Rhizopodin is a potent natural macrolide antibiotic that effectively affects the actin cytoskeleton at nanomolar concentrations.

Chalcomycin is a macrolide antibiotic effective against Gram-positive Staphylococcus aureus and Streptococcus pyogenes. It protects mice from infections caused by various Staphylococcus and Streptococcus strains and exhibits no significant toxicity (LD50>2500 mg/kg).

Diastovaricin I (30-Hydroxy-naphthomycin C) is an antibiotic that does not exhibit antimicrobial activity. It promotes differentiation in mouse Friend cells.

Carbomycin B is an intermediate in the synthesis of Carbomycin. Carbomycin is a macrolite antibiotic complex produced by Stroptomyces halstedii, that is similar to Leucomycin and Erythromycin.

Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases (IC50 = 5 nM), thereby blocking vacuolar organelle acidification and early to late endosomal transport. It interferes with bone resorption, maturation of CD8 T lymphocytes, and prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting MHC class II molecule expression on the cell surface.

10-Deoxymethymycin (AntibioticYC 17) exhibits antibiotic activity against Gram-positive bacteria.

Lankamycin is a macrolide antibiotic from various strains of Streptomyces. It may have significant activity against some Gram positive bacteria.

Onychocin B is a cyclic tetrapeptide isolated from Onychocola sclerotica. It functions as a calcium channel blocker with an IC50 value of 7.1 μM for Cav1.2.

Midecamycin A4 is a macrolide compound that exhibits strong activity against Gram-positive bacteria and shows weak activity against Gram-negative bacteria, mycobacteria, and fungi.

Dihydroniphimycin exhibits antifungal activity and is effective against yeasts and Gram-positive bacteria.

Monamycin IV is an ester peptide antibiotic active against Gram-positive bacteria.

Monamycin B is an ester peptide antibiotic with activity against Gram-positive bacteria.

Espinomycin A3 is a 16-membered macrolide antibiotic (antibiotic) that exhibits activity against Gram-positive bacteria.

Flavomycoin is an antibiotic known for its antifungal properties.

Mycoplanecin A is a cyclic peptide antibiotic with potent activity against mycobacteria, xanthomonads, and Staphylococcus aureus. Additionally, Mycoplanecin A exhibits moderate antibacterial effects on Xanthomonas oryzae. It also demonstrates antimicrobial activity against certain strains of actinobacteria.

Cirramycin B1 exhibits activity against both Gram-positive bacteria, Gram-negative bacteria, and mycoplasmas.

Juvenimicin A2 is effective against Gram-positive bacteria and certain Gram-negative bacteria.

Naphthomycin B is an antibiotic that was originally isolated from Streptomyces sp. It exhibits antibacterial activity against gram-positive bacteria and various fungi.

Diperamycin demonstrates activity against Gram-positive bacteria, including Enterococci and MRSA, with MIC ranging from 0.10 to 0.20 μg/mL. It also strongly inhibits the activity of cell lines L1210, P388, LS-180, KB, HeLaS3, Meth A, and B16-BL6, with IC50 values between 0.009 and 0.098 μg/mL.

Maridomycin V is a macrolide antibiotic. It is effective against both Gram-positive bacteria and mycoplasmas, and provides protective effects in mice with Gram-positive bacterial infections.

Pristinamycin IIB is a streptolysin antibiotic that exhibits activity against Gram-positive bacteria.

Hormaomycin is an effective and selective macrolide antibiotic with broad-spectrum antimicrobial activity against various Gram-positive bacteria.

Cochleamycin A exhibits strong inhibitory activity against tumor cells, with IC50 values (μg/mL) of 1.6, 14.0, 6.2, 16.5, and 19.1 for P388, HL60, K562, COL0205, and HT29 cells, respectively. Additionally, Cochleamycin A possesses activity against Gram-positive bacteria.

Desertomycin B is the guanidine form of an antibiotic and a minor fermentation product of *Streptomyces flavofungi*.