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Search Results for " pka "

Targets

147

Compounds

33

Natural Products

16

Recombinant Proteins

4

Libraries

Cat No. Product Name Synonyms Targets
T39217 PKA-IN-1 PKA
PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study diseases of the immune system.
T21674L PKA inhibitor fragment (6-22) amide Acetate PKA inhibitor fragment (6-22) amide Acetate(121932-06-7 Free base) PKA
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).
T75888 PKA Inhibitor Fragment (6-22) amide TFA PKI-(6-22)-amide TFA,PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base) PKA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of the highly potent cAMP-dependent protein kinase A (PKA) inhibitor (Ki: 2.8 nM).PKA Inhibitor Fragment (6-22) amide TFA ...
T36019 PKA Inhibitor (5-24) (trifluoroacetate salt)
PKI PKA Inhibitor (5-24) is a synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki= 2.3 nM) derived from the active site of the skeletal muscle inhibitor protein.1It mimics the protein substrate by bind...
T72885 Akt1&PKA-IN-1
Akt1&PKA-IN-1 is a potent dual inhibitor targeting Akt and PKA, exhibiting IC50 values of 0.11 μM for Akt, 0.03 μM for PKAα, and 9.8 μM for CDK2. Notably, it demonstrates selectivity for cyclin-dependent kinase 2 (CDK2).
T72886 Akt1&PKA-IN-2
Akt1&PKA-IN-2 ((R)-29), a compound with specificity towards PKB/AKT and notable selectivity for cyclin-dependent kinase 2 (CDK2), effectively inhibits AKT1, PKAa, and CDK2a with IC50 values of 0.007 µM, 0.01 µM, and 0.69...
T76381 H1-7 (histone H1 phosphorylation site), PKA Substrate
H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].
T3498 CCG215022 GRK , PKA
CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.
T6304 AT7867 Akt , PKA , S6 Kinase
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.
T12103 MR-L2 PDE
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
T3269 Metadoxine pyridoxine-pyrrolidone carboxylat,Metasin,Metadoxil 5-HT Receptor , PKA
Metadoxine (Metadoxil) is a neurotransmitter stimulant.
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T7648 HA-100 Myosin , PKA , PKC
HA-100 is an inhibitor of protein kinase
T14069 A-3 hydrochloride CaMK , Casein Kinase , PKA , PKC
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 µM and 80 µM, respectiv...
TP1351 Kemptide PKA
Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).
T6747 8-Bromo-cAMP sodium salt 8-Br-Camp sodium salt,8-Bromo-cAMP(sodium salt),8-Bromo-cAMP PKA
8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase(PKA), but resistant to degradation by cyclic AMP phosphodiesterase.
T6250 H-89 dihydrochloride Protein kinase inhibitor H-89 dihydrochloride,H 89 2HCl,5-Isoquinolinesulfonamide PKA , S6 Kinase , Autophagy
H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).
T1418 Bucladesine sodium dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt PKA , PDE
Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties. Bucladesine sodium is also a cAMP-dependent protein kinase (PKA) activator and a phosphodiester (PDE) inhibitor. Bucladesine sodium has anti-in...
T1606 Fasudil HA-1077,AT877 ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T3060 Fasudil hydrochloride Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
TP1957L PKI (5-24) Acetate(99534-03-9 free base) PKA
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).
T11020 DHODH-IN-11 Dehydrogenase , DNA/RNA Synthesis
DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
TP1789L Malantide acetate(86555-35-3 free base) PKA , PKC
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activ...
T6139L A-674563 2HCl(552325-73-2(fb-2hcl)) ERK , Akt , PKA , CDK , PKC
A-674563 2HCl is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T3050 ML-7 hydrochloride ML-7 HCl Serine/threonin kinase , Myosin , YAP , PKA , PKC
