COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme (specifically, a family of isozymes) that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member of the animal-type heme peroxidase family, it is also known as prostaglandin G/H synthase.

Cat. No.	Product name	CAS No.	Purity
TN4420	Latifolin	10154-42-4	98%
TN4420	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
T15345	FR-188582	189699-82-9	98%
T15345	FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).
T13263	COX/5-LO-IN-1	154355-75-6	98%
T13263	COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.
T13160	Timegadine	71079-19-1	98%
T13160	Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μM f...
T10152L	4-Methylamino antipyrine hydrochloride	856307-27-2	98%
T10152L	4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibit...
T16419	Oxyphenbutazone	129-20-4	98%
T16419	Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectively...
TN1871	Ligustroside	35897-92-8	98%
TN1871	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN2775	2-Methoxystypandrone	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TMA1122	N-Feruloylserotonin	68573-23-9	98%
TMA1122	Moschamine is a very potent compound that is able to inhibit COX-I by 58% and COX-II by 54%, at the concentration of 0.1 μmol L⁻1, it may suppress cAMP for...
T6470	Diclofenac Potassium	15307-81-0	98%
T6470	Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
T11761	Tarlox-TKI	2135696-72-7	98%
T11761	Kinase inhibitor-1 is a kinase inhibitor.
TN4675	Nortrachelogenin	34444-37-6	98%
TN4675	Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN4064	Flavoglaucin	523-73-9	98%
TN4064	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannab...
TN3587	Capillarisin	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4752	Perilloxin	263249-77-0	98%
TN4752	Perilloxin possesses inhibitory activities against cyclooxygenase-1,with IC(50) values of 23.2 microM.
TN6672	Cyclo(L-Phe-L-Pro)	3705-26-8	98%
TN6672	Cyclo(L-Phe-L-Pro) shows broad-spectrum antibacterial and antifungal activities. Cyclo(L-Phe-L-Pro) exhibits activity against methicillin-resistant S. aureus and...
T15687	Thioflosulide	158205-05-1	98%
T15687	Thioflosulide is a selective cyclooxygenase-2 inhibitor (IC50: 2.3 nM). It also shows anti-inflammatory activity.
TN1062	Peonidin chloride	134-01-0	98%
TN1062	Peonidin chloride has antioxidant activity. Peonidin has show potent inhibitory and apoptotic effects on cancer cells in vitro, notably metastatic human breast c...
TN1143	1-O-Acetyl britannilactone	681457-46-5	98%
TN1143	1-O-Acetyl britannilactone shows antifungal, and anti-cancer activities, it suppresses angiogenesis and lung cancer cell growth possibly via regulating the VEGFR...
TN3410	Anatabine	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...