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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39217 | PKA-IN-1 | PKA | |
PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study diseases of the immune system. | |||
T21674L | PKA inhibitor fragment (6-22) amide Acetate | PKA inhibitor fragment (6-22) amide Acetate(121932-06-7 Free base) | PKA |
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM). | |||
T75888 | PKA Inhibitor Fragment (6-22) amide TFA | PKI-(6-22)-amide TFA,PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base) | PKA |
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of the highly potent cAMP-dependent protein kinase A (PKA) inhibitor (Ki: 2.8 nM).PKA Inhibitor Fragment (6-22) amide TFA ... | |||
T36019 | PKA Inhibitor (5-24) (trifluoroacetate salt) | ||
PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki= 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.1It mimics the protein substrate by bind... | |||
T72885 | Akt1&PKA-IN-1 | ||
Akt1&PKA-IN-1 is a potent dual inhibitor targeting Akt and PKA, exhibiting IC50 values of 0.11 μM for Akt, 0.03 μM for PKAα, and 9.8 μM for CDK2. Notably, it demonstrates selectivity for cyclin-dependent kinase 2 (CDK2). | |||
T72886 | Akt1&PKA-IN-2 | ||
Akt1&PKA-IN-2 ((R)-29), a compound with specificity towards PKB/AKT and notable selectivity for cyclin-dependent kinase 2 (CDK2), effectively inhibits AKT1, PKAa, and CDK2a with IC50 values of 0.007 µM, 0.01 µM, and 0.69... | |||
T76381 | H1-7 (histone H1 phosphorylation site), PKA Substrate | ||
H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2]. | |||
T3498 | CCG215022 | GRK , PKA | |
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively. | |||
T6304 | AT7867 | Akt , PKA , S6 Kinase | |
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family. | |||
T12103 | MR-L2 | PDE | |
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4). | |||
T3269 | Metadoxine | pyridoxine-pyrrolidone carboxylat,Metasin,Metadoxil | 5-HT Receptor , PKA |
Metadoxine (Metadoxil) is a neurotransmitter stimulant. | |||
T2482 | AT13148 | ROCK , SGK , Akt , PKA , S6 Kinase | |
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. | |||
T7648 | HA-100 | Myosin , PKA , PKC | |
HA-100 is an inhibitor of protein kinase | |||
T14069 | A-3 hydrochloride | CaMK , Casein Kinase , PKA , PKC | |
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectiv... | |||
TP1351 | Kemptide | PKA | |
Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK). | |||
T6747 | 8-Bromo-cAMP sodium salt | 8-Br-Camp sodium salt,8-Bromo-cAMP(sodium salt),8-Bromo-cAMP | PKA |
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase(PKA), but resistant to degradation by cyclic AMP phosphodiesterase. | |||
T6250 | H-89 dihydrochloride | Protein kinase inhibitor H-89 dihydrochloride,H 89 2HCl,5-Isoquinolinesulfonamide | PKA , S6 Kinase , Autophagy |
H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM). | |||
T1418 | Bucladesine sodium | dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt | PKA , PDE |
Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-in... | |||
T1606 | Fasudil | HA-1077,AT877 | ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy |
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK. | |||
T3060 | Fasudil hydrochloride | Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 | ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy |
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively. | |||
TP1957L | PKI (5-24) Acetate(99534-03-9 free base) | PKA | |
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM). | |||
T11020 | DHODH-IN-11 | Dehydrogenase , DNA/RNA Synthesis | |
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03. | |||
TP1789L | Malantide acetate(86555-35-3 free base) | PKA , PKC | |
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activ... | |||
T6139L | A-674563 2HCl(552325-73-2(fb-2hcl)) | ERK , Akt , PKA , CDK , PKC | |
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. | |||
T3050 | ML-7 hydrochloride | ML-7 HCl | Serine/threonin kinase , Myosin , YAP , PKA , PKC |
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and... | |||
T6303L | CCT128930 hydrochloride | CCT128930 hydrochloride(885499-61-6 Free base) | Apoptosis , Akt , PKA , mTOR , Autophagy |
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28... | |||