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and...
T6303L CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base) Apoptosis , Akt , PKA , mTOR , Autophagy
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...
T27525 HA-1004 Serine/threonin kinase , PKA , PKC
HA-1004 is a inhibitor of PKG, PKA, PKC and MLC.
T8681 HA-1004 dihydrochloride Calcium Channel , PKA , PKC
HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
T9530 W 36017 Others
W36017 is an impurity of lidocaine with a PKA of 7.4 for blocking neurologic activity.
T17043 TES Others
TES is used to make buffer solutions in the pH range 6.8-8.2. TES has a pKa value of 7.550 (at 25°C).
T11021 DHODH-IN-12 Dehydrogenase
DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.
T6303 CCT128930 Akt , PKA , S6 Kinase , Autophagy
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase.
T8632 Anthracene-9-carboxylic acid Others
Anthracene-9-carboxylic acid is an inhibitor of chloride transport with a moderate to strong inhibitory action on PKA activated cardiac IcI.
T11234 ESI-08 cAMP
ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.
T32401 KL044 KL 044,KL-044 Others
KL044 is a cryptochrome 1 (CRY1) activator that prolongs circadian rhythms and inhibits PER2 activity. KL044 inhibits melanogenesis by inhibiting the cAMP/PKA/CREB pathway.
T21983L PKI 14-22 amide, myristoylated Acetate PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base) PKA
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.
TP1876L CREBtide acetate(149155-45-3 free base) PKA
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).
T6139 A-674563 A674563 ERK , GSK-3 , Akt , PKA , CDK
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.
T65641 TAPS Others
TAPS, a biochemical buffer, safeguards the integrity of lysozyme structures against thermal denaturation at high temperatures. At a pKa of 8.1, TAPS achieves half-maximal activity of conjugated protein channels.
T35328 H-1152 dihydrochloride H-1152 2HCl,H-1152 dihydrochloride ROCK
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 ...
T4444 A-674563 HCl (552325-73-2(free base)) ERK , Akt , PKA , CDK , PKC
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 (IC50: 16/46 nM) but is 10- to >1, 800-fold selective for A...
T6266 PP2 AGL 1879,AG 1879,AGL 1879 EGFR , Tyrosine Kinases , JAK , Src
PP2 (AG 1879,AGL 1879) is a effective inhibitor of Lck/Fyn (IC50:4/5 nM) , ~100-fold less potent to EGFR, inactive for ZAP-70, PKA and JAK2.
T6187 TDZD-8 GSK-3β Inhibitor I,NP 01139 GSK-3
TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
T5508 PF-AKT400 AKT protein kinase inhibitor Akt
PF-AKT400 (AKT protein kinase inhibitor) is a broadly selective and ATP-competitive inhibitor of Akt.
T3438 S107 Others
S107 is a RyR-selective 1, 4-benzothiazepine derivative that stabilizes RyR2 channels by enhancing the binding affinity of calstabin2 to mutant and/or PKA-phosphorylated channels.
T11662L INT-777 S-EMCA GPCR19
INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats...
T14507 Bay 60-7550 BAY 607550 PDE
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and mem...
T6837 Flavopiridol L868275,Alvocidib,NSC 649890 HCl,HMR-1275 Apoptosis , HIV Protease , CDK , Autophagy
Flavopiridol (Alvocidib) (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7. Flavopiridol is initially foun...
TP1890L1 MLCK inhibitor peptide 18 acetate MLCK inhibitor peptide 18 acetate(224579-74-2 free base) Serine/threonin kinase
MLCK inhibitor peptide 18 acetate is a selective competitive inhibitor of myosin light chain kinase (IC50 = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.
T6745 5-Iodotubercidin 5-ITu,NSC 113939 Adenosine Receptor
5-Iodotubercidin (NSC-113939) is a potent adenosine kinase inhibitor with IC50 of 26 nM. It inhibits nucleoside transporter, CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC.

