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STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1013 Cucurbitacin D 3877-86-9 98%
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
T14330 Ascochlorin 26166-39-2 98%
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlor...
TN2775 2-Methoxystypandrone 85122-21-0 98%
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
TN2511 Britannilactone diacetate 1286694-67-4 98%
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
T4571 Balsalazide 80573-04-2 98%
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
TN4490 Manassantin B 88497-88-5 98%
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
TN1840 Kurarinol 855746-98-4 98%
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
TN4604 Myricanone 32492-74-3 98%
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T11449 Golotimod hydrochloride (229305-39-9 free base) T11449 98%
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
T12905 SI-109 T12905 98%
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T121011 TLC1566-0618 708218-62-6 98%
TLC1566-0618 shows antitumor activity and targets stat.
TN4035 Eupalinolide I 1402067-84-8 98%
Eupalinolide I is a natural product from Eupatorium lindleyanum.
T13010 STAT3-IN-3 2361304-26-7 98%
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
T19886 Cirsilineol 41365-32-6 98%
Cirsilineol is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selective...
T11449L Golotimod 229305-39-9 98%
Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and spl...
TN3525 Boehmenan 57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN3410 Anatabine 581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4489 Manassantin A 88497-87-4 98%
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN1775 Isocryptotanshinone 22550-15-8 98%
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
TN1631 Eupalinolide K 108657-10-9 98%
Eupalinolide K is a natural product
Cucurbitacin D
TN1013
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
Ascochlorin
T14330
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlor...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Balsalazide
T4571
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
Manassantin B
TN4490
Manassantin B is a potent inhibitor of NF-κB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-κB. It also possesses anti-EBV ...
Kurarinol
TN1840
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
Myricanone
TN4604
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Golotimod hydrochloride (229305-39-9 free base)
T11449
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
SI-109
T12905
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
TLC1566-0618
T121011
TLC1566-0618 shows antitumor activity and targets stat.
Eupalinolide I
TN4035
Eupalinolide I is a natural product from Eupatorium lindleyanum.
STAT3-IN-3
T13010
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
Cirsilineol
T19886
Cirsilineol is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selective...
Golotimod
T11449L
Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and spl...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
Isocryptotanshinone
TN1775
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
Eupalinolide K
TN1631
Eupalinolide K is a natural product
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