T27525 | HA-1004 | Serine/threonin kinase , PKA , PKC | |
HA-1004 is a inhibitor of PKG, PKA, PKC and MLC. | |||
T8681 | HA-1004 dihydrochloride | Calcium Channel , PKA , PKC | |
HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein | |||
T9530 | W 36017 | Others | |
W36017 is an impurity of lidocaine with a PKA of 7.4 for blocking neurologic activity. | |||
T17043 | TES | Others | |
TES is used to make buffer solutions in the pH range 6.8-8.2. TES has a pKa value of 7.550 (at 25°C). | |||
T11021 | DHODH-IN-12 | Dehydrogenase | |
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07. | |||
T6303 | CCT128930 | Akt , PKA , S6 Kinase , Autophagy | |
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. | |||
T8632 | Anthracene-9-carboxylic acid | Others | |
Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI. | |||
T11234 | ESI-08 | cAMP | |
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation. | |||
T32401 | KL044 | KL 044,KL-044 | Others |
KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP/PKA/CREB pathway. | |||
T21983L | PKI 14-22 amide, myristoylated Acetate | PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base) | PKA |
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP. | |||
TP1876L | CREBtide acetate(149155-45-3 free base) | PKA | |
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein). | |||
T6139 | A-674563 | A674563 | ERK , GSK-3 , Akt , PKA , CDK |
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. | |||
T65641 | TAPS | Others | |
TAPS, a biochemical buffer, safeguards the integrity of lysozyme structures against thermal denaturation at high temperatures. At a pKa of 8.1, TAPS achieves half-maximal activity of conjugated protein channels. | |||
T35328 | H-1152 dihydrochloride | H-1152 2HCl,H-1152 dihydrochloride | ROCK |
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ... | |||
T4444 | A-674563 HCl (552325-73-2(free base)) | ERK , Akt , PKA , CDK , PKC | |
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for A... | |||
T6266 | PP2 | AGL 1879,AG 1879,AGL 1879 | EGFR , Tyrosine Kinases , JAK , Src |
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2. | |||
T6187 | TDZD-8 | GSK-3β Inhibitor I,NP 01139 | GSK-3 |
TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC. | |||
T5508 | PF-AKT400 | AKT protein kinase inhibitor | Akt |
PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt. | |||
T3438 | S107 | Others | |
S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels. | |||
T11662L | INT-777 | S-EMCA | GPCR19 |
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats... | |||
T14507 | Bay 60-7550 | BAY 607550 | PDE |
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem... | |||
T6837 | Flavopiridol | L868275,Alvocidib,NSC 649890 HCl,HMR-1275 | Apoptosis , HIV Protease , CDK , Autophagy |
Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially foun... | |||
TP1890L1 | MLCK inhibitor peptide 18 acetate | MLCK inhibitor peptide 18 acetate(224579-74-2 free base) | Serine/threonin kinase |
MLCK inhibitor peptide 18 acetate is a selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable. | |||
T6745 | 5-Iodotubercidin | 5-ITu,NSC 113939 | Adenosine Receptor |
5-Iodotubercidin (NSC-113939) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4S2128 | Bilobetin | PKA , PPAR | |
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet. | |||
T6680 | Staurosporine | Antibiotic AM-2282,AM-2282,CGP 41251 | Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal |
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces... | |||
TN1694 | Gliotoxin | Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection | |
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. | |||
T2851 | Daphnetin | 7,8-Dihydroxycoumarin,Daphnetol | EGFR , PKA , PKC , Parasite , Autophagy |
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-... | |||
TN4114 | Gardenin A | ERK , LDL , MAPK , PKA , PKC | |
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects. | |||
T9135 | Epirosmanol | Others | |
Epirosmanol belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety. Epirosmanol is an extremely weak basic (essentially neutral) compound (based on its p... | |||
T2S0531 | Pinoresinol dimethyl ether | (+)-Eudesmin | Others , PKC |
Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity. It stimulates upstream MAPK, PKC, and PKA pathways, inducing neurite outgrowth in PC12 cells. | |||
T13481 | 2-Methoxyestrone | Endogenous Metabolite | |
2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone (pKa: 10.81). | |||
T5S2178 | Fargesin | (+/-)-Fargesin | Adrenergic Receptor |
1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating... | |||
T4784 | (S)-(-)-Phenylethanol | (S)-(-)-1-Phenylethanol,(-)-Methyl phenyl carbinol,(S)-(-)-sec-Phenylethyl alcohol | Others , Endogenous Metabolite |
(S)-(-)-Phenylethanol ((-)-Methyl phenyl carbinol) exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). (S)-(-)-Phenylethanol has been detected in multiple biofluids, such as feces... | |||
T5082 | Calcium 2-hydroxy-4-(methylthio)butanoate | calcium hydroxymethionine,2-Hydroxy-4-(methylthio)butyric acid calcium salt | Others , Endogenous Metabolite |
Calcium 2-hydroxy-4-(methylthio)butanoate (Calcium 2-hydroxy-4-(calcium hydroxymethionine)) is a nutrition enhancer. It exists as a solid, soluble (in water), and a weakly acidic compound (based on its pKa). 2-Hydroxy-4-... | |||
T2834 | Nobiletin | Hexamethoxyflavone | Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy |
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic... | |||
T3739 | 2,6-Dimethoxyquinone | 2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone | Others |
2,6-Dimethoxyquinone (2,6-Dimethoxy-p-benzoquinone) is a member of the class of compounds known as P-benzoquinones. 2,6-Dimethoxyquinone is slightly soluble (in water) and an extremely weak basic (essentially neutral) co... | |||
T3836 | Eudesmin | MAPK , S6 Kinase | |
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m... | |||
T4973 | Paraxanthine | 1,7-DIMETHYLXANTHINE | Endogenous Metabolite |
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc... | |||
Fr13883 | 3-Methoxyphenylacetic acid | Others | |
3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid... | |||
T4773 | 3-Ethoxy-3-oxopropanoic acid | Monoethyl malonic acid,Ethyl hydrogen malonate | Others , Endogenous Metabolite |
3-Ethoxy-3-oxopropanoic acid (Monoethyl malonic acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. 3-Et... | |||
T4768 | Diethyl oxalpropionate | HYL 2-METHYL-3-OXOSUCCINATE | Others , Endogenous Metabolite |
Diethyl oxalpropionate (HYL 2-METHYL-3-OXOSUCCINATE), also known as methyloxalacetic acid diethyl ester or diethyl methyloxalacetate, is a member of the class of compounds known as beta-keto acids and derivatives. These ... | |||
T4798 | N-Acetyl-L-leucine | Others , Endogenous Metabolite | |
N-Acetylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino... | |||
T8105 | Indole-3-carboxaldehyde | 3-Formylindole | Endogenous Metabolite |
1H-Indole-3-carboxaldehyde (3-Formylindole), also known as 3-formylindole or 3-indolealdehyde, belongs to the class of organic compounds known as indoles. Indoles are compounds containing an indole moiety, which consists... | |||
T6S1684 | 8-Gingerol | Antioxidant , Antibacterial , TRP/TRPV Channel | |
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic... | |||
T4837 | Itaconic acid | methylene-butanedioicaci | Others , Endogenous Metabolite |
Itaconic acid (methylene-butanedioicaci), also known as itaconate, belongs to the class of organic compounds known as branched fatty acids. These are fatty acids containing a branched chain. Itaconic acid exists as a sol... | |||
T6S1740 | Nardosinone | Others | |
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t... | |||
T8274 | 3-Methyl-L-histidine | Endogenous Metabolite | |
3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t... | |||
T4826 | L-Histidine monohydrochloride monohydrat | Others , Endogenous Metabolite | |
Histidine (abbreviated as His or H) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a charged, polar because of the hydrophilic ... | |||
T8053 | N-Acetyl-L-arginine | Ac-Arg-OH | Endogenous Metabolite |
N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-... | |||
T17198 | UCN-02 | 7-epi-Hydroxystaurosporine | Others |
UCN-02 is a selective protein kinase C inhibitor produced by Streptomyces strain N-12 (IC50s: 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively). | |||
T15636 | K-252a | Antibiotic K 252a,Antibiotic SF 2370,SF2370 | Others |
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphoryla... | |||
