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Interleukins, ILs

Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes) as well as some other body cells. The human genome encodes more than 50 interleukins and related proteins. The function of the immune system primarily depends on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by CD4 helper T-lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.

  • IL-23 Protein, Mouse, Recombinant (His)
    TMPY-03526
    IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.3 kDa and the accession number is Q9EQ14&P43432.
    • $245
    In Stock
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    QTY
    TargetMol | Inhibitor Hot
  • IL-4 Protein, Mouse, Recombinant
    TMPY-02558
    IL-4 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.4 kDa and the accession number is P07750.
    • $52
    In Stock
    Size
    QTY
    TargetMol | Inhibitor Hot
  • IL-1 beta/IL-1F2 Protein, Mouse, Recombinant
    TMPY-02134
    IL-1 beta IL-1F2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P10749.
    • $197
    In Stock
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    QTY
  • IL-2 Protein, Mouse, Recombinant
    TMPY-02788
    IL-2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4kDa and the accession number is P04351.
    • $106
    In Stock
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    QTY
  • IL-4 Protein, Human, Recombinant
    TMPY-01862
    IL-4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is P05112-1.
    • $177
    In Stock
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    QTY
  • IL-1 beta/IL-1F2 Protein, Human, Recombinant
    TMPY-01049
    IL-1 beta IL-1F2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is P01584.
    • $177
    In Stock
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    QTY
  • IL-6 Protein, Mouse, Recombinant
    TMPY-03238
    IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.
    • $157
    7-10 days
    Size
    QTY
  • IL-1 alpha/IL-1A Protein, Human, Recombinant (hFc)
    TMPJ-00162
    IL-1 alpha IL-1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 54 KDa and the accession number is P01583.
    • $118
    In Stock
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    QTY
  • IL-15 Protein, Human, Recombinant
    TMPY-04632
    IL-15 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 12.8 kDa and the accession number is P40933-1.
    • $126
    In Stock
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    QTY
  • IL-7 Protein, Mouse, Recombinant (His)
    TMPJ-00038
    Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development. It is important for proliferation during certain stages of B-cell maturation. IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2. It is required for optimal T cell-dendritic cell interaction.
    • $118
    In Stock
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  • IL-6 Protein, Human, Recombinant
    TMPY-00863
    IL-6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.95 kDa and the accession number is P05231.
    • $177
    In Stock
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    QTY
  • IL-3 Protein, Mouse, Recombinant
    TMPY-04845
    IL-3 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.7 kDa and the accession number is P01586.
    • $114
    In Stock
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  • IL-13 Protein, Mouse, Recombinant
    TMPY-03123
    IL-13 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.35 kDa and the accession number is P20109.
    • $177
    In Stock
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    QTY
  • IL-13 Protein, Human, Recombinant
    TMPY-01993
    IL-13 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.5 kDa and the accession number is AAK53823.1.
    • $57
    In Stock
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  • IL-10 Protein, Human, Recombinant
    TMPY-03547
    IL-10 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is P22301.
    • $177
    In Stock
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    QTY
  • IL-17A Protein, Mouse, Recombinant
    TMPY-02900
    IL-17A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.5 kDa and the accession number is Q62386.
    • $228
    In Stock
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    QTY
  • IL-25/IL17E Protein, Mouse, Recombinant (His)
    TMPY-00855
    IL-25 IL17E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q8VHH8.
    • $296
    In Stock
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    QTY
  • IL-4 Protein, Human, Recombinant (His)
    TMPJ-00035
    IL-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P05112.
    • $83
    In Stock
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    QTY
  • IL-7 Protein, Human, Recombinant
    TMPY-03383
    IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1.
    • $126
    In Stock
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    QTY
  • IL-7 Protein, Mouse, Recombinant
    TMPY-00524
    IL-7 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P10168.
    • $107
    In Stock
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    QTY
  • IL-10 Protein, Mouse, Recombinant
    TMPY-05064
    IL-10 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.9 kDa and the accession number is A0A7R8GUQ3.
    • $126
    In Stock
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    QTY
  • IL-27 Protein, Mouse, Recombinant (His)
    TMPY-03153
    IL-27 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.5 kDa and the accession number is O35228&Q8K3I6.
    • $191
    In Stock
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    QTY
  • IL-6 Protein, Rat, Recombinant
    TMPY-03298
    IL-6 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is A6KJN3.
    • $177
    In Stock
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    QTY
  • IL-11 Protein, Human, Recombinant
    TMPY-03488
    IL-11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.1 kDa and the accession number is AAH12506.1.
    • $106
    In Stock
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  • IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated
    TMPY-05648
    IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.6 kDa and the accession number is NP_002178.2&NP_057668.1.
    • $296
    In Stock
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  • IL-1 beta/IL-1F2 Protein, Rat, Recombinant (mature form)
    TMPY-02227
    IL-1 beta IL-1F2 Protein, Rat, Recombinant (mature form) is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is Q63264-1.
