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Anabsinthin
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Catalog No. TN13753 Copy Product Info
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Anabsinthin is a sesquiterpene lactone dimer found in Artemisia absinthium L. (wormwood). It regulates intracellular calcium levels and mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits phorbol 12-myristate 13-acetate-induced superoxide anion generation, iNOS and MUC5AC protein expression upregulation, and IL-1β transcription. It is useful in studies related to citrus canker.
Anabsinthin
Cas No. 6903-12-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Anabsinthin is a sesquiterpene lactone dimer found in Artemisia absinthium L. (wormwood). It regulates intracellular calcium levels and mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits phorbol 12-myristate 13-acetate-induced superoxide anion generation, iNOS and MUC5AC protein expression upregulation, and IL-1β transcription. It is useful in studies related to citrus canker. |
| In vitro | Anabsinthin (1 mM) elevates cytosolic calcium levels in BEAS-2B cells independently of hTAS2R46. At concentrations of 1 and 10 μM, for 1 hour, Anabsinthin inhibits PMA-induced superoxide anion production in BEAS-2B cells, a process mediated by hTAS2R46. Furthermore, at the same concentrations for 18 hours, Anabsinthin suppresses PMA-induced iNOS protein expression (but not its mRNA expression), MUC5AC protein expression, and IL-1β mRNA expression in BEAS-2B cells, with the inhibition of IL-1β mRNA expression occurring independently of hTAS2R46 mediation. |
| Molecular Weight | 496.64 |
| Formula | C30H40O6 |
| Cas No. | 6903-12-4 |
| Smiles | C[C@@]12[C@]34C([C@@]([C@]5([C@@]3(C(C)=C6[C@@]5([C@@](C)(O)CC[C@@]7([C@@]6(OC(=O)[C@H]7C)[H])[H])[H])[H])[H])(C1)[H])([C@@](C)(O2)CC[C@@]8([C@@]4(OC(=O)[C@H]8C)[H])[H])[H] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
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For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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