T30784 | Cedrene | AI3-51328,AI3 51328,AI351328 | |
Cedrene can regulate hepatic steatosis via the cAMP-PKA pathway. | |||
T29462 | 5-OH-HxMF | ||
5-OH-HxMF is an inducer of neurite growth in PC12 cells through the camp / PKA / CREB pathway. | |||
TN4317 | Isopedicin | NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE | |
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE. | |||
T32329 | Juzirine | ||
Juzirine is a member of the class of benzylisoquinolines. Benzylisoquinolines are organic compounds containing an isoquinoline to which a benzyl group is attached. Juzirine, practically insoluble (in water), is a very we... | |||
T16791 | Rottlerin | Mallotoxin,NSC 56346,NSC 94525 | CaMK , Apoptosis , Others , HIV Protease , PKA , PKC , Autophagy |
Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00677 | PKA/PRKACA Protein, Canine, Recombinant (His) | Canine | E. coli |
The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide varie... | |||
TMPK-00696 | PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II) | Human | Baculovirus-Insect Cells |
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-... | |||
TMPY-04425 | PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated... | |||
TMPY-04378 | MAPKAPK3 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ... | |||
TMPY-05207 | PRKAR1A Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions... | |||
TMPY-03656 | PRKAR1A Protein, Human, Recombinant (His) | Human | HEK293 |
PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions... | |||
TMPJ-01309 | PKI-Beta Protein, Human, Recombinant (His) | Human | E. coli |
cAMP-Dependent Protein Kinase Inhibitor β (PKI-β) is a member of the PKI family. As a member of the cAMP-dependent protein kinase inhibitor family,It has been shown that PKI-β is an extremely potent competitive inhibitor... | |||
TMPH-00246 | Bovine coronavirus (strain Mebus) Non-structural Protein 4a (His & SUMOstar) | BCoV | Yeast |
age-related increase in cAMP-dependent protein kinase (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2+)-storing... | |||
TMPH-00120 | Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc) | Aspergillus clavatus | E. coli |
The authors present evidence that the transcription of the Gcn5-like acetyltransferase YfiQ of Escherichia coli (proposed name: PatZ) is regulated by cAMP-CRP and its implications on acetate metabolism regulation. PMID: ... | |||
TMPH-00704 | PatZ Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli |
The authors present evidence that the transcription of the Gcn5-like acetyltransferase YfiQ of Escherichia coli (proposed name: PatZ) is regulated by cAMP-CRP and its implications on acetate metabolism regulation. PMID: ... | |||
TMPJ-00528 | PPP1R1A Protein, Human, Recombinant (His) | Human | E. coli |
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein pla... | |||
TMPY-01117 | MRAP Protein, Human, Recombinant (hFc) | Human | HEK293 |
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,... | |||
TMPJ-00886 | ATF1 Protein, Human, Recombinant (His) | Human | E. coli |
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by r... | |||
TMPH-02617 | COX5A Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhib... | |||
TMPH-01670 | Metallothionein-4/MT4 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-contai... | |||
TMPH-00939 | Anoctamin-5/ANO5 Protein, Human, Recombinant (His) | Human | HEK293 |
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah... |
Cat No. | Product Name | ||
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L1610 | FDA-Approved Kinase Inhibitor Library | 280 compounds | |
Targetmol’s FDA-Approved Kinase Inhibitor Library contains 280 marketed drugs with proven kinase inhibitory activity. These kinases include Insulin/IGF Receptors、PI 3-Kinase、CaM Kinase II、JAK、PKA、CDK、JNK、PKC、CKI II、MAPK、... | |||
L1600 | Kinase Inhibitor Library | 2230 compounds | |
A unique collection of 2230 kinase inhibitors for high throughput screening and high content screening for drug discovery in kinase related diseases; | |||
L7700 | Neural Regeneration Compound Library | 529 compounds | |
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening; | |||
L5100 | Fluorochemical Library | 583 compounds | |
A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS); |