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STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN1631 Eupalinolide K 108657-10-9
Eupalinolide K
Eupalinolide K is a natural product
TN1840 Kurarinol 855746-98-4 98%
Kurarinol
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
T78983 STAT3 degrader-2 2497583-03-4 98%
STAT3 degrader-2
STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseas...
T79185 STAT6-IN-2 1355594-85-2 98%
STAT6-IN-2
STAT6-IN-2 (Comp R-84) serves as a STAT6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltrati...
T79186 STAT6-IN-3 371919-80-1 98%
STAT6-IN-3
STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain. It is utilized in ...
T79662 STAT3-IN-20 2768427-54-7 98%
STAT3-IN-20
STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear tra...
T80639 HJC0152 free base 1420290-88-5 98%
HJC0152 free base
HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograft ...
T80847 W1131 TFA 98%
W1131 TFA
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric...
T81690 Neocucurbitacin A 352359-53-6 98%
Neocucurbitacin A
Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].
T14925 Cenisertib 871357-89-0 98%
Cenisertib
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
TN4035 Eupalinolide I 1402067-84-8 98%
Eupalinolide I
Eupalinolide I is a natural product from Eupatorium lindleyanum.
TN3587 Capillarisin 56365-38-9 98%
Capillarisin
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
T13010 STAT3-IN-3 2361304-26-7 98%
STAT3-IN-3
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
TN3410 Anatabine 581-49-7 98%
Anatabine
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN3525 Boehmenan 57296-22-7 98%
Boehmenan
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN2511 Britannilactone diacetate 1286694-67-4 98%
Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
T11449L2 Golotimod (TFA) (229305-39-9 free base) T11449L2 98%
Golotimod (TFA) (229305-39-9 free base)
Golotimod TFA (SCV 07 TFA) is an immunomodulatory peptide with antibacterial properties that significantly increases the effectiveness of anti-tuberculosis studi...
TN4774 Physalin A 23027-91-0 98%
Physalin A
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T12905 SI-109 T12905 98%
SI-109
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T19886 Cirsilineol 41365-32-6 98%
Cirsilineol
Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineo...
Eupalinolide K
TN1631
Eupalinolide K is a natural product
Kurarinol
TN1840
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
STAT3 degrader-2
T78983
STAT3 Degrader-2 is a PROTAC-based compound that effectively reduces the total STAT3 protein levels, and is utilized in the research of cancer and various diseas...
STAT6-IN-2
T79185
STAT6-IN-2 (Comp R-84) serves as a STAT6 inhibitor, effectively reducing the secretion of the chemokine eotaxin-3, which is known to induce eosinophil infiltrati...
STAT6-IN-3
T79186
STAT6-IN-3 (Compound 18a) serves as an inhibitor of STAT6 with an IC50 value of 44 nM, specifically targeting the Src Homology 2 (SH2) domain. It is utilized in ...
STAT3-IN-20
T79662
STAT3-IN-20 (Compound 40), with an IC50 of 0.65 μM, is a selective inhibitor targeting the SH2 domain of STAT3, thereby impeding its phosphorylation, nuclear tra...
HJC0152 free base
T80639
HJC0152 (free base) is an orally active, potent STAT3 inhibitor that impedes cell cycle progression, induces apoptosis, and notably reduces MDA-MB-231 xenograft ...
W1131 TFA
T80847
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric...
Neocucurbitacin A
T81690
Neocucurbitacin A (compound 7), a STAT3 inhibitor extracted from the pericarp of Aquilaria crassna, serves as a potential agent for anticancer research [1].
Cenisertib
T14925
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
Eupalinolide I
TN4035
Eupalinolide I is a natural product from Eupatorium lindleyanum.
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
STAT3-IN-3
T13010
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Golotimod (TFA) (229305-39-9 free base)
T11449L2
Golotimod TFA (SCV 07 TFA) is an immunomodulatory peptide with antibacterial properties that significantly increases the effectiveness of anti-tuberculosis studi...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
SI-109
T12905
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
Cirsilineol
T19886
Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineo...
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