isomerase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T79928	Phosphomannose isomerase
	Phosphomannose isomerase, the initial enzyme in GDP-Man biosynthesis, catalytically facilitates the interconversion of fructose-6-phosphate (Fru6P) and mannose-6-phosphate (Man6P), playing a crucial role in cell wall syn...
T76154	Triosephosphate isomerase
	Triosephosphate isomerase (TPI), a glycolytic enzyme, efficiently catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The catalytic site of TPI is located at the dimer inter...
T76152	Glucose 6-phosphate isomerase
	Glucose 6-phosphate isomeras (GPI), i.e., phosphoglucose isomerase/phosphoglucoisomerase (PGI) or phosphohexose isomerase (PHI), is often used in biochemical studies. Glucose 6-phosphate isomeras is a highly conserved gl...
T14362	AY 9944		Others
	AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomera...		Others
T25821	ML359	ML-359,ML 359	Others
	ML359 is a protein disulfide isomerase inhibitor.		Others
T38862	Nandrolone acetate	19-Nortestosterone 17β-acetate	Others
	Nandrolone acetate (19-Nortestosterone 17β-acetate) is a competitive inhibitor of isomerase with the Ki of 7 μM for Δ5-3-ketosteroid isomerase of Pseudomonas testosreroni.		Others
T10185	6-Phosphogluconic acid		Others , Endogenous Metabolite
	6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor (Kis: 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate).		Others , Endogenous Metabolite
T77650	Topoisomerase II inhibitor 14		Apoptosis , Antioxidant , Topoisomerase , NO Synthase
	Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibitor with anticancer and antioxidant activities.Topoisomerase II inhibitor 14 induces apoptosis and blocks the cell cycle in S phase.Topoisomerase II inhibi...		Apoptosis , Antioxidant , Topoisomerase , NO Synthase
T67899	Topoisomerase II inhibitor 13		Topoisomerase
	Topoisomerase II inhibitor 13 inhibits topoisomerase II (Topo II) that shows strong anti-proliferation activity against HL-60/MX2 cancer cells derived from HL-60 against Topo II toxicity.		Topoisomerase
T63360	DNA topoisomerase II inhibitor 1
	DNA topoisomerase II inhibitor 1 is a potent inhibitor of DNA topoisomerase II that arrests the cell cycle in sub-G1 phase and induces apoptosis with anti-value-added effects.
T61045	Topoisomerase I/II inhibitor 2
	Topoisomerase I/II inhibitor 2 (compound 1a) can significantly reduce the xenograft tumor growth in mice model which can be used in treating liver cancer. Topoisomerase I/II inhibitor 2 is a DNA topoisomerase I/II dual i...
T61431	Topoisomerase IIα-IN-4
	Topoisomerase IIα-IN-4 (F2) is a non-intercalative ATP-competitive inhibitor of human DNA topoisomerase II, specifically inhibiting TopoIIα with an IC50 value of 3.8 μM and TopoIIβ with an IC50 value of 10.1 μM. It demon...
T60781	Topoisomerase II inhibitor 8
	Topoisomerase II inhibitor 8 (compound 22) shows good anti-proliferative activities and arrest the cell cycle at G2/M phase. Topoisomerase II inhibitor 8 is a potent inhibitor of topoisomerase II (IC 50 = 0.52 μM) [1].
T80967	Topoisomerase I inhibitor 9		Topoisomerase
	Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 value of 34.81μM against L. donovani promastigotes [1].		Topoisomerase
T63594	Topoisomerase IIα-IN-3
	Topoisomerase IIα-IN-3 is a DNA-inserting topoisomerase-Iiα inhibitor that blocks the cell cycle in G0/G1 phase and induces apoptosis.
T62223	Topoisomerase IIα-IN-1
	Topoisomerase IIα-IN-1 (compound 2) is a DNA-binding ligands and a potent inhibitor of TopoIIα, a topoisomerase. topoisomerase IIα-IN-1 shows good anti-proliferative effects on human cancer cell lines.
T62225	Topoisomerase I inhibitor 8
	Topoisomerase I inhibitor 8, a hexacyclic analogue of camptothecin, is also a potent inhibitor of topoisomerase I and is toxic to tumour cells.
T72153	Topoisomerase IV inhibitor 1		Topoisomerase
	Topoisomerase IV inhibitor 2 (compound 7d) is a potent inhibitor of DNA topoisomerase IV (TOPO IV), exhibiting IC50 values of 0.23 μM for TOPO IV and 0.43 μM for DNA gyrase. It also demonstrates antibacterial efficacy, w...		Topoisomerase
T72157	Topoisomerase II inhibitor 7
	Topoisomerase II inhibitor 7, a potent inhibitor of the topoisomerase II alpha subtype, exhibits an IC50 of 3.19 μM. It effectively induces cell cycle arrest and apoptosis.
T62002	Topoisomerase I inhibitor 7
	Topoisomerase I inhibitor 7 (Compound 8) is a potent inhibitor of Topoisomerase I. Topoisomerase I inhibitor 7 significantly inhibits tumor growth (up to 79%) and increases the lifespan (153%) of mice bearing P388 lympho...