Compounds

PKA-IN-1
T39217
Synonym:
Target: PKA
PKA inhibitor fragment (6-22) amide Acetate
T21674L
Synonym: PKA inhibitor fragment (6-22) amide Acetate(121932-06-7 Free base)
Target: PKA
PKA Inhibitor Fragment (6-22) amide TFA
T75888
Synonym: PKI-(6-22)-amide TFA,PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)
Target: PKA
PKA Inhibitor (5-24) (trifluoroacetate salt)
T36019
Synonym:
Target:
Akt1&PKA-IN-1
T72885
Synonym:
Target:
Akt1&PKA-IN-2
T72886
Synonym:
Target:
H1-7 (histone H1 phosphorylation site), PKA Substrate
T76381
Synonym:
Target:
CCG215022
T3498
Synonym:
Target: GRK, PKA
AT7867
T6304
Synonym:
Target: Akt, PKA, S6 Kinase
MR-L2
T12103
Synonym:
Target: PDE
Metadoxine
T3269
Synonym: pyridoxine-pyrrolidone carboxylat,Metasin,Metadoxil
Target: 5-HT Receptor, PKA
AT13148
T2482
Synonym:
Target: ROCK, SGK, Akt, PKA, S6 Kinase
HA-100
T7648
Synonym:
Target: Myosin, PKA, PKC
A-3 hydrochloride
T14069
Synonym:
Target: CaMK, Casein Kinase, PKA, PKC
Kemptide
TP1351
Synonym:
Target: PKA
8-Bromo-cAMP sodium salt
T6747
Synonym: 8-Br-Camp sodium salt,8-Bromo-cAMP(sodium salt),8-Bromo-cAMP
Target: PKA
H-89 dihydrochloride
T6250
Synonym: Protein kinase inhibitor H-89 dihydrochloride,H 89 2HCl,5-Isoquinolinesulfonamide
Target: PKA, S6 Kinase, Autophagy
Bucladesine sodium
T1418
Synonym: dbcAMP,Dibutyryl-cAMP sodium salt,Dibutyryl-cAMP,DC2797,Sodium dibutyryl cAMP,Bucladesine,Bucladesine sodium salt
Target: PKA, PDE
Fasudil
T1606
Synonym: HA-1077,AT877
Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy
Fasudil hydrochloride
T3060
Synonym: Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877
Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy
PKI (5-24) Acetate(99534-03-9 free base)
TP1957L
Synonym:
Target: PKA
DHODH-IN-11
T11020
Synonym:
Target: Dehydrogenase, DNA/RNA Synthesis
Malantide acetate(86555-35-3 free base)
TP1789L
Synonym:
Target: PKA, PKC
A-674563 2HCl(552325-73-2(fb-2hcl))
T6139L
Synonym:
Target: ERK, Akt, PKA, CDK, PKC
ML-7 hydrochloride
T3050
Synonym: ML-7 HCl
Target: Serine/threonin kinase, Myosin, YAP, PKA, PKC
CCT128930 hydrochloride
T6303L
Synonym: CCT128930 hydrochloride(885499-61-6 Free base)
Target: Apoptosis, Akt, PKA, mTOR, Autophagy
HA-1004
T27525
Synonym:
Target: Serine/threonin kinase, PKA, PKC
HA-1004 dihydrochloride
T8681
Synonym:
Target: Calcium Channel, PKA, PKC
W 36017
T9530
Synonym:
Target: Others
TES
T17043
Synonym:
Target: Others
DHODH-IN-12
T11021
Synonym:
Target: Dehydrogenase
CCT128930
T6303
Synonym:
Target: Akt, PKA, S6 Kinase, Autophagy
Anthracene-9-carboxylic acid
T8632
Synonym:
Target: Others
ESI-08
T11234
Synonym:
Target: cAMP
KL044
T32401
Synonym: KL 044,KL-044
Target: Others
PKI 14-22 amide, myristoylated Acetate
T21983L
Synonym: PKI 14-22 amide, myristoylated Acetate(201422-03-9 Free base)
Target: PKA
CREBtide acetate(149155-45-3 free base)
TP1876L
Synonym:
Target: PKA
A-674563
T6139
Synonym: A674563
Target: ERK, GSK-3, Akt, PKA, CDK
TAPS
T65641
Synonym:
Target: Others
H-1152 dihydrochloride
T35328
Synonym: H-1152 2HCl,H-1152 dihydrochloride
Target: ROCK
A-674563 HCl (552325-73-2(free base))
T4444
Synonym:
Target: ERK, Akt, PKA, CDK, PKC
PP2
T6266
Synonym: AGL 1879,AG 1879,AGL 1879
Target: EGFR, Tyrosine Kinases, JAK, Src
TDZD-8
T6187
Synonym: GSK-3β Inhibitor I,NP 01139
Target: GSK-3
PF-AKT400
T5508
Synonym: AKT protein kinase inhibitor
Target: Akt
S107
T3438
Synonym:
Target: Others
INT-777
T11662L
Synonym: S-EMCA
Target: GPCR19
Bay 60-7550
T14507
Synonym: BAY 607550
Target: PDE
Flavopiridol
T6837
Synonym: L868275,Alvocidib,NSC 649890 HCl,HMR-1275
