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NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule. It helps modulate vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development. It may function as a retrograde neurotransmitter. Nitric oxide is mediated in mammals by the calcium-calmodulin controlled isoenzymes eNOS (endothelial NOS) and nNOS (neuronal NOS). The inducible isoform, iNOS, involved in immune response, binds calmodulin at physiologically relevant concentrations, and produces NO as an immune defense mechanism, as NO is a free radical with an unpaired electron. It is the proximate cause of septic shock and may function in autoimmune disease.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1009 Epimagnolin B 1134188-26-3 98%
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
T7206 2-Iminobiotin 13395-35-2 98%
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
T2S0765 Epibetulinic acid 38736-77-5 98%
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
TN1109 3-O-Acetyl-16α-hydroxydehydrotrametenolic acid 168293-14-9 98%
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
TN2144 Resveratroloside 38963-95-0 98%
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
TN1058 Pelargonidin chloride 134-04-3 98%
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
TN1102 Physalin L 113146-74-0 98%
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
T7030 Anemarsaponin B 139051-27-7 98%
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
TN1624 Ethyl cinnamate 103-36-6 98%
Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
TJS1779 Protosappanin A 102036-28-2 98%
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
TP2057L Camstatin acetate 98%
Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calm...
T19930 Nitrosoglutathione 57564-91-7 98%
GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins.
TN1817 Kaempferol 3,7,4'-trimethyl ether 15486-34-7 98%
Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines.
T25865 NG-Nitroarginine methyl ester 50903-99-6 98%
NG-Nitroarginine methyl ester is a non-selective nitric oxide synthase inhibitor. It has been utilized experimentally to induce hypertension.
TQ0301 Kuwanon A 62949-77-3 98%
Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.
T9376 Nitroarginine 2149-70-4
Nitroarginine is a competitive inhibitor of nitric oxide synthase which causes the selective reduction of blood flow to tumor cells[1].
T21507 7-Ethoxyresorufin 5725-91-7
7-Ethoxyresorufin (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
T21546 NG,NG-dimethyl-L-Arginine dihydrochloride 220805-22-1
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to ...
TN1983 Neoisoastilbin 54141-72-9
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
T0358 Aminoguanidine hydrochloride 1937-19-5 100%
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
Epimagnolin B
TN1009
Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
2-Iminobiotin
T7206
2-Iminobiotin is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of ...
Epibetulinic acid
T2S0765
Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid
TN1109
3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid shows anti-inflammatory activity, it can inhibit NO production and iNOS expression in LPS-stimulated Raw264.7...
Resveratroloside
TN2144
Resveratroloside has cardioprotective effect, it exhibits α±-glucosidase inhibitory activity, it also can inhibit hydroxylation of testosterone by CYP3A4.
Pelargonidin chloride
TN1058
Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels t...
Physalin L
TN1102
Physalin L is a natural product,it shows a distinct fluorescence spot under UV 365 nm with good separation.
anemarsaponin B
T7030
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity,...
Ethyl cinnamate
TN1624
Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
Protosappanin A
TJS1779
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
Camstatin acetate
TP2057L
Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calm...
Nitrosoglutathione
T19930
GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins.
Kaempferol 3,7,4'-trimethyl ether
TN1817
Kaempferol 3,7,4'-trimethylether shows selective cyctoxic activities against the nine tested cancer cell lines.
NG-Nitroarginine methyl ester
T25865
NG-Nitroarginine methyl ester is a non-selective nitric oxide synthase inhibitor. It has been utilized experimentally to induce hypertension.
Kuwanon A
TQ0301
Kuwanon A inhibits nitric oxide production (IC50: 10.5 μM). Kuwanon A is a flavone derivative isolated from Morus alba L.
Nitroarginine
T9376
Nitroarginine is a competitive inhibitor of nitric oxide synthase which causes the selective reduction of blood flow to tumor cells[1].
7-Ethoxyresorufin
T21507
7-Ethoxyresorufin (7-ER) is a fluorometric substrate for and competitive inhibitor of cytochrome P450, especially CYP1A1.
NG,NG-dimethyl-L-Arginine dihydrochloride
T21546
NG,NG-dimethyl-L-Arginine dihydrochloride is an endogenous nitric oxide synthase inhibitor. Nitric oxide (NO) that is synthesised from L-arginine contributes to ...
Neoisoastilbin
TN1983
Neoisoastilbin may have antioxidant and anti-inflammatory activities.
Aminoguanidine hydrochloride
T0358
Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, used in the treatment of diabetic nephropathy.
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