hydrolase

EC5026 (BPN-19186) has the potential to relieve pain by stabilizing natural analgesic and anti-inflammatory mediators.

BI-1935 is an inhibitor of soluble epoxide hydrolase (sEH). For diseases related to cardiovascular disease.

JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2.

CUDA is an effective soluble cyclohydrolase inhibitor with IC50 of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively. CUDA selectively increases the activity of peroxisome proliferator-activated receptor (PPAR) alpha. CUDA may be valuable for the study of cardiovascular diseases.

trans-AUCB (t-AUCB) is an effective and selective soluble epoxide hydrolase inhibitor, with IC50 values of 1.3 nM for hsEH, 8 nM for mouse sEH, and 8 nM for rat sEH.

PF-3845 is a potent, selective, and irreversible FAAH inhibitor with a Ki of 230 nM, exhibiting negligible activity against FAAH2.

TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.

AUDA is an inhibitor of sEH(IC50 values of 18 and 69 nM for the mouse and human enzymes, respectively)

AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)

Soluble epoxide hydrolase inhibitor is a soluble epoxide hydrolase inhibitor (human soluble epoxide hydrolase (h-sEH) with pIC50 of 8.4).

α/β-Hydrolase-IN-1 demonstrates exceptional potency, with MICs of 50 μM (25 μg/mL) against M. smegmatis and 16 μM (8.4 μg/mL) against M. tuberculosis H37Ra, establishing it as a superior compound in this class.

Nucleoside hydrolase (IAGNH), a type of glycosidase, facilitates the recycling of nucleobases and ribose by catalyzing the cleavage of the N-glycosidic bond in nucleosides.

Serine Hydrolase Inhibitor-21 (compound 8), a pyridine-based serine hydrolase inhibitor, exhibits a K i of 429 nM against BuChE, and shows promise for Alzheimer's disease research [1].

Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) comprising a cereblon ligand linked to the sEH inhibitor t-TUCB via a linker, promoting selective sEH degradation and inhibiting its hydrolase activity (IC50 = 0.8 nM) significantly more than its phosphatase activity (IC50 = >10,000 nM). This compound preferentially targets cytosolic sEH for lysosomal rather than proteasomal degradation. Furthermore, it mitigates thapsigargin-induced upregulation of phosphorylated inositol-requiring enzyme 1α (IRE1α) and X-box binding protein 1 (XBP1) splicing in HepG2 and 293T cells, thereby reducing endoplasmic reticulum stress.

Rhamnogalacturonan hydrolase, Bacteroides thetaiotaomicron (EC 4.2.2.23), is an enzyme capable of hydrolyzing rhamnogalacturonan.

Rhamnogalacturonan hydrolase, Clostridium thermocellum (EC 4.2.2.23), is an enzyme capable of hydrolyzing rhamnogalacturonan.

Poly(ethylene terephthalate) hydrolase is an enzyme that facilitates the decomposition of poly(ethylene terephthalate) (PET), which is one of the most prevalent discarded plastics.

Trehalose-6-phosphate hydrolase, Escherichia coli (EC 3.2.1.93), is a member of the hydrolase family, functioning as a glycosidase that hydrolyzes O- and S-glycosyl compounds. This enzyme plays a role in the metabolism of starch and sucrose, with substrates α,α-trehalose-6-phosphate and water, producing D-glucose and D-glucose-6-phosphate.

Trehalose-6-phosphate hydrolase, also known as Bacillus subtilis (EC 3.2.1.93), is part of the hydrolase enzyme family specializing in the hydrolysis of O- and S-glycosidic compounds. It plays a role in the metabolism of starch and sucrose. The substrates for this enzyme are α,α'-trehalose-6-phosphate and water, producing D-glucose and D-glucose-6-phosphate as products.

Epoxide Hydrolase, Rhodococcus rhodochrous (EC 3.3.2.3), converts epoxides into trans-dihydrodiols, which can subsequently bind with other substances and be excreted from the body. Epoxides are byproducts of the degradation of aromatic compounds.

S-(5'-Adenosyl)-L-homocysteine Hydrolase, Rabbit (EC 3.3.1.1), is an enzyme found in vertebrates that catalyzes the breakdown of S-adenosyl-L-homocysteine.

γ-Glutamyl hydrolase is a biochemical reagent that serves as a biomaterial or organic compound for research in life sciences.

3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 µM). It has anti-inflammatory, anti-proliferative, and anti-HIV activity.

Gut restricted-7 (GR-7) is a potent, covalent, orally administered, gut-selective bile salt hydrolase (BSH) inhibitor with tissue specificity that localizes to the gut. Gut restricted-7 reduces BSH activity in gut bacteria and decreases levels of unconjugated bile acids in mouse feces, making it suitable for research into metabolism, inflammation, and intestinal diseases.