Target: Apoptosis, HIV Protease, CDK, Autophagy
MLCK inhibitor peptide 18 acetate
TP1890L1
Synonym: MLCK inhibitor peptide 18 acetate(224579-74-2 free base)
Target: Serine/threonin kinase
5-Iodotubercidin
T6745
Synonym: 5-ITu,NSC 113939
Target: Adenosine Receptor
1 2 3
Cat No. Product Name Synonyms Targets
T4S2128 Bilobetin PKA , PPAR
Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.
T6680 Staurosporine Antibiotic AM-2282,AM-2282,CGP 41251 Apoptosis , PKA , Antibacterial , Antibiotic , Src , PKC , Antifungal
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces...
TN1694 Gliotoxin Apoptosis , NF-κB , Wnt/beta-catenin , COX , PKA , Antibacterial , Antifection
Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway.
T2851 Daphnetin 7,8-Dihydroxycoumarin,Daphnetol EGFR , PKA , PKC , Parasite , Autophagy
Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...
TN4114 Gardenin A ERK , LDL , MAPK , PKA , PKC
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
T9135 Epirosmanol Others
Epirosmanol belongs to the class of organic compounds known as diterpene lactones. These are diterpenoids containing a lactone moiety. Epirosmanol is an extremely weak basic (essentially neutral) compound (based on its p...
T2S0531 Pinoresinol dimethyl ether (+)-Eudesmin Others , PKC
Pinoresinol dimethyl ether, a non-phenolic furan lignan isolated from the bark of Magnolia kobus, exhibits neuroactivity. It stimulates upstream MAPK, PKC, and PKA pathways, inducing neurite outgrowth in PC12 cells.
T13481 2-Methoxyestrone Endogenous Metabolite
2-Methoxyestrone is a methoxylated catechol estrogen and metabolite of estrone (pKa: 10.81).
T5S2178 Fargesin (+/-)-Fargesin Adrenergic Receptor
1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...
T4784 (S)-(-)-Phenylethanol (S)-(-)-1-Phenylethanol,(-)-Methyl phenyl carbinol,(S)-(-)-sec-Phenylethyl alcohol Others , Endogenous Metabolite
(S)-(-)-Phenylethanol ((-)-Methyl phenyl carbinol) exists as a solid, soluble (in water), and a very weakly acidic compound (based on its pKa). (S)-(-)-Phenylethanol has been detected in multiple biofluids, such as feces...
T5082 Calcium 2-hydroxy-4-(methylthio)butanoate calcium hydroxymethionine,2-Hydroxy-4-(methylthio)butyric acid calcium salt Others , Endogenous Metabolite
Calcium 2-hydroxy-4-(methylthio)butanoate (Calcium 2-hydroxy-4-(calcium hydroxymethionine)) is a nutrition enhancer. It exists as a solid, soluble (in water), and a weakly acidic compound (based on its pKa). 2-Hydroxy-4-...
T2834 Nobiletin Hexamethoxyflavone Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...
T3739 2,6-Dimethoxyquinone 2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone Others
2,6-Dimethoxyquinone (2,6-Dimethoxy-p-benzoquinone) is a member of the class of compounds known as P-benzoquinones. 2,6-Dimethoxyquinone is slightly soluble (in water) and an extremely weak basic (essentially neutral) co...
T3836 Eudesmin MAPK , S6 Kinase
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...
T4973 Paraxanthine 1,7-DIMETHYLXANTHINE Endogenous Metabolite
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc...
Fr13883 3-Methoxyphenylacetic acid Others
3-Methoxyphenylacetic acid belongs to the class of organic compounds known as anisoles. 3-Methoxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa).3-Methoxyphenylacetic acid...
T4773 3-Ethoxy-3-oxopropanoic acid Monoethyl malonic acid,Ethyl hydrogen malonate Others , Endogenous Metabolite
3-Ethoxy-3-oxopropanoic acid (Monoethyl malonic acid) belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups. 3-Et...
