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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

Immunology/Inflammation related

Both the inflammatory response and the immune response are the body's defense mechanisms against various internal and external stimuli. The inflammatory response is often part of the immune response, which is usually acute and non-specific, whereas the immune response can be specific and may last longer after the infection has cleared. The inflammatory response functions primarily through local effects, while the immune response involves systemic regulation.

Filter HomeSignaling PathwaysImmunology/InflammationImmunology/Inflammation related

Galiximab

T76809357613-77-5

Galiximab (IDEC 114) is a primate-type anti-CD80 immunoglobulin G1 (IgG1)-like monoclonal antibody with antitumor activity that induces in vivo growth inhibition and prolongs survival of B-NHL tumor xenografts. Galiximab has been used in the study of hematologic malignancies.

$247

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Tamarixetin

TN1039603-61-2

Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin that exhibits anti-inflammatory and antioxidative effects, offering protection against cardiac hypertrophy.

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Carotuximab

T769411268714-50-6

Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.

$129

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Glycyrrhisoflavone

TN1705116709-70-7

Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.

$119

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Dehydropachymic acid

TN156377012-31-8

(S)-Leucic acid is an amino acid metabolite used as a muscle builder.

$113

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MG-T-19

T201721328540-44-9

MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells.

$195

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N-trans-caffeoyltyramine

TN6457103188-48-3

N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) is a modulator of inflammatory responses and can be used in studies about treatment for chronic inflammatory diseases.

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Ac-YVAD-CMK

T36347178603-78-6

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.

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1,3,6-Tri-O-galloyl-beta-D-glucose

TN116618483-17-5

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.

$118

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Dehydrotumulosic acid

TN10856754-16-1

Dehydrotumulosic acid shows anti-inflammatory activity.

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GI254023X

T7522260264-93-5

GI254023X is a MMP9 and ADAM10 inhibitor with IC50 values of 2.5 and 5.3 nM, respectively. GI254023X can also significantly inhibit the proliferation of Jurkat cells and induce apoptosis.

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Pirazolac

T1248471002-09-0In house

Pirazolac (ZK-76604) is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.

$293

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Vadastuximab

T77389

Vadastuximab (Anti-Human CD33 Recombinant Antibody) is a humanized anti-CD33 monoclonal antibody that can be used for the synthesis of the ADC compound Vadastuximab talirine and for the study of acute myeloid leukemia (AML).

$328

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Sericoside

T12466355306-04-2

Sericoside, a triterpenoid compound, is obtained from Terminalia and exhibits potent anti-inflammatory properties. Additionally, sericoside displays robust lipolytic activity, thereby aiding in the reduction of skin wrinkles and improvement of skin texture.

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(+)-Isolariciresinol

TN1782548-29-8

(+)-Isolariciresinol ((+)-Cyclolariciresinol) is extracted from Radix Isatidis, exhibits antioxidant and anti-inflammatory activities, and is applicable in rheumatism studies.

$129

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Tafasitamab

T771351422527-84-1

Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.

$428

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Antalarmin hydrochloride

T22577220953-69-5

Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.

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beta-Escin

T884611072-93-8

beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.

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Telazorlimab

T773692126777-87-3

Telazorlimab (GBR-830) is a humanized monoclonal antibody targeting the OX40 co-stimulatory receptor on activated T cells, and is used to treat lupus erythematosus and atopic dermatitis.

$247

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Tormentic acid

TN111813850-16-3

Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,

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INCB3619

T27603791826-72-7In house

INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.

$183

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Schisantherin E

T3S192564917-83-5

Schisantherin E is a natural lignan isolated from Schisandra chinensis. Schisandra chinensis has antioxidant, hepatoprotective, sedative, anticancer, anti-SARS and anti-inflammatory activities.

$213

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Lintuzumab

T9901A-065166089-32-3

Lintuzumab (HuM-195) is a non-coupled humanized mouse monoclonal antibody directed against the cell-surface myelomonocyte differentiation antigen, CD33, with anti-leukemic activity that reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells.Lintuzumab has antitumor activity and induces cell death directly via CDC or ADCC. Lintuzumab has anti-tumor activity and induces cell death directly via CDC or ADCC.

$163

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Meranzin

TN101523971-42-8

Meranzin, a bioactive compound derived from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) and isolated from Murraya exotica L. leaves, targets the alpha 2-adrenoceptor and engages the AMPA-ERK1 2–BDNF signaling pathway. It offers promising potential for preventing the comorbidity of atherosclerosis and depression due to its significant anti-inflammatory and analgesic properties.

$106

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