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STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.
Cat. No. Product name CAS No. Purity Chemical Structure
TN1631 Eupalinolide K 108657-10-9
Eupalinolide K is a natural product
TN1840 Kurarinol 855746-98-4 98%
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
T14925 Cenisertib 871357-89-0 98%
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
TN4035 Eupalinolide I 1402067-84-8 98%
Eupalinolide I is a natural product from Eupatorium lindleyanum.
TN3587 Capillarisin 56365-38-9 98%
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
T13010 STAT3-IN-3 2361304-26-7 98%
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
TN3410 Anatabine 581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN3525 Boehmenan 57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
TN2511 Britannilactone diacetate 1286694-67-4 98%
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
T11449L2 Golotimod (TFA) (229305-39-9 free base) T11449L2 98%
Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and...
TN4774 Physalin A 23027-91-0 98%
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
T12905 SI-109 T12905 98%
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T19886 Cirsilineol 41365-32-6 98%
Cirsilineol is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selective...
TN1775 Isocryptotanshinone 22550-15-8 98%
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
TMA1743 Ergosterol peroxide 2061-64-5 98%
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T11449 Golotimod hydrochloride (229305-39-9 free base) T11449 98%
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
TN4489 Manassantin A 88497-87-4 98%
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
T15234 ENMD-1198 864668-87-1 98%
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
TN4356 Jolkinolide A 37905-07-0 98%
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
TN2775 2-Methoxystypandrone 85122-21-0 98%
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
Eupalinolide K
TN1631
Eupalinolide K is a natural product
Kurarinol
TN1840
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying...
Cenisertib
T14925
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well a...
Eupalinolide I
TN4035
Eupalinolide I is a natural product from Eupatorium lindleyanum.
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
STAT3-IN-3
T13010
STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Golotimod (TFA) (229305-39-9 free base)
T11449L2
Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and...
Physalin A
TN4774
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
SI-109
T12905
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
Cirsilineol
T19886
Cirsilineol is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selective...
Isocryptotanshinone
TN1775
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
Ergosterol peroxide
TMA1743
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
Golotimod hydrochloride (229305-39-9 free base)
T11449
Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
ENMD-1198
T15234
ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
Jolkinolide A
TN4356
Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
2-Methoxystypandrone
TN2775
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflamm...
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