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MAPK Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
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DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
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Search Result

Search Results for "obesity"

Libraries

Anti-Obesity Compound Library Anti-Metabolism Disease Compound Library Gut Microbial Metabolite Library Nuclear Receptor Compound Library Metabolism Compound Library Anti-Colorectal Cancer Compound Library Glycometabolism Compound Library
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Compounds

Cat No. Product Name
T9089 FTO-IN-1 UUN44923 Others
UUN44923 是脂肪及肥胖相关酶 (FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 可用于研究癌症。摘自专利文献 WO2018157843A1 中的化合物 32。
T3283 Cetilistat 新利司他,ATL-962 Lipid
Cetilistat 是胰腺脂肪酶 (pancreatic lipase) 抑制剂，能够抑制大鼠脂肪酶(IC50:54.8 nM)和人胰脂肪酶(IC50:5.95 nM)的活性，可用作有效的抗肥胖药。
TN3500 Beta-Amyrone β-香树脂酮,β-Amyron COX , AChR , Antifection , PPAR
beta-Amyrone 对基孔肯雅病毒复制具有抗真菌活性，EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。...
TN1418 Azaleatin 2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮,杜鹃黄素 DPP-4
Azaleatin 是分离自Rhododendron 种中的 O-甲基化黄酮醇。它是二肽基肽酶-IV 的抑制剂。它在 2 型糖尿病和肥胖症中有研究的价值。
T3672 Nomilin MAPK
Nomilin 是一种柠檬苦素类化合物，从柑桔类提取物中获得，是抗肥胖症和降糖药。
T5751 Tigogenin Others
Tigogenin 是甾体皂甙元，普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化，促使成骨细胞的分化。
T3836 Eudesmin MAPK , S6 Kinase
Eudesmin 通过抑制S6K1信号通路来干扰成脂分化，具有抗肿瘤、抗炎和抗菌活性。
TN6772 Malabaricone C Others
Malabaricone C 是天然的鞘磷脂合成酶抑制剂，对 SMS 1 和 SMS 2 的IC50分别为 3 和 1.5 μM。
T5583 Turanose 松二糖,D-(+)-Turanose Endogenous Metabolite
Turanose 是天然存在于蜂蜜中的蔗糖异构体。它具有抗炎和调节脂肪形成的活性。它具有肥胖症和相关慢性病的研究潜力。
T2057 BVT 2733 Dehydrogenase
BVT 2733 是具有口服活性的、强效的、非甾体类11β-HSD1选择性抑制剂。它对小鼠 11β-HSD1 酶的作用 (IC50:96 nM) 比对人 11β-HSD1 酶 (IC50:3341 nM) 的作用强。它对关节炎和肥胖相关疾病...
T9491 Pyraclostrobin Antifungal , Antibacterial
Pyraclostrobin 是一种球果苷杀菌剂，可诱导 3T3-L1 细胞内甘油三酯的积累，还可抑制真菌和哺乳动物细胞的线粒体复合物 III 。
T12580 PTUPB Epoxide Hydrolase , COX
PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。
T7482 3-chloro-5-hydroxybenzoic Acid GPR
3-Chloro-5-hydroxybenzoic acid 是一种口服具有活力的乳酸受体GPR81选择性激动剂，对人 GPR81 的EC50为 16 μM。肥胖小鼠模型中，它表现出良好的体内脂肪分解作用。
T5778 5,7-DIMETHOXYFLAVONE Anti-infection , P450
5,7-Dimethoxyflavone 是一种 Kaempferia parviflora 的主要成分，具有抗肿瘤、抗肥胖及抗炎活性。它对细胞色素 P450 (CYP) 3As 具有抑制作用，也是抗乳腺癌蛋白 (BCRP) 抑制剂。
T22447 Tri-Salicylic Acid 三水杨酸 Others
Tri-Salicylic acid 是一种和水杨酸具有相似性质的化合物。它对肥胖、炎症及心血管疾病具有潜在的研究价值（摘自专利 US20170368079A1，化合物 III）。
T7832 Ibrolipim NO-1886 LPL Receptor
Ibrolipim 是口服具有活力的脂蛋白脂肪酶 (LPL) 激活剂。它能够降低血浆甘油三酸酯，增加高密度脂蛋白胆固醇水平，具有肾保护和降血脂的作用。
T7704 KY-226 Phosphatase
KY-226 是选择性的，口服活性的和变构蛋白酪氨酸磷酸酶 1B 抑制剂，IC50=0.25 μM，且不激活 PPARγ 。它可以保护神经元免受脑缺血损伤。它通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。
T11590 (-)-Hydroxycitric acid Garcinia acid,(-)-羟基柠檬酸 ATP Citrate Lyase
(-)-Hydroxycitric acid 是Garcinia cambogia 果皮中的主要酸。它是 ATP 柠檬酸裂解酶的竞争性抑制剂，能够抑制脂肪酸的合成，减少脂肪生成，控制食物摄入，从而减轻体重。
T4733 Sucrose 蔗糖,D(+)-Sucrose,D-(+)-Saccharose Endogenous Metabolite , Others
Sucrose 是一种二糖，由果糖和葡萄糖组成。Sucrose 能够应用于一些动物模型，包括代谢性疾病、偏食、肥胖、糖尿病等。
T2626 SBC-115076 SBC115076 Serine/threonin kinase , Others
SBC115076 是前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(PCSK9)抑制剂。其中PCSK9 是一种前蛋白转化酶，在 LDL 受体代谢中的重要物质。
FTO-IN-1
T9089
synonym: UUN44923
Target:
Cetilistat
T3283
synonym: 新利司他,ATL-962
Target:
beta-Amyrone
TN3500
synonym: β-香树脂酮,β-Amyron
Target:
Azaleatin
TN1418
synonym: 2-(3,4-二羟基苯基)-3,7-二羟基-5-甲氧基苯并吡喃-4-酮,杜鹃黄素
Target:
Nomilin
T3672
synonym:
Target:
Tigogenin
T5751
synonym:
Target:
Eudesmin
T3836
synonym:
Target:
Malabaricone C
TN6772
synonym:
Target:
Turanose
T5583
synonym: 松二糖,D-(+)-Turanose
Target:
BVT 2733
T2057
synonym:
Target:
Pyraclostrobin
T9491
synonym:
Target:
PTUPB
T12580
synonym:
Target:
3-chloro-5-hydroxybenzoic Acid
T7482
synonym:
Target:
5,7-DIMETHOXYFLAVONE
T5778
synonym:
Target:
Tri-Salicylic Acid
T22447
synonym: 三水杨酸
Target:
Ibrolipim
T7832
synonym: NO-1886
Target:
KY-226
T7704
synonym:
Target:
(-)-Hydroxycitric acid
T11590
synonym: Garcinia acid,(-)-羟基柠檬酸
Target:
Sucrose
T4733
synonym: 蔗糖,D(+)-Sucrose,D-(+)-Saccharose
Target:
SBC-115076
T2626
synonym: SBC115076
Target:
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