    • $177
    In Stock
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  • IL-22 Protein, Human, Recombinant
    TMPY-03490
    IL-22 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.9 kDa and the accession number is A0A7R8C389.
    • $177
    In Stock
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    QTY
  • IL-15 & IL-15RA Protein, Mouse, Recombinant (His)
    TMPY-06531
    IL-15 & IL-15RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.46 kDa and the accession number is P48346-1 & Q60819-1.
    • $700
    In Stock
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  • IL-17 Protein, Mouse, Recombinant (His)
    TMPJ-01172
    Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.
    • $83
    In Stock
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  • IL-12 Protein, Mouse, Recombinant (hFc)
    TMPY-02349
    IL-12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 111.5 kDa and the accession number is P43431&P43432.
    • $695
    In Stock
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  • IL-9 Protein, Mouse, Recombinant (His)
    TMPY-05221
    IL-9 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is P15247.
    • $695
    In Stock
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    QTY
  • IL-27 Protein, Human, Recombinant (His)
    TMPY-03142
    IL-27 Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is NP_005746.2&NP_663634.2.
    • $57
    In Stock
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    QTY
  • IL-16 Protein, Mouse, Recombinant (His)
    TMPY-04212
    IL-16 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.5 kDa and the accession number is O54824-1.
    • $275
    In Stock
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    QTY
  • IL-1 alpha/IL-1A Protein, Mouse, Recombinant
    TMPY-01738
    IL-1 alpha IL-1A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is P01582.
    • $177
    In Stock
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    QTY
  • IL-17B Protein, Human, Recombinant (hFc)
    TMPY-00400
    IL-17B Protein, Human, Recombinant (hFc) is expressed in Baculovirus insect cells with hFc tag. The predicted molecular weight is 44.9 kDa and the accession number is Q9UHF5.
    • $539
    In Stock
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    QTY
  • IL-11 Protein, Mouse, Recombinant
    TMPY-04178
    IL-11 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.2 kDa and the accession number is A3KPB8.
    • $127
    In Stock
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    QTY
  • IL-2 Protein, Human, Recombinant (E. coli)
    TMPJ-01463
    IL-2 Protein, Human, Recombinant (E. coli) is expressed in E. coli expression system. The accession number is P60568.
    • $38
    In Stock
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    QTY
  • IL-31 Protein, Cynomolgus, Recombinant (His)
    TMPY-05523
    IL-31 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.8 kDa and the accession number is A0A8J8XFW3.
    • $296
    In Stock
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    QTY
  • IL-21 Protein, Mouse, Recombinant
    TMPY-02806
    IL-21 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.3kDa and the accession number is Q9ES17.
    • $275
    In Stock
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    QTY
  • IL-12 Protein, Human, Recombinant
    TMPY-04863
    IL-12 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.2 kDa and the accession number is P29459-1&NP_002178.2.
    • $106
    In Stock
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    QTY
  • IL-17F Protein, Mouse, Recombinant (His & Avi)
    TMPK-00041
    IL-17F Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17.8 kDa and the accession number is Q7TNI7-1.
    • $487
    In Stock
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    QTY
  • IL-18 Protein, Mouse, Recombinant
    TMPY-03273
    IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.
    • $191
    In Stock
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  • IL-32 Protein, Human, Recombinant (isoform alpha, His)
    TMPY-01033
    IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, Mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis, and in the human stomach cancer, human lung cancer, and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.
    • $462
    In Stock
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    QTY
  • IL-13 Protein, Human, Recombinant (His)
    TMPJ-00575
    IL-13 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 13-30 KDa and the accession number is AAH96139.
    • $118
    In Stock
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  • IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant
    TMPY-01956
    IL-36 alpha IL-1F6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q9JLA2-1.
    • $462
    In Stock
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  • IL-20 Protein, Mouse, Recombinant (His)
    TMPK-01198
    Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC. IL-20 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 19.5 kDa and the accession number is Q9JKV9.
    • $418
    In Stock
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    QTY
  • IL-36RN/IL-1F5 Protein, Mouse, Recombinant
    TMPY-04275
    IL-36RN IL-1F5 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is Q9QYY1.
    • $462
    In Stock
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  • IL-17A Protein, Rat, Recombinant (His)
    TMPH-03319
    IL-17A Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.0 kDa and the accession number is Q61453.
    • $237
    20 days
    Size
    QTY
  • IL-33 Protein, Mouse, Recombinant
    TMPJ-01210
    Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.
    • $83
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  • IL-1 beta/IL-1F2 Protein, Human, Recombinant (His & Avi)
    TMPK-00161
    Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after inflammasome-mediated activation. IL-1 signaling activates innate immune cells including antigen presenting cells, and drives polarization of CD4 T cells towards T helper type (Th) 1 and Th17 cells. IL-1 beta IL-1F2 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with C-His-Avi tag. The predicted molecular weight is 20.1 kDa and the accession number is P01584.
    • $418
    7-10 days
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