
TMPH-00886 | ATF7IP2 Protein, Human, Recombinant (His) | Human | E. coli |
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the conte... | |||
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L2140 | Cancer Cell Differentiation Compound Library | 413 compounds | |
A unique collection of 413 cancer cell differentiation inducing compounds for high throughput and high content screening; | |||
L3800 | NF-κB Signaling Compound Library | 740 compounds | |
A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening; | |||
L3500 | Histone Modification Compound Library | 480 compounds | |
A unique collection of 480 histone modification related compounds for high throughput screening (HTS) and high content screening (HCS); | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1352 compounds | |
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; | |||
L8300 | Chromatin Modification Compound Library | 256 compounds | |
A unique collection of 256 compounds targeting chromatin remodeling pathway for high throughput screening (HTS) and high content screening (HCS); | |||
L3510 | Methylation Compound Library | 131 compounds | |
131 methylation-related compounds that can be used for high-throughput and high-content screening. |