cdk — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TQ0078	CDK-IN-2	CDK inhibitor II	CDK
	CDK-IN-2 (CDK inhibitor II) is a potent and specific CDK9 inhibitor (IC50: <8 nM).		CDK
T60869	CDK-IN-10		CDK
	CDK-IN-10 is a cell cycle protein-dependent kinase (CDK) inhibitor with potential anticancer activity for cancer research.		CDK
T36741	CDK-IN-6
	CDK-IN-6, a pyrazolo[1,5-a]pyrimidine compound, exhibits potent anticancer activities as a CDK inhibitor[1].
T10734	CDK ligand for PROTAC		Others
	CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.		Others
T10734L	CDK ligand for PROTAC hydrochloride		Others
	CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.		Others
T75127	CDK-IN-12
	CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].
T62235	CDK-IN-9
	CDK-IN-9 (compound 24) is a potent inhibitor of CDK. CDK-IN-9 is also a molecular gel that induces interaction between CDK12 and DDB1 and is able to act on CDK2/E (IC50: 4 nM). CDK-IN-9 can be used to dephosphorylate ret...
T61583	CDK/HDAC-IN-1
	CDK/HDAC-IN-1 exhibits potent inhibitory activity towards CDK2/4/6 and HDAC6, with IC50 values of 60.9 ± 2.9 nM, 276 ± 22.3 nM, 27.2 ± 4.2 nM, and 128.6 ± 0.4 nM, respectively.
T78906	CDK/HDAC-IN-3		HDAC
	CDK/HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28...		HDAC
T63664	CDK/HDAC-IN-2
	CDK/HDAC-IN-2 is a potent dual HDAC/CDK inhibitor that acts on HDAC1 (IC50: 6.4 nM), HDAC2 (IC50: 0.25 nM), HDAC3 (IC50: 45 nM), HDAC6,8 (IC50>1000 nM), CDK1 (IC50: 8.63 nM), CDK4,6,7 (IC50>1000 nM), CDK2 (IC50: 0.30 nM)...
T14916	CDK2-IN-4		CDK
	CDK2-IN-4 is a potent and selective inhibitor of CDK2 with an IC50 of 44 nM for CDK2/cyclin A. It shows 2,000-fold selectivity over CDK1/cyclin B with IC50 of 86 uM.		CDK
T10736	CDK4/6-IN-2		CDK
	CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor (IC50s: 2.7 and 16 nM).		CDK
T39957	CDK4/6-IN-6		CDK
	CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.		CDK
T60025	Eciruciclib		CDK
	Eciruciclib is an inhibitor of CDK with antitumor properties.		CDK
T10740	CDK8-IN-1		CDK
	CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM).		CDK
T10742	CDK9-IN-10		CDK
	CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2.		CDK
T10745	CDK9-IN-7		CDK
	CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).		CDK
T10746	CDK9-IN-8		CDK
	CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM).		CDK
T5673	Senexin A		CDK
	Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.		CDK
T14914	Cdk1/2 Inhibitor III		CDK
	Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor with an IC50 value of 2.1 μM against CDK1/cyclin B.		CDK