T4768 Diethyl oxalpropionate HYL 2-METHYL-3-OXOSUCCINATE Others , Endogenous Metabolite
Diethyl oxalpropionate (HYL 2-METHYL-3-OXOSUCCINATE), also known as methyloxalacetic acid diethyl ester or diethyl methyloxalacetate, is a member of the class of compounds known as beta-keto acids and derivatives. These ...
T4798 N-Acetyl-L-leucine Others , Endogenous Metabolite
N-Acetylleucine belongs to the class of organic compounds known as leucine and derivatives. Leucine and derivatives are compounds containing leucine or a derivative thereof resulting from reaction of leucine at the amino...
T8105 Indole-3-carboxaldehyde 3-Formylindole Endogenous Metabolite
1H-Indole-3-carboxaldehyde (3-Formylindole), also known as 3-formylindole or 3-indolealdehyde, belongs to the class of organic compounds known as indoles. Indoles are compounds containing an indole moiety, which consists...
T6S1684 8-Gingerol Antioxidant , Antibacterial , TRP/TRPV Channel
1. 8-Gingerol has antioxidant activity. 2. 8-Gingerol has antimycobacterial activity. 3. 8-Gingerol could be used as an effective skin-whitening agent. 4. 8-Gingerol shows antipyretic and anti-inflammation characteristic...
T4837 Itaconic acid methylene-butanedioicaci Others , Endogenous Metabolite
Itaconic acid (methylene-butanedioicaci), also known as itaconate, belongs to the class of organic compounds known as branched fatty acids. These are fatty acids containing a branched chain. Itaconic acid exists as a sol...
T6S1740 Nardosinone Others
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t...
T8274 3-Methyl-L-histidine Endogenous Metabolite
3-Methylhistidine belongs to the class of organic compounds known as histidine and derivatives. Histidine and derivatives are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at t...
T4826 L-Histidine monohydrochloride monohydrat Others , Endogenous Metabolite
Histidine (abbreviated as His or H) is an alpha-amino acid. The L-isomer is one of the 22 proteinogenic amino acids, i.e., the building blocks of proteins. It is classified as a charged, polar because of the hydrophilic ...
T8053 N-Acetyl-L-arginine Ac-Arg-OH Endogenous Metabolite
N-Acetyl-L-arginine (Ac-Arg-OH) belongs to the class of organic compounds known as n-acyl-l-alpha-amino acids. These are n-acylated alpha amino acids which have the L-configuration of the alpha-carbon atom. N-a-Acetyl-L-...
T17198 UCN-02 7-epi-Hydroxystaurosporine Others
UCN-02 is a selective protein kinase C inhibitor produced by Streptomyces strain N-12 (IC50s: 62 nM and 250 nM for PKC and protein kinase A (PKA), respectively).
T15636 K-252a Antibiotic K 252a,Antibiotic SF 2370,SF2370 Others
K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphoryla...
T30784 Cedrene AI3-51328,AI3 51328,AI351328
Cedrene can regulate hepatic steatosis via the cAMP-PKA pathway.
T29462 5-OH-HxMF
5-OH-HxMF is an inducer of neurite growth in PC12 cells through the camp / PKA / CREB pathway.
TN4317 Isopedicin NADPH-oxidase , cAMP , p38 MAPK , PKA , JNK , PDE
Isopedicin has anti-inflammatory functions, it inhibits the O(2)(*)(-) production in human neutrophils by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.
T32329 Juzirine
Juzirine is a member of the class of benzylisoquinolines. Benzylisoquinolines are organic compounds containing an isoquinoline to which a benzyl group is attached. Juzirine, practically insoluble (in water), is a very we...
T16791 Rottlerin Mallotoxin,NSC 56346,NSC 94525 CaMK , Apoptosis , Others , HIV Protease , PKA , PKC , Autophagy
Rottlerin (NSC-56346) is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase...

