biochemical

β-D-Glucose pentaacetate (Penta-O-acetyl-β-D-glucopyranose) is a natural product.

CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).

DHX9-IN-18 is an inhibitor of RNA helicase DHX9 with an EC50 of 16.4 μM and a biochemical infection point of 0.32 μM. This compound can be used as a research tool in cancer-related research fields.

ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.

Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulinic acid synthetase activity through biochemical feedback.

Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.RP-3500 is 30-fold more selective for ATR than mTOR (IC50: 120 nM) and more than 2,000-fold more potent than ATM, DNA-PK and PI3Kα kinases. RP-3500 is 30 times more selective for ATR than mTOR (IC50: 120 nM), and 2,000 times more selective than ATM, DNA-PK and PI3Kα kinases.

Mutant IDH1-IN-2 is an inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with an IC50 of 16.6 nM in fluorescence biochemical assay and an IC50 of <22 nM in LS-MS biochemical assay.

Compound 9686314 is a high-purity biochemical reagent, suitable for biochemical experiments and drug synthesis research.

Compound 9686312 is a high-purity biochemical reagent, suitable for biochemical experiments and drug synthesis research.

Methyl 3-[2-[[(4R)-4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl]methylamino]ethyl]benzoate is a biochemical reagent that can be used to synthesize active compounds.

PAOPA belongs to natural product derivatives and serves as an allosteric modulator of the dopamine D2 receptor, possessing the characteristic of promoting binding between high-affinity D2 receptors and agonists. This compound finds application in preclinical studies for schizophrenia and extrapyramidal dysfunction, effectively alleviating behavioral and biochemical abnormalities in rodent models.

(R)-PF-04822163 is an isomer of PF-04822163. PF-04822163 is an oral, selective PDE1 inhibitor that can cross the blood-brain barrier. PF-04822163 can be used in studies about nervous system disorders such as attention deficit hyperactivity disorder (ADHD) and Parkinson’s disease.

Nafetolol (K 5407) exhibits selective efficacy on cardiac (β1)-adrenergic receptors and serves as an orally active beta-blocker, demonstrating a half-life of approximately 2 hours in canine models.

Itaconate-alkyne (ITalk) is a bioorthogonal probe for quantitative, site-specific chemoproteomic profiling of itaconate in inflammatory macrophages, facilitating biochemical evaluation and proteomic analysis of its direct targets.

PF-6689840 is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays; inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.25 uM; demonstrates superior kinase selectivity compared to the Type I inhibitors; inhibits tumor cell growth, which is independent of PTK6 expression levels in cells.

Iso-Samidorphan is a biochemical reagent that can be used in biological experiments.

EOB-DTPA is a biochemical reagent that can be synthesized from other compounds and is commonly used in MRI.

CCG-13514 is a biochemical reagent to be developed for biosynthesis.

2-Anilinoethanol can be used to synthesize biomarkers and assist biochemical studies.

Pyrazinamine is a synthetic intermediate that can be used in a variety of scientific research applications, including as a synthetic reagent and as a biochemical and physiological reagent.

2-Cyclohexen-1-one can be used as a specific reaction substrate or molecular probe in biochemical experiments, often assisting in exploring the interactions between cyclic unsaturated ketones and enzymes as well as biological macromolecules. 2-Cyclohexen-1-one is a practical reagent for analyzing the reaction mechanisms of related molecules in biochemical research.

Uracil is a common naturally occurring pyrimidine found in RNA, it base pairs with adenine and is replaced by thymine in DNA. Methylation of uracil produces thymine. Uracil's use in the body is to help carry out the synthesis of many enzymes necessary for cell function through bonding with riboses and phosphates. Uracil serves as allosteric regulator and coenzyme for many important biochemical reactions.

Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate.

3,4,5-Trimethoxybenzoic acid (Gallic acid trimethyl ether) are potent antioxidants and inhibitor of cytokine production. It can ameliorate chronic stress-induced various behavioral and biochemical alterations in mice. It also exerts hepatoprotective effects in CCl4-induced rats, specifically by modulating oxidative-nitrosative stress and inflammation.