Natural Products

Bilobetin
T4S2128
Synonym:
Target: PKA, PPAR
Staurosporine
T6680
Synonym: Antibiotic AM-2282,AM-2282,CGP 41251
Target: Apoptosis, PKA, Antibacterial, Antibiotic, Src, PKC, Antifungal
Gliotoxin
TN1694
Synonym:
Target: Apoptosis, NF-κB, Wnt/beta-catenin, COX, PKA, Antibacterial, Antifection
Daphnetin
T2851
Synonym: 7,8-Dihydroxycoumarin,Daphnetol
Target: EGFR, PKA, PKC, Parasite, Autophagy
Gardenin A
TN4114
Synonym:
Target: ERK, LDL, MAPK, PKA, PKC
Epirosmanol
T9135
Synonym:
Target: Others
Pinoresinol dimethyl ether
T2S0531
Synonym: (+)-Eudesmin
Target: Others, PKC
2-Methoxyestrone
T13481
Synonym:
Target: Endogenous Metabolite
Fargesin
T5S2178
Synonym: (+/-)-Fargesin
Target: Adrenergic Receptor
(S)-(-)-Phenylethanol
T4784
Synonym: (S)-(-)-1-Phenylethanol,(-)-Methyl phenyl carbinol,(S)-(-)-sec-Phenylethyl alcohol
Target: Others, Endogenous Metabolite
Calcium 2-hydroxy-4-(methylthio)butanoate
T5082
Synonym: calcium hydroxymethionine,2-Hydroxy-4-(methylthio)butyric acid calcium salt
Target: Others, Endogenous Metabolite
Nobiletin
T2834
Synonym: Hexamethoxyflavone
Target: Apoptosis, MMP, Reactive Oxygen Species, ROR, Autophagy
2,6-Dimethoxyquinone
T3739
Synonym: 2,6-Dimethoxy-1,4-benzoquinone,2,6-Dimethoxy-p-benzoquinone,2,6-Dimethoxybenzoquinone
Target: Others
Eudesmin
T3836
Synonym:
Target: MAPK, S6 Kinase
Paraxanthine
T4973
Synonym: 1,7-DIMETHYLXANTHINE
Target: Endogenous Metabolite
3-Methoxyphenylacetic acid
Fr13883
Synonym:
Target: Others
3-Ethoxy-3-oxopropanoic acid
T4773
Synonym: Monoethyl malonic acid,Ethyl hydrogen malonate
Target: Others, Endogenous Metabolite
Diethyl oxalpropionate
T4768
Synonym: HYL 2-METHYL-3-OXOSUCCINATE
Target: Others, Endogenous Metabolite
N-Acetyl-L-leucine
T4798
Synonym:
Target: Others, Endogenous Metabolite
Indole-3-carboxaldehyde
T8105
Synonym: 3-Formylindole
Target: Endogenous Metabolite
8-Gingerol
T6S1684
Synonym:
Target: Antioxidant, Antibacterial, TRP/TRPV Channel
Itaconic acid
T4837
Synonym: methylene-butanedioicaci
Target: Others, Endogenous Metabolite
Nardosinone
T6S1740
Synonym:
Target: Others
3-Methyl-L-histidine
T8274
Synonym:
Target: Endogenous Metabolite
L-Histidine monohydrochloride monohydrat
T4826
Synonym:
Target: Others, Endogenous Metabolite
N-Acetyl-L-arginine
T8053
Synonym: Ac-Arg-OH
Target: Endogenous Metabolite
UCN-02
T17198
Synonym: 7-epi-Hydroxystaurosporine
Target: Others
K-252a
T15636
Synonym: Antibiotic K 252a,Antibiotic SF 2370,SF2370
Target: Others
Cedrene
T30784
Synonym: AI3-51328,AI3 51328,AI351328
Target:
5-OH-HxMF
T29462
Synonym:
Target:
Isopedicin
TN4317
Synonym:
Target: NADPH-oxidase, cAMP, p38 MAPK, PKA, JNK, PDE
Juzirine
T32329
Synonym:
Target:
Rottlerin
T16791
Synonym: Mallotoxin,NSC 56346,NSC 94525
Target: CaMK, Apoptosis, Others, HIV Protease, PKA, PKC, Autophagy

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00677 PKA/PRKACA Protein, Canine, Recombinant (His) Canine E. coli
The cAMP-dependent protein kinase PKA is a well-characterized member of the serine-threonine protein AGC kinase family and is the effector kinase of cAMP signaling. As such, PKA is involved in the control of a wide varie...
TMPK-00696 PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II) Human Baculovirus-Insect Cells
The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-...
TMPY-04425 PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated...
TMPY-04378 MAPKAPK3 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases ...
TMPY-05207 PRKAR1A Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions...
TMPY-03656 PRKAR1A Protein, Human, Recombinant (His) Human HEK293
PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions...
TMPJ-01309 PKI-Beta Protein, Human, Recombinant (His) Human E. coli
cAMP-Dependent Protein Kinase Inhibitor β (PKI-β) is a member of the PKI family. As a member of the cAMP-dependent protein kinase inhibitor family,It has been shown that PKI-β is an extremely potent competitive inhibitor...
TMPH-00246 Bovine coronavirus (strain Mebus) Non-structural Protein 4a (His & SUMOstar) BCoV Yeast
age-related increase in cAMP-dependent protein kinase (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex specifically targets spine synapses and the Ca(2+)-storing...
TMPH-00120 Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc) Aspergillus clavatus E. coli
The authors present evidence that the transcription of the Gcn5-like acetyltransferase YfiQ of Escherichia coli (proposed name: PatZ) is regulated by cAMP-CRP and its implications on acetate metabolism regulation. PMID: ...
TMPH-00704 PatZ Protein, E. coli, Recombinant (His & Myc) E. coli E. coli
The authors present evidence that the transcription of the Gcn5-like acetyltransferase YfiQ of Escherichia coli (proposed name: PatZ) is regulated by cAMP-CRP and its implications on acetate metabolism regulation. PMID: ...
TMPJ-00528 PPP1R1A Protein, Human, Recombinant (His) Human E. coli
Protein Phosphatase 1 Regulatory Subunit 1A (PPP1R1A) is an inhibitor of protein-phosphatase 1. PPP1R1A is a cellular regulator of eIF2 alpha phosphorylation. In hormonal control of glycogen metabolism, IPP-1 protein pla...
TMPY-01117 MRAP Protein, Human, Recombinant (hFc) Human HEK293
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain,...
TMPJ-00886 ATF1 Protein, Human, Recombinant (His) Human E. coli
Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by r...
TMPH-02617 COX5A Protein, Mouse, Recombinant (His & SUMO) Mouse E. coli
Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhib...
TMPH-01670 Metallothionein-4/MT4 Protein, Human, Recombinant (His & SUMO) Human E. coli
Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-contai...
TMPH-00939 Anoctamin-5/ANO5 Protein, Human, Recombinant (His) Human HEK293
G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...
PKA/PRKACA Protein, Canine, Recombinant (His)
TMPK-00677
Species: Canine
Expression System: E. coli
PRAK/MAPKAPK5 Protein, Human, Recombinant (Strep-II)
TMPK-00696
Species: Human
Expression System: Baculovirus-Insect Cells
PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)
TMPY-04425
Species: Human
Expression System: Baculovirus-Insect Cells
MAPKAPK3 Protein, Human, Recombinant (GST)
TMPY-04378
Species: Human
Expression System: Baculovirus-Insect Cells
PRKAR1A Protein, Mouse, Recombinant (His)
TMPY-05207
Species: Mouse
Expression System: Baculovirus-Insect Cells
PRKAR1A Protein, Human, Recombinant (His)
TMPY-03656
Species: Human
Expression System: HEK293
PKI-Beta Protein, Human, Recombinant (His)
TMPJ-01309
Species: Human
Expression System: E. coli
Bovine coronavirus (strain Mebus) Non-structural Protein 4a (His & SUMOstar)
TMPH-00246
Species: BCoV
Expression System: Yeast
Ribonuclease clavin Protein, Aspergillus clavatus, Recombinant (His & Myc)
TMPH-00120
Species: Aspergillus clavatus
Expression System: E. coli
PatZ Protein, E. coli, Recombinant (His & Myc)
TMPH-00704
Species: E. coli
Expression System: E. coli
PPP1R1A Protein, Human, Recombinant (His)
TMPJ-00528
Species: Human
Expression System: E. coli
MRAP Protein, Human, Recombinant (hFc)
TMPY-01117
Species: Human
Expression System: HEK293
ATF1 Protein, Human, Recombinant (His)
TMPJ-00886
Species: Human
Expression System: E. coli
COX5A Protein, Mouse, Recombinant (His & SUMO)
TMPH-02617
Species: Mouse
Expression System: E. coli
Metallothionein-4/MT4 Protein, Human, Recombinant (His & SUMO)
TMPH-01670
Species: Human
Expression System: E. coli
Anoctamin-5/ANO5 Protein, Human, Recombinant (His)
TMPH-00939
Species: Human
Expression System: HEK293
Cat No. Product Name
L1610 FDA-Approved Kinase Inhibitor Library

280 compounds
Targetmol’s FDA-Approved Kinase Inhibitor Library contains 280 marketed drugs with proven kinase inhibitory activity. These kinases include Insulin/IGF Receptors、PI 3-Kinase、CaM Kinase II、JAK、PKA、CDK、JNK、PKC、CKI II、MAPK、...
L1600 Kinase Inhibitor Library

2230 compounds
A unique collection of 2230 kinase inhibitors for high throughput screening and high content screening for drug discovery in kinase related diseases;
L7700 Neural Regeneration Compound Library

529 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L5100 Fluorochemical Library

583 compounds
A unique collection of 583 fluorochemicals that can be used for high through-put screening (HTS) and high content screening (HCS);
TargetMol